Multi-color Optical Variability of the TeV Blazar Mrk 501 in the Low-State (2008)
Gupta, A. C., Deng, W. G., Joshi, U. C., Bai, J. M., Lee, M. G.
We report results based on the monitoring of the BL Lac object Mrk 501 in the optical (B, V and R) passbands from March to May 2000. Observations spread over 12 nights were carried out using 1.2...
Metaphorical reasoning with an economical set of mappings (2006)
Wallington,A.M., Barnden,J.A., Glasbey,S.R., Lee,M.G.
This paper discusses the nature of the metaphorical transfer from the source domain to the target domain. More specifically, it explores the question as to how the mapping links between features of...
The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology (2003)
Terwilliger, T.C., Park, M.S., Waldo, G.S., Berendzen, J., Hung, L.W., Kim, C.Y., ...
The TB Structural Genomics Consortium is an organization devoted to encouraging, coordinating, and facilitating the determination and analysis of structures of proteins from Mycobacterium...
ACTA ASTRONOMICA Vol. 51 (2001) pp. 49-63 Search for Variable Stars in Two Old Open Clusters: (2002)
M. G. Lee, ...
We present results of photometric observations of two old open clusters: NGC 2506 and NGC 2420. V-band time-series and UBVI absolute CCD photometric observations were carried out to search for...
Ann, H. B., Lee, S. H., Sung, H., Lee, M. G., ...
We have initiated a long-term project, the BOAO photometric survey of open clusters, to enlarge our understanding of galactic structure using UBVI CCD photometry of open clusters which have been...
Dynamical evolution of rotating stellar systems - II. Post-collapse, equal-mass system (2002)
Kim, E., Einsel, C., Lee, H. M., Spurzem, R., Lee, M. G.
We present the first post-core-collapse models of initially rotating star clusters, using the numerical solution of an orbit-averaged 2D Fokker-Planck equation. Based on the code developed by Einsel...
The Star Formation History of LGS 3 (2001)
Miller, B. W., Dolphin, A. E., Lee, M. G., Kim, S. C., Hodge, P.
We have determined the distance and star formation history of the Local Group dwarf galaxy LGS 3 from deep Hubble Space Telescope WFPC2 observations. LGS 3 is intriguing because ground-based...
Ann, H. B., Lee, M. G., Chun, M. Y., ...
Open clusters are useful tools to investigate the structure and evolution of the Galactic disk. We have started a long-term project to obtain UBVI CCD Photometry of open clusters which were little...
HST observations of the Local Group dwarf galaxy Leo I (1998)
Gallart, C., Freedman, W. L., Mateo, M., Chiosi, C., Thompson, I. B., Aparicio, A., ...
We present deep HST F555W (V) and F814W (I) observations of a central field in the Local Group dwarf spheroidal (dSph) galaxy Leo I. The resulting color-magnitude diagram (CMD) reaches I \simeq 26...
W. L. Freedman, S. M. Hughes, B. F. Madore, J. R. Mould, M. G. Lee, P. B. Stetson, ...
We report on the discovery of 30 new Cepheids in the nearby galaxy M81 based on observations using the Space Telescope The periods for these lie in the range of 10 to 55 days, based on 18 independent...
Disposition of Intravenous Pyrimethamine in Healthy Volunteers
Almond, D. S., Szwandt, I. S. F., Edwards, G., Lee, M. G., Winstanley, P. A.
A proportion of patients with AIDS and toxoplasmic encephalitis (TE) sustain low plasma pyrimethamine concentrations during oral treatment, possibly because of incomplete and variable...
An increase in the transcriptional efficiency at elevated temperatures is a characteristic of transcription of heat shock protein (hsp) coding genes in most eukaryotes analyzed to date. The...
We investigated plant cell division by testing for the presence and involvement in progress through the division cycle of the protein p34cdc2, a key participant in division control in other...
