Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold (2009)
Dixon, M J, Nathubhai, A., Andersen, O. A., Eggleston, Ian M.
A new, highly efficient, all-solid-phase synthesis of argifin, a natural product cyclic pentapeptide chitinase inhibitor, is reported. The synthesis features attachment of an orthogonally protected...
Watercress has long been believed to affect macroinvertebrate communities in chalk streams. Harvesting and washing watercress damages plant tissues and releases isothiocyanates which are potential...
Kelleher, M. O., McMahon, M., Eggleston, I. M., Dixon, M. J., Taguchi, K., Yamamoto, M., ...
Epithionitriles represent a previously unrecognized class of cancer chemopreventive phytochemical generated from alkenyl glucosinolates in cruciferous vegetables. In rat liver RL-34 epithelial cells,...
Dixon, M. J., Bourre, L., MacRobert, A. J., Eggleston, I. M.
The first example of the synthesis of a peptide incorporating 5-aminolaevulinic acid (5-ALA) using standard Fmoc solidphase chemistry is reported. The synthesised peptide contains residues 52-58 of...
Cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs (2007)
Dixon, M. J., Andersen, O. A., Nathubhai, A., Eggleston, I. M.
First synthesis of argadin: A nanomolar inhibitor of family-18 chitinases (2006)
Dixon, M. J., Andersen, O. A., Eggleston, I. M.
The first synthesis of the cyclic peptide natural product, argadin is reported. Use of a solid-phase approach featuring side-chain resin attachment through histidine and a novel protecting group...
Solid-phase synthesis of a focused library of trypanothione reductase inhibitors (2003)
De Luca, S., Ulhaq, S., Dixon, M. J., Essex, J., Bradley, M.
A focused library of inhibitors of the enzyme trypanothione reductase was prepared using solid-phase synthesis. The inhibitors were based on a previously identified, non-competitive, lead compound...
Dixon, M J, Small, K W, Jabs, E W, Leroy, B P, ...
Mutations in FOXL2, a forkhead transcription factor gene, have recently been shown to cause blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) types I and II, a rare genetic disorder. In...
Hargrave, M., James, K. M., Nield, K., Toomes, C., Georgas, K. M., Sullivan, T., ...
Members of the Sos gene family encode transcription factors that have diverse and important functions during development. We have recently described the cloning of chick and mouse Sox14 and the...
Hargrave, M., James, K. M., Nield, K., Toomes, C., Georgas, K. M., Sullivan, T., ...
Members of the Sos gene family encode transcription factors that have diverse and important functions during development. We have recently described the cloning of chick and mouse Sox14 and the...
Typescript (photocopy).
The effect of non-stationarity on extreme sea-level estimation. (1999)
The sea-level is the composition of astronomical tidal and meteorological surge processes. It exhibits temporal non-stationarity due to a combination of long-term trend in the mean level, the...
Spatial modelling of extreme sea-levels. (1998)
Dixon, M. J., Tawn, J. A., Vassie, J. M.
The problem of estimating the probability of extreme sea-levels along a coastline has received little attention. Most of the existing analyses are univariate approaches that are applied independently...
A semi-parametric model for multivariate extreme values. (1995)
Threshold methods for multivariate extreme values are based on the use of asymptotically justified approximations of both the marginal distributions and the dependence structure in the joint tail....
Trends in U.K. extreme sea levels: a spatial approach. (1992)
The majority of studies of long-term sea-level change have concentrated on the trend in mean sea-level which is just one constituent of the trend in extreme sea-level. By fitting a spatial model to...
Thesis submitted in partial fulfilment of the requirements of the Degree of Master of Science in the Department of Civil Engineering, University of Natal.
Role of fine needle aspiration cytology in breast cancer screening.
Lamb, J, Anderson, T J, Dixon, M J, Levack, P A
In a six year period up to the end of December 1985 fine needle aspiration cytology specimens of the breast were obtained from 562 apparently healthy women invited to participate in a breast cancer...
Annual review hospital visits for patients with cystic fibrosis.
Long, J M, Fauset-Jones, J, Dixon, M J, Worthington-Riley, D, Sharma, V, Patel, L, ...
Cis-elements governing trinucleotide repeat instability in Saccharomyces cerevisiae.
Rolfsmeier, M L, Dixon, M J, Pessoa-Brandão, L, Pelletier, R, Miret, J J, Lahue, R S
Trinucleotide repeat (TNR) instability in humans is governed by unique cis-elements. One element is a threshold, or minimal repeat length, conferring frequent mutations. Since thresholds have not...
Dixon, M J, Robinson, V, White, A, Ferguson, M W
Four monoclonal antibodies raised against murine embryonic palatal epithelium were used to stain frontal cryosections of embryonic mouse heads (d 11-15). One antibody (6A11) recognised the nasal...
How often is genital yeast infection sexually transmitted?
Thin, R N, Leighton, M, Dixon, M J
We analysed data from a computer-based bank of clinical records of patients seen in a clinic for sexually transmitted diseases over a three-year period to investigate the association between genital...
