Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state (1992)
Lichtenberg-Kraag, B, Döring, F, Mandelkow, E M, Biernat, J, ...
The microtubule-associated protein tau is a major component of the paired helical filaments (PHFs) observed in Alzheimer's disease brains. The pathological tau is distinguished from normal tau by its...
Galas, S, Barakat, H, Dorée, M, Picard, A
In most animals, the rate of cyclin B synthesis increases after nuclear envelope breakdown during the first meiotic cell cycle. We have found that cyclin B-cdc2 kinase activity drops earlier in...
Abrieu, A, Dorée, M, Picard, A
The G2 arrest of oocytes from frogs, clams, and starfish requires that preformed cyclin B-cdc2 complexes [prematuration-promoting factor (MPF)] be kept in an inactive form that is largely due to...
Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes
Fisher, D.L., Mandart, E., Dorée, M.
During Xenopus oocyte maturation, the Mos protein kinase is synthesized and activates the MAP kinase cascade. In this report, we demonstrate that the synthesis and activation of Mos are two separable...
Lorca, T, Fesquet, D, Zindy, F, Le Bouffant, F, Cerruti, M, Brechot, C, ...
Inhibition of okadaic acid-sensitive phosphatases released the cyclin degradation pathway from its inhibited state in extracts prepared from unfertilized Xenopus eggs arrested at the second meiotic...
Mitosis-specific phosphorylation of nucleolin by p34cdc2 protein kinase.
Belenguer, P, Caizergues-Ferrer, M, Labbé, J C, Dorée, M, Amalric, F
Nucleolin is a ubiquitous multifunctional protein involved in preribosome assembly and associated with both nucleolar chromatin in interphase and nucleolar organizer regions on metaphasic chromosomes...
Devault, A, Martinez, A M, Fesquet, D, Labbé, J C, Morin, N, Tassan, J P, ...
The kinase responsible for Thr161-Thr160 phosphorylation and activation of cdc2/cdk2 (CAK:cdk-activating kinase) has been shown previously to comprise at least two subunits, cdk7 and cyclin H. An...
Morin, N, Abrieu, A, Lorca, T, Martin, F, Dorée, M
It has been shown, using spindles assembled in vitro in extracts containing CSF (the cytostatic factor responsible for arresting unfertilized vertebrate eggs at metaphase), that onset of anaphase...
Labbé, J C, Martinez, A M, Fesquet, D, Capony, J P, Darbon, J M, Derancourt, J, ...
p40MO15, a cdc2-related protein, is the catalytic subunit of the kinase (CAK, cdk-activating kinase) responsible for Thr161/Thr160 phosphorylation and activation of cdk1/cdk2. We have found that...
Labbé, J C, Capony, J P, Caput, D, Cavadore, J C, Derancourt, J, Kaghad, M, ...
We have purified to near homogeneity the M-phase-specific protein kinase from starfish oocytes at first meiotic metaphase, using an improved procedure based on affinity chromatography on the...
Bailly, E, Dorée, M, Nurse, P, Bornens, M
The cdc2+ gene product p34cdc2 is located immunocytochemically in both the nucleus and cytoplasm of human cells. It is uniformly distributed throughout the cytoplasm and is irregularly distributed in...
Fesquet, D, Labbé, J C, Derancourt, J, Capony, J P, Galas, S, Girard, F, ...
Phosphorylation of Thr161, a residue conserved in all members of the cdc2 family, has been reported to be absolutely required for the catalytic activity of cdc2, the major regulator of eukaryotic...
Hormonal control of meiosis: specificity of the 1-methyladenine receptors in starfish oocytes.
Dorée, M, Guerrier, P, Leonard, N J
The specificity of the 1-methyladenine receptors, which are localized on the cell membrane of starfish oocytes, has been investigated in Marthasterias glacialis and Asterias rubens. Ability of...
Picard, A, Galas, S, Peaucellier, G, Dorée, M
Micro-injection of catalytically inactive GST-cdc2-K33R or GST-cdk2-K33R fusion proteins, each of which efficiently titrates cyclin B in oocytes and prevents assembly of cyclin B-cdc2 complexes,...
Lorca, T, Galas, S, Fesquet, D, Devault, A, Cavadore, J C, Dorée, M
Exit from M phase, which requires cyclin degradation, is prevented from occurring in unfertilized eggs of vertebrates arrested at second meiotic metaphase due to a cytostatic factor recently...
