M. Harada

Publication List Details

Period

1979 - 2009

Number

92

Co-Authors

Enhancement of quark number susceptibility with an alternative pattern of chiral symmetry breaking in dense matter (2009)

Harada, M., Sasaki, C., Takemoto, S.

We explore a possible phase where chiral $SU(2)_L \times SU(2)_R$ symmetry is spontaneously broken while its center $Z_2$ symmetry remains unbroken and its consequence on thermal quantities. In this...

A novel spectral broadening from vector--axial-vector mixing in dense matter (2009)

Harada, M., Sasaki, C.

The presence of baryonic matter leads to the mixing between transverse $\rho$ and $a_1$ mesons through a set of $\omega\rho a_1$-type interactions, which results in the modification to the dispersion...

Role of axial-vector mesons near the chiral phase transition (2009)

Sasaki, C., Harada, M., Weise, W.

We present a systematic study of the vector--axial-vector mixing (V-A mixing) in the current correlation functions and its evolution with temperature within an effective field theory. The...

Vector-axialvector mixing from a chiral effective field theory at finite temperature (2008)

Harada, M., Sasaki, C., Weise, W.

We study the vector-axialvector mixing in a hot medium and its evolution toward the chiral phase transition using different symmetry restoration scenarios based on the generalized hidden local...

Vector-axialvector mixing in hot matter and its hadronic effective field theory description (2008)

Sasaki, C., Harada, M., Weise, W.

We discuss the importance of the axialvector meson in chiral phase transition at finite temperature. We show that there exists a significant contribution in the vector spectral function from the...

A dose-escalation study of rituximab for treatment of systemic lupus erythematosus and Evans' syndrome: immunological analysis of B cells, T cells and cytokines (2008)

Tamimoto, Y., Horiuchi, T., Tsukamoto, H., Otsuka, J., Mitoma, H., Kimoto, Y., ...

Objective. Accumulating evidence suggests that B-cell depletion therapy by rituximab may be effective for autoimmune disorders. However, an optimal dose of rituximab and a mechanism of its action...

Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus (2008)

Miyagawa, H., Yamai, M., Sakaguchi, D., Kiyohara, C., Tsukamoto, H., Kimoto, Y., ...

Objective. Identification of the genes responsible for systemic lupus erythematosus (SLE). Methods. All the exons and putative promoter regions of 53 candidate genes (TNFRSF6/Fas, TNFSF6/FasL, Fli1,...

Thermal Dilepton Production from Dropping rho in the Vector Manifestation (2007)

Harada, M., Sasaki, C.

We study the pion electromagnetic form factor and the dilepton production rate in hot matter based on the vector manifestation (VM) of chiral symmetry in which the massless vector meson becomes the...

All Link Invariants for Two Dimensional Solutions of Yang-Baxter Equation and Dressings (2006)

Aizawa, N., Harada, M., Kawaguchi, M., Otsuki, E.

All polynomial invariants of links for two dimensional solutions of Yang-Baxter equation is constructed by employing Turaev's method. As a consequence, it is proved that the best invariant so...

A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations (2006)

Asahina, H., Yamazaki, K., Kinoshita, I., Sukoh, N., Harada, M., Yokouchi, H., ...

Retrospective analysis has shown that activating mutations in exons 18-21 of the epidermal growth factor receptor (EGFR) gene are a predictor of response to gefitinib. We conducted a phase II trial...

Thermal Dilepton Production from Dropping rho based on the Vector Manifestation (2006)

Harada, M., Sasaki, C.

We study the pion electromagnetic form factor and the dilepton production rate in hot matter using the hidden local symmetry theory as an effective field theory for pions and rho mesons. In this...

SO(10) SUSY GUT for Fermion Masses : Lepton Flavor and CP Violation (2006)

Dermisek, R., Harada, M., Raby, S.

We discuss the results of a global $\chi^2$ analysis of a simple SO(10) SUSY GUT with $D_3$ family symmetry and low energy R parity. The model describes fermion mass matrices with 14 parameters and...

