Scientific Commons: m. e.

A parallel proteomic and metabolomic analysis of the hydrogen peroxide- and Sty1p-dependent stress response in Schizosaccharomyces pombe (2006)

Weeks,
M.E.,
Sinclair,
J.,
Butt,
A,
...

The role of Hsp70 and its co-chaperones in protein misfolding, aggregation and disease (2006)

Van Der Spuy,
J.,
Cheetham,
M.E.,
Chapple,
J.P.

Sex-specific, male-line transgenerational responses in humans (2006)

Pembrey,
M.E.,
Bygren,
L.O.,
Kaati,
G.,
...

Transgenerational effects of maternal nutrition or other environmental 'exposures' are well recognised, but the possibility of exposure in the male influencing development and health in the next...

X-ray absorption spectroscopy and high-energy XRD study of the local environment of copper in antibacterial copper-releasing degradable phosphate glasses (2006)

Pickup,
D.M.,
Ahmed,
I.,
FitzGerald,
V.,
...

A parallel proteomic and metabolomic analysis of the hydrogen peroxide- and Sty1p-dependent stress response in Schizosaccharomyces pombe (2006)

Weeks,
M.E.,
Sinclair,
J.,
Butt,
A.,
...

Extraordinary plasticity in aging in Strongyloides ratti implies a gene-regulatory mechanism of lifespan evolution (2006)

Gardner,
M.P.,
Gems,
D.,
Viney,
M.E.

A novel calcium phosphate coating for biomedical applications (2006)

Thian,
E.S.,
Huang,
J.,
Best,
S.M.,
...

Non-Gaussianity in the Very Small Array cosmic microwave background maps with smooth goodness-of-fit tests (2006)

Rubiño-Martín,
J.A.,
Aliaga,
A.M.,
Barreiro,
R.B.,
...

We have used the Rayner and Best smooth tests of goodness-of-fit to study the Gaussianity of the Very Small Array (VSA) data. These tests are designed to be sensitive to the presence of `smooth'...

Cortical Concentrations of Metals and Protein in the Brain of Two Breeds of Goats in Nigeria. (2005)

Olopade,
J.O.,
Adejumo,
D.O.,
Ladokun,
A.O.,
...

Metal pollution and exposure is an increasing global problem. One of the best ways to assess the impact of this problem on the brain is by using animals raised in such environments. As a prelude to...

WHOLE CELL VERSUS TOTAL RNA EXTRACTION FOR THE ANALYSIS OF MICROBIAL COMMUNITY STRUCTURE USING 16S RRNA TARGETED OLIGONUCLEOTIDE PROBES IN SALTMARSH SEDIMENTS. (R825513C025) (2005)

M.E.,
D J.M.,
N M.A.,
F And,
Frischer

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the...

Heterogeneous duplications in patients with Pelizaeus-Merzbacher disease suggest a mechanism of coupled homologous and nonhomologous recombination (2005)

Woodward,
K.J.,
Cundall,
M.,
Sperle,
K.,
...

We describe genomic structures of 59 X-chromosome segmental duplications that include the proteolipid protein 1 gene (PLP1) in patients with Pelizaeus-Merzbacher disease. We provide the first report...

Laryngotracheal reconstruction in congenital laryngeal webs and atresias (2005)

Wyatt,
M.E.,
Hartley,
B.E.

OBJECTIVE: To review the role of open laryngotracheal reconstruction (LTR) in congenital laryngeal webs and atresias. STUDY DESIGN AND SETTING: A retrospective chart review was undertaken in a...

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms (2005)

Vella,
A.,
Cooper,
J.D.,
Lowe,
C.E.,
...

As part of an ongoing search for genes associated with type 1 diabetes (T1D), a common autoimmune disease, we tested the biological candidate gene IL2RA (CD25), which encodes a subunit (IL-2R alpha)...

GTF2IRD1 in craniofacial development of humans and mice (2005)

Tassabehji,
M.,
Hammond,
P.,
Karmiloff-Smith,
A.,
...

Craniofacial abnormalities account for about one-third of all human congenital defects, but our understanding of the genetic mechanisms governing craniofacial development is incomplete. We show that...

Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans (2005)

Petry,
C.J.,
Ong,
K.K.,
Barratt,
B.J.,
...

Background: Common genetic variation at genes that are imprinted and exclusively maternally expressed could explain the apparent maternal-specific inheritance of low birthweight reported in large...

