Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease. (2001)
Briand, C, Kozlov, S V, Sonderegger, P, Grütter, M G
The protease inhibitor neuroserpin regulates the development of the nervous system and its plasticity in the adult. Neuroserpins carrying the Ser53Pro or Ser56Arg mutation form polymers in neuronal...
Grütter, M.G., Oostrum, J.van, Priestle, J.P., Edelmann, E., Joss, U., Feige, U., ...
The 3-D crystal structure of interleukin-1β(IL-1β) has been used to define its receptor binding surface by mutational analysis. The surface of IL-1β was probed by site-directed mutagenesis. A...
Fonné-Pfister, R, Chemla, P, Ward, E, Girardet, M, Kreuz, K E, Honzatko, R B, ...
(+)-Hydantocidin, a recently discovered natural spironucleoside with potent herbicidal activity, is shown to be a proherbicide that, after phosphorylation at the 5' position, inhibits...
Crystallographic refinement of interleukin 1 beta at 2.0 A resolution.
Priestle, J P, Schär, H P, Grütter, M G
The structure of human recombinant interleukin 1 beta (IL-1 beta) has been refined by a restrained least-squares method to a crystallographic R factor of 17.2% to 2.0 A resolution. One-hundred...
Priestle, J P, Grütter, M G, White, J L, Vincent, M G, Kania, M, Wilson, E, ...
N-(5'-Phosphoribosyl)anthranilate isomerase-indole-3-glycerol-phosphate synthase from Escherichia coli is a monomeric bifunctional enzyme of Mr 49,500 that catalyzes two sequential reactions in the...
Crystal structure of the cytokine interleukin-1 beta.
Priestle, J P, Schär, H P, Grütter, M G
The crystal structure of human recombinant interleukin-1 beta has been determined at 3.0 A resolution by the isomorphous replacement method in conjunction with solvent flattening techniques. The...
Grütter, M G, Fendrich, G, Huber, R, Bode, W
Orthorhombic crystals of the complex formed between bovine alpha-chymotrypsin and a recombinant human mucous proteinase inhibitor (SLPI) were grown. Data to 2.3 A resolution were collected on the...
Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.
Grütter, M G, Priestle, J P, Rahuel, J, Grossenbacher, H, Bode, W, Hofsteenge, J, ...
Thrombin is a serine protease that plays a central role in blood coagulation. It is inhibited by hirudin, a polypeptide of 65 amino acids, through the formation of a tight, noncovalent complex....
Fonné-Pfister, R, Chemla, P, Ward, E, Girardet, M, Kreuz, K E, Honzatko, R B, ...
(+)-Hydantocidin, a recently discovered natural spironucleoside with potent herbicidal activity, is shown to be a proherbicide that, after phosphorylation at the 5' position, inhibits...
Crystallographic refinement of interleukin 1 beta at 2.0 A resolution.
Priestle, J P, Schär, H P, Grütter, M G
The structure of human recombinant interleukin 1 beta (IL-1 beta) has been refined by a restrained least-squares method to a crystallographic R factor of 17.2% to 2.0 A resolution. One-hundred...
Priestle, J P, Grütter, M G, White, J L, Vincent, M G, Kania, M, Wilson, E, ...
N-(5'-Phosphoribosyl)anthranilate isomerase-indole-3-glycerol-phosphate synthase from Escherichia coli is a monomeric bifunctional enzyme of Mr 49,500 that catalyzes two sequential reactions in the...
Crystal structure of the cytokine interleukin-1 beta.
Priestle, J P, Schär, H P, Grütter, M G
The crystal structure of human recombinant interleukin-1 beta has been determined at 3.0 A resolution by the isomorphous replacement method in conjunction with solvent flattening techniques. The...
Grütter, M G, Fendrich, G, Huber, R, Bode, W
Orthorhombic crystals of the complex formed between bovine alpha-chymotrypsin and a recombinant human mucous proteinase inhibitor (SLPI) were grown. Data to 2.3 A resolution were collected on the...
Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.
Grütter, M G, Priestle, J P, Rahuel, J, Grossenbacher, H, Bode, W, Hofsteenge, J, ...
Thrombin is a serine protease that plays a central role in blood coagulation. It is inhibited by hirudin, a polypeptide of 65 amino acids, through the formation of a tight, noncovalent complex....
Priestle, J. P., Rahuel, J., Rink, H., Tones, M., Grütter, M. G.
The three-dimensional structures of D-Phe-Pro-Arg-chloromethyl ketone-inhibited thrombin in complex with Tyr-63-sulfated hirudin (ternary complex) and of thrombin in complex with the bifunctional...
The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.
Mittl, P. R., Priestle, J. P., Cox, D. A., McMaster, G., Cerletti, N., Grütter, M. G.
Transforming growth factors beta belong to a group of cytokines that control cellular proliferation and differentiation. Five isoforms are known that share approximately 75% sequence identity, but...
Recombinant hirustasin: production in yeast, crystallization, and interaction with serine proteases.
Di Marco, S., Fendrich, G., Knecht, R., Strauss, A., Pohlig, G., Heim, J., ...
A synthetic gene coding for the 55-amino acid protein hirustasin, a novel tissue kallikrein inhibitor from the leech Hirudo medicinalis, was generated by polymerase chain reaction using overlapping...