Implications of Holographic QCD in ChPT with Hidden Local Symmetry (2006)

Harada, M., Matsuzaki, S., Yamawaki, K.

Based on the chiral perturbation theory (ChPT) with the hidden local symmetry, we propose a methodology to calculate the large $N_c$ corrections in the holographic QCD (HQCD). As an example, we apply...

Recurrence of ovarian endometrioma after laparoscopic excision (2006)

Koga, K., Takemura, Y., Osuga, Y., Yoshino, O., Hirota, Y., Hirata, T., ...

BACKGROUND: To analyse risk factors that influence the recurrence of endometrioma after laparoscopic excision. METHODS: A total of 224 patients who had a minimum of 2 years of post-operative...

Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor {alpha} (2006)

Karube, K., Ohshima, K., Suzumiya, J., Kawano, R., Kikuchi, M., Harada, M.

We microdissected Hodgkin and Reed–Sternberg (HRS) cells from 14 Hodgkin's lymphoma tissue samples (nodular sclerosis = 5; mixed cellularity = 9), and after isolation and...

Recurrence of ovarian endometrioma after laparoscopic excision (2006)

Koga, K., Takemura, Y., Osuga, Y., Yoshino, O., Hirota, Y., Hirata, T., ...

BACKGROUND: To analyse risk factors that influence the recurrence of endometrioma after laparoscopic excision. METHODS: A total of 224 patients who had a minimum of 2 years of post-operative...

Recurrence of ovarian endometrioma after laparoscopic excision (2006)

Koga, K., Takemura, Y., Osuga, Y., Yoshino, O., Hirota, Y., Hirata, T., ...

BACKGROUND: To analyse risk factors that influence the recurrence of endometrioma after laparoscopic excision. METHODS: A total of 224 patients who had a minimum of 2 years of post-operative...

Dropping rho and A_1 Meson Masses at Chiral Phase Transition in the Generalized Hidden Local Symmetry (2005)

Harada, M., Sasaki, C.

We study the chiral symmetry restoration using the generalized hidden local symmetry (GHLS) which incorporates the rho and A_1 mesons as the gauge bosons of the GHLS and the pion as the...

Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor {alpha} (2005)

Karube, K., Ohshima, K., Suzumiya, J., Kawano, R., Kikuchi, M., Harada, M.

We microdissected Hodgkin and Reed-Sternberg (HRS) cells from 14 Hodgkin's lymphoma tissue samples (nodular sclerosis = 5; mixed cellularity = 9), and after isolation and amplification of mRNA,...

Two-dimensional super Yang-Mills theory investigated with improved resolution (2004)

Hiller, J. R., Harada, M., Pinsky, S. S., Salwen, N., Trittmann, U.

In earlier work, N=(1,1) super Yang--Mills theory in two dimensions was found to have several interesting properties, though these properties could not be investigated in any detail. In this paper we...

Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/lpr mice (2004)

Shimizu, S., Nakashima, H., Masutani, K., Inoue, Y., Miyake, K., Akahoshi, M., ...

Objective. Monocyte chemoattractant protein-1 (MCP-1) is up-regulated and recruits and activates inflammatory cells in human diffuse proliferative lupus nephritis (DPLN) and in nephritis of lupus...

Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/lpr mice (2004)

Shimizu, S., Nakashima, H., Masutani, K., Inoue, Y., Miyake, K., Akahoshi, M., ...

Objective. Monocyte chemoattractant protein-1 (MCP-1) is up-regulated and recruits and activates inflammatory cells in human diffuse proliferative lupus nephritis (DPLN) and in nephritis of lupus...

Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/lpr mice (2004)

Shimizu, S., Nakashima, H., Masutani, K., Inoue, Y., Miyake, K., Akahoshi, M., ...

Objective. Monocyte chemoattractant protein-1 (MCP-1) is up-regulated and recruits and activates inflammatory cells in human diffuse proliferative lupus nephritis (DPLN) and in nephritis of lupus...

Large Nc and Chiral Dynamics (2003)

Harada, M., Sannino, F., Schechter, J.

