M. Gotoh

Regeneration of canine tracheal cartilage by slow release of basic fibroblast growth factor from gelatin sponge (2006)

Igai, H, Chang, SS, Gotoh, M, Yamamoto, Y, Misaki, N, Okamoto, T, ...

Regeneration of canine trachea and tracheal cartilage by slow release of growth factor from biodegradable materials (2006)

Yokomise, H, Yamamoto, Y, Igai, H, Gotoh, M, Tabata, Y

Tracheal cartilage regeneration by the synchronous slow release of basic fibroblast growth factor (b-FGF)/bone morphogenetic protein (BMP)-2 from gelatin sponges (2006)

Igai, H, Chang, SS, Gotoh, M, Yamamoto, Y, Okamoto, T, Yamamoto, M, ...

Regeneration of canine tracheal cartilage by slow release of BMP-2 from gelatin sponge: Eficiency of the BMPbmp-2 dosage and periosteum coverage (2006)

Yamamoto, Y, Igai, H, Gotoh, M, Yokomise, H, Tabata, Y

Slow release of bone morphogenetic protein 2 from a gelatin sponge to promote regeneration of tracheal cartilage in a canine model (2004)

Okamoto, T, Yamamoto, Y, Gotoh, M, Huang, CL, Nakamura, T, Shimizu, Y, ...

Phase I and pharmacokinetic study of MCC-465, a doxorubicin (DXR) encapsulated in PEG immunoliposome, in patients with metastatic stomach cancer (2004)

Matsumura, Y., Gotoh, M., Muro, K., Yamada, Y., Shirao, K., Shimada, Y., ...

Background: MCC-465 is an immunoliposome-encapsulated doxorubicin (DXR). The liposome is tagged with polyethylene glycol (PEG) and the F(ab′)2 fragment of human monoclonal antibody GAH, which...

Cartilage regeneration using slow release of bone morphogenetic protein-2 from a gelatin sponge to treat experimental canine tracheomalacia: A preliminary report (2003)

Okamoto, T, Yamamoto, Y, Gotoh, M, Liu, D, Kihara, M, Kameyama, K, ...

Interleukin-1-induced subacromial synovitis and shoulder pain in rotator cuff diseases (2001)

Gotoh, M., Hamada, K., Yamakawa, H., Yanagisawa, K., Nakamura, M., Yamazaki, H., ...

Objective. To determine the relationship between the expression of interleukin‐1β (IL‐1β) and IL‐1 receptor antagonists (IL‐1ra) in the subacromial...

High Voltage Solar Array for MPD Propulsion System (1998)

Ijichi,K., Fujii,H., Gohnai,T., Gotoh,M., Abe,T.

Series-Parallel switching of solar arrays has been demonstrated to provide high-voltage power to charge capacitors using ground-based solar arrays. To prevent arcing on solar arrays, a conductive...

Pulse Forming Network for MPD Propulsion System With Improved Capacitors (1998)

Harada,H., Gohnai,T., Gotoh,M., Ijichi,K., Okamura,T.

The pulse-forming network (PFN) to supply 1-RJ pulse energy for an MPD propulsion system has been designed, manufactured, and tested. Improved plastic film capacitors with energy density of 5.4 g/j...

Thiobarbituric acid reactive substances are increased in the subcutaneous fat tissue of patients with end-stage renal disease (1997)

Gotoh, M, Nagase, S, Aoyagi, K, Hirayama, A, Takemura, K, Ueda, A, ...

PHOSPHATTDYL SERINE-DEPENDENT ANTIPROTHROMBIN ANTIBODY IS EXCLUSIVE TO PATIENTS WITH LUPUS ANTICOAGULANT (1996)

MATSUDA, J., SAITOH, N., GOTOH, M., KAWASUGI, K., GOHCHI, K., TSUKAMOTO, M.

We conducted this study to determine whether antiprothrombin antibody (aPT) [to prothrombin (PT) alone or PT/phosphatidyl serine (PS) complex] actually existed in patients with lupus...

Clinical significance of serum 2,5-oligoadenylate synthetase and soluble interleukin-2 receptor in hemophiliacs positive and negative for human immunodeficiency virus type 1.

Matsuda, J, Gotoh, M, Gohchi, K, Tsukamoto, M, Saitoh, N, Kinoshita, T

We measured serum 2,5-oligoadenylate synthetase (2,5-AS) levels and soluble interleukin-2 receptor (sIL-2R) levels in human immune deficiency virus type 1 (HIV-1)-positive and HIV-1-negative...

Quasiperiodicity and chaos in cardiac fibrillation.

Garfinkel, A, Chen, P S, Walter, D O, Karagueuzian, H S, Kogan, B, Evans, S J, ...

In cardiac fibrillation, disorganized waves of electrical activity meander through the heart, and coherent contractile function is lost. We studied fibrillation in three stationary forms: in human...

Detection of genes expressed in primary colon cancers by in situ hybridisation: overexpression of RACK 1

Saito, A, Fujii, G, Sato, Y, Gotoh, M, Sakamoto, M, Toda, G, ...

