M. Dougados

Publication List Details

Period

1993 - 2009

Number

243

Co-Authors

The development of assessment of spondyloarthritis international society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal (2009)

Rudwaleit, M, Landewe, Rene, Listing, J, Brandt, J, Braun, J, ...

Objective: Non-radiographic axial spondyloarthritis (SpA) is characterised by a lack of definitive radiographic sacroiliitis and is considered an early stage of ankylosing spondylitis. The objective...

The development of assessment of spondyloarthritis international society classification criteria for axial spondyloarthritis (part II): validation and final selection (2009)

Rudwaleit, M, Landewe, R, Listing, J, Akkoc, N, Brandt, J, ...

Objective: To validate and refine two sets of candidate criteria for the classification/diagnosis of axial spondyloarthritis (SpA). Methods: All assessment of SpondyloArthritis international Society...

New criteria for inflammatory back pain in patients with chronic back pain: a real patient exercise by experts from the Assessment of Spondyloarthritis international Society (ASAS) (2009)

Sieper, J, Landewe, R, Brandt, J, Burgos-Vagas, R, Collantes-Estevez, E, ...

Objective: Inflammatory back pain (IBP) is an important clinical symptom in patients with axial spondyloarthritis (SpA), and relevant for classification and diagnosis. In the present report, a new...

Physical function in ankylosing spondylitis is independently determined by both disease activity and radiographic damage of the spine (2009)

Landewe, R, Dougados, M, Mielants, Herman

Aim: To study the relationship between disease activity, radiographic damage and physical function in patients with ankylosing spondylitis (AS) Patients and methods: Baseline and 2-year data of the...

OARSI recommendations for the management of hip and knee osteoarthritis, part II: OARSI evidence-based, expert consensus guidelines (2008)

Zhang, W., Moskowitz, R.W., Nuki, G., Abramson, S., Altman, R.P., Arden, N., ...

PURPOSE: To develop concise, patient-focussed, up to date, evidence-based, expert consensus recommendations for the management of hip and knee osteoarthritis (OA), which are adaptable and designed to...

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines (2008)

Zhang, W., Moskowitz, R.W., Nuki, G., Abramson, S., Altman, R.D., Arden, N., ...

PURPOSE: To develop concise, patient-focussed, up to date, evidence-based, expert consensus recommendations for the management of hip and knee osteoarthritis (OA), which are adaptable and designed to...

Dissemination and evaluation of the ASAS/EULAR recommendations for the management of ankylosing spondylitis: results of a study among 1507 rheumatologists (2008)

Gossec, L., Dougados, M., Phillips, C., Hammoudeh, M., De Vlam, K., Pavelka, K., ...

Background: Ten ASAS/EULAR recommendations for the management of ankylosing spondylitis (AS) were published in 2006. Objectives: (a) To disseminate and (b) to evaluate conceptual agreement with, and...

Evidence-based recommendations for the management of ankylosing spondylitis: systematic literature search of the 3E Initiative in Rheumatology involving a broad panel of experts and practising rheumatologists (2008)

Sidiropoulos, P. I., Hatemi, G., Avouac, J., Collantes, E., Hamuryudan, V., ...

Objective. Recommendations and/or guidelines represent a popular way of integrating evidence-based medicine into clinical practice. The 3E Initiatives is a multi-national effort to develop...

OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence (2007)

Zhang, W., Moskowitz, R.W., Nuki, G., Abramson, S., Altman, R.D., Arden, N., ...

PURPOSE: As a prelude to developing updated, evidence-based, international consensus recommendations for the management of hip and knee osteoarthritis (OA), the Osteoarthritis Research Society...

Infections during tumour necrosis factor-{alpha} blocker therapy for rheumatic diseases in daily practice: a systematic retrospective study of 709 patients (2007)

Salliot, C., Gossec, L., Ruyssen-Witrand, A., Luc, M., Duclos, M., Guignard, S., ...

Objective. To evaluate the rate of infections in rheumatic patients treated with tumour necrosis factor (TNF)-α blockers in daily practice and to determine potential risk factors of infections....

Determinants of hyperkyphosis in patients with ankylosing spondylitis. (2006)

Vosse, D., Landewé, R., Mielants, H., Dougados, M., ...

Objective: To determine clinical and radiographic determinants of hyperkyphosis in patients with ankylosing spondylitis.Methods: Spinal hyperkyphosis was assessed by occiput to wall distance (OWD) in...

Determinants of hyperkyphosis in patients with ankylosing spondylitis. (2006)

Vosse, D., Landewé, R., Mielants, H., Dougados, M., ...

Objective: To determine clinical and radiographic determinants of hyperkyphosis in patients with ankylosing spondylitis.Methods: Spinal hyperkyphosis was assessed by occiput to wall distance (OWD) in...

Determinants of hyperkyphosis in patients with ankylosing spondylitis. (2006)

Vosse, D., Landewé, R., GEUSENS, Piet, Mielants, H., Dougados, M., ...

Objective: To determine clinical and radiographic determinants of hyperkyphosis in patients with ankylosing spondylitis.Methods: Spinal hyperkyphosis was assessed by occiput to wall distance (OWD) in...

ASAS/EULAR recommendations for the management of ankylosing spondylitis. (2006)

Zochling, J, Burgos Vargas, R, Collantes, E, Davis, J C, Dijkmans, B, ...

OBJECTIVE: To develop evidence based recommendations for the management of ankylosing spondylitis (AS) as a combined effort of the 'ASsessment in AS' international working group and the European...

An international study on starting tumour necrosis factor-blocking agents in ankylosing spondylitis (2006)

Pham, T., Landewe, R., Dougados, M., Sieper, J., Braun, J., ...

Objectives: To determine the type and proportion of patients with ankylosing spondylitis who rheumatologists consider to be candidates for treatment with tumour necrosis factor (TNF)-blocking agents,...