Dixon, M J, Dixon, J, Houseal, T, Bhatt, M, Ward, D C, Klinger, K, ...
Treacher Collins syndrome (TCOF1) is an autosomal dominant disorder of craniofacial development, the features of which include conductive hearing loss and cleft palate. The TCOF1 locus has been...
Genetic and radiation hybrid mapping of the hyperekplexia region on chromosome 5q.
Ryan, S G, Dixon, M J, Nigro, M A, Kelts, K A, Markand, O N, Terry, J C, ...
Hyperekplexia, or startle disease (STHE), is an autosomal dominant neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by...
Dixon, M J, Haan, E, Baker, E, David, D, McKenzie, N, Williamson, R, ...
Treacher Collins syndrome (TCS) is an autosomal dominant defect of craniofacial development which has not been chromosomally localized. We have identified a mother and two children who have TCS and...
The gene for Treacher Collins syndrome maps to the long arm of chromosome 5.
Dixon, M J, Read, A P, Donnai, D, Colley, A, Dixon, J, Williamson, R
Treacher Collins syndrome (TCS) is an autosomal dominant disorder of craniofacial development, the features of which include conductive hearing loss and cleft palate. We have studied 12 unrelated TCS...
Role of fine needle aspiration cytology in breast cancer screening.
Lamb, J, Anderson, T J, Dixon, M J, Levack, P A
In a six year period up to the end of December 1985 fine needle aspiration cytology specimens of the breast were obtained from 562 apparently healthy women invited to participate in a breast cancer...
Dixon, M J, Robinson, V, White, A, Ferguson, M W
Four monoclonal antibodies raised against murine embryonic palatal epithelium were used to stain frontal cryosections of embryonic mouse heads (d 11-15). One antibody (6A11) recognised the nasal...
Annual review hospital visits for patients with cystic fibrosis.
Long, J M, Fauset-Jones, J, Dixon, M J, Worthington-Riley, D, Sharma, V, Patel, L, ...
Cis-elements governing trinucleotide repeat instability in Saccharomyces cerevisiae.
Rolfsmeier, M L, Dixon, M J, Pessoa-Brandão, L, Pelletier, R, Miret, J J, Lahue, R S
Trinucleotide repeat (TNR) instability in humans is governed by unique cis-elements. One element is a threshold, or minimal repeat length, conferring frequent mutations. Since thresholds have not...
How often is genital yeast infection sexually transmitted?
Thin, R N, Leighton, M, Dixon, M J
We analysed data from a computer-based bank of clinical records of patients seen in a clinic for sexually transmitted diseases over a three-year period to investigate the association between genital...
Dixon, M J, Dixon, J, Houseal, T, Bhatt, M, Ward, D C, Klinger, K, ...
Treacher Collins syndrome (TCOF1) is an autosomal dominant disorder of craniofacial development, the features of which include conductive hearing loss and cleft palate. The TCOF1 locus has been...
Genetic and radiation hybrid mapping of the hyperekplexia region on chromosome 5q.
Ryan, S G, Dixon, M J, Nigro, M A, Kelts, K A, Markand, O N, Terry, J C, ...
Hyperekplexia, or startle disease (STHE), is an autosomal dominant neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by...
Dixon, M J, Haan, E, Baker, E, David, D, McKenzie, N, Williamson, R, ...
Treacher Collins syndrome (TCS) is an autosomal dominant defect of craniofacial development which has not been chromosomally localized. We have identified a mother and two children who have TCS and...
The gene for Treacher Collins syndrome maps to the long arm of chromosome 5.
Dixon, M J, Read, A P, Donnai, D, Colley, A, Dixon, J, Williamson, R
Treacher Collins syndrome (TCS) is an autosomal dominant disorder of craniofacial development, the features of which include conductive hearing loss and cleft palate. We have studied 12 unrelated TCS...
Edwards, S J, Gladwin, A J, Dixon, M J
Treacher Collins syndrome (TCS) is an autosomal dominant disorder of craniofacial development, the features of which include conductive hearing loss and cleft palate. The TCS locus has been mapped to...
Genetic mapping of the dentinogenesis imperfecta type II locus.
Crosby, A H, Scherpbier-Heddema, T, Wijmenga, C, Altherr, M R, Murray, J C, Buetow, K H, ...
Dentinogenesis imperfecta type II (DGI-II) is an autosomal dominant disorder of dentin formation, which has previously been mapped to chromosome 4q12-21. In the current study, six novel short...
A YAC contig encompassing the Treacher Collins syndrome critical region at 5q31.3-32.
Dixon, J., Gladwin, A. J., Loftus, S. K., Riley, J. H., Perveen, R., Wasmuth, J. J., ...
Treacher Collins syndrome (TCOF1) is an autosomal dominant disorder of craniofacial development the features of which include conductive hearing loss and cleft palate. Previous studies have localized...
Edwards, S J, Fowlie, A, Cust, M P, Liu, D T, Young, I D, Dixon, M J
Treacher Collins syndrome is an autosomal dominant disorder of facial development, the features of which include conductive hearing loss and cleft palate. In the current investigation, linkage...