M. Funauchi

Amidolytic and peptidolytic activities of immunoglobulin G present in sera from patients with rheumatoid arthritis, Sjogren's syndrome and systemic lupus erythematosus.

Matsuura, K, Ikoma, S, Sugiyama, M, Funauchi, M, Sinohara, H

Polyclonal immunoglobulin G (IgG) from healthy subjects was found to be capable of hydrolyzing carbobenzoxy-Val-Gly-Arg-p-nitroanilide (a synthetic chromogenic substrate for trypsin) and...

A case of rheumatoid meningitis positive for perinuclear antineutrophil cytoplasmic antibody

FUNAUCHI, M, YOO, B, SUGIYAMA, M, IKOMA, S, OHNO, M, KINOSHITA, K, ...

Failure in antigen responses by T cells from patients with common variable immunodeficiency (CVID).

Stagg, A J, Funauchi, M, Knight, S C, Webster, A D, Farrant, J

Antigen-driven responses by T cells from patients with CVID and normal subjects have been assessed. Low-density cells enriched for antigen-presenting dendritic cells were cultured with T cells using...

Examination of the inhibitory effects of interferon-gamma on interleukin-4-induced stimulation of resting B cells from NZB/NZW F1 mice.

Minoda, M, Hamada, K, Higashikawa, M, Sugishima, H, Funauchi, M, Horiuchi, A

Percoll fractionation of NZB/NZW F1 mouse B cells revealed an increased ratio of low-density fraction ('activated' B cell fraction) and a decreased ratio of high-density fraction ('resting' B cell...

Co-stimulation with anti-CD28 (Kolt-2) enhances DNA synthesis by defective T cells in common variable immunodeficiency.

North, M E, Akbar, A N, Borthwick, N, Sagawa, K, Funauchi, M, Webster, A D, ...

In normal T cells, an anti-CD28 MoAb (Kolt-2) will synergize with the mitogenic stimuli phytohaemagglutinin (PHA), anti-CD3 (OKT3) or a combination of anti-CD2 antibodies (OKT11 and GT2) in the...

Defects in antigen-driven lymphocyte responses in common variable immunodeficiency (CVID) are due to a reduction in the number of antigen-specific CD4+ T cells.

Funauchi, M, Farrant, J, Moreno, C, Webster, A D

T cells from patients with CVID have defects that may relate to the failure in vivo of B cell production of antibodies. Antigen-driven responses of T cells from CVID patients and normal subjects have...

The beneficial effects of treatment with all-trans-retinoic acid plus corticosteroid on autoimmune nephritis in NZB/WF1 mice

Nozaki, Y, Yamagata, T, Yoo, B-S, Sugiyama, M, Ikoma, S, Kinoshita, K, ...

Corticosteroids are highly effective anti-inflammatory or immunosuppressive drugs used commonly to treat human systemic lupus erythematosus (SLE). All-trans-retinoic acid (ATRA), which belongs to a...

Intracellular cytokine production by human CD4+ and CD8+ T cells from normal and immunodeficient donors using directly conjugated anti-cytokine antibodies and three-colour flow cytometry

NORTH, M E, IVORY, K, FUNAUCHI, M, WEBSTER, A D B, LANE, A C, FARRANT, J

Using three-colour flow cytometry, we have measured intracellular IL-2, interferon-gamma (IFN-γ) and tumour necrosis factor-alpha (TNF-α) induced in human CD4+ and CD8+ T cells from normal donors...

Myelopathy associated with Hashimoto's disease

AZUMA, T., UEMICHI, T., FUNAUCHI, M., DOI, S., MATSUBARA, T.