We study the dependence on the number of colors of the leading pi pi scattering amplitude in chiral dynamics. We demonstrate the existence of a critical number of colors for and above which the low...

Study of Scalar Mesons and Related Radiative Decays (2003)

Black, D., Harada, M., Schechter, J.

After a brief review of the puzzling light scalar meson sector of QCD, a brief summary will be given of a paper concerning radiative decays involving the light scalars. There, a simple vector meson...

A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus (2003)

Koyama, T., Tsukamoto, H., Masumoto, K., Himeji, D., Hayashi, K., Harada, M., ...

Objective. We investigated the association of gene polymorphisms in APRIL, a new member of the TNF family, with systemic lupus erythematosus. Methods. To detect polymorphisms of the human APRIL gene...

A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus (2003)

Koyama, T., Tsukamoto, H., Masumoto, K., Himeji, D., Hayashi, K., Harada, M., ...

Objective. We investigated the association of gene polymorphisms in APRIL, a new member of the TNF family, with systemic lupus erythematosus. Methods. To detect polymorphisms of the human APRIL gene...

A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus (2003)

Koyama, T., Tsukamoto, H., Masumoto, K., Himeji, D., Hayashi, K., Harada, M., ...

Objective. We investigated the association of gene polymorphisms in APRIL, a new member of the TNF family, with systemic lupus erythematosus. Methods. To detect polymorphisms of the human APRIL gene...

Genetically determined interferon-{gamma} production influences the histological phenotype of lupus nephritis (2002)

Miyake, K., Nakashima, H., Akahoshi, M., Inoue, Y., Nagano, S., Tanaka, Y., ...

Objective. To clarify whether the interferon‐γ (IFN‐γ) gene (IFNG) is associated with the histological phenotype of lupus nephritis. Method. We analysed...

Penguins diagrams in Delta I=1/2 rule and \epsilon'/\epsilon with \sigma models (1999)

Harada, M., Keum, Y., Kiyo, Y., Morozumi, T., Onogi, T., Yamada, N.

We study the correlation between $\epe$ and $\Delta I=1/2$ rule in the framework of non-linear $\sigma$ model including scalar mesons. The matrix elements of QCD and Electroweak (EW) penguin...

Elasto-Plastic Analysis of ZrO2-Metal FGM in High Heat Flux Environment. (1998)

Maruyama, T., Harada, M., Ukai, S., Nomura, S., Shikakura, S.

This paper concerned mmc in some important way and contained information about, utilized, or discussed these subjects: basic topics:, analytical, cmc, composite materials, data, mmc, mmc data, models...

Hyperfine Splitting of Low-Lying Heavy Baryons (1997)

Harada, M., Qamar, A., Sannino, F., Schechter, J., Weigel, H.

We calculate the next-to-leading order contribution to the masses of the heavy baryons in the bound state approach for baryons containing a heavy quark. These $1/N_C$ corrections arise when states of...

Crystal and Electronic Structures and the Corrosion Resistance for Metal Nitrides in the TiN-AIN System (1997)

Takahashi, M., Kanamaru, F., Harada, M., Watanabe, I.

Both aluminum and titanium K-edge XAFS spectra of Ti1-xAlxN (0≤x≤1.0) films were measured to investigate the corrosion resistance of compounds in the TiN-AlN system. Analyses of both Al...

XAFS Characterization of Platinum Clusters Synthesized in the Channel of a Mesoporous Zeolite (1997)

Shido, T., Yamamoto, T., Harada, M., Ichikawa, M.

[Pt15(CO)30]2- was synthesized by reductive carbonylation of H2PtCl6 in the channels of FSM-16 modified with NEt4Cl. The platinum clusters in the channels whose diameter was 28 Å were characterized...

Crystal and Electronic Structures and the Corrosion Resistance for Metal Nitrides in the TiN-AIN System (1997)

Takahashi, M., Kanamaru, F., Harada, M., Watanabe, I.

Both aluminum and titanium K-edge XAFS spectra of Ti1-xAlxN (0≤x≤1.0) films were measured to investigate the corrosion resistance of compounds in the TiN-AlN system. Analyses of both Al...

