M. Cutolo

Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology

Buttgereit, F, Boers, M, Burmester, G, Cutolo, M, Jacobs, J, ...

In rheumatology and other medical specialties there is a discrepancy between the widespread use and the imprecise designation of glucocorticoid treatment regimens. Verbal descriptions of...

Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis

Cutolo, M, Sulli, A, Ghiorzo, P, Pizzorni, C, Craviotto, C, Villaggio, B

Background: Leflunomide and its active metabolite A77 1726 reversibly inhibits the enzyme dihydro-orotate dehydrogenase, the rate limiting step in de novo synthesis of pyrimidines and progression of...

Circadian melatonin and cortisol levels in rheumatoid arthritis patients in winter time: a north and south Europe comparison

Cutolo, M, Maestroni, G, Otsa, K, Aakre, O, Villaggio, B, Capellino, S, ...

Background: Altered functioning of the hypothalamic-pituitary-adrenal axis and altered melatonin production might modulate the circadian symptoms in patients with rheumatoid arthritis.

White matter hyperintensities on brain magnetic resonance in systemic sclerosis

Sardanelli, F, Iozzelli, A, Cotticelli, B, Losacco, C, Cutolo, M, Sulli, A, ...

Methods: Fourteen female patients with SSc aged 24–74, with a disease duration of 1–12 years and without other relevant systemic diseases, were enrolled. All patients and an age matched female...

Androgen metabolism and inhibition of interleukin-1 synthesis in primary cultured human synovial macrophages

Cutolo, M., Accardo, S., Villaggio, B., Barone, A., Sulli, A., Balleari, E., ...

The presence of androgen receptors on synovial macrophages in human normal and rheumatoid synovial tissues has been described previously. It is now reported that primary cultured human macrophages...