M. Hirata

Publication List Details

Period

1983 - 2007

Number

82

Co-Authors

SAM analysis in frontal lobe epilepsy for the surgical strategy (2007)

H. Ninomiya, A. Kato, K. Imai, Y. Nii, M. Taniguchi, M. Hirata, ...

When surgical treatment against intractable frontal lobe epilepsy (FLE) is considered, epileptogenic zone is not easy to delineate by scalp EEG. Epileptogenic zone often does not involve

magnetic (2007)

M. Hirata, A. Kato, M. Taniguchi, H. Ninomiya, D. Cheyne, S. E. Robinson, ...

volumetric distribution of somatosensory evoked

Increased Inflammation Delays Wound Healing in Mice Deficient in Collagenase-2 (MMP-8) (2007)

Gutierrez-Fernandez, A, Inada, M, Balbin, M, Fueyo, A, Pitiot, AS, Astudillo, A, ...

Matrix metalloproteinases (MMPs) have been implicated in numerous tissue-remodeling processes. The finding that mice deficient in collagenase-2 (MMP-8) are more susceptible to develop skin cancer,...

$\pi$NN coupling and two-pion photoproduction on the nucleon (2002)

Hirata, M., Katagiri, N., Takaki, T.

Effects of non-resonant photoproductions arising from two different $\pi NN$ couplings are investigated in the $\gamma N\to\pi\pi N$ reaction. We find that the pseudoscalar (PS) $\pi NN$ coupling is...

Nuclear Photoabsorption at Photon Energies between 300 and 850 Mev (2001)

Hirata, M., Katagiri, N., Ochi, K., Takaki, T.

We construct the formula for the photonuclear total absorption cross section using the projection method and the unitarity relation. Our treatment is very effective when interference effects in the...

High Dynamic-Range and Very Low Noise K-Band p-HEMT LNA MMIC for LMDS and Satellite Communication (2001)

Hirata, M., Mimino, Y., Hasegawa, Y., Fukaya, J.

An excellent noise figure and high linearity, K-band p-HEMT LNA MMIC, that incorporates single-bias configuration and negative feedback circuit, has be en developed for LMDS (Local Multi-point...

Effect of $\rho N$ channel in the $\gamma N \to \pi \pi N$ reactions (1997)

Hirata, M., Ochi, K., Takaki, T.

A model for the two-pion photoproduction on the nucleon proposedearlier is modified to simultaneously explain the total cross sections and the invariant mass spectra. Using this model, we discuss the...

Cooperative damping mechanism of the resonance in the nuclear photoabsorption (1997)

Hirata, M., Ochi, K., Takaki, T.

We propose a resonance damping mechanism to explain the disappearance of the peaks around the position of the resonances higher than the $\Delta$ resonance in the nuclear photoabsorption. This...

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

Yoshida, K, Taga, T, Saito, M, Suematsu, S, Kumanogoh, A, Tanaka, T, ...

gp130 is a ubiquitously expressed signal-transducing receptor component shared by interleukin 6, interleukin 11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and...

Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene.

Hirata, M, Kakizuka, A, Aizawa, M, Ushikubi, F, Narumiya, S

Prostanoid receptors belong to the family of G protein-coupled receptors with seven transmembrane domains. By taking advantage of nucleotide sequence homology among the prostanoid receptors, we have...

Immunocytochemical localization of the alpha subspecies of protein kinase C in rat brain.

Ito, A, Saito, N, Hirata, M, Kose, A, Tsujino, T, Yoshihara, C, ...

The distribution of the alpha subspecies of protein kinase C (PKC) in rat brain was demonstrated immunocytochemically by using polyclonal antibodies raised against a synthetic oligopeptide...

Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein.

Larrick, J W, Hirata, M, Balint, R F, Lee, J, Zhong, J, Wright, S C

CAP18 (18-kDa cationic antimicrobial protein) is a protein originally identified and purified from rabbit leukocytes on the basis of its capacity to bind and inhibit various activities of...

Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity.

