Valles, J, Santos, M T, Marcus, A J, Safier, L B, Broekman, M J, Islam, N, ...
Unstimulated neutrophils inhibited activation and recruitment of thrombin- or collagen-stimulated platelets in an agonist-specific manner. This occurred under conditions of close physical cell-cell...
Pinsky, D J, Oz, M C, Koga, S, Taha, Z, Broekman, M J, Marcus, A J, ...
Nitric oxide (NO) is a novel biologic messenger with diverse effects but its role in organ transplantation remains poorly understood. Using a porphyrinic microsensor, the first direct measurements of...
Marcus, A J, Safier, L B, Hajjar, K A, Ullman, H L, Islam, N, Broekman, M J, ...
We previously reported that platelets become unresponsive to agonists when stimulated in combined suspension with aspirin-treated human umbilical vein endothelial cells. Inhibition occurred...
Santos, M T, Valles, J, Marcus, A J, Safier, L B, Broekman, M J, Islam, N, ...
Erythrocytes are known to influence hemostasis. Bleeding times are prolonged in anemia and corrected by normalizing the hematocrit. We now demonstrate that intact erythrocytes modulate biochemical...
Marcus, A J, Safier, L B, Ullman, H L, Broekman, M J, Islam, N, Oglesby, T D, ...
A new metabolite of arachidonic acid, formed during interaction between thrombin- or collagen-stimulated platelets and unstimulated neutrophils, has been demonstrated by both thin-layer...
Enhancement of mononuclear procoagulant activity by platelet 12-hydroxyeicosatetraenoic acid.
Lorenzet, R, Niemetz, J, Marcus, A J, Broekman, M J
Platelets induce generation of procoagulant tissue factor activity (TFa) by mononuclear leukocytes, and also enhance the TFa induced by endotoxin. Our present investigation demonstrated that...
Marcus, A J, Safier, L B, Ullman, H L, Islam, N, Broekman, M J, Von Schacky, C
Stimulated platelets, in the presence or absence of aspirin, synthesize significant quantities of 12-hydroxyeicosatetraenoic acid (12-HETE), which is chemotactic and chemokinetic, and enhances...
The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.
Marcus, A J, Broekman, M J, Drosopoulos, J H, Islam, N, Alyonycheva, T N, Safier, L B, ...
We previously demonstrated that when platelets are in motion and in proximity to endothelial cells, they become unresponsive to agonists (Marcus, A.J., L.B. Safier, K.A. Hajjar, H.L. Ullman, N....
Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39.
Gayle, R B, Maliszewski, C R, Gimpel, S D, Schoenborn, M A, Caspary, R G, Richards, C, ...
Excessive platelet accumulation and recruitment, leading to vessel occlusion at sites of vascular injury, present major therapeutic challenges in cardiovascular medicine. Endothelial cell CD39, an...
Wynkoop, E M, Broekman, M J, Korchak, H M, Marcus, A J, Weissmann, G
Neutrophils respond to chemoattractants by aggregating, degranulating, remodelling of phospholipids and releasing arachidonic acid. To determine whether ligand-induced remodelling of phospholipids...
Valles, J, Santos, M T, Marcus, A J, Safier, L B, Broekman, M J, Islam, N, ...
Unstimulated neutrophils inhibited activation and recruitment of thrombin- or collagen-stimulated platelets in an agonist-specific manner. This occurred under conditions of close physical cell-cell...
Pinsky, D J, Oz, M C, Koga, S, Taha, Z, Broekman, M J, Marcus, A J, ...
Nitric oxide (NO) is a novel biologic messenger with diverse effects but its role in organ transplantation remains poorly understood. Using a porphyrinic microsensor, the first direct measurements of...
Marcus, A J, Safier, L B, Hajjar, K A, Ullman, H L, Islam, N, Broekman, M J, ...
We previously reported that platelets become unresponsive to agonists when stimulated in combined suspension with aspirin-treated human umbilical vein endothelial cells. Inhibition occurred...
Santos, M T, Valles, J, Marcus, A J, Safier, L B, Broekman, M J, Islam, N, ...
Erythrocytes are known to influence hemostasis. Bleeding times are prolonged in anemia and corrected by normalizing the hematocrit. We now demonstrate that intact erythrocytes modulate biochemical...
Marcus, A J, Safier, L B, Ullman, H L, Broekman, M J, Islam, N, Oglesby, T D, ...
A new metabolite of arachidonic acid, formed during interaction between thrombin- or collagen-stimulated platelets and unstimulated neutrophils, has been demonstrated by both thin-layer...
Enhancement of mononuclear procoagulant activity by platelet 12-hydroxyeicosatetraenoic acid.
Lorenzet, R, Niemetz, J, Marcus, A J, Broekman, M J
Platelets induce generation of procoagulant tissue factor activity (TFa) by mononuclear leukocytes, and also enhance the TFa induced by endotoxin. Our present investigation demonstrated that...
Marcus, A J, Safier, L B, Ullman, H L, Islam, N, Broekman, M J, Von Schacky, C
Stimulated platelets, in the presence or absence of aspirin, synthesize significant quantities of 12-hydroxyeicosatetraenoic acid (12-HETE), which is chemotactic and chemokinetic, and enhances...
The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.
Marcus, A J, Broekman, M J, Drosopoulos, J H, Islam, N, Alyonycheva, T N, Safier, L B, ...
We previously demonstrated that when platelets are in motion and in proximity to endothelial cells, they become unresponsive to agonists (Marcus, A.J., L.B. Safier, K.A. Hajjar, H.L. Ullman, N....
Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39.
Gayle, R B, Maliszewski, C R, Gimpel, S D, Schoenborn, M A, Caspary, R G, Richards, C, ...
Excessive platelet accumulation and recruitment, leading to vessel occlusion at sites of vascular injury, present major therapeutic challenges in cardiovascular medicine. Endothelial cell CD39, an...
Wynkoop, E M, Broekman, M J, Korchak, H M, Marcus, A J, Weissmann, G
Neutrophils respond to chemoattractants by aggregating, degranulating, remodelling of phospholipids and releasing arachidonic acid. To determine whether ligand-induced remodelling of phospholipids...