Continuation of treatment with infliximab in ankylosing spondylitis: 2-yr open follow-up (2006)

Gossec, L., Le Henanff, A., Breban, M., Vignon, E., Claudepierre, P., Devauchelle, V., ...

Objective. To evaluate the continuation and safety of treatment with infliximab in ankylosing spondylitis (AS) over a 2-yr period. Methods. This study was an open, observational, 2-yr extension study...

Continuation of treatment with infliximab in ankylosing spondylitis: 2-yr open follow-up (2006)

Gossec, L., Henanff, A. Le, Breban, M., Vignon, E., Claudepierre, P., Devauchelle, V., ...

Objective. To evaluate the continuation and safety of treatment with infliximab in ankylosing spondylitis (AS) over a 2-yr period. Methods. This study was an open, observational, 2-yr extension study...

Infections during tumour necrosis factor-{alpha} blocker therapy for rheumatic diseases in daily practice: a systematic retrospective study of 709 patients (2006)

Salliot, C., Gossec, L., Ruyssen-Witrand, A., Luc, M., Duclos, M., Guignard, S., ...

Objective. To evaluate the rate of infections in rheumatic patients treated with tumour necrosis factor (TNF)-α blockers in daily practice and to determine potential risk factors of infections....

Continuation of treatment with infliximab in ankylosing spondylitis: 2-yr open follow-up (2006)

Gossec, L., Henanff, A. Le, Breban, M., Vignon, E., Claudepierre, P., Devauchelle, V., ...

Objective. To evaluate the continuation and safety of treatment with infliximab in ankylosing spondylitis (AS) over a 2-yr period. Methods. This study was an open, observational, 2-yr extension study...

Infections during tumour necrosis factor-{alpha} blocker therapy for rheumatic diseases in daily practice: a systematic retrospective study of 709 patients (2006)

Salliot, C., Gossec, L., Ruyssen-Witrand, A., Luc, M., Duclos, M., Guignard, S., ...

Objective. To evaluate the rate of infections in rheumatic patients treated with tumour necrosis factor (TNF)-α blockers in daily practice and to determine potential risk factors of infections....

EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT) (2005)

Zhang, W., Doherty, M., Arden, N., Bannwarth, B., Bijlsma, J., ...

Objective: To develop evidence based recommendations for the management of hip osteoarthritis (OA). Methods: The multidisciplinary guideline development group comprised 18 rheumatologists, 4...

Measuring disease activity in ankylosing spondylitis: patient and physician have different perspectives (2005)

Spoorenberg, A, Van Tubergen, A, Landewe, R, Dougados, M, Mielants, H, ...

Objective. There is no 'gold standard' to assess disease activity in patients with ankylosing spondylitis (AS). It is known that patients and physicians have different opinions about disease...

Minimal disease activity for rheumatoid arthritis: A preliminary definition (2005)

Wells, G. A., Boers, M., Shea, B., Brooks, P. M., Simon, L. S., Strand, C. V., ...

Agreement on response criteria in rheumatoid arthritis (RA) has allowed better standardization and interpretation of clinical trial reports. With recent advances in therapy, the proportion of...

Measuring disease activity in ankylosing spondylitis: patient and physician have different perspectives (2005)

Spoorenberg, A, Van Tubergen, A, Landewe, R, Dougados, M, Mielants, H, ...

Objective. There is no 'gold standard' to assess disease activity in patients with ankylosing spondylitis (AS). It is known that patients and physicians have different opinions about disease...

Minimal disease activity for rheumatoid arthritis: A preliminary definition (2005)

Wells, G. A., Boers, M., Shea, B., Brooks, P. M., Simon, L. S., Strand, C. V., ...

Agreement on response criteria in rheumatoid arthritis (RA) has allowed better standardization and interpretation of clinical trial reports. With recent advances in therapy, the proportion of...

Minimal disease activity for rheumatoid arthritis: A preliminary definition (2005)

Wells, G. A., Boers, M., Shea, B., Brooks, P. M., Simon, L. S., Strand, C. V., ...

Agreement on response criteria in rheumatoid arthritis (RA) has allowed better standardization and interpretation of clinical trial reports. With recent advances in therapy, the proportion of...

Using patients' and rheumatologists' opinions to specify a short form of the WOMAC function subscale (2005)

Tubach, F, Baron, G, Falissard, B, Logeart, I, Dougados, M, Bellamy, N, ...

Background: The WOMAC ( Western Ontario and McMaster Universities) function subscale is widely used in clinical trials of hip and knee osteoarthritis. Reducing the number of items of the subscale...

Evaluation of clinically relevant changes in patient reported outcomes in knee and hip osteoarthritis: the minimal clinically important improvement (2005)

Tubach, F, Ravaud, P, Baron, G, Falissard, B, Logeart, I, Bellamy, N, ...

Background: In clinical trials, at the group level, results are usually reported as mean and standard deviation of the change in score, which is not meaningful for most readers. Objective: To...

Evaluation of clinically relevant states in patient reported outcomes in knee and hip osteoarthritis: the patient acceptable symptom state (2005)

Tubach, F, Ravaud, P, Baron, G, Falissard, B, Logeart, I, Bellamy, N, ...

Background: The patient acceptable symptom state ( PASS) is the value beyond which patients can consider themselves well. This concept can help in interpreting results of clinical trials. Objective:...

Using patients' and rheumatologists' opinions to specify a short form of the WOMAC function subscale (2005)

Tubach, F, Baron, G, Falissard, B, Logeart, I, Dougados, M, Bellamy, N, ...

Background: The WOMAC ( Western Ontario and McMaster Universities) function subscale is widely used in clinical trials of hip and knee osteoarthritis. Reducing the number of items of the subscale...