Lane, H A, Morley, S J, Dorée, M, Kozma, S C, Thomas, G
Employing oligonucleotide primers derived from the DNA sequence of rat p70s6k a homologous sequence was shown by polymerase chain reaction (PCR) to be present as a maternal transcript in stage IV-VI...
Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.
Drewes, G, Lichtenberg-Kraag, B, Döring, F, Mandelkow, E M, Biernat, J, Goris, J, ...
The microtubule-associated protein tau is a major component of the paired helical filaments (PHFs) observed in Alzheimer's disease brains. The pathological tau is distinguished from normal tau by its...
Lorca, T, Labbé, J C, Devault, A, Fesquet, D, Capony, J P, Cavadore, J C, ...
Exit from metaphase of the cell cycle requires inactivation of MPF, a stoichiometric complex between the cdc2 catalytic and the cyclin B regulatory subunits, as well as that of cyclin A-cdc2 kinase....
Martinez, A M, Afshar, M, Martin, F, Cavadore, J C, Labbé, J C, Dorée, M
A cyclin-dependent kinase (cdk)-activating kinase (CAK) has been shown previously to catalyze T-loop phosphorylation of cdks in most eukaryotic cells. This enzyme exists in either of two forms: the...
Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis.
Tournebize, R, Andersen, S S, Verde, F, Dorée, M, Karsenti, E, Hyman, A A
Assembly of a mitotic spindle requires the accurate regulation of microtubule dynamics which is accomplished, at least in part, by phosphorylation-dephosphorylation reactions. Here we have...
Faure, S, Vigneron, S, Dorée, M, Morin, N
We have identified new members (X-PAKs) of the Ste20/PAK family of protein kinases in Xenopus, and investigated their role in the process that maintains oocytes arrested in the cell cycle....
MAPK inactivation is required for the G2 to M-phase transition of the first mitotic cell cycle.
Abrieu, A, Fisher, D, Simon, M N, Dorée, M, Picard, A
Down-regulation of MAP kinase (MAPK) is a universal consequence of fertilization in the animal kingdom, although its role is not known. Here we show that MAPK inactivation is essential for embryos,...
Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts.
Lorca, T, Castro, A, Martinez, A M, Vigneron, S, Morin, N, Sigrist, S, ...
The Xenopus homologue of Drosophila Fizzy and budding yeast CDC20 has been characterized. The encoded protein (X-FZY) is a component of a high molecular weight complex distinct from the...
Galas, S, Barakat, H, Dorée, M, Picard, A
In most animals, the rate of cyclin B synthesis increases after nuclear envelope breakdown during the first meiotic cell cycle. We have found that cyclin B-cdc2 kinase activity drops earlier in...
Abrieu, A, Dorée, M, Picard, A
The G2 arrest of oocytes from frogs, clams, and starfish requires that preformed cyclin B-cdc2 complexes [prematuration-promoting factor (MPF)] be kept in an inactive form that is largely due to...
Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes
Fisher, D.L., Mandart, E., Dorée, M.
During Xenopus oocyte maturation, the Mos protein kinase is synthesized and activates the MAP kinase cascade. In this report, we demonstrate that the synthesis and activation of Mos are two separable...
Lorca, T, Fesquet, D, Zindy, F, Le Bouffant, F, Cerruti, M, Brechot, C, ...
Inhibition of okadaic acid-sensitive phosphatases released the cyclin degradation pathway from its inhibited state in extracts prepared from unfertilized Xenopus eggs arrested at the second meiotic...
Mitosis-specific phosphorylation of nucleolin by p34cdc2 protein kinase.
Belenguer, P, Caizergues-Ferrer, M, Labbé, J C, Dorée, M, Amalric, F
Nucleolin is a ubiquitous multifunctional protein involved in preribosome assembly and associated with both nucleolar chromatin in interphase and nucleolar organizer regions on metaphasic chromosomes...
Devault, A, Martinez, A M, Fesquet, D, Labbé, J C, Morin, N, Tassan, J P, ...
The kinase responsible for Thr161-Thr160 phosphorylation and activation of cdc2/cdk2 (CAK:cdk-activating kinase) has been shown previously to comprise at least two subunits, cdk7 and cyclin H. An...
Morin, N, Abrieu, A, Lorca, T, Martin, F, Dorée, M
It has been shown, using spindles assembled in vitro in extracts containing CSF (the cytostatic factor responsible for arresting unfertilized vertebrate eggs at metaphase), that onset of anaphase...