XAFS Characterization of Platinum Clusters Synthesized in the Channel of a Mesoporous Zeolite (1997)

Shido, T., Yamamoto, T., Harada, M., Ichikawa, M.

[Pt15(CO)30]2- was synthesized by reductive carbonylation of H2PtCl6 in the channels of FSM-16 modified with NEt4Cl. The platinum clusters in the channels whose diameter was 28 Å were characterized...

Crystal and Electronic Structures and the Corrosion Resistance for Metal Nitrides in the TiN-AIN System (1997)

Takahashi, M., Kanamaru, F., Harada, M., Watanabe, I.

Both aluminum and titanium K-edge XAFS spectra of Ti1-xAlxN (0≤x≤1.0) films were measured to investigate the corrosion resistance of compounds in the TiN-AlN system. Analyses of both Al...

XAFS Characterization of Platinum Clusters Synthesized in the Channel of a Mesoporous Zeolite (1997)

Shido, T., Yamamoto, T., Harada, M., Ichikawa, M.

[Pt15(CO)30]2- was synthesized by reductive carbonylation of H2PtCl6 in the channels of FSM-16 modified with NEt4Cl. The platinum clusters in the channels whose diameter was 28 Å were characterized...

Scaling Behavior in Soliton Models (1996)

Harada, M., Sannino, F., Schechter, J., Weigel, H.

In the framework of chiral soliton models we study the behavior of static nucleon properties under rescaling of the parameters describing the effective meson theory. In particular we investigate the...

Nontriviality of Gauge-Higgs-Yukawa System and Renormalizability of Gauged NJL Model (1994)

Harada, M., Kikukawa, Y., Kugo, T., Nakano, H.

In the leading order of a modified 1/Nc expansion, we show that a class of gauge-Higgs-Yukawa systems in four dimensions give non-trivial and well-defined theories in the continuum limit. The...

AFTER EFFECTS OF EC-DECAY 57Co - LABELLED TRIS (OXINATO) COBALT (III) AND TRIS (β-DIKETONATO) COBALT( I I I ) (1979)

Endo, K., Harada, M., Sakai, Y., Sano, H.

The emission Mössbauer spectra of diamagnetic (S=O) 57Co-labelled tris(oxinato) cobalt (III) and tris (β-diketonato) cobalt (III) were compared with the absorption spectra of paramagnetic...

PARTIAL QUADRUPOLE SPLITTING OF Fe-57 SPECIES PRODUCED FROM Co-57-LABELLED WERNER COMPLEXES (1979)

Sakai, Y., Harada, M., Endo, K., Sano, H.

The quadrupole splitting values of the species produced from the 57Co(EC) 57Fe process were investigated in the various 57Co-labelled Werner-type co-ordination compounds. One of the two components of...

AFTER EFFECTS OF EC-DECAY 57Co - LABELLED TRIS (OXINATO) COBALT (III) AND TRIS (β-DIKETONATO) COBALT( I I I ) (1979)

Endo, K., Harada, M., Sakai, Y., Sano, H.

The emission Mössbauer spectra of diamagnetic (S=O) 57Co-labelled tris(oxinato) cobalt (III) and tris (β-diketonato) cobalt (III) were compared with the absorption spectra of paramagnetic...

PARTIAL QUADRUPOLE SPLITTING OF Fe-57 SPECIES PRODUCED FROM Co-57-LABELLED WERNER COMPLEXES (1979)

Sakai, Y., Harada, M., Endo, K., Sano, H.

The quadrupole splitting values of the species produced from the 57Co(EC) 57Fe process were investigated in the various 57Co-labelled Werner-type co-ordination compounds. One of the two components of...

AFTER EFFECTS OF EC-DECAY 57Co - LABELLED TRIS (OXINATO) COBALT (III) AND TRIS (β-DIKETONATO) COBALT( I I I ) (1979)

Endo, K., Harada, M., Sakai, Y., Sano, H.