Measurement of total pulmonary arterial compliance using invasive pressure monitoring and MR flow quantification during MR-guided cardiac catheterization (2005)

Muthurangu,
V.,
Atkinson,
D.,
Sermesant,
M.,
...

Pulmonary hypertensive disease is assessed by quantification of pulmonary vascular resistance. Pulmonary total arterial compliance is also an indicator of pulmonary hypertensive disease. However,...

Mannose-binding lectin enhances phagocytosis and killing of Neisseria meningitidis by human macrophages (2005)

Jack,
D.L.,
Lee,
M.E.,
Turner,
M.W.,
...

Deficiency of mannose-binding lectin (MBL) is probably the most common human immunodeficiency and is associated with an increased risk of mucosally acquired infections including meningococcal...

Common arterial trunk associated with a homeodomain mutation of NKX2.6 (2005)

Heathcote,
K.,
Braybrook,
C.,
Abushaban,
L.,
...

Persistent truncus arteriosus (PTA) is a failure of septation of the cardiac outflow tract (OFT) into the pulmonary artery and the aorta. A common arterial trunk (CAT) is often diagnosed as PTA in...

Investigation of UBE3A and MECP2 in Angelman syndrome (AS) and patients with features of AS (Am J Med Genet 125A: 167-172) (2005)

Hitchins,
M.P.,
Rickard,
S.,
Dhalla,
F.,
...

Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis (2005)

Fraser,
S.P.,
Diss,
J.K.J.,
Chioni,
A.M.,
...

Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral to metastasis (e.g., proliferation, motility, secretion, and invasion), although their contribution to...

Physiotherapy management of cystic fibrosis (2005)

Dodd,
M.E.,
Prasad,
S.A.

For many years physiotherapy for cystic fibrosis (CF) was synonymous with a daily routine of postural drainage and percussion. Improved longevity and a desire for independence, together with a...

The role of the anterior cricoid split in facilitating extubation in infants (2005)

Eze,
N.N.,
Wyatt,
M.E.,
Hartley,
B.E.

OBJECTIVE:: The use of the anterior cricoid split (ACS) procedure has facilitated the extubation of children with early subglottic stenosis who may otherwise have required a tracheostomy. Criteria...

Primary spontaneous pneumothorax in children: the role of CT in guiding management (2005)

Choudhary,
A.K.,
Sellars,
M.E.,
Wallis,
C.,
...

How we do it: BAHA positioning in patients with microtia requiring auricular reconstruction (2005)

Bajaj,
Y.,
Wyatt,
M.E.,
Gault,
D.,
...

Bilateral microtia is a challenging problem as these patients require both reconstruction of the auricle and rehabilitation of hearing. Our aim was to find the optimal position for bone-anchored...

Effects of quinine, quinidine, and chloroquine on alpha9alpha10 nicotinic cholinergic receptors (2005)

Ballestero,
J.A.,
Plazas,
P.V.,
Kracun,
S.,
...

In this study, we report the effects of the quinoline derivatives quinine, its optical isomer quinidine, and chloroquine on alpha9alpha10-containing nicotinic acetylcholine receptors (nAChRs). The...

Stress-induced changes in the Schizosaccharomyces pombe proteome using two-dimensional difference gel electrophoresis, mass spectrometry and a novel integrated robotics platform (2005)

Weeks,
M.E.,
Sinclair,
J.,
Jacob,
R.J.,
...

Robotic and manual methods have been used to obtain identification of significantly changing proteins regulated when Schizosaccharomyces pombe is exposed to oxidative stress. Differently treated S....

Fundamental subchondral bone changes in spontaneous knee osteoarthritis. (2005)

Anderson-MacKenzie,
J.M.,
Quasnichka,
H.L.,
Starr,
R.L.,
...

Non-travel associated hepatitis E in England and Wales: Demographic, clinical and molecular epidemiological characteristics. (2005)

Ijaz,
S.,
Arnold,
E.,
Banks,
M.,
...

Sol-gel synthesis of the P2O5-CaO-Na2O-SiO2 system as a novel bioresorbable glass (2005)

Carta,
D.,
Pickup,
D.M.,
Knowles,
J.C.,
...

Influence of short stature on the change in pulse pressure, systolic and diastolic blood pressure from age 36 to 53 years: an analysis using multilevel models. (2005)

Langenberg,
C.,
Hardy,
R.,
Breeze,
E.,
...

Assay and functional analysis of the ARL3 effector RP2 involved in X-linked retinitis pigmentosa (2005)

Evans,
R.J.,
Chapple,
J.P.,
Grayson,
C.,
...