Evaluation of clinically relevant changes in patient reported outcomes in knee and hip osteoarthritis: the minimal clinically important improvement (2005)

Tubach, F, Ravaud, P, Baron, G, Falissard, B, Logeart, I, Bellamy, N, ...

Background: In clinical trials, at the group level, results are usually reported as mean and standard deviation of the change in score, which is not meaningful for most readers. Objective: To...

Evaluation of clinically relevant states in patient reported outcomes in knee and hip osteoarthritis: the patient acceptable symptom state (2005)

Tubach, F, Ravaud, P, Baron, G, Falissard, B, Logeart, I, Bellamy, N, ...

Background: The patient acceptable symptom state ( PASS) is the value beyond which patients can consider themselves well. This concept can help in interpreting results of clinical trials. Objective:...

Minimal disease activity for rheumatoid arthritis: A preliminary definition (2005)

Wells, G. A., Boers, M., Shea, B., Brooks, P. M., Simon, L. S., Strand, C. V., ...

Agreement on response criteria in rheumatoid arthritis (RA) has allowed better standardization and interpretation of clinical trial reports. With recent advances in therapy, the proportion of...

Minimal disease activity for rheumatoid arthritis: a preliminary definition (2005)

Wells, G. A., Boers, M., Shea, B., Brooks, P. M., Simon, L. S., Strand, C. V., ...

Agreement on response criteria in rheumatoid arthritis (RA) has allowed better standardization and interpretation of clinical trial reports. With recent advances in therapy, the proportion of...

Measuring disease activity in ankylosing spondylitis: patient and physician have different perspectives (2005)

Spoorenberg, A., Van Tubergen, A., Landewé, R., Dougados, M., Mielants, H., ...

Objective. There is no ‘gold standard’ to assess disease activity in patients with ankylosing spondylitis (AS). It is known that patients and physicians have different opinions about disease...

Measuring disease activity in ankylosing spondylitis: patient and physician have different perspectives (2005)

Spoorenberg, A., Van Tubergen, A., Landewé, R., Dougados, M., Mielants, H., ...

Objective. There is no ‘gold standard’ to assess disease activity in patients with ankylosing spondylitis (AS). It is known that patients and physicians have different opinions about disease...

Updated consensus statement on biological agents, specifically tumour necrosis factor alpha (TNF alpha) blocking agents and interleukin-1 receptor antagonist (IL-1ra), for the treatment of rheumatic diseases, 2004 (2004)

Furst, Daniel E, Breedveld, F C, Kalden, J R, Smolen, J S, Burmester, G R, Bijlsma, JWJ, ...

As in previous years, the consensus group to consider the use of biological agents was constituted by rheumatologists from the Universities of Erlangen, Leiden, and Vienna in Europe in cooperation...

Radiological scoring methods in Ankylosing Spondylitis. Reliability and change over 1 and 2 years (2004)

De Vlam, K, Dougados, M, Mielants, H, De Tempel, HV, VAN DER HEIJDE, Desiree, ...

Objective. To compare reliability and change over time of radiological scoring methods in ankylosing spondylitis (AS). Methods. Two trained observers scored 217 sets of radiographs from baseline and...

Radiological scoring methods in Ankylosing Spondylitis. Reliability and change over 1 and 2 years (2004)

Spoorenberg, B, De Vlam, K, Dougados, M, Mielants, H, De Tempel, HV, ...

Objective. To compare reliability and change over time of radiological scoring methods in ankylosing spondylitis (AS). Methods. Two trained observers scored 217 sets of radiographs from baseline and...

OMERACT-OARSI Initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. (2004)

Pham, T, Altman, RD, Anderson, JJ, Bellamy, N, Hochberg, M, ...

Background: The OARSI Standing Committee for Clinical Trials Response Criteria Initiative had developed two sets of responder criteria to present the results of changes after treatment in three...

OMERACT-OARSI Initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. (2004)

Pham, T, Altman, RD, Anderson, JJ, Bellamy, N, Hochberg, M, ...

Background: The OARSI Standing Committee for Clinical Trials Response Criteria Initiative had developed two sets of responder criteria to present the results of changes after treatment in three...

EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT) (2003)

Jordan, K.M., Arden, N.K., Doherty, M., Bannwarth, B., Bijlsma, J.W., Dieppe, P., ...

Objectives: To update the EULAR recommendations for management of knee osteoarthritis (OA) by an evidence based medicine and expert opinion approach. Methods: The literature search and guidelines...

Comparison of statistically derived ASAS improvement criteria for ankylosing spondylitis with clinically relevant improvement according to an expert panel (2003)

Van Tubergen, A, Anderson, J, Landewe, R, Dougados, M, Braun, J, Bellamy, N, ...

Objective: To investigate whether the recently developed (statistically derived) "ASsessment in Ankylosing Spondylitis Working Group" improvement criteria (ASAS-IC) for ankylosing spondylitis (AS)...

Comparison of statistically derived ASAS improvement criteria for ankylosing spondylitis with clinically relevant improvement according to an expert panel (2003)

Van Tubergen, A, Anderson, J, Landewe, R, Dougados, M, Braun, J, Bellamy, N, ...

Objective: To investigate whether the recently developed (statistically derived) "ASsessment in Ankylosing Spondylitis Working Group" improvement criteria (ASAS-IC) for ankylosing spondylitis (AS)...

Initiation of biological agents in patients with ankylosing spondylitis: results of a Delphi study by the ASAS Group (2003)

Pham, T, Calin, A, Khan, MA, Bellamy, N, ...

Background: There is ample evidence of important symptomatic efficacy of tumour necrosis factor alpha (TNFalpha) inhibition in ankylosing spondylitis (AS). Moreover, studies suggest that anti-TNF...

Outcome variables for osteoarthritis clinical trials: the OMERACT-OARSI set of responder criteria (2003)

Pham, T., Lassere, M., Altman, R. D., Andersen, J., Bellamy, N., ...