Hirata, M, Shimomura, Y, Yoshida, M, Morgan, J G, Palings, I, Wilson, D, ...

Cationic antibacterial proteins (CAP) were purified from rabbit granulocytes, and the effects of CAP on lipopolysaccharide (LPS)-induced tissue factor generation by murine peritoneal macrophages and...

Antimicrobial activity of rabbit CAP18-derived peptides.

Larrick, J W, Hirata, M, Shimomoura, Y, Yoshida, M, Zheng, H, Zhong, J, ...

A cationic antimicrobial protein of 18 kDa (CAP18) was originally isolated from rabbit granulocytes by using as an assay the agglutination of Re-lipopolysaccharide-coated erythrocytes. The C-terminal...

Local skin response in mice induced by a single intradermal injection of bacterial lipopolysaccharide and lipid A.

Ishikawa, Y, Kirikae, T, Hirata, M, Yoshida, M, Haishima, Y, Kondo, S, ...

Dermal inflammation and hemorrhagic necrosis induced by bacterial lipopolysaccharide (LPS) and lipid A were studied in mice. In ddY mice, a single intradermal injection of Salmonella typhimurium...

Lack of tuberculin activity of synthetic peptides.

Toida, I, Yamamoto, S, Takuma, S, Suzuki, T, Hirata, M

We synthesized an octapeptide, H-Asp-Gly-Gly-Ser-Glu-Ser-Glu-Gly-OH, and a hexadecapeptide, H-Asp-Gly-Gly-Ser-Glu-Ser-Glu-Gly-Lys-Asn-Gly-Ser-Gln-Met-Arg-Leu-OH, which corresponded to amino acids 61...

Immunocytochemical localization of beta II subspecies of protein kinase C in rat brain.

Saito, N, Kose, A, Ito, A, Hosoda, K, Mori, M, Hirata, M, ...

The distribution of a subspecies of protein kinase C (PKC) encoded by the beta II sequence in rat central nervous tissue was demonstrated immunocytochemically by using antibodies raised against an...

Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate.

Hirata, M, Suematsu, E, Hashimoto, T, Hamachi, T, Koga, T

The effects of inositol 1,4,5-trisphosphate, prepared from human erythrocyte ghosts, on Ca2+ release from intracellular store sites were studied in saponin-treated guinea pig peritoneal macrophages....

Guanine nucleotide binding protein involved in muscarinic responses in the pig coronary artery is insensitive to islet-activating protein.

Sasaguri, T, Hirata, M, Itoh, T, Koga, T, Kuriyama, H

In an attempt to identify the nature of guanine nucleotide binding protein(s) (G-protein) involved in the acetylcholine (ACh)-induced (muscarinic) response of pig coronary-artery smooth muscle, we...

Effect of guanosine triphosphate on the release and uptake of Ca2+ in saponin-permeabilized macrophages and the skeletal-muscle sarcoplasmic reticulum.

Hamachi, T, Hirata, M, Kimura, Y, Ikebe, T, Ishimatsu, T, Yamaguchi, K, ...

The effects of GTP, with or without polyethylene glycol (PEG), on the release and uptake of Ca2+ were examined by using saponin-treated macrophages and sarcoplasmic reticulum isolated from skeletal...

Calmodulin activates inositol 1,4,5-trisphosphate 3-kinase activity in pig aortic smooth muscle.

Yamaguchi, K, Hirata, M, Kuriyama, H

The effects of calmodulin (CaM) on inositol 1,4,5-trisphosphate (InsP3) 3-kinase activity in pig aortic smooth muscle were examined. The cytosol fraction of muscle cells, containing 1.2-2.0...

Possible physiological role of guanosine triphosphate and inositol 1,4,5-trisphosphate in Ca2+ release in macrophages stimulated with chemotactic peptide.

Kimura, Y, Hirata, M, Hamachi, T, Koga, T

The release of Ca2+ induced by inositol 1,4,5-trisphosphate (InsP3) in the presence of GTP was examined by using saponin-permeabilized macrophages. The origin and the amount of mobilized Ca2+ in...

