Kagnoff, M. F., Kivy-Rosenberg, E.
Adult male rats were sacrificed between 20 minutes and 3 days following 1500 R whole-body x irradiation to record and study the spontaneous contractions of isolated in vitro segments of jejunum....
IN VITRO MOTOR ACTIVITY OF RAT SMALL INTESTINE FOLLOWING WHOLE-BODY X IRRADIATION. (1998)
In vitro contractions of small intestinal segments were studied at varying times following exposure of rats to whole-body x irradiation. Jejunal contractions were measured 20 to 40 minutes, 4 to 6...
A SYSTEM TO TELEMETER INTRALUMINAL INTESTINAL PRESSURES FROM MEDIUM-SIZED LABORATORY ANIMALS. (1998)
A system for telemetering intraluminal pressure from the small intestine is described. A radio transmitter capsule, calibrating apparatus, and receiving equipment form the essential components....
Chen, C Y, Eckmann, L, Libby, S J, Fang, F C, Okamoto, S, Kagnoff, M F, ...
Adaptation to the intracellular environment of host cells is crucial for the pathogenesis of Salmonella infections. The alternative sigma factor RpoS is a global regulator of gene expression during...
Laurent, F, Eckmann, L, Savidge, T C, Morgan, G, Theodos, C, Naciri, M, ...
Cryptosporidium parvum infects intestinal epithelial cells and does not invade deeper layers of the intestinal mucosa. Nonetheless, an inflammatory cell infiltrate that consists of neutrophils and...
Cole, S P, Cirillo, D, Kagnoff, M F, Guiney, D G, Eckmann, L
Helicobacter pylori exists as an actively dividing spiral form and a nonculturable, but viable, metabolizing coccoid form. Both forms are present in the stomach, but their relative pathophysiologic...
Holtmeier, W, Chowers, Y, Lumeng, A, Morzycka-Wroblewska, E, Kagnoff, M F
The majority of gamma/delta T cell receptors (TCR) in the human intestinal mucosa are thought to use the TCRDV1 (V delta 1) variable region gene segment, whereas gamma/delta T cells in the...
Eckmann, L, Reed, S L, Smith, J R, Kagnoff, M F
Infection with the protozoan parasite Entamoeba histolytica results in a high mortality worldwide. To initiate infection, E. histolytica trophozoites in the bowel lumen penetrate the epithelium, and...
Sensitive radioimmunoassay for the broad-spectrum antiviral agent ribavirin.
Austin, R K, Trefts, P E, Hintz, M, Connor, J D, Kagnoff, M F
Ribavirin, 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxyamide (Virazole; Viratek, Inc., Covina, Calif.), has a broad spectrum of antiviral activity. However, the study of the absorption,...
An extended HLA-D region haplotype associated with celiac disease.
Howell, M D, Smith, J R, Austin, R K, Kelleher, D, Nepom, G T, Volk, B, ...
Celiac disease has one of the strongest associations with HLA (human leukocyte antigen) class II markers of the known HLA-linked diseases. This association is primarily with the class II serologic...
Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry.
Eckmann, L, Kagnoff, M F, Fierer, J
Bacterial invasion of mucosal surfaces results in a rapid influx of polymorphonuclear leukocytes. The chemotactic stimulus responsible for this response is not known. Since epithelial cells are among...
Roebuck, K A, Brenner, D A, Kagnoff, M F
Activation of HIV-1 requires the binding of host cell transcription factors to cis elements in the proviral long terminal repeat (LTR). This study identifies c-fos-responsive sequence motifs in the...
Jung, H C, Eckmann, L, Yang, S K, Panja, A, Fierer, J, Morzycka-Wroblewska, E, ...
Pathogenic bacteria that penetrate the intestinal epithelial barrier stimulate an inflammatory response in the adjacent intestinal mucosa. The present studies asked whether colon epithelial cells can...
Kagnoff, M F, Harwood, J I, Bugawan, T L, Erlich, H A
Celiac disease is strongly associated with the HLA class II D-region serologic markers DR3 (DRw17) and DQw2. Moreover, by restriction fragment length polymorphism analysis, greater than 90% of DR3...
Huang, G T, Eckmann, L, Savidge, T C, Kagnoff, M F
The acute host response to gastrointestinal infection with invasive bacteria is characterized by an accumulation of neutrophils in the lamina propria, and neutrophil transmigration to the luminal...