Improvement in analysis and reporting results of osteoarthritis (OA) clinical trials has been recently obtained because of harmonization and standardization of the selection of outcome variables...

Comparison of statistically derived ASAS improvement criteria for ankylosing spondylitis with clinically relevant improvement according to an expert panel (2003)

Van Tubergen, A., Anderson, J., Landewe, R., Dougados, M., Braun, J., ...

Objective: To investigate whether the recently developed (statistically derived) "ASsessment in Ankylosing Spondylitis Working Group" improvement criteria (ASAS-IC) for ankylosing spondylitis (AS)...

Outcome variables for osteoarthritis clinical trials: The OMERACT-OARSI set of responder criteria (2003)

Pham, T, Lassere, M, Altman, RD, Anderson, JJ, Bellamy, N, ...

Improvement in analysis and reporting results of osteoarthritis (OA) clinical trials has been recently obtained because of harmonization and standardization of the selection of outcome variables...

Initiation of biological agents in patients with ankylosing spondylitis: results of a Delphi study by the ASAS Group (2003)

Pham, T, Calin, A, Khan, MA, Bellamy, N, ...

Background: There is ample evidence of important symptomatic efficacy of tumour necrosis factor alpha (TNFalpha) inhibition in ankylosing spondylitis (AS). Moreover, studies suggest that anti-TNF...

Outcome variables for osteoarthritis clinical trials: the OMERACT-OARSI set of responder criteria (2003)

Pham, T., Lassere, M., Altman, R. D., Andersen, J., Bellamy, N., ...

Improvement in analysis and reporting results of osteoarthritis (OA) clinical trials has been recently obtained because of harmonization and standardization of the selection of outcome variables...

Comparison of statistically derived ASAS improvement criteria for ankylosing spondylitis with clinically relevant improvement according to an expert panel (2003)

Van Tubergen, A., Anderson, J., Landewe, R., Dougados, M., Braun, J., ...

Objective: To investigate whether the recently developed (statistically derived) "ASsessment in Ankylosing Spondylitis Working Group" improvement criteria (ASAS-IC) for ankylosing spondylitis (AS)...

Assessment of fatigue in the management of patients with ankylosing spondylitis (2003)

Dernis-Labous, E., Messow, M., Dougados, M.

Background. Pain, stiffness, functional impairment, range of motion and quality of life are the main conventional domains used in studies evaluating ankylosing spondylitis (AS). However, fatigue has...

Assessment of fatigue in the management of patients with ankylosing spondylitis (2003)

Dernis-Labous, E., Messow, M., Dougados, M.

Background. Pain, stiffness, functional impairment, range of motion and quality of life are the main conventional domains used in studies evaluating ankylosing spondylitis (AS). However, fatigue has...

Assessment of fatigue in the management of patients with ankylosing spondylitis (2003)

Dernis-Labous, E., Messow, M., Dougados, M.

Background. Pain, stiffness, functional impairment, range of motion and quality of life are the main conventional domains used in studies evaluating ankylosing spondylitis (AS). However, fatigue has...

Reliability of self assessed joint counts in ankylosing spondylitis (2002)

Spoorenberg, A, Dougados, M, De Vlam, K, Mielants, H, ...

Objective: To determine the reliability of self reported joint counts to assess pain or swelling in ankylosing spondylitis (AS). Methods: 2 17 outpatients fulfilling the modified New York criteria...

Reliability of self assessed joint counts in ankylosing spondylitis (2002)

Spoorenberg, A, Dougados, M, De Vlam, K, Mielants, H, ...

Objective: To determine the reliability of self reported joint counts to assess pain or swelling in ankylosing spondylitis (AS). Methods: 2 17 outpatients fulfilling the modified New York criteria...

Comparison of ASAS improvement criteria for ankylosing spondylitis with clinically relevant improvement according to an expert panel (2002)

Van Tubergen, A., Andersen, J., Landewe, R., Dougados, M., Bellamy, N., ...

Objective: To investigate whether the recently developed (statistically derived) "ASsessment in Ankylosing Spondylitis Working Group" improvement criteria (ASAS-IC) for ankylosing spondylitis (AS)...

Comparison of ASAS improvement criteria for ankylosing spondylitis with clinically relevant improvement according to an expert panel (2002)

Van Tubergen, A., Andersen, J., Landewe, R., Dougados, M., Bellamy, N., ...

Objective: To investigate whether the recently developed (statistically derived) "ASsessment in Ankylosing Spondylitis Working Group" improvement criteria (ASAS-IC) for ankylosing spondylitis (AS)...

Rapid diagnosis of inflammatory synovial fluid with reagent strips (2002)

Ravaud, P., Hudry, C., Giraudeau, B., Weill, B., Dougados, M.

Objective. To determine the usefulness of reagent test strips for screening inflammatory synovial fluid (SF). Methods. Consecutive patients undergoing diagnostic arthrocentesis,...

Efficacy of infliximab in refractory ankylosing spondylitis: results of a six-month open-label study (2002)

Breban, M., Vignon, E., Claudepierre, P., Devauchelle, V., Wendling, D., Lespessailles, E., ...

Objective. To evaluate the efficacy and safety of a loading regimen of the anti‐tumour necrosis factor α (TNF‐α) antibody infliximab in predominantly axial severe ankylosing...

Relevant change in radiological progression in patients with hip osteoarthritis. I. Determination using predictive validity for total hip arthroplasty (2002)

Maillefert, J. F., Gueguen, A., Nguyen, M., Berdah, L., Lequesne, M., Mazières, B., ...

Objective. To determine a cut‐off point above which a change in joint space width (JSW) could be considered as relevant in patients with hip osteoarthritis (OA) on the...