Aims: The isolation of various genes that are expressed in a region specific manner is considered useful for research in molecular pathology. In situ hybridisation (ISH) was used in a screening...

Determination of the presence of interleukin-6 in bile after orthotopic liver transplantation. Its role in the diagnosis of acute rejection.

Umeshita, K, Monden, M, Tono, T, Hasuike, Y, Kanai, T, Gotoh, M, ...

OBJECTIVE: The authors evaluated the significance of interleukin-6 (IL-6) in bile in the diagnosis of acute rejection after liver transplantation. SUMMARY BACKGROUND DATA: Interleukin-6 in blood has...

Clinical significance of serum 2,5-oligoadenylate synthetase and soluble interleukin-2 receptor in hemophiliacs positive and negative for human immunodeficiency virus type 1.

Matsuda, J, Gotoh, M, Gohchi, K, Tsukamoto, M, Saitoh, N, Kinoshita, T

We measured serum 2,5-oligoadenylate synthetase (2,5-AS) levels and soluble interleukin-2 receptor (sIL-2R) levels in human immune deficiency virus type 1 (HIV-1)-positive and HIV-1-negative...

Quasiperiodicity and chaos in cardiac fibrillation.

Garfinkel, A, Chen, P S, Walter, D O, Karagueuzian, H S, Kogan, B, Evans, S J, ...

In cardiac fibrillation, disorganized waves of electrical activity meander through the heart, and coherent contractile function is lost. We studied fibrillation in three stationary forms: in human...

Detection of genes expressed in primary colon cancers by in situ hybridisation: overexpression of RACK 1

Saito, A, Fujii, G, Sato, Y, Gotoh, M, Sakamoto, M, Toda, G, ...

Aims: The isolation of various genes that are expressed in a region specific manner is considered useful for research in molecular pathology. In situ hybridisation (ISH) was used in a screening...

Determination of the presence of interleukin-6 in bile after orthotopic liver transplantation. Its role in the diagnosis of acute rejection.

Umeshita, K, Monden, M, Tono, T, Hasuike, Y, Kanai, T, Gotoh, M, ...

OBJECTIVE: The authors evaluated the significance of interleukin-6 (IL-6) in bile in the diagnosis of acute rejection after liver transplantation. SUMMARY BACKGROUND DATA: Interleukin-6 in blood has...

The distribution of antigen in flare up reaction in contact sensitivity to DNCB.

Fukushiro, S, Nakagawa, S, Gotoh, M, Koshizawa, M, Tanioku, K

The distribution of DNP groups in various tissues of guinea-pigs following intravenous injection of DNBSO3Na was investigated by an immunofluorescent method using FITC-labelled anti-DNP antibody. DNP...

The distribution of 2,4-dinitrophenyl groups in lymphoid tissue of guinea-pigs following skin painting with 2,4-dinitrochlorobenzene.

Nakagawa, S, Amos, H E, Gotoh, M, Tanioku, K

Cellular localization of 2,4-dinitrophenyl (DNP) groups in the peripheral lymphoid system of guinea-pigs was studied at various times after painting the skin with 2,4-dinitrochlorobenzene (DNCB) by...

Absence of an association between antibodies to retroviral proteins and anticardiolipin antibody and/or lupus anticoagulant in systemic lupus erythematosus.

Matsuda, J, Gotoh, M, Gohchi, K, Tsukamoto, M, Saitoh, N

Prevalence of beta 2-glycoprotein I antibody in systemic lupus erythematosus patients with beta 2-glycoprotein I dependent antiphospholipid antibodies.

Matsuda, J, Saitoh, N, Gotoh, M, Gohchi, K, Tsukamoto, M

OBJECTIVE--To investigate whether beta 2-glycoprotein I antibody (aGPI) exists in sera that are positive for antiphospholipid antibodies (aPL). METHODS--Thirty six patients with systemic lupus...

Molecular cloning of a cell-surface glycoprotein that can potentially discriminate mesothelium from epithelium: its identification as vascular cell adhesion molecule 1.

Yamada, T., Jiping, J., Endo, R., Gotoh, M., Shimosato, Y., Hirohashi, S.

It has long been a practical problem for surgical pathologists to distinguish mesothelium from epithelium in order to make a positive diagnosis of mesothelioma. In this study, we developed a new...

Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes.

Hirano, T., Abe, K., Gotoh, M., Oka, K.

Certain anti-cancer agents are known to induce apoptosis in human tumour cells. However, these agents are intrinsically cytotoxic against cells of normal tissue origin, including myelocytes and...

Gene expression profiles in human gastric cancer: expression of maspin correlates with lymph node metastasis

Terashima, M, Maesawa, C, Oyama, K, Ohtani, S, Akiyama, Y, Ogasawara, S, ...

To seek for a candidate gene that would regulate tumour progression and metastasis in gastric cancer, we investigated gene expression profiles by using DNA microarray. Tumour tissue and adjacent...

Phase I/II study of S-1 combined with cisplatin in patients with advanced gastric cancer

Koizumi, W, Tanabe, S, Saigenji, K, Ohtsu, A, Boku, N, Nagashima, F, ...