Purification and characterization of inositol 1,4,5-trisphosphate 3-kinase from pig aortic smooth muscle.

Yamaguchi, K, Hirata, M, Kuriyama, H

Inositol 1,4,5-trisphosphate (InsP3) 3-kinase, which phosphorylates InsP3 to form inositol 1,3,4,5-tetrakisphosphate, was purified to apparent homogeneity by (NH4)2SO4 fractionation and sequential...

Synthetic inositol 1,3,4,5-tetrakisphosphate analogues.

Hirata, M, Kimura, Y, Ishimatsu, T, Yanaga, F, Shuto, T, Sasaguri, T, ...

Inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4] analogues were synthesized and their effects on [3H]Ins(1,3,4,5)P4 5-phosphatase, [3H]Ins(1,3,4,5)P4 3-phosphatase and [3H]inositol...

Dependence on Ca2+ of the activities of phosphatidylinositol 4,5-bisphosphate phosphodiesterase and inositol 1,4,5-trisphosphate phosphatase in smooth muscles of the porcine coronary artery.

Sasaguri, T, Hirata, M, Kuriyama, H

The activities of phosphatidylinositol 4,5-bisphosphate (PIP2) phosphodiesterase (PDE) and inositol 1,4,5,-trisphosphate (IP3) phosphatase in the particulate and cytosol fractions prepared from...

A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

Izumi, Y, Hirata, M, Hasuwa, H, Iwamoto, R, Umata, T, Miyado, K, ...

The ectodomains of many proteins located at the cell surface are shed upon cell stimulation. One such protein is the heparin-binding EGF-like growth factor (HB-EGF) that exists in a membrane-anchored...

A new inositol 1,4,5-trisphosphate binding protein similar to phospholipase C-delta 1.

Kanematsu, T, Misumi, Y, Watanabe, Y, Ozaki, S, Koga, T, Iwanaga, S, ...

We have reported that two inositol 1,4,5-trisphosphate binding proteins, with molecular masses of 85 and 130 kDa, were purified from rat brain; the former protein was found to be the delta...

Localization of a high-affinity inositol 1,4,5-trisphosphate/inositol 1,4,5,6-tetrakisphosphate binding domain to the pleckstrin homology module of a new 130 kDa protein: characterization of the determinants of structural specificity.

Takeuchi, H, Kanematsu, T, Misumi, Y, Yaakob, H B, Yagisawa, H, Ikehara, Y, ...

We have previously identified a novel 130 kDa protein (p130) which binds Ins(1,4,5)P3 and shares 38% sequence identity with phospholipase C-delta 1 [Kanematsu, Misumi, Watanabe, Ozaki, Koga, Iwanaga,...

Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate.

Hirata, M, Takeuchi, H, Riley, A M, Mills, S J, Watanabe, Y, Potter, B V

The Ins(1,4,5)P3 regioisomers, Ins(1,4,6)P3 and Ins(1,3,6)P3, which can mimic the 1,4,5-arrangement on the inositol ring of Ins(1,4,5)P3, were examined for Ca2+ release by using four types of...

PTB domain of insulin receptor substrate-1 binds inositol compounds.

Takeuchi, H, Matsuda, M, Yamamoto, T, Kanematsu, T, Kikkawa, U, Yagisawa, H, ...

We examined whether a phosphotyrosine binding (PTB) domain from the human insulin receptor substrate-1 (hIRS-1) is capable of binding inositol phosphates/phosphoinositides. The binding specificity...

Inhibition of Ca(2+) signalling by p130, a phospholipase-C-related catalytically inactive protein: critical role of the p130 pleckstrin homology domain.

Takeuchi, H, Oike, M, Paterson, H F, Allen, V, Kanematsu, T, Ito, Y, ...

p130 was originally identified as an Ins(1,4,5)P(3)-binding protein similar to phospholipase C-delta but lacking any phospholipase activity. In the present study we have further analysed the...

Serum amylase level on admission in the diagnosis of blunt injury to the pancreas: its significance and limitations.