Relevant change in radiological progression in patients with hip osteoarthritis. II. Determination using an expert opinion approach (2002)

Maillefert, J. F., Nguyen, M., Gueguen, A., Berdah, L., Lequesne, M., Mazières, B., ...

Aim. To determine the minimum clinically important difference (MCID) in joint space width (JSW) progression in patients with hip osteoarthritis (OA), based upon...

Towards a definition of "difference" in osteoarthritis (2001)

Bellamy, N, Carr, A, Dougados, M, Shea, B, Wells, G

To assess existing information regarding detectable differences in osteoarthritis (OA), a systematic literature search was conducted up to December 1999. Thirty-three articles were considered...

Towards a definition of "difference" in osteoarthritis (2001)

Bellamy, N, Carr, A, Dougados, M, Shea, B, Wells, G

To assess existing information regarding detectable differences in osteoarthritis (OA), a systematic literature search was conducted up to December 1999. Thirty-three articles were considered...

Measurement of joint space width in hip osteoarthritis: influence of joint positioning and radiographic procedure (2001)

Duche, A., Dougados, M., Ravaud, P.

Objectives. We assessed the influence of patient positioning and radiographic procedure, and defined a smallest detectable difference (SDD) in hip osteoarthritis (OA)....

Response criteria for clinical trials on osteoarthritis of the knee and hip - A report of The Osteoarthritis Research Society International Standing Committee for Clinical Trials Response Criteria Initiative (2000)

Dougados, M, LeClaire, P, Bloch, DA, Bellamy, N, Altman, RD, VAN DER HEIJDE, Desiree

Background: The domains of pain, function and patient's global assessment are identified as core variables and frequently measured in clinical trials of patients with osteoarthritis (OA) of the hip...

Response criteria for clinical trials on osteoarthritis of the knee and hip - A report of The Osteoarthritis Research Society International Standing Committee for Clinical Trials Response Criteria Initiative (2000)

Dougados, M, LeClaire, P, Bloch, DA, Bellamy, N, Altman, RD, VAN DER HEIJDE, Desiree

Background: The domains of pain, function and patient's global assessment are identified as core variables and frequently measured in clinical trials of patients with osteoarthritis (OA) of the hip...

Defining disease activity in ankylosing spondylitis: is a combination of variables (Bath Ankylosing Spondylitis Disease Activity Index) an appropriate instrument? (1999)

Calin, A., Gueguen, A., Zeidler, H., Mielants, H., Dougados, M.

Objective. Disease activity has been defined using a self-administered instrument, focusing on fatigue, axial pain, peripheral pain, enthesopathy and morning stiffness [Bath Ankylosing Spondylitis...

Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2 (1999)

Brooks, P., Emery, P., Evans, J. F., Fenner, H., Hawkey, C. J., Patrono, C., ...

The International Consensus Meeting on the Mode of Action of COX-2 Inhibition (ICMMAC) brought together 17 international experts in arthritis, gastroenterology and pharmacology on 5–6 December...

Ankylosing spondylitis: what is the optimum duration of a clinical study? A one year versus a 6 weeks non-steroidal anti-inflammatory drug trial (1999)

Dougados, M, Gueguen, A, Nakache, JP, Velicitat, P, Veys, EM, Zeidler, H, ...

Objective. To consider the re3levance of the duration of a clinical trial in ankylosing spondylitis: long-term (i.e. 1 yr) vs short-term (i.e. 6 weeks) assessment of a non-steroidal anti-inflammatory...

KNEE JOINT SPACE WIDTH MEASUREMENT: AN EXPERIMENTAL STUDY OF THE INFLUENCE OF RADIOGRAPHIC PROCEDURE AND JOINT POSITIONING (1996)

RAVAUD, P., CHASTANG, C., ROUSSELIN, B., PAOLOZZI, L., AMOR, B., ...

We studied the influence of the radiographic procedure and joint positioning on knee joint space width (JSW) in 10 healthy volunteers, and the intrareader reproducibility of JSW measurements on...

PREDICTIVE FACTORS OF SEVERITY OF SPONDYLOARTHROPATHY IN NORTH AFRICA (1995)

CLAUDEPIERRE, P., GUEGUEN, A., LADJOUZE, A., HAJJAJ-HASSOUNI, N., SELLAMI, S., AMOR, B., ...

Both genetic and environmental factors probably influence the severity of spondyloarthropathies. Hip involvement, which may be used as a marker of disease severity, is more frequent in...

Sulphasalazine in ankylosing spondylitis: a double blind controlled study in 60 patients.

Dougados, M, Boumier, P, Amor, B

Sulphasalazine has been reported to be effective in ankylosing spondylitis with peripheral arthritis, but its efficacy in spondylitis is unknown. Thus 60 patients with active ankylosing spondylitis...

Sulphasalazine in ankylosing spondylitis: a double blind controlled study in 60 patients.

Dougados, M, Boumier, P, Amor, B

Sulphasalazine has been reported to be effective in ankylosing spondylitis with peripheral arthritis, but its efficacy in spondylitis is unknown. Thus 60 patients with active ankylosing spondylitis...

Nonathymulin in rheumatoid arthritis: two double blind, placebo controlled trials.

Amor, B, Dougados, M, Mery, C, Dardenne, M, Bach, J F

Two randomised double blind, placebo controlled trials have been carried out to assess the effectiveness of nonathymulin, a synthetic thymic peptide hormone, in the treatment of rheumatoid arthritis...

Cyclosporin in rheumatoid arthritis: a double blind, placebo controlled study in 52 patients.

Dougados, M, Awada, H, Amor, B

The efficacy and safety of cyclosporin A (CyA) for patients with rheumatoid arthritis were assessed in a four month double blind, placebo controlled study using an initial dosage of 5 mg/kg daily....

Assessment of efficacy and acceptability of low dose cyclosporin in patients with rheumatoid arthritis.