The emission Mössbauer spectra of diamagnetic (S=O) 57Co-labelled tris(oxinato) cobalt (III) and tris (β-diketonato) cobalt (III) were compared with the absorption spectra of paramagnetic...

PARTIAL QUADRUPOLE SPLITTING OF Fe-57 SPECIES PRODUCED FROM Co-57-LABELLED WERNER COMPLEXES (1979)

Sakai, Y., Harada, M., Endo, K., Sano, H.

The quadrupole splitting values of the species produced from the 57Co(EC) 57Fe process were investigated in the various 57Co-labelled Werner-type co-ordination compounds. One of the two components of...

Growth and N Allocation in Rice Plants under CO2 Enrichment.

Makino, A., Harada, M., Sato, T., Nakano, H., Mae, T.

The effects of CO2 enrichment on growth and N allocation of rice (Oryza sativa L.) were examined. The plants were grown hydroponically in growth chambers with a 14-h photoperiod (1000 [mu]mol quanta...

Interleukin 4 suppresses the spontaneous growth of chronic myelomonocytic leukemia cells.

Akashi, K, Shibuya, T, Harada, M, Takamatsu, Y, Uike, N, Eto, T, ...

We studied the effects of IL-4 on the spontaneous proliferation of chronic myelomonocytic leukemia (CMMoL) cells in vitro. IL-4 (100 U/ml) suppressed the spontaneous DNA synthesis by approximately...

Deficiency of coagulation factor XIII A subunit caused by the dinucleotide deletion at the 5' end of exon III.

Kamura, T, Okamura, T, Murakawa, M, Tsuda, H, Teshima, T, Shibuya, T, ...

A congenital deficiency of the coagulation Factor XIII A subunit (F XIII A) is a rare autosomal recessive disorder that is characterized by a life-long bleeding tendency complicated by a difficulty...

Dipeptidyl peptidase III is a zinc metallo-exopeptidase. Molecular cloning and expression.

Fukasawa, K, Fukasawa, K M, Kanai, M, Fujii, S, Hirose, J, Harada, M

We have purified dipeptidyl peptidase III (EC 3.4.14.4) from human placenta. It had a pH optimum of 8.8 and readily hydrolysed Arg-Arg-beta-naphthylamide. Monoamino acid-, Gly-Phe-, Gly-Pro- and...

Aminopeptidase B is structurally related to leukotriene-A4 hydrolase but is not a bifunctional enzyme with epoxide hydrolase activity.

Fukasawa, K M, Fukasawa, K, Harada, M, Hirose, J, Izumi, T, Shimizu, T

Aminopeptidase B (Ap B; EC 3.4.11.6) is a zinc-binding protein that contains the consensus sequence HEXXHX18E (324-347), conserved among the M1 family of metallopeptidases. To determine if these...

Growth and N Allocation in Rice Plants under CO2 Enrichment.

Makino, A., Harada, M., Sato, T., Nakano, H., Mae, T.

The effects of CO2 enrichment on growth and N allocation of rice (Oryza sativa L.) were examined. The plants were grown hydroponically in growth chambers with a 14-h photoperiod (1000 [mu]mol quanta...

Interleukin 4 suppresses the spontaneous growth of chronic myelomonocytic leukemia cells.

Akashi, K, Shibuya, T, Harada, M, Takamatsu, Y, Uike, N, Eto, T, ...

We studied the effects of IL-4 on the spontaneous proliferation of chronic myelomonocytic leukemia (CMMoL) cells in vitro. IL-4 (100 U/ml) suppressed the spontaneous DNA synthesis by approximately...

Deficiency of coagulation factor XIII A subunit caused by the dinucleotide deletion at the 5' end of exon III.

Kamura, T, Okamura, T, Murakawa, M, Tsuda, H, Teshima, T, Shibuya, T, ...

A congenital deficiency of the coagulation Factor XIII A subunit (F XIII A) is a rare autosomal recessive disorder that is characterized by a life-long bleeding tendency complicated by a difficulty...

Dipeptidyl peptidase III is a zinc metallo-exopeptidase. Molecular cloning and expression.

