T-cell receptor alpha chain plays a critical role in antigen-specific suppressor cell function.
Kuchroo, V K, Byrne, M C, Atsumi, Y, Greenfield, E, Connolly, J B, Whitters, M J, ...
Antigen-specific suppressor T-cell hybridomas release soluble suppressor factors (TsF) in the supernatant that modulate both in vivo delayed-type hypersensitivity and in vitro plaque-forming cell...
Expression of CD3-associated antigen-binding receptors on suppressor T cells.
Kuchroo, V K, Steele, J K, Billings, P R, Selvaraj, P, Dorf, M E
Three suppressor T (Ts)-cell hybridomas specific for 4-hydroxy-3-nitrophenyl acetyl (NP) hapten were selected for surface expression of cluster determinant 3 (CD3) by using antibody (anti-CD3) or...
Okuda, K, Minami, M, Ju, S T, Dorf, M E
The serological characteristics of the antigen receptor on 4-hydroxy-3-nitrophenylacetyl (NP) specific suppressor T cell hybridomas were analyzed. Three T-cell hybrids could be lysed with...
Burakoff, S J, Germain, R N, Dorf, M E, Benacerrah, B
The role of the products of the K and D loci of the H-2 complex as target antigens for cytotoxic T cells generated to modified syngeneic cells has been investigated. Spleen cells, when cocultured...
Genetic control of murine IgD structural heterogeneity.
Pollock, R R, Dorf, M E, Mescher, M F
Murine B lymphocytes express two native forms of surface IgD: IgDI consists of two delta heavy chains and two light chains; IgDII consists of one heavy chain and one light chain. The relative amounts...
Perry, L L, Dorf, M E, Benacerraf, B, Greene, M I
We present evidence for a role of I-A subregion-encoded determinants in syngeneic tumor immunity. In animals rendered immune to the S1509a fibrosarcoma, daily treatment with microliter quantities of...
Fine specificity of antibodies to poly(Glu60Ala30Tyr10) produced by hybrid cell lines.
Pierres, M, Ju, S T, Waltenbaugh, C, Dorf, M E, Benacerraf, B, Germain, R N
The polyethylene glycol-mediated cell fusion technique has been used to analyze the diversity of the antibody response to the terpolymer poly(Glu60Ala30Tyr10)(GAT). Nine stable clones (all producing...
Idiotypic analysis of monoclonal antibodies to poly(Glu60Ala30Tyr10).
Ju, S T, Pierres, M, Waltenbaugh, C, Germain, R N, Benacerraf, B, Dorf, M E
Fifteen hybridoma anti-poly(Glu60Ala30Tyr10) (anti-GAT) antibodies were analyzed for the presence of a common set of idiotypic specificities associated with murine anti-GAT antibodies, termed CGAT...
Schwartz, R H, David, C S, Dorf, M E, Benacerraf, B, Paul, W E
Previous studies have demonstrated that both the antibody and T-lymphocyte proliferative immune responses to poly(Glu53Lys36Phe11)n (GLphi) are under the control of two major...
Kipps, T J, Benacerraf, B, Dorf, M E
The anti-hapten responses to the dinitrophenyl (Dnp) conjugate of the random linear terpolymers poly(L-Glu,LLys,LPhe), GLphi, or poly(LGlu,LLys,LAla), GLA, are of highly restricted heterogeneity....
Ju, S T, Benacerraf, B, Dorf, M E
A common idiotype was defined by a guinea pig anti-idiotypic antiserum made against D1.LP antibodies specific to the synthetic terpolymer poly(Glu60Ala30Tyr10), referred to as GAT. This idiotype was...
Ruf, J, Tonnelle, C, Rocca-Serra, J, Moinier, D, Pierres, M, Ju, S T, ...
NH2-terminal amino acid sequences of heavy and light chains of seven poly(Glu60Ala30Tyr10) (GAT) specific hybridoma products derived from DBA/2 and (DBA/2 X BALB/c)F1 hybrid mice and those of BALB/B...
Farr, A G, Dorf, M E, Unanue, E R
In this study we show that T cells from mice infected with Listeria monocytogenes can interact in vitro with normal macrophages to produce a number of soluble mediators, including lymphostimulatory...
Pierres, M, Germain, R N, Dorf, M E, Benacerraf, B
Mice were immunized intravenously with suboptimal numbers (3.5-5 X 10(5)) of sheep erythrocytes together with various anti-Ia antisera or with sheep erythrocytes alone, and the primary IgM and IgG...
Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum.
Greene, M I, Dorf, M E, Pierres, M, Benacerraf, B
Highly significant suppression of the growth of S1509a and Sa-I syngeneic sarcomas was observed in A/J mice following daily intravenous injections of 2 microliter of anti-I-Jk alloantiserum. This...
Complementation of H-2-linked Ir genes in the mouse.
The immune response to the random linear terpolymer of L-glutamic acid, L-lysine, and L-phenylalanine (GLphi) is under dominant H-2-linked Ir gene control in the mouse. Matings between two...
T-cell receptor alpha chain plays a critical role in antigen-specific suppressor cell function.
Kuchroo, V K, Byrne, M C, Atsumi, Y, Greenfield, E, Connolly, J B, Whitters, M J, ...
Antigen-specific suppressor T-cell hybridomas release soluble suppressor factors (TsF) in the supernatant that modulate both in vivo delayed-type hypersensitivity and in vitro plaque-forming cell...
Expression of CD3-associated antigen-binding receptors on suppressor T cells.