Dougados, M, Duchesne, L, Awada, H, Amor, B

The efficacy of cyclosporin in a double blind, placebo controlled trial of four months' duration has previously been reported by us. To assess the benefit-to-risk of cyclosporin this study was...

Evaluation of sulphasalazine in the treatment of spondyloarthropathies.

Dougados, M, Maetzel, A, Mijiyawa, M, Amor, B

Sulphasalazine has been shown to have an effect in patients with spondyloarthropathies, but the clinical indication for its use is controversial and its long term effect has not yet been evaluated....

Effect of cyclosporin A on interleukin-6 and soluble interleukin-2 receptor in patients with rheumatoid arthritis.

Crilly, A, Kolta, S, Dougados, M, Sturrock, R D, Amor, B, Capell, H A, ...

OBJECTIVE--To investigate the effect of cyclosporin A (CyA) therapy on circulating concentrations of interleukin-6 (IL-6) and soluble interleukin-2 receptor (sIL-2R) in patients with rheumatoid...

Radiological progression of hip osteoarthritis: definition, risk factors and correlations with clinical status.

Dougados, M, Gueguen, A, Nguyen, M, Berdah, L, Lequesne, M, Mazieres, B, ...

OBJECTIVES: To determine a cut off value for changes in radiological joint space width that allowed definition of radiological progression of hip osteoarthritis not related to measurement method...

Variability in knee radiographing: implication for definition of radiological progression in medial knee osteoarthritis

Ravaud, P., Giraudeau, B., Auleley, G., Drape, J., Rousselin, B., Paolozzi, L., ...

OBJECTIVES—(1) To assess reproducibility of medial knee joint space width (JSW) measurement in healthy subjects and osteoarthritic (OA) patients. (2) To define minimal relevant radiological change...

Osteoarthritis of the hip: agreement between joint space width measurements on standing and supine conventional radiographs

Auleley, G., Rousselin, B., Ayral, X., Edouard-Noel, R., Dougados, M., Ravaud, P.

OBJECTIVE—To assess the effect of standing position on joint space width (JSW) measurements of the hips with and without osteoarthritis (OA) on pelvic radiographs.
METHODS—Adult patients aged...

Are radiological joint space widths of normal hips asymmetrical?

Reis, P., Nahal-Said, R., Ravaud, P., Dougados, M., Amor, B.

BACKGROUND—To be certain that the joint space width is abnormal in the case of hip joint pain when compared with the contralateral hip requires knowledge of physiological dissymmetry.
AIM OF THE...

Combination therapy in early rheumatoid arthritis: a randomised, controlled, double blind 52 week clinical trial of sulphasalazine and methotrexate compared with the single components

Dougados, M., Combe, B., Cantagrel, A., Goupille, P., Olive, P., Schattenkirchner, M., ...

OBJECTIVES—To investigate the potential clinical benefit of a combination therapy.
METHODS—205 patients fulfilling the ACR criteria for rheumatoid arthritis (RA), not treated with disease...

EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)

Pendleton, A, Arden, N, Dougados, M, Doherty, M, Bannwarth, B, Bijlsma, J, ...

BACKGROUND—Osteoarthritis (OA) is the most common joint disease encountered throughout Europe. A task force for the EULAR Standing Committee for Clinical Trials met in 1998 to determine the...

Radiographic assessment of hip osteoarthritis progression: impact of reading procedures for longitudinal studies

Auleley, G., Giraudeau, B., Dougados, M., Ravaud, P.

OBJECTIVE—To compare radiographic reading procedures and evaluate their impact on sample size in hip osteoarthritis (OA) longitudinal studies.
METHODS—Pelvic radiographs performed twice, three...

The role of HLA genes in familial spondyloarthropathy: a comprehensive study of 70 multiplex families

Said-Nahal, R, Miceli-Richard, C, Gautreau, C, Tamouza, R, Borot, N, Porcher, R, ...

Objectives: To investigate whether HLA alleles, other than HLA-B27, influence predisposition to spondyloarthropathy (SpA) in multiplex families.

Early referral recommendation for newly diagnosed rheumatoid arthritis: evidence based development of a clinical guide

Emery, P, Breedveld, F, Dougados, M, Kalden, J, Schiff, M, Smolen, J

Objective: To develop a referral recommendation that may serve as a clinical guide for primary care doctors, enabling them to identify patients with suspected RA during the early inflammatory stages.

Work status and productivity costs due to ankylosing spondylitis: comparison of three European countries

Boonen, A, Landewe, R, Spoorenberg, A, Schouten, H, Rutten-Van, M, ...

Objective: To compare work disability, sick leave, and productivity costs due to ankylosing spondylitis (AS) of three European countries.

Reliability of self assessed joint counts in ankylosing spondylitis

Spoorenberg, A, Dougados, M, De Vlam, K, Mielants, H, ...

Objective: To determine the reliability of self reported joint counts to assess pain or swelling in ankylosing spondylitis (AS).

Sex differences in hip osteoarthritis: results of a longitudinal study in 508 patients

Maillefert, J, Gueguen, A, Monreal, M, Nguyen, M, Berdah, L, Lequesne, M, ...

Objective: To evaluate sex differences in the clinical and structural presentation, and natural history of hip OA.

Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage

Meyer, O, Labarre, C, Dougados, M, Goupille, P., Cantagrel, A, Dubois, A, ...

Objective: To study the value of antibodies to citrullinated proteins/peptides for predicting joint outcomes in patients with recent onset rheumatoid arthritis (RA).

Assessment of enthesitis in ankylosing spondylitis

Heuft-Dorenbosch, L, Spoorenberg, A, Van Tubergen, A, Landewe, R, Mielants, H, ...

Objective: To assess, firstly, the validity of the enthesis index published by Mander (Mander enthesis index (MEI)) and, secondly, to investigate whether it is possible to define a new enthesis index...