Takishima, T, Sugimoto, K, Hirata, M, Asari, Y, Ohwada, T, Kakita, A

OBJECTIVE: The objective of this study was to elucidate the significance and limitations of serum amylase levels in the diagnosis of blunt injury to the pancreas. SUMMARY BACKGROUND DATA: Several...

Inositol 1,4,5-trisphosphate activates pharmacomechanical coupling in smooth muscle of the rabbit mesenteric artery.

Hashimoto, T, Hirata, M, Itoh, T, Kanmura, Y, Kuriyama, H

To clarify the nature of the noradrenaline (NA)-induced contraction, the effects of NA on inositol phospholipid metabolism and the actions of inositol 1,4,5-trisphosphate (InsP3) on skinned muscle of...

Effects of external cations on calcium efflux from single cells of the guinea-pig taenia coli and porcine coronary artery.

Hirata, M, Itoh, T, Kuriyama, H

1. Single smooth muscle cells were prepared from the guinea-pig taenia coli and the porcine coronary artery by treatment with collagenase, in order to measure the 45Ca flux with special reference to...

Does activation of cyclic AMP dependent phosphorylation induced by beta-adrenergic agent control the tone of vascular muscle?

Hirata, M, Kuriyama, H

1. The relaxing action of the beta-adrenergic agent, isoprenaline, on the porcine coronary artery was investigated in relation to the cyclic AMP level, the endogenous binding of cyclic AMP to the...

Onset of spermatogenesis is accelerated by gestational administration of 1,2,3,4,6,7-hexachlorinated naphthalene in male rat offspring.

Omura, M, Masuda, Y, Hirata, M, Tanaka, A, Makita, Y, Ogata, R, ...

We treated pregnant rats with 1 microg/kg body weight/day 1,2,3,4,6,7-hexachlorinated naphthalene (1,2,3,4,6,7-HxCN) on days 14-16 of gestation and examined the effects on the reproductive systems of...

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

Yoshida, K, Taga, T, Saito, M, Suematsu, S, Kumanogoh, A, Tanaka, T, ...

gp130 is a ubiquitously expressed signal-transducing receptor component shared by interleukin 6, interleukin 11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and...

Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene.

Hirata, M, Kakizuka, A, Aizawa, M, Ushikubi, F, Narumiya, S

Prostanoid receptors belong to the family of G protein-coupled receptors with seven transmembrane domains. By taking advantage of nucleotide sequence homology among the prostanoid receptors, we have...

Immunocytochemical localization of the alpha subspecies of protein kinase C in rat brain.

Ito, A, Saito, N, Hirata, M, Kose, A, Tsujino, T, Yoshihara, C, ...

The distribution of the alpha subspecies of protein kinase C (PKC) in rat brain was demonstrated immunocytochemically by using polyclonal antibodies raised against a synthetic oligopeptide...

Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein.

Larrick, J W, Hirata, M, Balint, R F, Lee, J, Zhong, J, Wright, S C

CAP18 (18-kDa cationic antimicrobial protein) is a protein originally identified and purified from rabbit leukocytes on the basis of its capacity to bind and inhibit various activities of...

Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity.

Hirata, M, Shimomura, Y, Yoshida, M, Morgan, J G, Palings, I, Wilson, D, ...

Cationic antibacterial proteins (CAP) were purified from rabbit granulocytes, and the effects of CAP on lipopolysaccharide (LPS)-induced tissue factor generation by murine peritoneal macrophages and...

Antimicrobial activity of rabbit CAP18-derived peptides.

Larrick, J W, Hirata, M, Shimomoura, Y, Yoshida, M, Zheng, H, Zhong, J, ...

A cationic antimicrobial protein of 18 kDa (CAP18) was originally isolated from rabbit granulocytes by using as an assay the agglutination of Re-lipopolysaccharide-coated erythrocytes. The C-terminal...

Local skin response in mice induced by a single intradermal injection of bacterial lipopolysaccharide and lipid A.

Ishikawa, Y, Kirikae, T, Hirata, M, Yoshida, M, Haishima, Y, Kondo, S, ...