Mutations in RP2 cause X-linked retinitis pigmentosa and also macular and peripapillary atrophy. RP2 is a functional homologue of the tubulin folding cofactor, cofactor C, as it can replace the beta...

Focus on molecules: nyctalopin (2005)

Poopalasundaram,
S.,
Erskine,
L.,
Cheetham,
M.E.,
...

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome (2005)

Westhoff,
B.,
Chapple,
J.P.,
Van Der,
Spuy J.,
...

Protein degradation in eukaryotic cells usually involves the attachment of a ubiquitin chain to a substrate protein and its subsequent sorting to the proteasome. Molecular mechanisms underlying the...

Identification of novel RPGR ORF15 mutations in X-linked progressive cone-rod dystrophy (XLCORD) families (2005)

Ebenezer,
N.D.,
Michaelides,
M.,
Jenkins,
S.A.,
...

PURPOSE: To test the incidence of mutations in RPGR ORF15 in six families with X-linked progressive retinal degeneration (cone-rod dystrophy [XLCORD], macular or cone dystrophy) and to undertake a...

Inherited ACTH insensitivity illuminates the mechanisms of ACTH action (2005)

Clark,
A.J.,
Metherell,
L.A.,
Cheetham,
M.E.,
...

Adrenocorticotrophin (ACTH) insensitivity is a potentially lethal inherited disorder of ACTH signalling in the adrenal. Inactivating mutations of the ACTH receptor account for approximately 25% of...

Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2 (2005)

Inglis-Broadgate,
S.L.,
Ocaka,
L.,
Banerjee,
R.,
...

Phototransduction in Drosophila is a phosphoinositide-mediated signalling pathway. Phosphatidylinositol 4,5-bisphosphate (PIP2) plays a central role in this process, and its levels are tightly...

Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy (2005)

Mendes,
H.F.,
Van Der,
Spuy J.,
Chapple,
J.P.,
...

Retinitis pigmentosa (RP) is a group of retinal degenerative diseases that are characterised primarily by the loss of rod photoreceptor cells. Mutations in rhodopsin are the most common cause of...

Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2 (2005)

Metherell,
L.A.,
Chapple,
J.P.,
Cooray,
S.,
...

Familial glucocorticoid deficiency (FGD), or hereditary unresponsiveness to adrenocorticotropin (ACTH; OMIM 202200), is an autosomal recessive disorder resulting from resistance to the action of ACTH...

Predominant rod photoreceptor degeneration in Leber congenital amaurosis (2005)

Van Der,
Spuy J.,
Munro,
P.M.,
Luthert,
P.J.,
...

PURPOSE: An unusual retinal vascular morphology in an enucleated eye from a patient with Leber congenital amaurosis (LCA) has been associated with a mutation in AIPL1. The AIPL1 protein is expressed...

Treatment with extracellular HSP70/HSC70 protein can reduce polyglutamine toxicity and aggregation (2005)

Novoselova,
T.V.,
Margulis,
B.A.,
Novoselov,
S.S.,
...

The accumulation of insoluble protein aggregates is a feature of neurodegenerative disease. Overexpression of Heat Shock Protein 70 (HSP70) can protect cells with protein aggregates from apoptosis....

Impaired vision and the ability to take medications (2005)

Windham,
B.G.,
Griswold,
M.E.,
Fried,
L.P.,
...

OBJECTIVES: To assess relationships between vision (contrast sensitivity, stereopsis, visual acuity) and a performance-based measure of ability to implement new medications. DESIGN: Cross-sectional...

Role of interferon-gamma in a mouse model of allergic conjunctivitis (2005)

Stern,
M.E.,
Siemasko,
K.,
Gao,
J.,
...

PURPOSE: To characterize the effect of repeated topical exposure to allergen in a mouse model of allergic conjunctivitis and to determine the role of interferon-gamma (IFN-gamma) in the pathogenesis...

Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction (2005)

Gegg,
M.E.,
Harry,
R.,
Hankey,
D.,
...

Intraocular inflammatory diseases are a common cause of severe visual impairment and blindness. In an acute mouse model of autoimmune retinal disease, we demonstrate that treatment with the...

MINLPModels for the Synthesis of Optimal Peptide Tags and downstream protein processing (2005)

Simeonidis,
E.,
Pinto,
J.M.,
Lienqueo,
M.E.,
...

