M. D. Wyatt

Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase. (1997)

Engelward, B.P., Weeda, G., Wyatt, M.D., Broekhof, J.L.M., Wit, J. De, Donker, I., ...

3-methyladenine (3MeA) DNA glycosylases remove 3MeAs from alkylated DNA to initiate the base excision repair pathway. Here we report the generation of mice deficient in the 3MeA DNA glycosylase...

The sequence specificity of alkylation for a series of benzoic acid mustard and imidazole-containing distamycin analogues: the importance of local sequence conformation.

Wyatt, M D, Lee, M, Hartley, J A

The covalent sequence specificity of a series of nitrogen mustard and imidazole-containing analogues of distamycin was determined using modified sequencing techniques. The analogues tether benzoic...

DNA sequence-specific adenine alkylation by the novel antitumor drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin.

Broggini, M, Coley, H M, Mongelli, N, Pesenti, E, Wyatt, M D, Hartley, J A, ...

FCE 24517, a novel distamycin derivative possessing potent antitumor activity, is under initial clinical investigation in Europe. In spite of the presence of a benzoyl nitrogen mustard group this...

The sequence specificity of alkylation for a series of benzoic acid mustard and imidazole-containing distamycin analogues: the importance of local sequence conformation.

Wyatt, M D, Lee, M, Hartley, J A

The covalent sequence specificity of a series of nitrogen mustard and imidazole-containing analogues of distamycin was determined using modified sequencing techniques. The analogues tether benzoic...

DNA sequence-specific adenine alkylation by the novel antitumor drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin.

Broggini, M, Coley, H M, Mongelli, N, Pesenti, E, Wyatt, M D, Hartley, J A, ...

FCE 24517, a novel distamycin derivative possessing potent antitumor activity, is under initial clinical investigation in Europe. In spite of the presence of a benzoyl nitrogen mustard group this...