An RNA polymerase II promoter in the hsp70 locus of Trypanosoma brucei.
To study of structure of RNA polymerase (pol) II transcription units a nd the influence of temperature on the regulation of gene expression in Trypanosoma brucei, and hsp70 intergenic region promoter...
Structure of a frequently rearranged rRNA-encoding chromosome in Giardia lamblia.
Hou, G, Le Blancq, S M, Zhu, H, Lee, M G
It has been shown previously that the rRNA encoding chromosomes in Giardia lamblia undergo frequent rearrangements with an estimated rate of approximately 1% per cell per division (Le Blancq et al.,...
Construction of trypanosome artificial mini-chromosomes.
We report the preparation of two linear constructs which, when transformed into the procyclic form of Trypanosoma brucei, become stably inherited artificial mini-chromosomes. Both of the two...
Rudenko, G, Lee, M G, Van Der Ploeg, L H
Addition of the ionic detergent N-lauroylsarcosine (Sarkosyl) affects the efficiency of transcription of genes of the protozoan Trypanosoma brucei in nuclear run-on assays. Transcription of the PARP...
Sequence of an expressed human beta-tubulin gene containing ten Alu family members.
Lee, M G, Loomis, C, Cowan, N J
The complete sequence of a functionally expressed human beta-tubulin gene (5 beta) is presented. The amino acid sequence encoded by this gene constitutes a distinct isotype, differing from a...
A putative flagellar Ca2(+)-binding protein of the flagellum of trypanosomatid protozoan parasites.
Lee, M G, Chen, J F, Ho, A W, D'Alesandro, P A, Van Der Ploeg, L H
Structure and expression of the hsp 70 gene family of Leishmania major.
Lee, M G, Atkinson, B L, Giannini, S H, Van Der Ploeg, L H
The parasitic protozoan Leishmania major differentiates in vitro, from the insect-adapted promastigote to the mammalian infective amastigote, in response to a temperature shift from 25 degrees C to...
Disruption of largest subunit RNA polymerase II genes in Trypanosoma brucei.
Chung, H M, Lee, M G, Dietrich, P, Huang, J, Van Der Ploeg, L H
Two types of largest subunit RNA polymerase II (pol II) genes (pol IIA and pol IIB), differing in 3 amino acid substitutions, are encoded in the Trypanosoma brucei (stock 427-60) genome. As a result,...
Gottesdiener, K, Chung, H M, Brown, S D, Lee, M G, Van Der Ploeg, L H
The expressed variant cell surface glycoprotein (VSG) gene of Trypanosoma brucei is located at the 3' end of a large, telomeric, polycistronic transcription unit or expression site. We show that the...
Rudenko, G, Le Blancq, S, Smith, J, Lee, M G, Rattray, A, Van Der Ploeg, L H
At least one of the procyclic acidic repetitive protein (PARP or procyclin) loci of Trypanosoma brucei is a small (5- to 6-kilobase) polycistronic transcription unit which is transcribed in an...
Lee, M G, Bihain, B E, Russell, D G, Deckelbaum, R J, Van Der Ploeg, L H
We have characterized a cDNA encoding a cysteine-rich, acidic integral membrane protein (CRAM) of the parasitic protozoa Trypanosoma brucei and Trypanosoma equiperdum. Unlike other membrane proteins...
Chromosome organization of the protozoan Trypanosoma brucei.
Gottesdiener, K, Garciá-Anoveros, J, Lee, M G, Van Der Ploeg, L H
The genome of the protozoan Trypanosoma brucei is known to be diploid. Karyotype analysis has, however, failed to identify homologous chromosomes. Having refined the technique for separating...
Frequent independent duplicative transpositions activate a single VSG gene.
The expression of several surface antigen genes in Trypanosoma brucei is mediated by the duplicative transposition of a basic-copy variant surface glycoprotein (VSG) gene into an expression site. We...
Cloning of the RNA2 gene of Saccharomyces cerevisiae.
