M. J. Flens

Multidrug resistance: related proteins in primary chorpoidal melanoma and in vitro cell lines (1997)

Blom, D.J.R., Flens, M.J., Luyten, G.P.M., Waard-Siebenga, I. De, Koornneef, L., ...

MRP is frequently expressed in human lung-cancer cell lines, in non-small cell lung cancer and in normal lung (1996)

Giaccone, G., Ark-Otte, J. Van, Rubio, G.J., Gazdar, A.F., Flens, M.J., Scheper, R.J., ...

The drug-resistance-related protein LRP is the human major vault protein (1995)

Scheffer, G.L., Wijngaard, P.L.J., Flens, M.J., Izquierdo, M.A., Slovak, M.L., Pinedo, H.M., ...

Drug resistance-associated marker LRP for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma (1995)

Izquierdo, M.A., Zee, A. Van Der, Vermorken, J.B., Valk, P. Van Der, Giaccone, G., ...

The drug resistance-related protein LRP is the human major vault protein (1995)

Scheffer, G.L., Wijngaard, P.L.J., Flens, M.J., Izquierdo, M.A., Slovak, M.L., Pinedo, H.M., ...

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump (1994)

Zaman, G.J.R., Flens, M.J., Leusden, M.R. Van, Haas, M. De, Mülder, H.S., Lankelma, J., ...

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

Zaman, G J, Flens, M J, Van Leusden, M R, De Haas, M, Mülder, H S, Lankelma, J, ...

The multidrug-resistance associated protein MRP is a 180- to 195-kDa membrane protein associated with resistance of human tumor cells to cytotoxic drugs. We have investigated how MRP confers drug...

Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis.

Meijer, G A, Schroeijers, A B, Flens, M J, Meuwissen, S G, Baak, J P, ...

AIM: To analyse the expression of multidrug resistance (MDR) related proteins at different steps in colorectal carcinogenesis. METHODS: The presence of three MDR related proteins (Pgp, MRP1, and...

Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues.

Schroeijers, A. B., Scheffer, G. L., Flens, M. J., Meijer, G. A., Izquierdo, M. A., ...

Multidrug resistant cancer cells frequently overexpress the 110-kd lung resistance-related protein (LRP) as detected with the monoclonal antibody (MAb) LRP-56. Recently, we identified LRP as the...

Tissue distribution of the multidrug resistance protein.

Flens, M. J., Zaman, G. J., Izquierdo, M. A., Schroeijers, A. B., Scheffer, G. L., ...

The human multidrug resistance protein (MRP) is a 190 kd membrane glycoprotein that can cause resistance of human tumor cells to various anticancer drugs, by extruding these drugs out of the cell....

Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors.

Izquierdo, M. A., Scheffer, G. L., Flens, M. J., Giaccone, G., Broxterman, H. J., Meijer, C. J., ...

Multidrug resistance (MDR) to anticancer drugs is a major cause of treatment failure in cancer. The lung resistance protein LRP is a newly described protein related to MDR in several in vitro models....

Membrane transport proteins associated with drug resistance expressed in human melanoma.

Schadendorf, D., Makki, A., Stahr, C., Van Dyck, A., Wanner, R., Scheffer, G. L., ...

Melanoma cells often display a multidrug-resistant phenotype, but the mechanisms involved are largely unknown. We have studied here the recently identified transport-associated proteins, MRP and LRP,...