M. D. Appleman

Comparative in vitro activities of trovafloxacin (CP-99,219) against 221 aerobic and 217 anaerobic bacteria isolated from patients with intra-abdominal infections.

Citron, D M, Appleman, M D

Four hundred thirty-eight bacteria cultured from specimens of patients with serious intra-abdominal infections were tested by agar dilution against trovafloxacin and other quinolones and...

Intraoperative concentrations of ofloxacin in serum, bile fluid, and gallbladder wall tissue.

Chin, A, Okamoto, M P, Gill, M A, Sclar, D A, Berne, T V, Yellin, A E, ...

To evaluate concentrations of ofloxacin in serum, bile fluid, and gallbladder wall tissue after intravenous administration, patients greater than or equal to 16 years old diagnosed with acute...

Degradation of Oil Shale by Sulfur-Oxidizing Bacteria

Findley, J., Appleman, M. D., Yen, T. F.

Approximately 40% of oil shale can be solubilized by the action of sulfur-oxidizing bacteria. Thiobacillus thiooxidans and Thiobacillus concretivorous are equally effective in solubilization....

Requirement of heme for growth of Bacteroides fragilis.

Sperry, J F, Appleman, M D, Wilkins, T D

Heme or protoporphyrin IX was required for growth of Bacteroides fragilis in a defined medium. The amount of heme necessary for half-maximal growth was 2 to 10 ng/ml (3.8 to 15 pmol/ml) among the...

Evaluation of the Antibiotic Removal Device.

Appleman, M D, Swinney, R S, Heseltine, P N

A new system called an Antibiotic Removal Device (ARD), used for the removal of residual antibiotics in blood specimens, was studied in 300 patients diagnosed as clinically septic despite...

Pharmacokinetics of meropenem in patients with intra-abdominal infections.

Bedikian, A, Okamoto, M P, Nakahiro, R K, Farino, J, Heseltine, P N, Appleman, M D, ...

Noncompartmental and compartmental analyses of meropenem disposition in patients receiving 1-g intravenous intermittent infusions every 8 h were performed. Twelve patients (one woman and 11 men)...

Comparison of Tellurite Resistance and Tetracycline Resistance among the Enterococci12

Appleman, M. D., Heinmiller, I. M.

A correlation was found to exist between tellurite and tetracycline resistance in the enterococci.

Surgically treated gangrenous or perforated appendicitis. A comparison of aztreonam and clindamycin versus gentamicin and clindamycin.

Berne, T V, Yellin, A E, Appleman, M D, Gill, M A, Chenella, F C, Heseltine, P N

A randomized, double-blinded, controlled clinical study of 84 patients with surgically treated gangrenous or perforated appendicitis was done to compare the efficacy of the combination of aztreonam,...

Comparative in vitro activities of trovafloxacin (CP-99,219) against 221 aerobic and 217 anaerobic bacteria isolated from patients with intra-abdominal infections.

Citron, D M, Appleman, M D

Four hundred thirty-eight bacteria cultured from specimens of patients with serious intra-abdominal infections were tested by agar dilution against trovafloxacin and other quinolones and...

Intraoperative concentrations of ofloxacin in serum, bile fluid, and gallbladder wall tissue.

Chin, A, Okamoto, M P, Gill, M A, Sclar, D A, Berne, T V, Yellin, A E, ...

To evaluate concentrations of ofloxacin in serum, bile fluid, and gallbladder wall tissue after intravenous administration, patients greater than or equal to 16 years old diagnosed with acute...

Degradation of Oil Shale by Sulfur-Oxidizing Bacteria

Findley, J., Appleman, M. D., Yen, T. F.

Approximately 40% of oil shale can be solubilized by the action of sulfur-oxidizing bacteria. Thiobacillus thiooxidans and Thiobacillus concretivorous are equally effective in solubilization....

Requirement of heme for growth of Bacteroides fragilis.

Sperry, J F, Appleman, M D, Wilkins, T D

Heme or protoporphyrin IX was required for growth of Bacteroides fragilis in a defined medium. The amount of heme necessary for half-maximal growth was 2 to 10 ng/ml (3.8 to 15 pmol/ml) among the...

Evaluation of the Antibiotic Removal Device.

Appleman, M D, Swinney, R S, Heseltine, P N

A new system called an Antibiotic Removal Device (ARD), used for the removal of residual antibiotics in blood specimens, was studied in 300 patients diagnosed as clinically septic despite...

Pharmacokinetics of meropenem in patients with intra-abdominal infections.

Bedikian, A, Okamoto, M P, Nakahiro, R K, Farino, J, Heseltine, P N, Appleman, M D, ...

Noncompartmental and compartmental analyses of meropenem disposition in patients receiving 1-g intravenous intermittent infusions every 8 h were performed. Twelve patients (one woman and 11 men)...

Comparison of Tellurite Resistance and Tetracycline Resistance among the Enterococci12

Appleman, M. D., Heinmiller, I. M.

A correlation was found to exist between tellurite and tetracycline resistance in the enterococci.

Surgically treated gangrenous or perforated appendicitis. A comparison of aztreonam and clindamycin versus gentamicin and clindamycin.

Berne, T V, Yellin, A E, Appleman, M D, Gill, M A, Chenella, F C, Heseltine, P N

A randomized, double-blinded, controlled clinical study of 84 patients with surgically treated gangrenous or perforated appendicitis was done to compare the efficacy of the combination of aztreonam,...

Coccidioides immitis presenting as a hyphal form in cerebrospinal fluid.

Zepeda, M. R., Kobayashi, G. K., Appleman, M. D., Navarro, A.

This article reports a case of Coccidioides immitis that presented as a hyphal form in a 38-year-old patient. The organism was observed growing exclusively as hyphae in the cerebrospinal fluid by...