MINLP models for the Synthesis of Optimal Peptide Tags and Downstream protein processing. (2005)

Simeonidis,
E.,
Pinto,
J.M.,
Lienqueo,
M.E.,
...

Proton modulation of recombinant GABA(A) receptors: influence of GABA concentration and the beta subunit TM2-TM3 domain (2005)

Wilkins,
M.E.,
Hosie,
A.M.,
Smart,
T.G.

DNA Molecular motor driven micromechanical Cantilever Arrays (2005)

Shu,
W.,
Lui,
D.,
Watari,
M.,
...

High-significance sunyaev-zel'dovich measurement: abell 1914 seen with the arcminute microkelvin imager. (2005)

Barker,
R.,
Biddulph,
P.,
Bly,
D.,
...

We report the first detection of a Sunyaev-Zel'dovich (S-Z) decrement with the Arcminute Microkelvin Imager (AMI). We have made commissioning observations towards the cluster A1914 and have measured...

Cosmic microwave background observations from the Cosmic Background Imager and Very Small Array: a comparison of coincident maps and parameter estimation methods (2005)

Rajguru,
N.,
Myers,
S.T.,
Battye,
R.A.,
...

WWe present coincident observations of the cosmic microwave background (CMB) from the Very Small Array (VSA) and Cosmic Background Imager (CBI) telescopes. The consistency of the full data sets is...

Selection Criteria for Dental Radiography (2004)

Pendlebury,
M.E.,
Horner,
K.,
Eaton,
K.A.

Visualization and tracking of an inflatable balloon catheter using SSFP in a flow phantom and in the heart and great vessels of patients (2004)

Miquel,
M.E.,
Hegde,
S.,
Muthurangu,
V.,
...

Passive catheter tracking involves direct interaction between the device and its surroundings, creating a local signal loss or enhancement of the image. Using only standard balloon catheters filled...

Characterisation and Mitigation of Chemical Erosion of Doped Carbon Materials (2004)

Juan Pardo,
M. E.

Principal component analysis of non-linear chromatography (2004)

Pate,
M.E.,
Turner,
M.K.,
Thornhill,
N.F.,
...

International League of Associations for Rheumatology classification of juvenile arthritis: second revision (2004)

Petty,
R.E.,
Southwood,
T.T.,
Manners,
P.,
...

Cosmological parameter estimation using Very Small Array data out to l= 1500 (2004)

Rebolo,
R.,
Battye,
R.A.,
Carreira,
P.,
...

We estimate cosmological parameters using data obtained by the Very Small Array (VSA) in its extended configuration, in conjunction with a variety of other cosmic microwave background (CMB) data and...

Estimating the bispectrum of the Very Small Array data (2004)

Smith,
S.,
Rocha,
G.,
Challinor,
A.,
...

We estimate the bispectrum of the Very Small Array data from the compact and extended configuration observations released in 2002 December, and compare our results with those obtained from Gaussian...

High-sensitivity measurements of the cosmic microwave background power spectrum with the extended Very Small Array (2004)

Dickinson,
C.,
Battye,
R.A.,
Carreira,
P.,
...

We present deep Ka-band (ν~ 33 GHz) observations of the cosmic microwave background (CMB) made with the extended Very Small Array (VSA). This configuration produces a naturally weighted...

Searching for non-Gaussianity in the Very Small Array data (2004)

Savage,
R.,
Battye,
R.A.,
Carreira,
P.,
...

We have tested Very Small Array (VSA) observations of three regions of sky for the presence of non-Gaussianity, using high-order cumulants, Minkowski functionals, a wavelet-based test and a Bayesian...

Cardiac catheterisation guided by MRI in children and adults with congenital heart disease (2003)

Razavi,
R.,
Hill,
D.L.,
Keevil,
S.F.,
...

BACKGROUND: Fluoroscopically guided cardiac catheterisation is an essential tool for diagnosis and treatment of congenital heart disease. Drawbacks include poor soft tissue visualisation and exposure...

Organization on the plasma membrane of the retinitis pigmentosa protein RP2: investigation of association with detergent-resistant membranes and polarized sorting (2003)

Chapple,
J.P.,
Grayson,
C.,
Hardcastle,
A.J.,
...

Mutations in the retinitis pigmentosa protein gene RP2 account for up to 15% of X-linked retinitis pigmentosa. RP2 is a novel protein of unknown function, which is targeted to the plasma membrane by...

The early surface cell response to flexor tendon injury. (2003)

Jones,
M.E.,
Mudera,
V.,
Brown,
R.A.,
...

