M. Inmaculada Barrasa

The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors (2009)

Reece-Hoyes, John S., Deplancke, Bart, Barrasa, M. Inmaculada, Hatzold, Julia, Smit, Ryan B., Arda, H. Efsun, ...

Snail-type transcription factors (TFs) are found in numerous metazoan organisms and function in a plethora of cellular and developmental processes including mesoderm and neuronal development,...

Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity (2008)

Martinez, Natalia Julia, Ow, Maria C., Reece-Hoyes, John S., Barrasa, M. Inmaculada, Ambros, Victor R., Walhout, Albertha J. M.

The Caenorhabditis elegans genome encodes more than 100 microRNAs (miRNAs). Genetic analyses of miRNA deletion mutants have only provided limited insights into miRNA function. To gain insight into...

A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity (2008)

Martinez, Natalia J., Ow, Maria C., Barrasa, M. Inmaculada, Hammell, Molly, Sequerra, Reynaldo, Doucette-Stamm, Lynn, ...

MicroRNAs (miRNAs) and transcription factors (TFs) are primary metazoan gene regulators. Whereas much attention has focused on finding the targets of both miRNAs and TFs, the transcriptional networks...

The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans (2008)

Ow, Maria C., Martinez, Natalia J., Olsen, Philip H., Silverman, Howard S., Barrasa, M. Inmaculada, Conradt, Barbara, ...

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally via antisense base-pairing. Although miRNAs are involved in a variety of important biological...

The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans (2008)

Ow, Maria C., Martinez, Natalia J., Olsen, Philip H., Silverman, Howard S., Barrasa, M. Inmaculada, Conradt, Barbara, ...

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally via antisense base-pairing. Although miRNAs are involved in a variety of important biological...

A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity (2008)

Martinez, Natalia J., Ow, Maria C., Barrasa, M. Inmaculada, Hammell, Molly, Sequerra, Reynaldo, Doucette-Stamm, Lynn, ...

MicroRNAs (miRNAs) and transcription factors (TFs) are primary metazoan gene regulators. Whereas much attention has focused on finding the targets of both miRNAs and TFs, the transcriptional networks...

Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity (2008)

Martinez, Natalia J., Ow, Maria C., Reece-Hoyes, John S., Barrasa, M. Inmaculada, Ambros, Victor R., Walhout, Albertha J.M.

The Caenorhabditis elegans genome encodes more than 100 microRNAs (miRNAs). Genetic analyses of miRNA deletion mutants have only provided limited insights into miRNA function. To gain insight into...

Transcription factor modularity in a gene-centered C. elegans core neuronal protein-DNA interaction network (2007)

Vermeirssen, Vanessa, Barrasa, M. Inmaculada, Hidalgo, César A., Babon, Jenny Aurielle B., Sequerra, Reynaldo, Doucette-Stamm, Lynn, ...

Transcription regulatory networks play a pivotal role in the development, function, and pathology of metazoan organisms. Such networks are comprised of protein–DNA interactions between...

Matrix and Steiner-triple-system smart pooling assays for high-performance transcription regulatory network mapping (2007)

Vermeirssen, Vanessa, Deplancke, Bart, Barrasa, M. Inmaculada, Reece-Hoyes, John S., Arda, H. Efsun, Grove, Christian A., ...

Yeast one-hybrid (Y1H) assays provide a gene-centered method for the identification of interactions between gene promoters and regulatory transcription factors (TFs). To date, Y1H assays have...

Matrix and Steiner-triple-system smart pooling assays for high-performance transcription regulatory network mapping (2007)

Vermeirssen, Vanessa, Deplancke, Bart, Barrasa, M. Inmaculada, Reece-Hoyes, John S., Arda, H. Efsun, Grove, Christian A., ...

Yeast one-hybrid (Y1H) assays provide a gene-centered method for the identification of interactions between gene promoters and regulatory transcription factors (TFs). To date, Y1H assays have...