Lee, M G, Young, R A, Beggs, J D
The RNA2 gene of Saccharomyces cerevisiae, which has been implicated in splicing the transcripts of nuclear protein coding genes, has been cloned by complementation of the temperature-sensitive...
The gene family of EF-hand calcium-binding proteins from the flagellum of Trypanosoma brucei.
Wu, Y, Deford, J, Benjamin, R, Lee, M G, Ruben, L
The flagellum of Trypanosoma brucei contains calmodulin, and a separate family of antigenically related EF-hand calcium-binding proteins which we call calflagins. The following study evaluates the...
Disposition of Intravenous Pyrimethamine in Healthy Volunteers
Almond, D. S., Szwandt, I. S. F., Edwards, G., Lee, M. G., Winstanley, P. A.
A proportion of patients with AIDS and toxoplasmic encephalitis (TE) sustain low plasma pyrimethamine concentrations during oral treatment, possibly because of incomplete and variable...
An increase in the transcriptional efficiency at elevated temperatures is a characteristic of transcription of heat shock protein (hsp) coding genes in most eukaryotes analyzed to date. The...
We investigated plant cell division by testing for the presence and involvement in progress through the division cycle of the protein p34cdc2, a key participant in division control in other...
An RNA polymerase II promoter in the hsp70 locus of Trypanosoma brucei.
To study of structure of RNA polymerase (pol) II transcription units a nd the influence of temperature on the regulation of gene expression in Trypanosoma brucei, and hsp70 intergenic region promoter...
Structure of a frequently rearranged rRNA-encoding chromosome in Giardia lamblia.
Hou, G, Le Blancq, S M, Zhu, H, Lee, M G
It has been shown previously that the rRNA encoding chromosomes in Giardia lamblia undergo frequent rearrangements with an estimated rate of approximately 1% per cell per division (Le Blancq et al.,...
Construction of trypanosome artificial mini-chromosomes.
We report the preparation of two linear constructs which, when transformed into the procyclic form of Trypanosoma brucei, become stably inherited artificial mini-chromosomes. Both of the two...
Rudenko, G, Lee, M G, Van Der Ploeg, L H
Addition of the ionic detergent N-lauroylsarcosine (Sarkosyl) affects the efficiency of transcription of genes of the protozoan Trypanosoma brucei in nuclear run-on assays. Transcription of the PARP...
Sequence of an expressed human beta-tubulin gene containing ten Alu family members.
Lee, M G, Loomis, C, Cowan, N J
The complete sequence of a functionally expressed human beta-tubulin gene (5 beta) is presented. The amino acid sequence encoded by this gene constitutes a distinct isotype, differing from a...
A putative flagellar Ca2(+)-binding protein of the flagellum of trypanosomatid protozoan parasites.
Lee, M G, Chen, J F, Ho, A W, D'Alesandro, P A, Van Der Ploeg, L H
Structure and expression of the hsp 70 gene family of Leishmania major.
Lee, M G, Atkinson, B L, Giannini, S H, Van Der Ploeg, L H
The parasitic protozoan Leishmania major differentiates in vitro, from the insect-adapted promastigote to the mammalian infective amastigote, in response to a temperature shift from 25 degrees C to...
Disruption of largest subunit RNA polymerase II genes in Trypanosoma brucei.
Chung, H M, Lee, M G, Dietrich, P, Huang, J, Van Der Ploeg, L H
Two types of largest subunit RNA polymerase II (pol II) genes (pol IIA and pol IIB), differing in 3 amino acid substitutions, are encoded in the Trypanosoma brucei (stock 427-60) genome. As a result,...
Gottesdiener, K, Chung, H M, Brown, S D, Lee, M G, Van Der Ploeg, L H
The expressed variant cell surface glycoprotein (VSG) gene of Trypanosoma brucei is located at the 3' end of a large, telomeric, polycistronic transcription unit or expression site. We show that the...
