Recognition and treatment of abdominal wall pain.
In some patients with abdominal pain, the source of the pain may be the abdominal wall. A simple test is described which allows these patients to be identified and treated with injections of local...
How accurately can direct and indirect inguinal hernias be distinguished?
Ralphs, D N, Brain, A J, Grundy, D J, Hobsley, M
An inguinal hernia was clinically diagnosed as direct or indirect by paired surgeons of 134 occasions. When compared with the findings at operation the hernia was correctly diagnosed in 60 of 78...
Positioning of Subject and of Nasogastric Tube during a Gastric Secretion Study
The histamine-infusion test was conducted in 50 subjects with a modification that allowed the completeness of recovery of the maximal gastric secretion to be assessed. The effects of the exact...
Recognition and treatment of abdominal wall pain.
In some patients with abdominal pain, the source of the pain may be the abdominal wall. A simple test is described which allows these patients to be identified and treated with injections of local...
How accurately can direct and indirect inguinal hernias be distinguished?
Ralphs, D N, Brain, A J, Grundy, D J, Hobsley, M
An inguinal hernia was clinically diagnosed as direct or indirect by paired surgeons of 134 occasions. When compared with the findings at operation the hernia was correctly diagnosed in 60 of 78...
Positioning of Subject and of Nasogastric Tube during a Gastric Secretion Study
The histamine-infusion test was conducted in 50 subjects with a modification that allowed the completeness of recovery of the maximal gastric secretion to be assessed. The effects of the exact...
Ahmed, A, Salmon, P R, Cairns, C R, Hobsley, M, Hoult, J R
The release of immunoreactive prostaglandin E2 (PGE2) and leukotriene C4 (LTC4) from antral and duodenal mucosal biopsy specimens taken from 20 patients with duodenal ulcer disease was measured by...
Duodenal ulcer, Helicobacter pylori, and gastric secretion.
Chandrakumaran, K, Vaira, D, Hobsley, M
Patients with chronic dyspepsia were categorised by macroscopic appearance at oesophagogastroduodenoscopy as having duodenal ulceration (DU), other diagnosed lesions such as reflux oesophagitis,...
Effect of acute cigarette smoking on gastric secretion.
Roxburgh, J C, Whitfield, P F, Hobsley, M
The effects of smoking one cigarette on a plateau of submaximal gastric secretion induced by histamine acid phosphate (16 nmol kg-1 h-1 (0.005 mg kg-1 h-1)) were measured in eight normal volunteers...
Epidermal growth factor in saliva and gastric juice: response to histamine.
Epidermal growth factor (EGF) was measured in saliva and in gastric juice under basal conditions and after histamine stimulation (0.04 mg kg-1h-1). Sixty subjects studied comprised 20 normal...
The predictive accuracy of the postvagotomy insulin test: A new interpretation.
Faber, R G, Russell, R C, Parkin, J V, Whitfield, P, Hobsley, M
Insulin-stimulated gastric secretion alone, without reference to basal secretion, has been examined in 45 male patients with duodenal ulcer in whom no gastric operation had been performed and in 124...
Stability of insulin-induced gastric secretion after vagotomy.
Faber, R G, Parkin, J V, Whitfied, P, Hobsley, M
Gastric secretory response to insulin-induced hypoglycaemia was stuided in 21 subjects following vagotomy and a drainage procedure for duodenal ulcer. Eighteen subjects had one early test, ie, within...
Basal gastric secretion: reproducibility and relationship with duodenal ulceration.
Basal gastric secretion was examined in control subjects, patients with duodenal ulcer, and patients after vagotomy with or without a drainage procedure, not only in terms of conventional indices of...
Maybury, N K, Faber, R G, Hobsley, M
Insulin stimulated gastric secretion was studied in 74 unoperated duodenal ulcer patients (DUs), (20 women and 54 men). Three indices of secretion were studied--observed volume, acid output, and...
Gastric secretion and basal gastrin concentration in bilharzial hepatic fibrosis.
