Alfarez, D.N., Karst, H., Velzing, E., Joels, M., Krugers, H.J.
Remodeling of synaptic networks is believed to contribute to synaptic plasticity and long-term memory performance, both of which are modulated by chronic stress. We here examined whether chronic...
The coming out of the brain mineralocorticoid receptor. (2008)
Joels, M., Karst, H., DeRijk, R.H., Kloet, E.R. De
Corticosteroids - secreted after stress - have profound effects on brain and behavior. These effects are mediated by mineralocorticoid and glucocorticoid receptors, which are abundantly expressed in...
Liebmann, L., Karst, H., Sidiropoulou, K., Gemert, N.G. Van, Meijer, O.C., Poirazi, P., ...
The stress hormone corticosterone increases the amplitude of the slow afterhyperpolarization (sAHP) in CA1 pyramidal neurons, without affecting resting membrane potential, input resistance, or action...
Functional actions of corticosteroids in the hippocampus. (2008)
Corticosteroid hormones are released in high amounts after stress. The hormones enter the brain compartment and bind to high affinity mineralocorticoid receptors -particularly enriched in limbic...
Chronic stress: Implications for neuronal morphology, function and neurogenesis. (2007)
Joels, M., Karst, H., Krugers, H., Lucassen, P.J.
In normal life, organisms are repeatedly exposed to brief periods of stress, most of which can be controlled and adequately dealt with. The presently available data indicate that such brief periods...
Vrede, Van De Y., Fossier, P., Baux, G., Joels, M., Chameau, P.J.P.
In several neuronal preparations, the ryanodine-sensitive calcium store was reported to participate in the generation of slow afterhyperpolarization currents (IsAHP) involved in spike frequency...
LTP after stress: up or down? (2007)
When an organism is exposed to a stressful situation, corticosteroid levels in the brain rise. This rise has consequences for behavioral performance, including memory formation. Over the past...
Pu, Z., Krugers, H., Joels, M.
Previous experiments in the hippocampal CA1 area have shown that corticosterone can facilitate long-term potentiation (LTP) in a rapid non-genomic fashion, while the same hormone suppresses LTP that...
Sennvik, K., Boekhoorn, K., Lasrado, R., Terwel, D., Verhaeghe, S., Korr, H., ...
Differential isoform expression and phosphorylation of protein tau are believed to regulate the assembly and stabilization of microtubuli in fetal and adult neurons. To define the functions of tau in...
Morsink, M.C., Gemert, N.G. Van, Steenbergen, P.J., Joels, M., Kloet, E.R. De, Datson, N.A.
We previously assessed corticosterone mediated gene expression in acute explant hippocampal slices and found over 200 responsive genes 1, 3 and 5 h after glucocorticoid receptor (GR) activation by a...
Chronic stress alters many properties in rat brain, like serotonin responsiveness and dendritic morphology. In the present study, we examined (i) whether unpredictable stress during 21 days affects...
Krugers, H., Linden, S. Van Der, Olst, E Van, Alfarez, D.N., Maslam, S., Lucassen, P.J., ...
Removal of adrenal hormone corticosterone in rats aged 3-4 months results within 3 days in acceleration of apoptosis and proliferation of newborn cells in the dentate gyrus (DG). A critical question...
Alfarez, D.N., Karst, H., Velzing, E., Joels, M., Krugers, H.
Remodeling of synaptic networks is believed to contribute to synaptic plasticity and long-term memory performance, both of which are modulated by chronic stress. We here examined whether chronic...
Role of corticosteroid hormones in the dentate gyrus. (2007)
Dentate granule cells are enriched with receptors for the stress hormone corticosterone, i.e., the high-affinity mineralocorticoid receptor (MR), which is already extensively occupied with low levels...
Wiegert, O., Joels, M., Krugers, H.
Emotionally loaded and stressful events modulate cognitive performance. This modulation of cognitive performance is at least partially dependent on corticosteroid hormones that are released in high...
Chameau, P.J.P., Qin, Y.J., Smit, G., Joels, M.
Previous studies have shown that corticosterone enhances whole cell calcium currents in CA1 pyramidal neurons, through a pathway involving binding of glucocorticoid receptor homodimers to the DNA. We...
Stress-induced changes in hippocampal function. (2007)
Joels, M., Krugers, H., Karst, H.