Transcription factor modularity in a gene-centered C. elegans core neuronal protein-DNA interaction network (2007)

Vermeirssen, Vanessa, Barrasa, M. Inmaculada, Hidalgo, Cesar A., Babon, Jenny Aurielle B., Sequerra, Reynaldo, Doucette-Stamm, Lynn, ...

Transcription regulatory networks play a pivotal role in the development, function, and pathology of metazoan organisms. Such networks are comprised of protein-DNA interactions between transcription...

EDGEdb: a transcription factor-DNA interaction database for the analysis of C. elegans differential gene expression (2007)

Barrasa, M. Inmaculada, Vaglio, Philippe, Cavasino, Fabien, Jacotot, Laurent, Walhout, Albertha J. M.

BACKGROUND: Transcription regulatory networks are composed of protein-DNA interactions between transcription factors and their target genes. A long-term goal in genome biology is to map protein-DNA...

EDGEdb: a transcription factor-DNA Interaction database for the analysis of C. elegansdifferential gene expression (2007)

Barrasa, M Inmaculada, Vaglio, Philippe, Cavasino, Fabien, Jacotot, Laurent, Walhout, Albertha JM

Abstract Background Transcription regulatory networks are composed of protein-DNA interactions between transcription factors and their target genes. A long-term goal in genome biology is to map...

Computational identification of regulatory factors involved in microRNA transcription (2005)

Praveen Sethupathy, Molly Megraw, M. Inmaculada Barrasa, Artemis G. Hatzigeorgiou

Abstract. MicroRNAs (miRNAs) are non-coding RNA molecules that bind to and translationally repress mRNA transcripts. Currently ~1345 miRNAs have been identified in at least twelve species through...

Apoptosis and Regeneration of Hepatocytes during Recovery from Transient Hepadnavirus Infections

Guo, Ju-Tao, Zhou, Huan, Liu, Chen, Aldrich, Carol, Saputelli, Jeffrey, Whitaker, Tony, ...

It is well known that hepatitis B virus infections can be transient or chronic, but the basis for this dichotomy is not known. To gain insight into the mechanism responsible for the clearance of...

Does a cdc2 Kinase-Like Recognition Motif on the Core Protein of Hepadnaviruses Regulate Assembly and Disintegration of Capsids?

Barrasa, M. Inmaculada, Guo, Ju-Tao, Saputelli, Jeffrey, Mason, William S., Seeger, Christoph

Hepadnaviruses are enveloped viruses, each with a DNA genome packaged in an icosahedral nucleocapsid, which is the site of viral DNA synthesis. In the presence of envelope proteins, DNA-containing...

Conditional Replication of Duck Hepatitis B Virus in Hepatoma Cells

Guo, Ju-Tao, Pryce, Melissa, Wang, Xingtai, Barrasa, M. Inmaculada, Hu, Jianming, Seeger, Christoph

To facilitate investigations of replication and host cell interactions in the hepadnavirus system, we have developed cell lines permitting the conditional replication of duck hepatitis B virus...

Strain Variations in Single Amino Acids of the 86-Kilodalton Human Cytomegalovirus Major Immediate-Early Protein (IE2) Affect Its Functional and Biochemical Properties: Implications of Dynamic Protein Conformation

Barrasa, M. Inmaculada, Harel, Noam, Yu, Yongjun, Alwine, James C.

The 86-kDa major immediate-early protein, IEP86 (IE2, IE2579aa, or ppUL122a), from the Towne and AD169 strains of human cytomegalovirus show four amino acid variations, namely, R68Q, K455E, T541A,...

The Phosphorylation Status of the Serine-Rich Region of the Human Cytomegalovirus 86-Kilodalton Major Immediate-Early Protein IE2/IEP86 Affects Temporal Viral Gene Expression

Barrasa, M. Inmaculada, Harel, Noam Y., Alwine, James C.

The 86-kDa major immediate-early protein (IE2/IEP86) of human cytomegalovirus (HCMV) contains a serine-rich region (amino acids 258 to 275) with several consensus casein kinase II (CKII) sites. We...

Apoptosis and Regeneration of Hepatocytes during Recovery from Transient Hepadnavirus Infections

Guo, Ju-Tao, Zhou, Huan, Liu, Chen, Aldrich, Carol, Saputelli, Jeffrey, Whitaker, Tony, ...