Boulos, P B, Okosdonossian, E T, Elmunshid, H A, Elmasri, S H, Hassan, M A, Hobsley, M
Gastric secretion and fasting plasma gastrin levels were investigated in 26 patients with bilharzial hepatic fibrosis and 26 controls. The groups did not differ in their basal secretion. When...
Recurrent unilateral swelling of the parotid gland.
Suleiman, S I, Thomson, J P, Hobsley, M
The clinical features of 109 patients with recurrent unilateral parotid swelling (24 patients with Sjögren's disease were excluded) have been analysed to explore the best system of management. The...
The dumping syndrome and the hydrogen ion concentration of the gastric contents
Thomson, James P. S., Russell, R. C. G., Hobsley, M., Le Quesne, L. P.
Forty patients after vagotomy (truncal vagotomy 18, selective vagotomy 22) with a drainage procedure were given 200 ml of 50% dextrose by mouth (dumping provocation test), the symptoms induced being...
Duodenal reflux during insulin-stimulated secretion
Faber, R. G., Russell, R. C. G., Royston, C. M. S., Whitfield, P., Hobsley, M.
Insulin-stimulated secretion has been studied in 67 subjects with intact vagi. The relationship between the changes in the concentrations of hydrogen and sodium ions in individual 10-minute samples...
Thiocyanate as a marker of saliva in gastric juice?
Boulos, P B, Whitfield, P F, Dave, M, Faber, R G, Hobsley, M
One source of error in gastric secretion studies is swallowed saliva. The possibility that salivary thiocyanate might be used to measure this contamination has been investigated. Thiocyanate...
Butterfield, D J, Whitfield, P F, Hobsley, M
We studied 29 patients who had gastric secretion tests after a vagotomy for duodenal ulcer. There were 14 patients who developed a recurrent duodenal ulcer during the follow-up period and 15 patients...
Relationship between insulin- and histamine-stimulated gastric secretion before and after vagotomy.
Boulos, P B, Faber, R G, Whitfield, P F, Parkin, J V, Hobsley, M
The relationship of gastric secretion in response to a single injection of insulin and in response to a histamine infusion, in unoperated patients with duodenal ulcer was studied before and after...
Effect of cimetidine on gastric secretion and duodenogastric reflux.
Melville, R J, Suleiman, S I, Whitfield, P F, Parkin, J V, Nwabunike, T O, Hobsley, M
In 19 subjects (four controls, one gastric ulcer and 14 duodenal ulcer) maximal gastric secretion was evoked with histamine 0.13 mumol/kg/h (0.04 mg/kg/h) for two to two and a half hours. A slow...
Comparison of maximal gastric secretion in smokers and non-smokers with and without duodenal ulcer.
Maximal gastric secretion was induced in 122 control subjects (without peptic ulcer) and 201 preoperative duodenal ulcer patients by intravenous histamine acid phosphate (130 nmol/kg/h), and measured...
Use of an inert marker (phenol red) to improve accuracy in gastric secretion studies
Gastric secretion from 24 subjects was collected by continuous nasogastric aspiration during the plateau of secretion evoked by intravenous histamine diphosphate, 0·01 mg/kg/hr. Simultaneously,...
Effect of Insulin on the Dumping Syndrome
Howf, C. T., Candy, J., Le Quesne, L. P., Hobsley, M., Spence, M. P.
A simple clinical approach to quantifying losses from the extracellular and plasma compartments.
Robarts, W. M., Parkin, J. V., Hobsley, M.
It is possible to estimate the category and volume of lost liquid in patients who have become acutely depleted of body fluids by measuring the haematocrit and plasma protein concentration in venous...
Is the undeniably palpable liver ever 'normal'?
Ralphs, D. N., Venn, G., Khan, O., Palmer, J. G., Cameron, D. E., Hobsley, M.
A study of whether the lower border of the normal liver, if it extended below the costal margin, could be reliably identified by clinical examination was undertaken in 42 patients in whom there was...
Dragstedt, gastric acid and duodenal ulcer.
Dragstedt believed that basal hypersecretion of gastric acid was the root cause of duodenal ulcer, that the hypersecretion was due to an increased vagal stimulation, and that vagotomy would therefore...