Dermal inflammation and hemorrhagic necrosis induced by bacterial lipopolysaccharide (LPS) and lipid A were studied in mice. In ddY mice, a single intradermal injection of Salmonella typhimurium...

Lack of tuberculin activity of synthetic peptides.

Toida, I, Yamamoto, S, Takuma, S, Suzuki, T, Hirata, M

We synthesized an octapeptide, H-Asp-Gly-Gly-Ser-Glu-Ser-Glu-Gly-OH, and a hexadecapeptide, H-Asp-Gly-Gly-Ser-Glu-Ser-Glu-Gly-Lys-Asn-Gly-Ser-Gln-Met-Arg-Leu-OH, which corresponded to amino acids 61...

Immunocytochemical localization of beta II subspecies of protein kinase C in rat brain.

Saito, N, Kose, A, Ito, A, Hosoda, K, Mori, M, Hirata, M, ...

The distribution of a subspecies of protein kinase C (PKC) encoded by the beta II sequence in rat central nervous tissue was demonstrated immunocytochemically by using antibodies raised against an...

Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate.

Hirata, M, Suematsu, E, Hashimoto, T, Hamachi, T, Koga, T

The effects of inositol 1,4,5-trisphosphate, prepared from human erythrocyte ghosts, on Ca2+ release from intracellular store sites were studied in saponin-treated guinea pig peritoneal macrophages....

Guanine nucleotide binding protein involved in muscarinic responses in the pig coronary artery is insensitive to islet-activating protein.

Sasaguri, T, Hirata, M, Itoh, T, Koga, T, Kuriyama, H

In an attempt to identify the nature of guanine nucleotide binding protein(s) (G-protein) involved in the acetylcholine (ACh)-induced (muscarinic) response of pig coronary-artery smooth muscle, we...

Effect of guanosine triphosphate on the release and uptake of Ca2+ in saponin-permeabilized macrophages and the skeletal-muscle sarcoplasmic reticulum.

Hamachi, T, Hirata, M, Kimura, Y, Ikebe, T, Ishimatsu, T, Yamaguchi, K, ...

The effects of GTP, with or without polyethylene glycol (PEG), on the release and uptake of Ca2+ were examined by using saponin-treated macrophages and sarcoplasmic reticulum isolated from skeletal...

Calmodulin activates inositol 1,4,5-trisphosphate 3-kinase activity in pig aortic smooth muscle.

Yamaguchi, K, Hirata, M, Kuriyama, H

The effects of calmodulin (CaM) on inositol 1,4,5-trisphosphate (InsP3) 3-kinase activity in pig aortic smooth muscle were examined. The cytosol fraction of muscle cells, containing 1.2-2.0...

Possible physiological role of guanosine triphosphate and inositol 1,4,5-trisphosphate in Ca2+ release in macrophages stimulated with chemotactic peptide.

Kimura, Y, Hirata, M, Hamachi, T, Koga, T

The release of Ca2+ induced by inositol 1,4,5-trisphosphate (InsP3) in the presence of GTP was examined by using saponin-permeabilized macrophages. The origin and the amount of mobilized Ca2+ in...

Purification and characterization of inositol 1,4,5-trisphosphate 3-kinase from pig aortic smooth muscle.

Yamaguchi, K, Hirata, M, Kuriyama, H

Inositol 1,4,5-trisphosphate (InsP3) 3-kinase, which phosphorylates InsP3 to form inositol 1,3,4,5-tetrakisphosphate, was purified to apparent homogeneity by (NH4)2SO4 fractionation and sequential...

Synthetic inositol 1,3,4,5-tetrakisphosphate analogues.

Hirata, M, Kimura, Y, Ishimatsu, T, Yanaga, F, Shuto, T, Sasaguri, T, ...

Inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4] analogues were synthesized and their effects on [3H]Ins(1,3,4,5)P4 5-phosphatase, [3H]Ins(1,3,4,5)P4 3-phosphatase and [3H]inositol...

Dependence on Ca2+ of the activities of phosphatidylinositol 4,5-bisphosphate phosphodiesterase and inositol 1,4,5-trisphosphate phosphatase in smooth muscles of the porcine coronary artery.