Comparison of statistically derived ASAS improvement criteria for ankylosing spondylitis with clinically relevant improvement according to an expert panel

Van Tubergen, A, Anderson, J, Landewe, R, Dougados, M, Braun, J, ...

Objective: To investigate whether the recently developed (statistically derived) "ASsessment in Ankylosing Spondylitis Working Group" improvement criteria (ASAS-IC) for ankylosing spondylitis (AS)...

Increase in bone mineral density of patients with spondyloarthropathy treated with anti-tumour necrosis factor α

Allali, F, Breban, M, Porcher, R, Maillefert, J, Dougados, M, Roux, C

Patients and methods: 29 patients (six women; 23 men) aged 22–68 years, with persistently active SpA despite a high dose of non-steroidal anti-inflammatory drug and/or treatment with methotrexate...

Long term structural effects of combination therapy in patients with early rheumatoid arthritis: five year follow up of a prospective double blind controlled study

Maillefert, J, Combe, B, Goupille, P, Cantagrel, A, Dougados, M

Methods: Study design: five year multicentre prospective longitudinal trial. Participants: 146/205 patients with RA previously included in a one year prospective randomised trial comparing the...

Direct costs of ankylosing spondylitis and its determinants: an analysis among three European countries

Boonen, A, Landewe, R, Guillemin, F, Rutten-van, M, Dougados, M, ...

Objective: To assess direct costs associated with ankylosing spondylitis (AS). To determine which variables, including country, predict costs.

Costs of ankylosing spondylitis in three European countries: the patient's perspective

Boonen, A, Landewe, R, Guillemin, F, Spoorenberg, A, Schouten, H, ...

Objective: To assess a patient's out of pocket costs, income loss, time consumption, and quality of life (QoL) due to ankylosing spondylitis (AS) in three European countries and to assess variables...

Disability in adults with hip and knee arthroplasty: a French national community based survey

Boutron, I, Poiraudeau, S, Ravaud, J, Baron, G, Revel, M, Nizard, R, ...

Objectives: To compare levels of disability of people with and without hip and knee arthroplasty in a random national sample.

Initiation of biological agents in patients with ankylosing spondylitis: results of a Delphi study by the ASAS Group

Pham, T, Calin, A, Khan, M, Bellamy, N, ...

Background: There is ample evidence of important symptomatic efficacy of tumour necrosis factor α (TNFα) inhibition in ankylosing spondylitis (AS). Moreover, studies suggest that anti-TNF could be...

International ASAS consensus statement for the use of anti-tumour necrosis factor agents in patients with ankylosing spondylitis

Braun, J, Pham, T, Sieper, J, Davis, J, Dougados, M, ...

Objective: To obtain an international consensus about the use of anti-tumour necrosis factor α (anti-TNFα) for treating patients with ankylosing spondylitis (AS).

Conventional treatments for ankylosing spondylitis

Dougados, M, Dijkmans, B, Khan, M, Maksymowych, W, Brandt, J

Management of ankylosing spondylitis (AS) is challenged by the progressive nature of the disease. To date, no intervention is available that alters the underlying mechanism of inflammation in AS....

Staging of patients with ankylosing spondylitis: a preliminary proposal

Braun, J, Dougados, M, Emery, P, Khan, M, Sieper, J, ...

Patients with ankylosing spondylitis (AS) are characterised by a wide range of clinical presentations, radiographic profiles, and outcomes, which are not well differentiated by current diagnostic and...

Efficacy and safety of adalimumab as monotherapy in patients with rheumatoid arthritis for whom previous disease modifying antirheumatic drug treatment has failed

Atkins, C, Malaise, M, Sany, J, Russell, A, ...

Objective: To evaluate the efficacy and safety of monotherapy with adalimumab in patients with RA for whom previous DMARD treatment has failed.

Management of osteoarthritis (OA) with an unsupervised home based exercise programme and/or patient administered assessment tools. A cluster randomised controlled trial with a 2x2 factorial design

Ravaud, P, Giraudeau, B, Logeart, I, Larguier, J, Rolland, D, Treves, R, ...

Background: Diary recording of pain and disabling activities in osteoarthritis (OA) is widely recommended, but, to our knowledge, its impact on symptoms has not been investigated. Exercise programmes...

The in vitro production and regulation of anti-double stranded DNA antibodies by peripheral blood mononuclear cells from normals and patients with systemic lupus erythematosus.

Mach, P S, Kharouby, M, Lutcher, F, Olivier, J L, Bazely, N, Dougados, M, ...

The in vitro production of anti-double stranded DNA antibodies (anti-DNA) by peripheral blood mononuclear cells (PBMC) was investigated in 19 patients with systemic lupus erythematosus (SLE) and in...

The in vitro production of anti-nuclear antibodies by human peripheral blood mononuclear cells. Demonstration of T cell requirement and soluble inducing factor(s) for anti-nuclear antibodies triggering in patients with systemic lupus erythematosus.

Mach, P S, Kharouby, M, Lutcher, F, Olivier, J L, Bazely, N, Dougados, M, ...

Peripheral blood mononuclear cells (PBMC) of 29 patients with systemic lupus erythematosus (SLE) and 14 normal individuals were investigated for the in vitro production of anti-nuclear antibodies...

Neutrophil expression of tumour necrosis factor receptors (TNF-R) and of activation markers (CD11b, CD43, CD63) in rheumatoid arthritis.

Lopez, S, Halbwachs-Mecarelli, L, Ravaud, P, Bessou, G, Dougados, M, Porteu, F

In vitro analysis of polymorphonuclear neutrophils (PMN) has allowed various stages of cell activation to be distinguished, characterized by the expression level of specific membrane markers and of...

