Smart, D.E., Vincent, K.J., Arthur, M.J., Eickelberg, O., Castellazzi, M., Mann, J., ...
Activation of hepatic stellate cells (HSCs) to a myofibroblast-like phenotype is the pivotal event in hepatic wound healing and fibrosis. Rat HSCs activated in vitro express JunD, Fra2, and FosB as...
Hepatic lipocytes appear to be central to the pathogenesis of hepatic fibrosis, undergoing activation during inflammation to a matrix-producing, proliferative cell type. We have studied the...
Arthur, M J, Friedman, S L, Roll, F J, Bissell, D M
We report a proteinase that degrades basement-membrane (type IV) collagen and is produced by the liver. Its cellular source is lipocytes (fat-storing or Ito cells). Lipocytes were isolated from...
Iredale, J P, Murphy, G, Hembry, R M, Friedman, S L, Arthur, M J
Hepatic lipocytes play a central role in the pathogenesis of liver fibrosis, both via production of extracellular matrix proteins and through secretion of matrix metalloproteinases. In this study, we...
Iredale, J P, Benyon, R C, Pickering, J, McCullen, M, Northrop, M, Pawley, S, ...
Liver fibrosis results from the excessive secretion of matrix proteins by hepatic stellate cells (HSC), which proliferate during fibrotic liver injury. We have studied a model of spontaneous recovery...
Arthur, M J, Stanley, A, Iredale, J P, Rafferty, J A, Hembry, R M, Friedman, S L
The matrix metalloproteinases play an important role in matrix degradation, but there is limited information about this family of enzymes in either normal or diseased human liver. In this study, we...
Hepatic lipocytes appear to be central to the pathogenesis of hepatic fibrosis, undergoing activation during inflammation to a matrix-producing, proliferative cell type. We have studied the...
Arthur, M J, Friedman, S L, Roll, F J, Bissell, D M
We report a proteinase that degrades basement-membrane (type IV) collagen and is produced by the liver. Its cellular source is lipocytes (fat-storing or Ito cells). Lipocytes were isolated from...
Iredale, J P, Murphy, G, Hembry, R M, Friedman, S L, Arthur, M J
Hepatic lipocytes play a central role in the pathogenesis of liver fibrosis, both via production of extracellular matrix proteins and through secretion of matrix metalloproteinases. In this study, we...
Iredale, J P, Benyon, R C, Pickering, J, McCullen, M, Northrop, M, Pawley, S, ...
Liver fibrosis results from the excessive secretion of matrix proteins by hepatic stellate cells (HSC), which proliferate during fibrotic liver injury. We have studied a model of spontaneous recovery...
Arthur, M J, Stanley, A, Iredale, J P, Rafferty, J A, Hembry, R M, Friedman, S L
The matrix metalloproteinases play an important role in matrix degradation, but there is limited information about this family of enzymes in either normal or diseased human liver. In this study, we...
Familial and idiopathic colonic varices: an unusual cause of lower gastrointestinal haemorrhage.
Iredale, J P, Ridings, P, McGinn, F P, Arthur, M J
A patient is described presenting with an acute lower gastrointestinal haemorrhage as a result of extensive colonic varices. Further investigation revealed that there were no oesophageal varices or...
Pharmacology of propranolol in patients with cirrhosis and portal hypertension.
Arthur, M J, Tanner, A R, Patel, C, Wright, R, Renwick, A G, George, C F
Ten patients with cirrhosis and protal hypertension received an initial 20 mg oral test dose of propranolol and subsequently 160 mg of a slow release preparation, orally, each day for seven days....
Duodenal mucosa synthesis of prostaglandins in duodenal ulcer disease.
Hillier, K, Smith, C L, Jewell, R, Arthur, M J, Ross, G
Synthesis of prostaglandins (PGE2, PGI2 and PGF2 alpha) and thromboxane A2 was investigated in short term incubates of duodenal mucosa biopsies. Mucosa close to the ulcer site synthesised...
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis
Xu, L, Hui, A Y, Albanis, E, Arthur, M J, O’Byrne, S M, Blaner, W S, ...
Background: Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to collagen accumulation during chronic liver disease. With increasing interest in developing antifibrotic...
Herbert, C. A., Arthur, M. J., Robinson, C.
1. We have studied the release of gelatin-degrading enzymes from isolated sheets of bronchial mucosa in the presence and absence of eosinophils. 2. Isolated sheets of bovine bronchial mucosa released...