Fukasawa, K, Fukasawa, K M, Kanai, M, Fujii, S, Hirose, J, Harada, M

We have purified dipeptidyl peptidase III (EC 3.4.14.4) from human placenta. It had a pH optimum of 8.8 and readily hydrolysed Arg-Arg-beta-naphthylamide. Monoamino acid-, Gly-Phe-, Gly-Pro- and...

Aminopeptidase B is structurally related to leukotriene-A4 hydrolase but is not a bifunctional enzyme with epoxide hydrolase activity.

Fukasawa, K M, Fukasawa, K, Harada, M, Hirose, J, Izumi, T, Shimizu, T

Aminopeptidase B (Ap B; EC 3.4.11.6) is a zinc-binding protein that contains the consensus sequence HEXXHX18E (324-347), conserved among the M1 family of metallopeptidases. To determine if these...

Involvement of both donor cytotoxic T lymphocytes and host NK1.1+ T cells in the thymic atrophy of mice suffering from acute graft-versus-host disease.

Onoe, Y, Harada, M, Tamada, K, Abe, K, Li, T, Tada, H, ...

It has been reported that a dramatic decrease in the number of thymocytes (thymic atrophy) in mice suffering from acute graft-versus-host disease (GVHD) is ascribed to glucocorticoids. In this study,...

Early-appearing tumour-infiltrating natural killer cells play a crucial role in the generation of anti-tumour T lymphocytes.

Kurosawa, S, Harada, M, Matsuzaki, G, Shinomiya, Y, Terao, H, Kobayashi, N, ...

Natural killer (NK) cells that infiltrated into the primary tumour site at an early stage of tumour development, were examined for their participation in the generation of anti-tumour cytotoxic T...

Specific immunotherapy with tumour-draining lymph node cells cultured with both anti-CD3 and anti-CD28 monoclonal antibodies.

Harada, M, Okamoto, T, Omoto, K, Tamada, K, Takenoyama, M, Hirashima, C, ...

For providing costimulatory signals, we utilized anti-CD28 monoclonal antibody (mAb) for the in vitro culture of tumour-draining lymph node (LN) cells. The proliferation of B16 melanoma-draining LN...

The emergence of non-cytolytic NK1.1+ T cells in the long-term culture of murine tumour-infiltrating lymphocytes: a possible role of transforming growth factor-beta.

Tamada, K, Harada, M, Ito, O, Takenoyama, M, Mori, T, Matsuzaki, G, ...

The mechanism by which murine tumour-infiltrating lymphocytes (TIL) decreased their anti-tumour activity during an in vitro culture with interleukin-2 (IL-2) was investigated. A phenotype analysis...

Mouse anti-benzylpenicilloyl IgE monoclonal antibody: preparation, characterization and cross-reactivity.

Fukushima, H, Misaki, R, Takeuchi, M, Niinomi, Y, Harada, M

Anti-benzylpenicilloyl (BPO-) monoclonal antibody of the IgE class was prepared from spleens of immune C57BL/6 mice whose sera reacted with BPO-hapten, penicillin G(PCG) polymer, cephalothin...

Circulating immunoglobulin-bound transforming growth factor β at a late tumour-bearing stage impairs antigen-specific responses of CD4+ T cells

HARADA, M, TATSUGAMI, K, NOMOTO, M, NOMOTO, K

In order to elucidate the mechanisms by which tumour-specific CD4+ T-cell responses are impaired during tumour development, an attempt was made to identify factors which impair CD4+ T-cell responses...

Contribution of thromboxane A2 to the antigen-induced immediate asthmatic response mediated by IgG1 antibody by augmentation of bronchial responsiveness in guinea-pigs.

Arimura, A., Asanuma, F., Kurosawa, A., Harada, M.

1. IgG1-mediated anaphylactic bronchoconstriction was elicited by intravenous administration of antigen to guinea-pig 2 days after passive sensitization with IgG1-rich serum, and this response was...

