The origins of lactase persistence in Europe (2009)
Itan, Y., Powell, A., Beaumont, M.A., Burger, J., Thomas, M.G.
Lactase persistence (LP) is common among people of European ancestry, but with the exception of some African, Middle Eastern and southern Asian groups, is rare or absent elsewhere in the world....
Thomas, M.G., Härke, H., Strumpf, M.P.H.
Book description: Data from molecular genetics have changed our views on the origin, spread and timescale of our species across this planet. But how can we reveal more detail about the demography of...
Genetic structure and extinction of the woolly mammoth, mammuthus primigenius (2007)
Barnes, I., Shapiro, B., Lister, A., Kuznetsova, T., Sher, A., Guthrie, D., ...
The interval since circa 50 Ka has been a period of significant species extinctions among the large mammal fauna. However, the relative roles of an increasing human presence and a synchronous series...
Edwards, C. J., Bollongino, R., Scheu, A., Chamberlain, A., Tresset, A., Vigne, J. D., ...
The extinct aurochs (Bos primigenius primigenius) was a large type of cattle that ranged over almost the whole Eurasian continent. The aurochs is the wild progenitor of modern cattle, but it is...
Absence of the lactase-persistence-associated allele in early Neolithic Europeans (2007)
Burger, J., Kirchner, M., Bramanti, B., Haak, W., Thomas, M.G.
Lactase persistence (LP), the dominant Mendelian trait conferring the ability to digest the milk sugar lactose in adults, has risen to high frequency in central and northern Europeans in the last...
Ingram, C.J.E., Elamin, M.F., Mulcare, C.A., Weale, M.E., Tarekegn, A., Raga, T.O., ...
Persistence or non-persistence of lactase expression into adult life is a polymorphic trait that has been attributed to a single nucleotide polymorphism (C-13910T) in an enhancer element 13.9 kb...
Absence of the lactase-persistence-associated allele in early Neolithic Europeans (2007)
Burger, J., Kirchner, M., Bramanti, B., Haak, Wolfgang, Thomas, M. G.
Copyright © 2007 by the National Academy of Sciences
Absence of the lactase-persistence-associated allele in early Neolithic Europeans (2007)
Burger, J., Kirchner, M., Bramanti, B., Haak, Wolfgang, Thomas, M. G.
Copyright © 2007 by the National Academy of Sciences
The phylogenetic position of the ‘giant deer’ megaloceros giganteus (2005)
Lister, A.M., Edwards, C.J., Nock, D.A.W., Bunce, M., Van Pijlen, I.A., Bradley, D.G., ...
The giant deer, or 'Irish elk', has featured extensively in debates on adaptation, sexual selection, and extinction. Its huge antlers—the largest of any deer species, living or extinct—formed a...
The phylogenetic position of the 'giant deer' Megaloceros giganteus (2005)
Lister, A.M., Edwards, C.J., Nock, D.A., Bunce, M., Van Pijlen, I.A., Bradley, D.G., ...
The giant deer, or 'Irish elk', has featured extensively in debates on adaptation, sexual selection, and extinction. Its huge antlers—the largest of any deer species, living or extinct—formed a...
Prevention of group B meningococcal disease by vaccination: A difficult task (2004)
An open access copy of this article is available and complies with the copyright holder/publisher conditions.
Prevention of group B meningococcal disease by vaccination: A difficult task (2004)
An open access copy of this article is available and complies with the copyright holder/publisher conditions.
Y-chromosome evidence for differing ancient demographic histories in the Americas (2003)
Salzano, F.M., Thomas, M.G., Stuart, S., Nasanen, S.P.K., Bau, C.H.D., ...
To scrutinize the male ancestry of extant Native American populations, we examined eight biallelic and six microsatellite polymorphisms from the nonrecombining portion of the Y chromosome, in 438...
Y chromosome evidence for Anglo-Saxon mass migration (2002)
Weale, M.E., Weiss, D.A., Jager, R.E., Bradman, N., Thomas, M.G.