Rasmussen, S J, Eckmann, L, Quayle, A J, Shen, L, Zhang, Y X, Anderson, D J, ...
Chlamydia species infect epithelial cells at mucosal surfaces, and are major causes of sexually transmitted diseases. Infection is characterized by inflammation which is exacerbated upon reinfection,...
Eckmann, L, Stenson, W F, Savidge, T C, Lowe, D C, Barrett, K E, Fierer, J, ...
Increased intestinal fluid secretion is a protective host response after enteric infection with invasive bacteria that is initiated within hours after infection, and is mediated by prostaglandin H...
Apoptosis of human intestinal epithelial cells after bacterial invasion.
Kim, J M, Eckmann, L, Savidge, T C, Lowe, D C, Witthöft, T, Kagnoff, M F
Epithelial cells that line the human intestinal mucosa are the initial site of host invasion by bacterial pathogens. The studies herein define apoptosis as a new category of intestinal epithelial...
Weiss, J B, Austin, R K, Schanfield, M S, Kagnoff, M F
Anti-gliadin antibody was measured by radioimmunoassay in 30 Caucasians with gluten-sensitive enteropathy (GSE). 22 GSE patients maintained on a gluten-free diet for 1.5 to 20 yr (mean duration 76...
Chen, C Y, Eckmann, L, Libby, S J, Fang, F C, Okamoto, S, Kagnoff, M F, ...
Adaptation to the intracellular environment of host cells is crucial for the pathogenesis of Salmonella infections. The alternative sigma factor RpoS is a global regulator of gene expression during...
Laurent, F, Eckmann, L, Savidge, T C, Morgan, G, Theodos, C, Naciri, M, ...
Cryptosporidium parvum infects intestinal epithelial cells and does not invade deeper layers of the intestinal mucosa. Nonetheless, an inflammatory cell infiltrate that consists of neutrophils and...
Cole, S P, Cirillo, D, Kagnoff, M F, Guiney, D G, Eckmann, L
Helicobacter pylori exists as an actively dividing spiral form and a nonculturable, but viable, metabolizing coccoid form. Both forms are present in the stomach, but their relative pathophysiologic...
Holtmeier, W, Chowers, Y, Lumeng, A, Morzycka-Wroblewska, E, Kagnoff, M F
The majority of gamma/delta T cell receptors (TCR) in the human intestinal mucosa are thought to use the TCRDV1 (V delta 1) variable region gene segment, whereas gamma/delta T cells in the...
Eckmann, L, Reed, S L, Smith, J R, Kagnoff, M F
Infection with the protozoan parasite Entamoeba histolytica results in a high mortality worldwide. To initiate infection, E. histolytica trophozoites in the bowel lumen penetrate the epithelium, and...
Sensitive radioimmunoassay for the broad-spectrum antiviral agent ribavirin.
Austin, R K, Trefts, P E, Hintz, M, Connor, J D, Kagnoff, M F
Ribavirin, 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxyamide (Virazole; Viratek, Inc., Covina, Calif.), has a broad spectrum of antiviral activity. However, the study of the absorption,...
An extended HLA-D region haplotype associated with celiac disease.
Howell, M D, Smith, J R, Austin, R K, Kelleher, D, Nepom, G T, Volk, B, ...
Celiac disease has one of the strongest associations with HLA (human leukocyte antigen) class II markers of the known HLA-linked diseases. This association is primarily with the class II serologic...
Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry.
Eckmann, L, Kagnoff, M F, Fierer, J
Bacterial invasion of mucosal surfaces results in a rapid influx of polymorphonuclear leukocytes. The chemotactic stimulus responsible for this response is not known. Since epithelial cells are among...
Roebuck, K A, Brenner, D A, Kagnoff, M F
Activation of HIV-1 requires the binding of host cell transcription factors to cis elements in the proviral long terminal repeat (LTR). This study identifies c-fos-responsive sequence motifs in the...
Jung, H C, Eckmann, L, Yang, S K, Panja, A, Fierer, J, Morzycka-Wroblewska, E, ...
Pathogenic bacteria that penetrate the intestinal epithelial barrier stimulate an inflammatory response in the adjacent intestinal mucosa. The present studies asked whether colon epithelial cells can...