Sasaguri, T, Hirata, M, Kuriyama, H

The activities of phosphatidylinositol 4,5-bisphosphate (PIP2) phosphodiesterase (PDE) and inositol 1,4,5,-trisphosphate (IP3) phosphatase in the particulate and cytosol fractions prepared from...

A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

Izumi, Y, Hirata, M, Hasuwa, H, Iwamoto, R, Umata, T, Miyado, K, ...

The ectodomains of many proteins located at the cell surface are shed upon cell stimulation. One such protein is the heparin-binding EGF-like growth factor (HB-EGF) that exists in a membrane-anchored...

Serum amylase level on admission in the diagnosis of blunt injury to the pancreas: its significance and limitations.

Takishima, T, Sugimoto, K, Hirata, M, Asari, Y, Ohwada, T, Kakita, A

OBJECTIVE: The objective of this study was to elucidate the significance and limitations of serum amylase levels in the diagnosis of blunt injury to the pancreas. SUMMARY BACKGROUND DATA: Several...

Inositol 1,4,5-trisphosphate activates pharmacomechanical coupling in smooth muscle of the rabbit mesenteric artery.

Hashimoto, T, Hirata, M, Itoh, T, Kanmura, Y, Kuriyama, H

To clarify the nature of the noradrenaline (NA)-induced contraction, the effects of NA on inositol phospholipid metabolism and the actions of inositol 1,4,5-trisphosphate (InsP3) on skinned muscle of...

A new inositol 1,4,5-trisphosphate binding protein similar to phospholipase C-delta 1.

Kanematsu, T, Misumi, Y, Watanabe, Y, Ozaki, S, Koga, T, Iwanaga, S, ...

We have reported that two inositol 1,4,5-trisphosphate binding proteins, with molecular masses of 85 and 130 kDa, were purified from rat brain; the former protein was found to be the delta...

Localization of a high-affinity inositol 1,4,5-trisphosphate/inositol 1,4,5,6-tetrakisphosphate binding domain to the pleckstrin homology module of a new 130 kDa protein: characterization of the determinants of structural specificity.

Takeuchi, H, Kanematsu, T, Misumi, Y, Yaakob, H B, Yagisawa, H, Ikehara, Y, ...

We have previously identified a novel 130 kDa protein (p130) which binds Ins(1,4,5)P3 and shares 38% sequence identity with phospholipase C-delta 1 [Kanematsu, Misumi, Watanabe, Ozaki, Koga, Iwanaga,...

Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate.

Hirata, M, Takeuchi, H, Riley, A M, Mills, S J, Watanabe, Y, Potter, B V

The Ins(1,4,5)P3 regioisomers, Ins(1,4,6)P3 and Ins(1,3,6)P3, which can mimic the 1,4,5-arrangement on the inositol ring of Ins(1,4,5)P3, were examined for Ca2+ release by using four types of...

PTB domain of insulin receptor substrate-1 binds inositol compounds.

Takeuchi, H, Matsuda, M, Yamamoto, T, Kanematsu, T, Kikkawa, U, Yagisawa, H, ...

We examined whether a phosphotyrosine binding (PTB) domain from the human insulin receptor substrate-1 (hIRS-1) is capable of binding inositol phosphates/phosphoinositides. The binding specificity...

Inhibition of Ca(2+) signalling by p130, a phospholipase-C-related catalytically inactive protein: critical role of the p130 pleckstrin homology domain.

Takeuchi, H, Oike, M, Paterson, H F, Allen, V, Kanematsu, T, Ito, Y, ...

p130 was originally identified as an Ins(1,4,5)P(3)-binding protein similar to phospholipase C-delta but lacking any phospholipase activity. In the present study we have further analysed the...

Effects of external cations on calcium efflux from single cells of the guinea-pig taenia coli and porcine coronary artery.

Hirata, M, Itoh, T, Kuriyama, H

1. Single smooth muscle cells were prepared from the guinea-pig taenia coli and the porcine coronary artery by treatment with collagenase, in order to measure the 45Ca flux with special reference to...