IL-3 derived from CD4+ T cells is essential for the in vitro expansion of mast cells from the normal adult mouse spleen

HARADA, M, SUMICHIKA, H, HAMANO, S, ITO, O, TAMADA, K, TAKENOYAMA, M, ...

A null cell line (SCM1) was established by a culture of spleen cells (SC) from normal adult C57Bl/6 mice with complete medium alone for 10 days and followed by weekly cultures with a 25% WEHI-3 cell...

SHP-1/immunoreceptor tyrosine-based inhibition motif-independent inhibitory signalling through murine natural killer cell receptor Ly-49A in a transfected B-cell line

Motoda, K, Takata, M, Kiura, K, Nakamura, I, Harada, M

Ly-49A is a member of the Ly-49 family of mouse natural killer cell receptors that inhibit cytotoxicity upon recognition of their ligands, the major histocompatibility complex (MHC) class I...

Raised serum APRIL levels in patients with systemic lupus erythematosus

Koyama, T, Tsukamoto, H, Miyagi, Y, Himeji, D, Otsuka, J, Miyagawa, H, ...

Methods: Serum samples from 48 patients with SLE, 41 normal healthy subjects, and 21 patients with rheumatoid arthritis (RA) were assayed for APRIL by enzyme linked immunosorbent assay. Medical...

Identification of Lck-derived peptides applicable to anti-cancer vaccine for patients with human leukocyte antigen-A3 supertype alleles

Naito, M, Komohara, Y, Ishihara, Y, Noguchi, M, Yamashita, Y, Shirakusa, T, ...

The identification of peptide vaccine candidates to date has been focused on human leukocyte antigen (HLA)-A2 and -A24 alleles. In this study, we attempted to identify cytotoxic T lymphocyte...

A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations

Asahina, H, Yamazaki, K, Kinoshita, I, Sukoh, N, Harada, M, Yokouchi, H, ...

Retrospective analysis has shown that activating mutations in exons 18–21 of the epidermal growth factor receptor (EGFR) gene are a predictor of response to gefitinib. We conducted a phase II trial...

Fractionated administration of irinotecan and cisplatin for treatment of lung cancer: a phase I study

Ueoka, H, Tabata, M, Kiura, K, Shibayama, T, Gemba, K, Segawa, Y, ...

A combination chemotherapy of irinotecan (CPT-11) and cisplatin (CDDP) has been reported to be active for lung cancer. In the previous trial, however, diarrhoea and leucopenia became the major...

Fractionated administration of irinotecan and cisplatin for treatment of non-small-cell lung cancer: a phase II study of Okayama Lung Cancer Study Group

Ueoka, H, Tanimoto, M, Kiura, K, Tabata, M, Takigawa, N, Segawa, Y, ...

A phase II study of fractionated administration of irinotecan (CPT-11) and cisplatin (CDDP) in patients with non-small-cell lung cancer (NSCLC) was conducted. Between January 1996 and January 1998,...

Detection of peptide-specific CTL-precursors in peripheral blood lymphocytes of cancer patients

Maeda, Y, Hida, N, Niiya, F, Katagiri, K, Harada, M, Yamana, H, ...

Development of therapeutic vaccines is one of the major areas of tumour immunotherapy today. However, clinical trials of peptide-based cancer vaccines have rarely resulted in tumour regression. This...

UDP-Gal: βGlcNAc β1, 3-galactosyltransferase, polypeptide 3 (GALT3) is a tumour antigen recognised by HLA-A2-restricted cytotoxic T lymphocytes from patients with brain tumour

Tsuda, N, Nonaka, Y, Shichijo, S, Yamada, A, Ito, M, Maeda, Y, ...

Patient prognosis in the case of malignant brain tumours is generally poor, despite significant improvements in the early detection of the tumours, and thus the development of new treatment...

Estimation of water levels in a main drainage canal in a flat low-lying agricultural area using artificial neural network models

Chinh, L.V., Hiramatsu, K., Harada, M., Mori, M.

The Chiyoda basin is located in the Saga Prefecture of the Kyushu Island, Japan, and lies next to the tidal compartment of the Chikugo River, into which excess water in the basin is drained away....