Exposure of an organism to stress leads to activation of the sympatho-adrenomedullary system and the hypothalamo-pituitary-adrenal axis. Consequently, levels of noradrenaline, peptides like...
Oomen, C.A., Mayer, J.L., Kloet, E.R. De, Joels, M., Lucassen, P.J.
In rodents, stress suppresses adult neurogenesis. This is thought to involve activation of glucocorticoid receptors in the brain. In the present study, we therefore questioned whether glucocorticoid...
Sennvik, K., Boekhoorn, K., Lasrado, R., Terwel, D., Verhaege, S., Korr, H., ...
Differential isoform expression and phosphorylation of protein tau are believed to regulate the assembly and stabilization of microtubuli in fetal and adult neurons. To define the functions of tau in...
Stress, depression and hippocampal apoptosis (2006)
Lucassen, P.J., Heine, V.M., Muller, M.B., Wiegant, V.M., ...
In this review, we summarize and discuss recent studies on structural plasticity changes, particularly apoptosis, in the mammalian hippocampus in relation to stress and depression. Apoptosis...
Stress, Depression and Hippocampal Apoptosis. (2006)
Lucassen, P.J., Heine, V.M., Beek, E. Van Der, Wiegant, V., Kloet, E.R. De, Joels, M., ...
In this review, we summarize and discuss recent studies on structural plasticity changes, particularly apoptosis, in the mammalian hippocampus in relation to stress and depression. Apoptosis...
Boekhoorn, K., Terwel, D., Biemans, B., Borghgraef, P., Wiegert, O., Ramakers, G.J.A., ...
The microtubule binding protein tau is implicated in neurodegenerative tauopathies, including frontotemporal dementia (FTD) with Parkinsonism caused by diverse mutations in the tau gene....
Gemert, N.G. Van, Meijer, O.C., Morsink, M.C., Joels, M.
Acute stress and corticosterone enhance 5-HT1A receptor-mediated responses in rat hippocampal CA1 cells within 1-2 h, through a process involving transcriptional regulation of unknown genes. Earlier...
Morsink, M.C., Joels, M., Sarabdjitsingh, R.A., Meijer, O.C., Kloet, E.R. De, Datson, N.A.
The aim of the current study was (i) to examine the overlap in the pattern of glucocorticoid receptor (GR)-mediated transcriptional responses between different neuronal substrates and (ii) to assess...
Gemert, N.G. Van, Riel, E. Van, Meijer, O.C., Fehr, S., Schachner, M., Joels, M.
Prolonged over-exposure of rats to corticosterone attenuates 5-HT(1A)-receptor-mediated responses in hippocampal CA1 cells through an unknown mechanism, not involving downregulation of 5-HT(1A)...
Chronic unpredictable stress affects many properties in rat brain. In the dentate gyrus, among other things, increased mRNA expression of the Ca2+ channel alpha1C subunit has been found after 21 days...
Boekhoorn, K., Joels, M., Lucassen, P.J.
Adult proliferation and hippocampal neurogenesis are stimulated by injury. In agreement, aberrant cell-cycle-related protein expression has been reported in senile Alzheimer's disease (AD), where the...
Mayer, J., Klumpers, L., Maslam, S., Kloet, E.R. De, Joels, M., Lucassen, P.J.
The glucocorticoid receptor antagonist mifepristone has been shown to rapidly and effectively ameliorate symptoms of psychotic major depression. To better understand its mechanism, we investigated...
Morsink, M.C., Steenbergen, P.J., Vos, J.B., Karst, H., Joels, M., Kloet, E.R. De, ...
Several aspects of hippocampal cell function are influenced by adrenal-secreted glucocorticoids in a delayed, genomic fashion. Previously, we used Serial Analysis of Gene Expression to identify...
Wiegert, O., Joels, M., Krugers, H.
Stress facilitates memory formation, but only when the stressor is closely linked to the learning context. These effects are, at least in part, mediated by corticosteroid hormones. Here we...
Boekhoorn, K., Terwel, D., Biemans, B., Borghgraef, P., Wiegert, O., Ramakers, G.J.A., ...
The microtubule binding protein tau is implicated in neurodegenerative tauopathies, including frontotemporal dementia (FTD) with Parkinsonism caused by diverse mutations in the tau gene....
Learning under stress: how does it work? (2006)
Joels, M., Pu, Z., Wiegert, O., Oitzl, M.S., Krugers, H.