Rudenko, G, Le Blancq, S, Smith, J, Lee, M G, Rattray, A, Van Der Ploeg, L H
At least one of the procyclic acidic repetitive protein (PARP or procyclin) loci of Trypanosoma brucei is a small (5- to 6-kilobase) polycistronic transcription unit which is transcribed in an...
Lee, M G, Bihain, B E, Russell, D G, Deckelbaum, R J, Van Der Ploeg, L H
We have characterized a cDNA encoding a cysteine-rich, acidic integral membrane protein (CRAM) of the parasitic protozoa Trypanosoma brucei and Trypanosoma equiperdum. Unlike other membrane proteins...
Chromosome organization of the protozoan Trypanosoma brucei.
Gottesdiener, K, Garciá-Anoveros, J, Lee, M G, Van Der Ploeg, L H
The genome of the protozoan Trypanosoma brucei is known to be diploid. Karyotype analysis has, however, failed to identify homologous chromosomes. Having refined the technique for separating...
Frequent independent duplicative transpositions activate a single VSG gene.
The expression of several surface antigen genes in Trypanosoma brucei is mediated by the duplicative transposition of a basic-copy variant surface glycoprotein (VSG) gene into an expression site. We...
Cloning of the RNA2 gene of Saccharomyces cerevisiae.
Lee, M G, Young, R A, Beggs, J D
The RNA2 gene of Saccharomyces cerevisiae, which has been implicated in splicing the transcripts of nuclear protein coding genes, has been cloned by complementation of the temperature-sensitive...
The gene family of EF-hand calcium-binding proteins from the flagellum of Trypanosoma brucei.
Wu, Y, Deford, J, Benjamin, R, Lee, M G, Ruben, L
The flagellum of Trypanosoma brucei contains calmodulin, and a separate family of antigenically related EF-hand calcium-binding proteins which we call calflagins. The following study evaluates the...
Infective arthritis due to Blastocystis hominis.
Lee, M G, Rawlins, S C, Didier, M, DeCeulaer, K
A patient with rheumatoid arthritis taking prednisone developed Blastocystis hominis acute diarrhoea, which was associated with increased inflammation and effusion of the left knee. B hominis...
Myers, B, Evans, D N, Rhodes, J, Evans, B K, Hughes, B R, Lee, M G, ...
In six healthy subjects serum concentrations of 5 amino salicylic acid (5ASA) and acetyl 5ASA were measured for up to 24 hours, and urinary excretion over 48 hours. After an intravenous injection of...
Endoscopic and gastric acid studies in homozygous sickle cell disease and upper abdominal pain.
Lee, M G, Thirumalai, C H, Terry, S I, Serjeant, G R
Upper endoscopic and gastric acid output studies were done in 51 patients with homozygous sickle cell (SS) disease and recurrent epigastric pain. Twenty (39%) had abnormalities in the upper...
An oral preparation to release drugs in the human colon.
Dew, M J, Hughes, P J, Lee, M G, Evans, B K, Rhodes, J
1 A colonic delivery system is described to deliver orally ingested drugs to the colon and release them at that site by coating with an acrylic based resin (Eudragit S). The technique is validated...
An unusual form of secondary syphilis, characterised by oozing tumours on the forehead and scalp concomitantly with plaques in the genital area, is presented. The patient was diagnosed as having...
Chang, S N, Chung, K Y, Lee, M G, Lee, J B
BACKGROUND--IgG antibodies from mothers adequately treated for syphilis can cross the placenta and appear in the sera of healthy newborns without infection. In such infants, a false diagnosis of...
Drug-induced acute liver disease.
Lee, M. G., Hanchard, B., Williams, N. P.
Fifty-three patients with drug-induced acute liver disease are reported. There were 35 females and 18 males with a mean age of 41 years. All but one patient had jaundice or hyperbilirubinaemia and 51...