Kagnoff, M F, Harwood, J I, Bugawan, T L, Erlich, H A
Celiac disease is strongly associated with the HLA class II D-region serologic markers DR3 (DRw17) and DQw2. Moreover, by restriction fragment length polymorphism analysis, greater than 90% of DR3...
Huang, G T, Eckmann, L, Savidge, T C, Kagnoff, M F
The acute host response to gastrointestinal infection with invasive bacteria is characterized by an accumulation of neutrophils in the lamina propria, and neutrophil transmigration to the luminal...
Rasmussen, S J, Eckmann, L, Quayle, A J, Shen, L, Zhang, Y X, Anderson, D J, ...
Chlamydia species infect epithelial cells at mucosal surfaces, and are major causes of sexually transmitted diseases. Infection is characterized by inflammation which is exacerbated upon reinfection,...
Eckmann, L, Stenson, W F, Savidge, T C, Lowe, D C, Barrett, K E, Fierer, J, ...
Increased intestinal fluid secretion is a protective host response after enteric infection with invasive bacteria that is initiated within hours after infection, and is mediated by prostaglandin H...
Apoptosis of human intestinal epithelial cells after bacterial invasion.
Kim, J M, Eckmann, L, Savidge, T C, Lowe, D C, Witthöft, T, Kagnoff, M F
Epithelial cells that line the human intestinal mucosa are the initial site of host invasion by bacterial pathogens. The studies herein define apoptosis as a new category of intestinal epithelial...
Weiss, J B, Austin, R K, Schanfield, M S, Kagnoff, M F
Anti-gliadin antibody was measured by radioimmunoassay in 30 Caucasians with gluten-sensitive enteropathy (GSE). 22 GSE patients maintained on a gluten-free diet for 1.5 to 20 yr (mean duration 76...
Kelleher, D, Pandol, S J, Kagnoff, M F
The protein kinase C (PKC) inhibitor H-7 was used to study the role of PKC in IL-2 secretion. In Jurkat E6.1, a phenotypically non-activated human T-cell line, IL-2 secretion in response to a...
Cytokine-induced differentiation of IgA B cells: studies using an IgA expressing B-cell lymphoma.
Eckmann, L, Morzycka-Wroblewska, E, Smith, J R, Kagnoff, M F
Cytokines such as interleukin-5 (IL-5) and transforming growth factor beta 1 (TGF beta 1) increase IgA production by heterogeneous populations of lipopolysaccharide (LPS)-activated murine B cells. We...
Schuerer-Maly, C C, Eckmann, L, Kagnoff, M F, Falco, M T, Maly, F E
Cytokines produced by intestinal epithelial cells may function as signals to neighbouring immune and inflammatory cells. We investigated production of the neutrophil and T-lymphocyte chemotactic...
Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease.
Kagnoff, M F, Paterson, Y J, Kumar, P J, Kasarda, D D, Carbone, F R, Unsworth, D J, ...
We previously noted a region of amino acid sequence homology between A-gliadin, a major alpha-gliadin component known to activate coeliac disease, and the early region E1b protein of human adenovirus...
Development and characterisation of T lymphocyte lines from human small intestinal biopsies.
T lymphocyte lines were developed from human small intestinal biopsies obtained at the time of gastroduodenoscopy. Lines were established as outgrowths from biopsy specimens in microculture using a...
Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies.
Volk, B A, Brenner, D A, Kagnoff, M F
Studies of the expression of selected genes within the intestinal mucosa will provide important new information about physiologic pathological processes that effect mucosal growth, differentiation,...
CHOWERS, Y, MARSH, M N, DE GRANDPRE, L, NYBERG, A, THEOFILOPOULOS, A N, KAGNOFF, M F
Activation of T cells in the intestinal mucosa in response to gluten exposure is thought to play a key role in the pathogenesis of coeliac disease. Moreover, the response of the rectal mucosa to...
Distinct δ T cell receptor repertoires in monozygotic twins concordant for coeliac disease
HOLTMEIER, W, ROWELL, D L, NYBERG, A, KAGNOFF, M F
One of the hallmarks of coeliac disease, both active and treated, is an increased number and proportion of γ/δ intraepithelial T lymphocytes in the small intestinal mucosa, and an increased number...