Three- and four-dimensional reconstruction of intra-cardiac anatomy from two-dimensional magnetic resonance images (2003)

Miquel,
M.E.,
Hill,
D.L.,
Baker,
E.J.,
...

The present study was designed to evaluate the feasibility and clinical usefulness of three-dimensional (3D) reconstruction of intra-cardiac anatomy from a series of two-dimensional (2D) MR images...

Three-dimensional magnetic resonance imaging of congenital cardiac anomalies (2003)

Razavi,
R.S.,
Hill,
D.L.,
Muthurangu,
V.,
...

We describe a new method of three-dimensional magnetic resonance imaging of the heart that has been used to produce high quality diagnostic images in 274 patients with congenital cardiac disease,...

North Avenue Review, [Fall 2002, Issue 50] (2002)

Dijet photoproduction at HERA and the structure of the photon (2002)

ZEUS Collaboration,
Butterworth,
J.M.,
Gwenlan,
C.,
Hall-Wilton,
...

Among 46 near full length HIV type 1 genome sequences from Rakai District, Uganda, subtype D and AD recombinants predominate. (2002)

Harris,
M.E.,
Serwadda,
D.,
Sewankambo,
N.,
...

The Leber congenital amaurosis gene product AIPL1 is localized exclusively in rod photoreceptors of the adult human retina (2002)

Van Der Spuy,
J.,
Chapple,
J.P.,
Clark,
B.J.,
...

Leber congenital amaurosis (LCA) is the most severe inherited retinal dystrophy resulting in markedly impaired vision or blindness at birth. LCA is characterized by an extinguished electroretinogram...

The role of extraocular photoreceptors in newt magnetic compass orientation: parallels between light-dependent magnetoreception and polarized light detection in vertebrates. (2001)

Phillips,
J.B.,
Deutschlander,
M.E.,
Freake,
M.J.,
...

Gene polymorphism in Netherton and common atopic disease (2001)

Walley,
A.J.,
Chavanas,
S.,
Moffatt,
M.E.,
...

Multiple groups of novel retroviral genomes in pigs and related species (2001)

Patience,
C.,
Switzer,
W.M.,
Takeuchi,
Y.,
...

In view of the concern over potential infection hazards in the use of porcine tissues and organs for xenotransplantation to humans, we investigated the diversity of porcine endogenous retrovirus...

Multiple groups of novel retroviral genomes in pigs and related species (2001)

Patience,
C.,
Switzer,
W.M.,
Takeuchi,
Y.,
...

In view of the concern over potential infection hazards in the use of porcine tissues and organs for xenotransplantation to humans, we investigated the diversity of porcine endogenous retrovirus...

On some dyadic properties of curves (2001)

Anderson,
J.M.,
Grifkin,
M.E.,
Lesley,
F.D.

A phase II study of gastrimmune in advanced pancreatic cancer (2000)

Brett,
B.T.,
Smith,
S.C.,
Bouvier,
C.V.,
...

Cervicography to triage women with borderline or mild dyskaryotic cervical PAP smears (2000)

Mould,
T.A.J.,
Singer,
A.,
Mansell,
M.E.,
...

Importance of sperm to epithelial cell contact for the capacitation of human spermatozoa in human Fallopian tube-epithelial cell coculture (2000)

Kervancioglu,
M.E.,
Saridogan,
E.,
Aitken,
R.J.,
...

Expression of CCK-B/gastrin receptor and endocytosis of anti-CCK-B/gastrin receptor antibody (2000)

Savage,
K.,
Waller,
H.A.,
Khan,
K.,
...

Expression of CCK-B/gastrin receptor and endocytosis of anti-CCK-B/gastrin receptor antibody (2000)

Savage,
K.,
Waller,
H.A.,
Khan,
K.,
...

Hepatitis C virus-specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C (2000)

Cramp,
M.E.,
Rossol,
S.,
Chokshi,
S.,
...

BACKGROUND & AIMS: The role of virus-specific T-helper lymphocyte reactivity in determining the therapeutic response in chronic hepatitis C virus (HCV) infection is not fully understood. METHODS: We...

Productive infection of primary human endothelial cells by pig endogenous retrovirus (PERV) (2000)

Martin,
U.,
Winkler,
M.E.,
Id,
M.,
...

The potential risk of viral transmission in the setting of xenotransplantation has gained major attention. Different porcine cell types have been shown to release retroviral particles, which are...

Extraocular magnetic compass in newts. (1999)