Treatment of Parkinson's disease.
Pharmacotherapy with levodopa for Parkinson's disease provides symptomatic benefit, but fluctuations in (or loss of) response may eventually occur. Dopamine agonists are also helpful and, when taken...
Spinal integration of segmental, cortical and breathing inputs to thoracic respiratory motoneurones
1. The spinal integration of cortical, segmental and breathing inputs to thoracic motoneurones was studied in anaesthetized, paralysed cats: the breathing input was intensified by underventilation or...
Treatment of Parkinson's disease.
Pharmacotherapy with levodopa for Parkinson's disease provides symptomatic benefit, but fluctuations in (or loss of) response may eventually occur. Dopamine agonists are also helpful and, when taken...
Spinal integration of segmental, cortical and breathing inputs to thoracic respiratory motoneurones
1. The spinal integration of cortical, segmental and breathing inputs to thoracic motoneurones was studied in anaesthetized, paralysed cats: the breathing input was intensified by underventilation or...
Assessment of Autonomic Function in Patients with a Parkinsonian Syndrome
The integrity of the autonomic nervous system was assessed in 11 Parkinsonian patients with symptoms suggestive of autonomic dysfunction. Three had the additional clinical features of the Shy-Drager...
Studies of pulse rate and blood pressure responses to graded intravenous infusions of noradrenaline and dopamine were performed on five patients with Parkinson's disease, five with the Shy-Drager...
A trial of brolitene in the treatment of spasticity.
A new anti-spasticity agent, brolitene, has been assessed in patients with spasticity of spinal or cerebral origin. Twenty-seven patients were entered in a double-blind cross-over trial lasting 6...
Effects of droperidol on activity of carotid body chemoreceptors in cat.
Aminoff, M J, Jaffe, R A, Sampson, S R, Vidruk, E H
1 The effect of droperidol on the spontaneous activity of carotid body chemoreceptors and on their response to various stimuli was studied in 21 anaesthetized, paralyzed and artificially ventilated...
Involvement of peripheral vasomotor fibres in carpal tunnel syndrome.
It is often assumed that large diameter nerve fibres are affected selectively in patients with compressive peripheral nerve lesions. However, in five of 13 patients with the carpal tunnel syndrome,...
Pattern-onset visual evoked potentials in suspected multiple sclerosis.
Visual evoked potentials (VEPs) were obtained by monocular stimulation using a checkerboard pattern-reversal and pattern-onset technique. In 11 normal subjects, pattern-onset VEPs were generally...
Periodic EEG complexes in infectious mononucleosis encephalitis.
Greenberg, D A, Weinkle, D J, Aminoff, M J
The presence of periodic EEG complexes in patients with an acute viral encephalitis is generally held to suggest that infection is due to herpes simplex. We now report a patient with clinical and...
Arterial blood pressure in patients with Parkinson's disease
Aminoff, M. J., Gross, M., Laatz, B., Vakil, S. D., Petrie, A., Calne, D. B.
The casual arterial blood pressure of 411 patients with Parkinson's disease was compared with that of a representative sample of the general population. The patients were also divided into various...
Clinical aspects of spasmodic dysphonia.
Aminoff, M J, Dedo, H H, Izdebski, K
The clinical features of 12 patients with spasmodic dysphonia are described. In 11 patients, the voice was strained, harsh, tight, and tremulous, and was low in volume and pitch. Speech, which was...
Uptake of dopamine and 5-hydroxytryptamine by platelets of patients with Parkinsonism.
Aminoff, M J, Ehsanullah, R S, Turner, P
The uptake of tritiated dopamine and 5-hydroxytryptamine by platelets from 11 patients with Parkinsonism who were not receiving any medication, and from 11 control subjects matched for sex and for...
Levodopa therapy for Parkinsonism in the Shy-Drager syndrome
Aminoff, M. J., Wilcox, C. S., Woakes, M. M., Kremer, M.
The results of levodopa treatment in five patients with Parkinsonism of the Shy-Drager syndrome are reported. There was no improvement in the neurological signs or functional disability in any...
Basis of nocturnal polyuria in patients with autonomic failure
Wilcox, C. S., Aminoff, M. J., Penn, W.
Five dysautonomic patients with the Shy-Drager syndrome were studied to determine the basis of their nocturnal polyuria. The results indicated excessive postural modification of renal function in...
Results of surgical treatment for patients with a spinal angioma
Logue, Valentine, Aminoff, M. J., Kendall, B. E.
The clinical, angiographic, and operative findings in 16 patients with a spinal angioma are reviewed, and the results of surgery are assessed. The surgical procedure employed in 15 patients consisted...
The effect on plasma prolactin levels of interictal epileptiform EEG activity.
Aminoff, M J, Simon, R P, Wiedemann, E
Because of the known effects of seizures on plasma prolactin, the plasma prolactin levels were measured before and after generalised interictal epileptiform activity was provoked in the EEG in five...