Cannabinoid receptor localization in brain.
Herkenham, M, Lynn, A B, Little, M D, Johnson, M R, Melvin, L S, De Costa, B R, ...
[3H]CP 55,940, a radiolabeled synthetic cannabinoid, which is 10-100 times more potent in vivo than delta 9-tetrahydrocannabinol, was used to characterize and localize a specific cannabinoid receptor...
Brady, L S, Lynn, A B, Glowa, J R, Le, D Q, Herkenham, M
Electroconvulsive shock (ECS) is a highly effective therapy for the treatment of major depression, but its mechanisms of action are not known. We report that repeated ECS in rats produces enduring...
Interconverting mu and delta forms of the opiate receptor in rat striatal patches.
Bowen, W D, Gentleman, S, Herkenham, M, Pert, C B
The binding of a radiolabeled "mu receptor" prototype opiate, dihydromorphine (H2morphine), and the binding of a "delta receptor" prototype, [D-Ala2,D-Leu5]enkephalin (D-Enk), to slide-mounted rat...
Brady, L S, Whitfield, H J, Fox, R J, Gold, P W, Herkenham, M
Imipramine is the prototypic tricyclic antidepressant utilized in the treatment of major depression and exerts its therapeutic efficacy only after prolonged administration. We report a study of the...
Hammer, R P, Herkenham, M, Pert, C B, Quirion, R
LKB film autoradiography of 2-]3H]deoxy-D-glucose uptake shows that ketamine, administered in anesthetic doses, alters the pattern of metabolic activity in rat hippocampus. The labeled metabolic...
Phencyclidine (angel dust)/sigma "opiate" receptor: visualization by tritium-sensitive film.
Quirion, R, Hammer, R P, Herkenham, M, Pert, C B
[3H]Phencyclidine ([3H]PCP) binds specifically to an apparently single class of binding sites on slide-mounted sections of rat olfactory bulb (Kd = 46 nM; Bmax = 10.5 fmol per slice). Bound [3H]PCP...
In vitro autoradiography of opiate receptors in rat brain suggests loci of "opiatergic" pathways.
Slide-mounted sections of unfixed frozen rat brain can be labeled in vitro with [3H]naloxone to show the mu-like ligand selectivity characterized in previous studies. We have developed an...
Cannabinoid receptor localization in brain.
Herkenham, M, Lynn, A B, Little, M D, Johnson, M R, Melvin, L S, De Costa, B R, ...
[3H]CP 55,940, a radiolabeled synthetic cannabinoid, which is 10-100 times more potent in vivo than delta 9-tetrahydrocannabinol, was used to characterize and localize a specific cannabinoid receptor...
Brady, L S, Lynn, A B, Glowa, J R, Le, D Q, Herkenham, M
Electroconvulsive shock (ECS) is a highly effective therapy for the treatment of major depression, but its mechanisms of action are not known. We report that repeated ECS in rats produces enduring...
Interconverting mu and delta forms of the opiate receptor in rat striatal patches.
Bowen, W D, Gentleman, S, Herkenham, M, Pert, C B
The binding of a radiolabeled "mu receptor" prototype opiate, dihydromorphine (H2morphine), and the binding of a "delta receptor" prototype, [D-Ala2,D-Leu5]enkephalin (D-Enk), to slide-mounted rat...
Brady, L S, Whitfield, H J, Fox, R J, Gold, P W, Herkenham, M
Imipramine is the prototypic tricyclic antidepressant utilized in the treatment of major depression and exerts its therapeutic efficacy only after prolonged administration. We report a study of the...
Hammer, R P, Herkenham, M, Pert, C B, Quirion, R
LKB film autoradiography of 2-]3H]deoxy-D-glucose uptake shows that ketamine, administered in anesthetic doses, alters the pattern of metabolic activity in rat hippocampus. The labeled metabolic...
Phencyclidine (angel dust)/sigma "opiate" receptor: visualization by tritium-sensitive film.
Quirion, R, Hammer, R P, Herkenham, M, Pert, C B
[3H]Phencyclidine ([3H]PCP) binds specifically to an apparently single class of binding sites on slide-mounted sections of rat olfactory bulb (Kd = 46 nM; Bmax = 10.5 fmol per slice). Bound [3H]PCP...
In vitro autoradiography of opiate receptors in rat brain suggests loci of "opiatergic" pathways.
Slide-mounted sections of unfixed frozen rat brain can be labeled in vitro with [3H]naloxone to show the mu-like ligand selectivity characterized in previous studies. We have developed an...