Labbé, J C, Martinez, A M, Fesquet, D, Capony, J P, Darbon, J M, Derancourt, J, ...
p40MO15, a cdc2-related protein, is the catalytic subunit of the kinase (CAK, cdk-activating kinase) responsible for Thr161/Thr160 phosphorylation and activation of cdk1/cdk2. We have found that...
Labbé, J C, Capony, J P, Caput, D, Cavadore, J C, Derancourt, J, Kaghad, M, ...
We have purified to near homogeneity the M-phase-specific protein kinase from starfish oocytes at first meiotic metaphase, using an improved procedure based on affinity chromatography on the...
Bailly, E, Dorée, M, Nurse, P, Bornens, M
The cdc2+ gene product p34cdc2 is located immunocytochemically in both the nucleus and cytoplasm of human cells. It is uniformly distributed throughout the cytoplasm and is irregularly distributed in...
Fesquet, D, Labbé, J C, Derancourt, J, Capony, J P, Galas, S, Girard, F, ...
Phosphorylation of Thr161, a residue conserved in all members of the cdc2 family, has been reported to be absolutely required for the catalytic activity of cdc2, the major regulator of eukaryotic...
Hormonal control of meiosis: specificity of the 1-methyladenine receptors in starfish oocytes.
Dorée, M, Guerrier, P, Leonard, N J
The specificity of the 1-methyladenine receptors, which are localized on the cell membrane of starfish oocytes, has been investigated in Marthasterias glacialis and Asterias rubens. Ability of...
Picard, A, Galas, S, Peaucellier, G, Dorée, M
Micro-injection of catalytically inactive GST-cdc2-K33R or GST-cdk2-K33R fusion proteins, each of which efficiently titrates cyclin B in oocytes and prevents assembly of cyclin B-cdc2 complexes,...
Lorca, T, Galas, S, Fesquet, D, Devault, A, Cavadore, J C, Dorée, M
Exit from M phase, which requires cyclin degradation, is prevented from occurring in unfertilized eggs of vertebrates arrested at second meiotic metaphase due to a cytostatic factor recently...
Lane, H A, Morley, S J, Dorée, M, Kozma, S C, Thomas, G
Employing oligonucleotide primers derived from the DNA sequence of rat p70s6k a homologous sequence was shown by polymerase chain reaction (PCR) to be present as a maternal transcript in stage IV-VI...
Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.
Drewes, G, Lichtenberg-Kraag, B, Döring, F, Mandelkow, E M, Biernat, J, Goris, J, ...
The microtubule-associated protein tau is a major component of the paired helical filaments (PHFs) observed in Alzheimer's disease brains. The pathological tau is distinguished from normal tau by its...
Lorca, T, Labbé, J C, Devault, A, Fesquet, D, Capony, J P, Cavadore, J C, ...
Exit from metaphase of the cell cycle requires inactivation of MPF, a stoichiometric complex between the cdc2 catalytic and the cyclin B regulatory subunits, as well as that of cyclin A-cdc2 kinase....
Martinez, A M, Afshar, M, Martin, F, Cavadore, J C, Labbé, J C, Dorée, M
A cyclin-dependent kinase (cdk)-activating kinase (CAK) has been shown previously to catalyze T-loop phosphorylation of cdks in most eukaryotic cells. This enzyme exists in either of two forms: the...
Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis.
Tournebize, R, Andersen, S S, Verde, F, Dorée, M, Karsenti, E, Hyman, A A
Assembly of a mitotic spindle requires the accurate regulation of microtubule dynamics which is accomplished, at least in part, by phosphorylation-dephosphorylation reactions. Here we have...
Faure, S, Vigneron, S, Dorée, M, Morin, N
We have identified new members (X-PAKs) of the Ste20/PAK family of protein kinases in Xenopus, and investigated their role in the process that maintains oocytes arrested in the cell cycle....
MAPK inactivation is required for the G2 to M-phase transition of the first mitotic cell cycle.
Abrieu, A, Fisher, D, Simon, M N, Dorée, M, Picard, A
Down-regulation of MAP kinase (MAPK) is a universal consequence of fertilization in the animal kingdom, although its role is not known. Here we show that MAPK inactivation is essential for embryos,...
Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts.
Lorca, T, Castro, A, Martinez, A M, Vigneron, S, Morin, N, Sigrist, S, ...
The Xenopus homologue of Drosophila Fizzy and budding yeast CDC20 has been characterized. The encoded protein (X-FZY) is a component of a high molecular weight complex distinct from the...