Paracetamol in osteoarthritis of the knee

Miceli-Richard, C, Le Bars, M, Schmidely, N, Dougados, M

Background: Paracetamol is a recommended symptomatic treatment of osteoarthritis (OA), but in clinical trials sample sizes have been relatively small and variable daily doses of paracetamol have been...

Detection of small joint synovitis by ultrasonography: the learning curve of rheumatologists

D'Agostino, M, Maillefert, J, Said-Nahal, R, Breban, M, Ravaud, P, Dougados, M

Background: Ultrasonography allows assessment of soft tissue structures and has become a valued tool for diagnosing synovitis.

Scoring of radiographic progression in randomised clinical trials in ankylosing spondylitis: a preference for paired reading order

Wanders, A, Landewe, R, Spoorenberg, A, De Vlam, K, Mielants, H, Dougados, M, ...

Objectives: To describe the influence of the reading order (chronological v paired) on radiographic scoring results in ankylosing spondylitis. To investigate whether this method is sufficiently...

Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis

Pham, T, Le Henanff, A, Ravaud, P., Dieppe, P, Paolozzi, L, Dougados, M

Objective: To evaluate long term efficacy of three iterative courses of three weekly intra-articular (IA) injections of NRD101 in the treatment of symptomatic knee osteoarthritis (OA).

Evaluation of clinically relevant states in patient reported outcomes in knee and hip osteoarthritis: the patient acceptable symptom state

Tubach, F, Ravaud, P, Baron, G, Falissard, B, Logeart, I, Bellamy, N, ...

Background: The patient acceptable symptom state (PASS) is the value beyond which patients can consider themselves well. This concept can help in interpreting results of clinical trials.

Using patients' and rheumatologists' opinions to specify a short form of the WOMAC function subscale

Tubach, F, Baron, G, Falissard, B, Logeart, I, Dougados, M, Bellamy, N, ...

Background: The WOMAC (Western Ontario and McMaster Universities) function subscale is widely used in clinical trials of hip and knee osteoarthritis. Reducing the number of items of the subscale...

When a DMARD fails, should patients switch to sulfasalazine or add sulfasalazine to continuing leflunomide?

Dougados, M, Emery, P, Lemmel, E, Zerbini, C, Brin, S, Van Riel, P

Objective: To evaluate the efficacy and safety of adding sulfasalazine to leflunomide treatment compared with switching to sulfasalazine alone in patients with RA with an inadequate response to...

Evaluation of clinically relevant changes in patient reported outcomes in knee and hip osteoarthritis: the minimal clinically important improvement

Tubach, F, Ravaud, P, Baron, G, Falissard, B, Logeart, I, Bellamy, N, ...

Background: In clinical trials, at the group level, results are usually reported as mean and standard deviation of the change in score, which is not meaningful for most readers.

Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases

Gottenberg, J, Guillevin, L, Lambotte, O, Combe, B, Allanore, Y, Cantagrel, A, ...

Objective: To assess the tolerance and efficacy of rituximab in patients with various autoimmune diseases seen in daily rheumatological practice.

Association between radiographic damage of the spine and spinal mobility for individual patients with ankylosing spondylitis: can assessment of spinal mobility be a proxy for radiographic evaluation?

Wanders, A, Landewe, R, Dougados, M, Mielants, H

Objective: To demonstrate the association between various measures of spinal mobility and radiographic damage of the spine in individual patients with ankylosing spondylitis, and to determine whether...

Predictive factors of total hip replacement due to primary osteoarthritis: a prospective 2 year study of 505 patients

Gossec, L, Tubach, F, Baron, G, Ravaud, P, Logeart, I, Dougados, M

Objectives: To determine the 2 year total hip replacement (THR) rate and to identify factors predictive of THR due to primary osteoarthritis (OA).

Body weight, body composition, and bone turnover changes in patients with spondyloarthropathy receiving anti-tumour necrosis factor α treatment

Briot, K, Garnero, P, Le Henanff, A, Dougados, M, Roux, C

Objectives: To determine the changes in body weight, body composition, and bone turnover in patients with spondyloarthropathy (SpA) treated with anti-tumour necrosis factor α (TNFα).

Sustained durability and tolerability of etanercept in ankylosing spondylitis for 96 weeks

Davis, J, Van Der Heijde, D M, Braun, J, Dougados, M, Cush, J, Clegg, D, ...

Objective: To evaluate the continued safety and durability of clinical response in patients with ankylosing spondylitis receiving etanercept.

Efficacy of cyclo-oxygenase-2 inhibition by etoricoxib and naproxen on the axial manifestations of ankylosing spondylitis in the presence of peripheral arthritis

Gossec, L, Melian, A, Krupa, D, James, M, Cavanaugh, P, ...

Objective: The combined efficacy of selective and non-selective cyclo-oxygenase-2 (COX-2) inhibition on the axial manifestations of ankylosing spondylitis (AS) in the presence or absence of chronic...

EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: Prevalence of inflammation in osteoarthritis

D'Agostino, M, Conaghan, P, Le Bars, M, Baron, G, Grassi, W, Martin-Mola, E, ...

Objectives: To assess the prevalence of inflammation in subjects with chronic painful knee osteoarthritis (OA), as determined by the presence of synovitis or joint effusion at ultrasonography (US);...

EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: Exploring decision rules for clinical utility

Conaghan, P, D'Agostino, M, Ravaud, P, Baron, G, Le Bars, M, Grassi, W, ...

Background: Synovial inflammation (as defined by hypertrophy and effusion) is common in osteoarthritis (OA) and may be important in both pain and structural progression.

Definition of disease duration in ankylosing spondylitis: reassessing the concept

Davis, J C, Dougados, M, Braun, J, Sieper, J

The concept and definition of disease duration in patients with ankylosing spondylitis is ambiguous, and often many years pass between the onset of symptoms and diagnosis. Members of the Assessment...