British history contains several periods of major cultural change. It remains controversial as to how much these periods coincided with substantial immigration from continental Europe, even for those...
Thomas, M.G., Weale, M.E., Jones, A.L., Richards, M., Smith, A., Redhead, N., ...
We have analyzed the maternally inherited mitochondrial DNA from each of nine geographically separated Jewish groups, eight non-Jewish host populations, and an Israeli Arab/Palestinian population,...
Lau, G.K.K., Suri, D., Liang, R., Rigopoulou, E.I., Thomas, M.G., Mullerova, I., ...
Background & aims: Impaired T-cell reactivity is believed to be the dominant cause of chronic hepatitis B virus (HBV) infection. We characterized HBV-specific T-cell responses in chronic hepatitis B...
"Just say no" - Reducing the use of antibiotics for colds, bronchitis and sinusitis (2000)
An open access copy of this article is available and complies with the copyright holder/publisher conditions.
Thesis (Ph. D.)--University of Leeds, 1991.
Comparative in-vitro activity of antibiotics incorporated in acrylic bone cement (1986)
Beeching, N. J., Thomas, M. G., Roberts, S., Lang, S. D. R.
We compared the persistence of antibacterial activity around antibiotic-impregnated acrylic bone cement discs which were serially transferred on seeded agar plates. On plates inoculated with...
Enoxacin treatment of urinary tract infections (1985)
Thomas, M. G., Effis-Pegler, R. B.
We treated 20 patients with unnary tract infections with enoxacun, a new nalidixic acid analogue, in an open uncontrolled tnal. Twelve of 13 patients with covert bacteriuria or cystitis and four of...
Ahmer, B M, Thomas, M G, Larsen, R A, Postle, K
TonB protein appears to couple the electrochemical potential of the cytoplasmic membrane to active transport across the essentially unenergized outer membrane of gram-negative bacteria. ExbB protein...
Gäken, J A, Tavassoli, M, Gan, S U, Vallian, S, Giddings, I, Darling, D C, ...
Integration of proviral DNA into the host cell genome is a characteristic feature of the retroviral life cycle. This process involves coordinate DNA strand break formation and rejoining reactions....
Antimicrobial spectrum of Ro 15-8074/001, a new oral cephalosporin.
The activity of Ro 15-8074/001 was compared with that of cefaclor, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, norfloxacin, and ceftriaxone against 225 clinical isolates. It was more...
Metal clusters in catalysis: Hydrocarbon reactions*
Caulton, K. G., Thomas, M. G., Sosinsky, B. A., Muetterties, E. L.
A set of metal carbonyl clusters, Ru3(CO)12, Os3(CO)12, and Ir4(CO)12, has been evaluated as catalysts for a series of hydrocarbon reactions which comprise skeletal rearrangement, metathesis,...
Vitamin D receptor expression in colorectal cancer.
Thomas, M G, Sylvester, P A, Newcomb, P, Longman, R J
AIMS: To determine whether the vitamin D receptor is expressed in colorectal cancer, and its relation to stage of disease. METHODS: Paraffin embedded sections of colorectal cancer from 30 patients...
Ahmer, B M, Thomas, M G, Larsen, R A, Postle, K
TonB protein appears to couple the electrochemical potential of the cytoplasmic membrane to active transport across the essentially unenergized outer membrane of gram-negative bacteria. ExbB protein...
Gäken, J A, Tavassoli, M, Gan, S U, Vallian, S, Giddings, I, Darling, D C, ...
Integration of proviral DNA into the host cell genome is a characteristic feature of the retroviral life cycle. This process involves coordinate DNA strand break formation and rejoining reactions....
Antimicrobial spectrum of Ro 15-8074/001, a new oral cephalosporin.
The activity of Ro 15-8074/001 was compared with that of cefaclor, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, norfloxacin, and ceftriaxone against 225 clinical isolates. It was more...