The effects of stress on learning and memory are not always clear: both facilitating and impairing influences are described in the literature. Here we propose a unifying theory, which states that...
Corticosteroid effects in the brain: U-shape it. (2006)
The existence of U-shaped dose dependencies has been known for a long time. With regard to corticosteroid action in brain cells, a dual receptor system that works in opposing directions can explain...
Stress and the brain: from adaptation to disease (2005)
Kloet, E.R. De, Joels, M., Holsboer, F.
In response to stress, the brain activates several neuropeptide-secreting systems. This eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain...
Corticosteroid hormones are released in high amounts after stress and bind to intracellular receptors in the brain, which in activated form function as transcription factors. We here tested the...
Wiegert, O., Pu, Z., Shor, S., Joels, M., Krugers, H.
Corticosterone and exposure to stressful experiences have been reported to decrease hippocampal synaptic plasticity, in particular when relatively mild stimulation paradigms-presumably activating...
Verkuyl, M., Karst, H., Joels, M.
Parvocellular neurons in the hypothalamic paraventricular nucleus receive hormonal inputs mediated by corticosterone as well as neuronal inputs, prominent among which is a GABAergic inhibitory...
Heine, V.M., Zareno, J., Maslam, S., Joels, M., Lucassen, P.J.
Recent evidence has shown that cell proliferation in the adult hippocampal dentate gyrus occurs in tight clusters located near the vasculature. Also, changes in neurogenesis often appear parallel to...
Corticosterone shifts different forms of synaptic potentiation in opposite directions (2005)
Krugers, H., Alfarez, D.N., Karst, H., Parashkouhi, K., Gemert, N.G. Van, Joels, M.
Calcium entering the cell via different routes, e.g.,N-methyl-D-aspartate (NMDA) receptors or voltage-dependent calcium channels (VDCCs), plays a pivotal role in hippocampal synaptic potentiation....
Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus (2004)
Joels, M., Karst, H., Alfarez, D.N., Heine, V.M., Qin, Y.J., Riel, E. Van, ...
It has become increasingly clear that the increase in corticosteroid levels, e.g. after a brief stressor induce molecular and cellular changes in brain, including the hippocampal formation. These...
Nair, S.M., Karst, H., Dumas, T., Philips, R., Sapolsky, R.M., ...
Removal of circulating corticosterone by adrenalectomy (ADX) leads to apoptosis after 3 days in a small population of rat dentate granule neurons, whereas most surrounding cells remain viable....
Corticosterone is released in large amounts from the rat and mouse adrenal gland after stress. The hormone enters the brain and binds to intracellular receptors. Previously, we found that rises in...
Heine, V.M., Maslam, S., Joels, M., Lucassen, P.J.
Various chronic stress paradigms decrease new cell proliferation in the hippocampal dentate gyrus, yet the exact underlying mechanism is still unclear. In the first gap (G1) phase of the cell cycle,...
Effect of early Life stress on serotonin responses in the hippocampus of young adult rats (2004)
Riel, E. Van, Gemert, N.G. Van, Meijer, O.C., Joels, M.
In this study, we investigated the effects of early life stress on several aspects of serotonin (5-HT) transmission in hippocampus, later on in life. Three-day-old rats were subjected to 24-hour...
Chronic unpredictable stress alters gene expression in rat single dentate granule cells (2004)
Qin, Y.J., Karst, H., Joels, M.
The rat adrenal hormone corticosterone binds to low and high affinity receptors, discretely localized in brain, including the dentate gyrus. Differential activation of the two receptor types under...
Verkuyl, M., Hemby, S.E., Joels, M.
Chronic stress causes disinhibition of the hypothalamus-pituitary-adrenal axis. Consequently, the brain is overexposed to glucocorticoids which in humans may precipitate stress-related disorders,...
Heine, V.M., Maslam, S., Zareno, J., Joels, M., Lucassen, P.J.
Acute stress suppresses new cell birth in the hippocampus in several species. Relatively little is known, however, on how chronic stress affects the turnover, i.e. proliferation and apoptosis, of the...
Gene expression changes in single dentate granule neurons after adrenalectomy of rats (2003)
Qin, Y.J., Nair, S.M., Karst, H., Vreugdenhil, E., Datson, N.A., Joels, M.