Intracellular σ1 receptor modulates phospholipase C and protein kinase C activities in the brainstem
Morin-Surun, M. P., Collin, T., Denavit-Saubié, M., Baulieu, E.-E., Monnet, F. P.
Most physiological effects of σ1 receptor ligands are sensitive to pertussis toxin, suggesting a coupling with cell membrane-bound G proteins. However, the cloning of the σ1 receptor has allowed...
Jacquin, T, Champagnat, J, Madamba, S, Denavit-Saubié, M, Siggins, G R
The synaptic function of somatostatin-containing fibers in the nervous system is controversial. Therefore, we used a slice preparation of the rat brain stem to test the electrophysiological effects...
Schmitt, P, Soulier, V, Péquignot, J M, Pujol, J F, Denavit-Saubié, M
1. The relationship between ventilatory acclimatization to chronic hypoxia (10% O2-90% N2) and noradrenaline metabolism was examined in two regions located immediately caudal and rostral to the obex...
Localization of chemosensitive structures in the isolated brainstem of adult guinea-pig.
Morin-Surun, M P, Boudinot, E, Schäfer, T, Denavit-Saubié, M
1. Central respiratory chemosensitivity has been intensively examined but some questions remain unsolved; namely, what is the nature of the stimulus (fixed acid and/or CO2) and where is the site of...
Pierrefiche, O, Foutz, A S, Champagnat, J, Denavit-Saubié, M
1. Activation of N-methyl-D-aspartate (NMDA) glutamate receptors in the brainstem network of respiratory neurones is required to terminate inspiration in the absence of lung afferents, but it is not...
Membrane potentials of respiratory neurones during dizocilpine-induced apneusis in adult cats.
Haji, A, Pierrefiche, O, Takeda, R, Foutz, A S, Champagnat, J, Denavit-Saubié, M
1. In the vagotomized cat, blockade of NMDA receptors by dizocilpine (MK-801) produces an apneustic pattern of respiration characterized by a large increase in the duration of inspiration. 2. To...
Kato, F, Morin-Surun, M P, Denavit-Saubié, M
1. To understand the neural organization of respiratory movement control and its developmental transformation, we studied the temporal characteristics of inspiratory activities, especially...
Organization of synaptic transmission in the mammalian solitary complex, studied in vitro.
Champagnat, J, Denavit-Saubié, M, Grant, K, Shen, K F
1. Synaptic transmission and neuronal morphology were studied in the nucleus tractus solitarius and in the dorsal vagal motor nucleus (solitary complex), in coronal brain-stem slices of rat or cat,...
Intracellular σ1 receptor modulates phospholipase C and protein kinase C activities in the brainstem
Morin-Surun, M. P., Collin, T., Denavit-Saubié, M., Baulieu, E.-E., Monnet, F. P.
Most physiological effects of σ1 receptor ligands are sensitive to pertussis toxin, suggesting a coupling with cell membrane-bound G proteins. However, the cloning of the σ1 receptor has allowed...
Jacquin, T, Champagnat, J, Madamba, S, Denavit-Saubié, M, Siggins, G R
The synaptic function of somatostatin-containing fibers in the nervous system is controversial. Therefore, we used a slice preparation of the rat brain stem to test the electrophysiological effects...
Schmitt, P, Soulier, V, Péquignot, J M, Pujol, J F, Denavit-Saubié, M
1. The relationship between ventilatory acclimatization to chronic hypoxia (10% O2-90% N2) and noradrenaline metabolism was examined in two regions located immediately caudal and rostral to the obex...
Localization of chemosensitive structures in the isolated brainstem of adult guinea-pig.
Morin-Surun, M P, Boudinot, E, Schäfer, T, Denavit-Saubié, M
1. Central respiratory chemosensitivity has been intensively examined but some questions remain unsolved; namely, what is the nature of the stimulus (fixed acid and/or CO2) and where is the site of...
Pierrefiche, O, Foutz, A S, Champagnat, J, Denavit-Saubié, M
1. Activation of N-methyl-D-aspartate (NMDA) glutamate receptors in the brainstem network of respiratory neurones is required to terminate inspiration in the absence of lung afferents, but it is not...
Membrane potentials of respiratory neurones during dizocilpine-induced apneusis in adult cats.
Haji, A, Pierrefiche, O, Takeda, R, Foutz, A S, Champagnat, J, Denavit-Saubié, M
1. In the vagotomized cat, blockade of NMDA receptors by dizocilpine (MK-801) produces an apneustic pattern of respiration characterized by a large increase in the duration of inspiration. 2. To...
Kato, F, Morin-Surun, M P, Denavit-Saubié, M
1. To understand the neural organization of respiratory movement control and its developmental transformation, we studied the temporal characteristics of inspiratory activities, especially...
Organization of synaptic transmission in the mammalian solitary complex, studied in vitro.
Champagnat, J, Denavit-Saubié, M, Grant, K, Shen, K F
1. Synaptic transmission and neuronal morphology were studied in the nucleus tractus solitarius and in the dorsal vagal motor nucleus (solitary complex), in coronal brain-stem slices of rat or cat,...
Pierrefiche, O, Haji, A, Foutz, A S, Takeda, R, Champagnat, J, Denavit-Saubié, M
Blockade of NMDA receptors by dizocilpine impairs the inspiratory off-switch (IOS) of central origin but not the IOS evoked by stimulation of sensory afferents. To investigate whether this difference...