Metal clusters in catalysis: Hydrocarbon reactions*
Caulton, K. G., Thomas, M. G., Sosinsky, B. A., Muetterties, E. L.
A set of metal carbonyl clusters, Ru3(CO)12, Os3(CO)12, and Ir4(CO)12, has been evaluated as catalysts for a series of hydrocarbon reactions which comprise skeletal rearrangement, metathesis,...
Vitamin D receptor expression in colorectal cancer.
Thomas, M G, Sylvester, P A, Newcomb, P, Longman, R J
AIMS: To determine whether the vitamin D receptor is expressed in colorectal cancer, and its relation to stage of disease. METHODS: Paraffin embedded sections of colorectal cancer from 30 patients...
Molecular and morphological evidence on the phylogeny of the Elephantidae.
Thomas, M G, Hagelberg, E, Jone, H B, Yang, Z, Lister, A M
The African and Asian elephants and the mammoth diverged ca. 4-6 million years ago and their phylogenetic relationship has been controversial. Morphological studies have suggested a mammoth Asian...
Thomas, M G, Cook, C E, Miller, K W, Waring, M J, Hagelberg, E
We have identified two individuals from Glasgow in Scotland who have a deletion of one of two copies of the intergenic 9-bp sequence motif CCCCCTCTA, located between the cytochrome oxidase II (COII)...
Calcipotriol inhibits rectal epithelial cell proliferation in ulcerative proctocolitis.
Thomas, M G, Nugent, K P, Forbes, A, Williamson, R C
Vitamin D3 reduces human rectal crypt cell production rate (CCPR) and may thereby protect against colorectal cancer. Cell turnover is increased in ulcerative proctocolitis, which might therefore...
Divergent effects of epidermal growth factor and calcipotriol on human rectal cell proliferation.
Thomas, M G, Brown, G R, Alison, M R, Williamson, R C
Vitamin D may protect against colorectal cancer by reducing cell proliferation and inducing differentiation. By contrast, epidermal growth factor (EGF) stimulates cell proliferation and may encourage...
Thomas, M G, Tebbutt, S, Williamson, R C
Like calcium, vitamin D may protect against colorectal neoplasia as it reduces epithelial cell proliferation and induces differentiation. Although its therapeutic use is limited by its effects on...
Sylvester, P A, Walsh, M, Myerscough, N, Warren, B F, Corfield, A P, Thomas, M G, ...
Background: Adaptive colonic phenotypic change of the ileal mucosa is a feature of the ileoanal reservoir (IAR) with time, as described by mucin glycoprotein and histological analysis. Mucin gene...
Absence of the lactase-persistence-associated allele in early Neolithic Europeans
Burger, J., Kirchner, M., Bramanti, B., Haak, W., Thomas, M. G.
Lactase persistence (LP), the dominant Mendelian trait conferring the ability to digest the milk sugar lactose in adults, has risen to high frequency in central and northern Europeans in the last...
Pulmonary staging in colorectal cancer--is computerised tomography the answer?
McIntosh, J., Sylvester, P. A., Virjee, J., Callaway, M., Thomas, M. G.
INTRODUCTION: Pulmonary staging in colorectal cancer (CRC) has traditionally been carried out by means of plain chest radiograph (CXR), although computerised tomography (CT) imaging of the chest is...
Herpes zoster meningoencephalitis without rash: varicella zoster virus DNA in CSF.
Powell, K F, Wilson, H G, Croxson, M O, Marshall, M R, Wong, E H, Anderson, N E, ...
Severe hypoxaemia in pertussis.
Southall, D P, Thomas, M G, Lambert, H P
Overnight tape recordings of breathing movements, airflow, and arterial oxygen saturation from six infants aged 3 weeks to 7 months, who had cyanotic episodes associated with pertussis, were compared...
Luminal and humoral influences on human rectal epithelial cytokinetics.
Multiple genetic and environmental steps may underpin the development of human colorectal neoplasia, and experimental evidence suggests that promoters of colorectal cancer also induce colorectal...