Krishna, R, Bergman, A, Jin, B, Fallon, M, Cote, J, Van Hoydonck, P, ...
Cholesteryl ester transfer protein (CETP) is a plasma protein that catalyzes the heteroexchange of cholesteryl esters from high-density lipoprotein (HDL) and trglycerides to apolipoprotein...
De Visser, S. J, Van Der Post, J. P, De Smet, M, Schoemaker, R. C, Rijnbeek, B, ...
TPA023, a GABA(A) alpha 2,3 alpha subtype-selective partial agonist, is expected to have comparable anxiotytic efficacy as benzodiazepines with reduced sedating effects. The compound lacks efficacy...
Influence of life stress on immunological reactivity to mild psychological stress (2007)
Brosschot, J F, Benschop, R J, Godaert, G L, Olff, M, De Smet, M, Heijnen, C J, ...
This study investigated the effects of self-reported life stress and locus of control on reactivity of several immune parameters to a mild and short-lasting interpersonal stressor. Subjects were 86...
Interaction between vinblastine and ionizing radiation in the mouse MO4 fibrosarcoma in vivo (2007)
Van Belle, S, Fortan, L, De Smet, M, De Neve, W, Storme, G
The effect of combining vinblastine (VLB) and ionizing radiation (IR) on tumor response was investigated in CDF1 mice bearing the MO4 mouse fibrosarcoma. Favorable interactions were assumed to occur...
Earthquakes and crush syndrome casualties: lessons learned from the Kashmir disaster (2007)
Vanholder, R, De Smet, M, Hoste, E, Koç, M, Hussain, A, ...
Major earthquakes may provoke a substantial number of crush casualties complicated by acute kidney injury (AKI). After the 1988 Armenian earthquake, the International Society of Nephrology (ISN)...
Earthquakes and crush syndrome casualties: Lessons learned from the Kashmir disaster (2007)
Vanholder, Raymond, VAN DER TOL, ARJAN, DE SMET, M, Hoste, Eric, KOC, M, HUSSAIN, A, ...
Improving method capability of a drug substance HPLC assay (2006)
Dejaegher, B, Jimidar, M, De Smet, M, Cockaerts, P, Smeyers-Verbeke, J, Vander Heyden, Y
The assay of a drug substance (DS) is one of the tests required to confirm the active pharmaceutical ingredient (API) quality at release. In the past, usually volumetric titration methods were...
Van Gyseghem, Elke; U0049174, Jimidar, M, Sneyers, R, De Smet, M, Verhoeven, E, Vander Heyden, Y
The classification or characterization of stationary phases based on chromatographic parameters, in general, requires different test solutes/mixtures and several mobile phases. To simplify the...
Bergman, AJ, Stevens, C, Zhou, YY, Yi, BM, Laethem, M, De Smet, M, ...
Background: Dipeptidyl peptidase-IV (DPP-IV) inhibitors represent a new class of oral antihyperglycemic agents. Sitagliptin is an orally active and selective DPP-IV inhibitor currently in Phase III...
Tinke, A P, Vanhoutte, K, Vanhoutte, F, De Smet, M, De Winter, H
Immediate release direct compression tablet formulations require a strict control of the particle characteristics (i.e. particle size (distribution) and shape) of both the active pharmaceutical...
Lack of effect of aprepitant on the pharmacokinetics of docetaxel in cancer patients (2005)
Nygren, P, Hande, K, Petty, KJ, Fedgchin, M, Van Dyck, K, Majumdar, A, ...
Background: Aprepitant is a selective neurokinin-1 receptor antagonist that is effective for the prevention of nausea and vomiting caused by highly emetogenic chemotherapy. In vitro, aprepitant is a...
Lack of effect of aprepitant on the pharmacokinetics of docetaxel in cancer patients (2005)
NYGREN, P, HANDE, K, PETTY, KJ, FEDGCHIN, M, VAN DYCK, K, MAJUMDAR, A, ...
Upper gastrointestinal responses to intraduodenal nutrient in type 1 diabetes mellitus (2004)
Rayner, Christopher Keith, Schwartz, M. P., Van Dam, P. S., Renooij, W., De Smet, M, Horowitz, Michael, ...
Copyright © 2004 Lippincott Williams & Wilkins
Upper gastrointestinal responses to intraduodenal nutrient in type 1 diabetes mellitus (2004)
Rayner, Christopher Keith, Schwartz, M. P., Van Dam, P. S., Renooij, W., De Smet, M, Horowitz, Michael, ...
Copyright © 2004 Lippincott Williams & Wilkins
Jimidar, ML, Van Ael, W, Van Nyen, P, Peeters, M, Redlich, D, De Smet, M
Method development of enantiomeric separations in capillary electrophoresis (CE) is a time-consuming task, since finding the appropriate chiral selector is usually a "trial and error" process. It is...
Lichinitser, MR, Navari, RM, Garin, AM, Decramer, Marc; U0004666, Riviere, A, ...
BACKGROUND: Recent studies have suggested that antiemetic therapy with a triple combination of the neurokinin-1 receptor antagonist MK-869, a serotonin (5-HT(3)) antagonist, and dexamethasone...
Small intestinal glucose absorption and duodenal motility in type 1 diabetes mellitus (2002)
Rayner, Christopher Keith, Schwartz, M. P., Van Dam, P. S., Renooij, W., De Smet, M., Horowitz, Michael, ...
The definitive version is available at www.blackwell-synergy.com
Small intestinal glucose absorption and duodenal motility in type 1 diabetes mellitus (2002)
Rayner, Christopher Keith, Schwartz, M. P., Van Dam, P. S., Renooij, W., De Smet, M., Horowitz, Michael, ...