Kuchroo, V K, Steele, J K, Billings, P R, Selvaraj, P, Dorf, M E
Three suppressor T (Ts)-cell hybridomas specific for 4-hydroxy-3-nitrophenyl acetyl (NP) hapten were selected for surface expression of cluster determinant 3 (CD3) by using antibody (anti-CD3) or...
Okuda, K, Minami, M, Ju, S T, Dorf, M E
The serological characteristics of the antigen receptor on 4-hydroxy-3-nitrophenylacetyl (NP) specific suppressor T cell hybridomas were analyzed. Three T-cell hybrids could be lysed with...
Burakoff, S J, Germain, R N, Dorf, M E, Benacerrah, B
The role of the products of the K and D loci of the H-2 complex as target antigens for cytotoxic T cells generated to modified syngeneic cells has been investigated. Spleen cells, when cocultured...
Genetic control of murine IgD structural heterogeneity.
Pollock, R R, Dorf, M E, Mescher, M F
Murine B lymphocytes express two native forms of surface IgD: IgDI consists of two delta heavy chains and two light chains; IgDII consists of one heavy chain and one light chain. The relative amounts...
Perry, L L, Dorf, M E, Benacerraf, B, Greene, M I
We present evidence for a role of I-A subregion-encoded determinants in syngeneic tumor immunity. In animals rendered immune to the S1509a fibrosarcoma, daily treatment with microliter quantities of...
Fine specificity of antibodies to poly(Glu60Ala30Tyr10) produced by hybrid cell lines.
Pierres, M, Ju, S T, Waltenbaugh, C, Dorf, M E, Benacerraf, B, Germain, R N
The polyethylene glycol-mediated cell fusion technique has been used to analyze the diversity of the antibody response to the terpolymer poly(Glu60Ala30Tyr10)(GAT). Nine stable clones (all producing...
Idiotypic analysis of monoclonal antibodies to poly(Glu60Ala30Tyr10).
Ju, S T, Pierres, M, Waltenbaugh, C, Germain, R N, Benacerraf, B, Dorf, M E
Fifteen hybridoma anti-poly(Glu60Ala30Tyr10) (anti-GAT) antibodies were analyzed for the presence of a common set of idiotypic specificities associated with murine anti-GAT antibodies, termed CGAT...
Schwartz, R H, David, C S, Dorf, M E, Benacerraf, B, Paul, W E
Previous studies have demonstrated that both the antibody and T-lymphocyte proliferative immune responses to poly(Glu53Lys36Phe11)n (GLphi) are under the control of two major...
Kipps, T J, Benacerraf, B, Dorf, M E
The anti-hapten responses to the dinitrophenyl (Dnp) conjugate of the random linear terpolymers poly(L-Glu,LLys,LPhe), GLphi, or poly(LGlu,LLys,LAla), GLA, are of highly restricted heterogeneity....
Ju, S T, Benacerraf, B, Dorf, M E
A common idiotype was defined by a guinea pig anti-idiotypic antiserum made against D1.LP antibodies specific to the synthetic terpolymer poly(Glu60Ala30Tyr10), referred to as GAT. This idiotype was...
Ruf, J, Tonnelle, C, Rocca-Serra, J, Moinier, D, Pierres, M, Ju, S T, ...
NH2-terminal amino acid sequences of heavy and light chains of seven poly(Glu60Ala30Tyr10) (GAT) specific hybridoma products derived from DBA/2 and (DBA/2 X BALB/c)F1 hybrid mice and those of BALB/B...
Farr, A G, Dorf, M E, Unanue, E R
In this study we show that T cells from mice infected with Listeria monocytogenes can interact in vitro with normal macrophages to produce a number of soluble mediators, including lymphostimulatory...
Pierres, M, Germain, R N, Dorf, M E, Benacerraf, B
Mice were immunized intravenously with suboptimal numbers (3.5-5 X 10(5)) of sheep erythrocytes together with various anti-Ia antisera or with sheep erythrocytes alone, and the primary IgM and IgG...
Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum.
Greene, M I, Dorf, M E, Pierres, M, Benacerraf, B
Highly significant suppression of the growth of S1509a and Sa-I syngeneic sarcomas was observed in A/J mice following daily intravenous injections of 2 microliter of anti-I-Jk alloantiserum. This...
Complementation of H-2-linked Ir genes in the mouse.
The immune response to the random linear terpolymer of L-glutamic acid, L-lysine, and L-phenylalanine (GLphi) is under dominant H-2-linked Ir gene control in the mouse. Matings between two...
Down-regulation of suppressor cell induction.
Kuchroo, V K, Noma, T, Minami, M, Dorf, M E
A unidirectional cascade of cell interactions has been described previously that involves at least three distinct populations of suppressor T cells (Ts) that interact in appropriate succession to...
Asherson, G L, Dorf, M E, Colizzi, V, Zembala, M, James, B M
There is considerable confusion over whether the antigen-specific T suppressor factors (TsF) described by different authors are indeed equivalent. This paper investigates whether monoclonal TsF3,...
Tsuji, T, Fukushima, J, Hamajima, K, Ishii, N, Aoki, I, Bukawa, H, ...
We developed a candidate DNA vaccine designated pCMV160IIIB with pcREV (pCMV160IIIB/REV) that encodes gp160 of human immunodeficiency virus (HIV)-1IIIB and Rev driven by the cytomegalovirus (CMV)...
Warnock, R.A., Campbell, J.J., Dorf, M.E., Matsuzawa, A., McEvoy, L.M., Butcher, E.C.
Chemokines have been hypothesized to contribute to the selectivity of lymphocyte trafficking not only as chemoattractants, but also by triggering integrin-dependent sticking (arrest) of circulating...