Does activation of cyclic AMP dependent phosphorylation induced by beta-adrenergic agent control the tone of vascular muscle?

Hirata, M, Kuriyama, H

1. The relaxing action of the beta-adrenergic agent, isoprenaline, on the porcine coronary artery was investigated in relation to the cyclic AMP level, the endogenous binding of cyclic AMP to the...

Onset of spermatogenesis is accelerated by gestational administration of 1,2,3,4,6,7-hexachlorinated naphthalene in male rat offspring.

Omura, M, Masuda, Y, Hirata, M, Tanaka, A, Makita, Y, Ogata, R, ...

We treated pregnant rats with 1 microg/kg body weight/day 1,2,3,4,6,7-hexachlorinated naphthalene (1,2,3,4,6,7-HxCN) on days 14-16 of gestation and examined the effects on the reproductive systems of...

Tolerogenic activity of polyethylene glycol-conjugated lysozyme distinct from that of the native counterpart.

Ito, H O, So, T, Hirata, M, Koga, T, Ueda, T, Imoto, T

Conjugation of proteins with polyethylene glycol (PEG) has been reported to make the proteins tolerogenic. Native proteins are also potentially tolerogenic when given without adjuvants. We compared...

Synergism between muramyl dipeptide and lipopolysaccharide in the inhibition of glycosaminoglycan synthesis in cultured rat costal chondrocytes.

Ikebe, T, Hirata, M, Yanaga, F, Koga, T

The effect of synthetic muramyl dipeptide on glycosaminoglycan synthesis in cultured rat costal chondrocytes was examined. Muramyl dipeptide alone had no effect on the glycosaminoglycan synthesis of...

A role for inositol 1,4,5-trisphosphate in the initiation of agonist-induced contractions of dog tracheal smooth muscle.

Hashimoto, T., Hirata, M., Ito, Y.

To elucidate the role of inositol 1,4,5-trisphosphate (Ins-P3) in the initiation of agonist-induced contraction of the smooth muscle cells of the dog trachea, we investigated the effects of...

Latency of the Achilles tendon reflex for detection of reduced functions of the peripheral nervous system in workers exposed to lead.

Ogawa, Y, Hirata, M, Okayama, A, Ichikawa, Y E, Goto, S

The latency of the soleus muscle potential, evoked by a tap of the Achilles tendon, was used in the mass assessment of healthy male workers exposed to lead. Three groups were studied: a control, a...

Retrograde temporal order amnesia resulting from damage to the fornix

Yasuno, F., Hirata, M., Takimoto, H., Taniguchi, M., Nakagawa, Y., Ikejiri, Y., ...

Some amnesic patients show an impairment of temporal order memory that cannot be accounted for by content memory deficits. The performance of an amnesic patient on memory tasks assessing the...

Cerebral motor control in patients with gliomas around the central sulcus studied with spatially filtered magnetoencephalography

Taniguchi, M, Kato, A, Ninomiya, H, Hirata, M, Cheyne, D, Robinson, S, ...

Objective: Application of spatially filtered magnetoencephalography (MEG) to investigate changes in the mechanism of cerebral motor control in patients with tumours around the central sulcus.

Osteoblastic differentiation and P-glycoprotein multidrug resistance in a murine osteosarcoma model

Takeshita, H, Kusuzaki, K, Murata, H, Suginoshita, T, Hirata, M, Hashiguchi, S, ...

A recent study of multidrug resistance (MDR) 1 gene transfected osteosarcoma cells found a cause-effect relationship between increased expression of P-glycoprotein (P-gp) and a low aggressive...

Anti-angiogenic action of hyperthermia by suppressing gene expression and production of tumour-derived vascular endothelial growth factor in vivo and in vitro

Sawaji, Y, Sato, T, Takeuchi, A, Hirata, M, Ito, A

Vascular endothelial growth factor is an important angiogenic factor for tumour progression because it increases endothelial-cell proliferation and remodels extracellular matrix in blood vessels. We...