It is well known that hepatitis B virus infections can be transient or chronic, but the basis for this dichotomy is not known. To gain insight into the mechanism responsible for the clearance of...

Does a cdc2 Kinase-Like Recognition Motif on the Core Protein of Hepadnaviruses Regulate Assembly and Disintegration of Capsids?

Barrasa, M. Inmaculada, Guo, Ju-Tao, Saputelli, Jeffrey, Mason, William S., Seeger, Christoph

Hepadnaviruses are enveloped viruses, each with a DNA genome packaged in an icosahedral nucleocapsid, which is the site of viral DNA synthesis. In the presence of envelope proteins, DNA-containing...

Conditional Replication of Duck Hepatitis B Virus in Hepatoma Cells

Guo, Ju-Tao, Pryce, Melissa, Wang, Xingtai, Barrasa, M. Inmaculada, Hu, Jianming, Seeger, Christoph

To facilitate investigations of replication and host cell interactions in the hepadnavirus system, we have developed cell lines permitting the conditional replication of duck hepatitis B virus...

Strain Variations in Single Amino Acids of the 86-Kilodalton Human Cytomegalovirus Major Immediate-Early Protein (IE2) Affect Its Functional and Biochemical Properties: Implications of Dynamic Protein Conformation

Barrasa, M. Inmaculada, Harel, Noam, Yu, Yongjun, Alwine, James C.

The 86-kDa major immediate-early protein, IEP86 (IE2, IE2579aa, or ppUL122a), from the Towne and AD169 strains of human cytomegalovirus show four amino acid variations, namely, R68Q, K455E, T541A,...

The Phosphorylation Status of the Serine-Rich Region of the Human Cytomegalovirus 86-Kilodalton Major Immediate-Early Protein IE2/IEP86 Affects Temporal Viral Gene Expression

Barrasa, M. Inmaculada, Harel, Noam Y., Alwine, James C.

The 86-kDa major immediate-early protein (IE2/IEP86) of human cytomegalovirus (HCMV) contains a serine-rich region (amino acids 258 to 275) with several consensus casein kinase II (CKII) sites. We...

Transcription factor modularity in a gene-centered C. elegans core neuronal protein–DNA interaction network

Vermeirssen, Vanessa, Barrasa, M. Inmaculada, Hidalgo, César A., Babon, Jenny Aurielle B., Sequerra, Reynaldo, Doucette-Stamm, Lynn, ...

Transcription regulatory networks play a pivotal role in the development, function, and pathology of metazoan organisms. Such networks are comprised of protein–DNA interactions between...

A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity

Martinez, Natalia J., Ow, Maria C., Barrasa, M. Inmaculada, Hammell, Molly, Sequerra, Reynaldo, Doucette-Stamm, Lynn, ...

MicroRNAs (miRNAs) and transcription factors (TFs) are primary metazoan gene regulators. Whereas much attention has focused on finding the targets of both miRNAs and TFs, the transcriptional networks...

The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans

Ow, Maria C., Martinez, Natalia J., Olsen, Philip H., Silverman, Howard S., Barrasa, M. Inmaculada, Conradt, Barbara, ...

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally via antisense base-pairing. Although miRNAs are involved in a variety of important biological...

Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity

Martinez, Natalia J., Ow, Maria C., Reece-Hoyes, John S., Barrasa, M. Inmaculada, Ambros, Victor R., Walhout, Albertha J.M.

The Caenorhabditis elegans genome encodes more than 100 microRNAs (miRNAs). Genetic analyses of miRNA deletion mutants have only provided limited insights into miRNA function. To gain insight into...

The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors

Reece-Hoyes, John S., Deplancke, Bart, Barrasa, M. Inmaculada, Hatzold, Julia, Smit, Ryan B., Arda, H. Efsun, ...

Snail-type transcription factors (TFs) are found in numerous metazoan organisms and function in a plethora of cellular and developmental processes including mesoderm and neuronal development,...