The definitive version is available at www.blackwell-synergy.com
Van Belie, S, Reinhardt, RR, O'Brien, M, Schellens, JHM, ...
Substance P is localised ill brainstem regions associated with emesis. Based on studies in the ferret, it was postulated that a neurokinin-1 (NK1) receptor antagonist would have antiemetic activity...
Effect of rofecoxib on the pharmacokinetics of digoxin in healthy volunteers (2001)
Schwartz, JI, De Smet, M, Larson, PJ, Verbesselt, René; U0018460, Ebel, DL, Lins, R, ...
The authors examined the effect of the cyclooxygenase-2 (COX-2) inhibitor, rofecoxib, at steady state on the pharmacokinetics of digoxin following a single dose in healthy subjects. Each healthy...
Intervention of the Renal Disaster Relief Task Force in the 1999 Marmara, Turkey earthquake. (2001)
Vanholder, Raymond, SEVER, MS, DE SMET, M, EREK, E, Lameire, Norbert
The effect of rofecoxib on the pharmacodynamics and pharmacokinetics of warfarin (2000)
Schwartz, JI, Bugianesi, KJ, Ebel, DL, De Smet, M, Haesen, R, Larson, PJ, ...
Objective: The objective of this study was to examine the effect of 3 doses of rofecoxib (12.5, 25, and 50 mg) on the pharmacodynamics and pharmacokinetics of warfarin.
VAN DER LELIE, Daniel, SPELMANS, Nele, VANGRONSVELD, Jaak, Corbisier, P., Taghavi, S., Mergeay, M., ...
VAN DER LELIE, Daniel, SPELMANS, Nele, VANGRONSVELD, Jaak, Corbisier, P., Taghavi, S., Mergeay, M., ...
Pharmacokinetics and tolerability of oral rizatriptan in healthy male and female volunteers (1999)
Lee, Y, Conroy, JA, Stepanavage, ME, Mendel, CM, Somers, Geert; U0048845, McLoughlin, DA, ...
Aims The pharmacokinetics and dose proportionality of rizatriptan single oral doses from 2.5 to 15 mg administered as solutions to healthy volunteers were studied.
VAN DER LELIE, Daniel, SPELMANS, Nele, VANGRONSVELD, Jaak, Corbisier, P., De Smet, M., Hannes, L., ...
VAN DER LELIE, Daniel, SPELMANS, Nele, VANGRONSVELD, Jaak, Corbisier, P., De Smet, M., Hannes, L., ...
Pharmacokinetics of Intravenous Alendronate (1998)
Cocquyt, Veronique, KLINE, WF, GERTZ, BJ, Van Belle, Simon, HOLLAND, SD, DE SMET, M, ...
Cheng, HY, Leff, JA, Amin, R, Gertz, BJ, De Smet, M, Noonan, N, ...
Purpose. The safety, tolerability, and pharmacokinetics of intravenous (i.v.) montelukast sodium (Singulair(TM), MK-0476), and the oral bioavailability of montelukast sodium in healthy males and...
De Smet, M, Schoors, DF, DeMeyer, G, Verbesselt, René; U0018460, Goldberg, MR, Fitzpatrick, V, ...
1 Losartan (DuP 753, MK-954) is a novel, potent and highly selective AT(1) angiotensin II receptor antagonist. The effect of multiple oral doses of losartan on digoxin pharmacokinetics was evaluated...
Schoors, Df, De Smet, M, Reiss, T, Margolskee, D, Cheng, H, Larson, P, ...
MK-0476 or sodium 1-(1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)-ethenyl)phenyl) 3-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cycloproprane) acetate is a novel, potent, and specific...
Diamant, Z, Timmers, Mc, Vanderveen, H, Friedman, Bs, De Smet, M, ...
Background: The 5-lipoxygenase metabolites of arachidonic acid are likely to be involved in the pathophysiology of atopic asthma. We investigated the effect of pretreatment with MK-0591, a novel...
Increasing peak levels of vinblastine given in repeated divided doses. (1992)
VAN BELLE, SJP, DE SMET, M, DE MEY, JE, De Neve, Wilfried, STORME, GA, MASSART, DL
De Wit, S., Debier, M., De Smet, M., McCrea, J., Stone, J., Carides, A., ...
To evaluate a potential pharmacokinetic interaction of coadministration of fluconazole, and indinavir, a human immunodeficiency virus (HIV) protease inhibitor, 13 patients were enrolled in a...
De Wit, S., Debier, M., De Smet, M., McCrea, J., Stone, J., Carides, A., ...
To evaluate a potential pharmacokinetic interaction of coadministration of fluconazole, and indinavir, a human immunodeficiency virus (HIV) protease inhibitor, 13 patients were enrolled in a...
Schoors, D F, De Smet, M, Reiss, T, Margolskee, D, Cheng, H, Larson, P, ...
MK-4076 or sodium 1-(1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)- ethenyl)phenyl) 3-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl) cycloproprane) acetate is a novel, potent, and specific...
De Smet, M, Schoors, D F, De Meyer, G, Verbesselt, R, Goldberg, M R, Fitzpatrick, V, ...
1. Losartan (DuP 753, MK-954) is a novel, potent and highly selective AT1 angiotensin II receptor antagonist. The effect of multiple oral doses of losartan on digoxin pharmacokinetics was evaluated...
Pharmacokinetics and tolerability of oral rizatriptan in healthy male and female volunteers
Lee, Y, Conroy, J A, Stepanavage, M E, Mendel, C M, Somers, G, McLoughlin, D A, ...