M. Kähönen

C-reactive protein genetics is associated with carotid artery compliance in men in the cardiovascular risk in Young Finns study (2008)

Eklund, C, Kivimäki, M, Islam, M.S., Juonala, M, Kähönen, M, Marniemi, J, ...

Although C-reactive protein (CRP) is known to predict cardiovascular events, its status as a causal risk factor is still controversial. CRP gene single nucleotide polymorphisms (SNPs) have been shown...

Autoimmunity and atherosclerosis: functional polymorphism of PTPN22 is associated with phenotypes related to the risk of atherosclerosis. The Cardiovascular Risk in Young Finns Study

Pertovaara, M, Raitala, A, Juonala, M, Kähönen, M, Lehtimäki, T, Viikari, J S A, ...

There is a growing body of evidence attesting the significance of inflammation in the pathogenesis of atherosclerosis. Protein tyrosine phosphate PTPN22 C/T single nucleotide polymorphism (SNP) at...

Endothelial function in spontaneously hypertensive rats: influence of quinapril treatment.

Kähönen, M., Mäkynen, H., Wu, X., Arvola, P., Pörsti, I.

1. Angiotensin converting enzyme (ACE) inhibition has been shown to restore the impaired endothelial function in hypertension, but the mediators underlying the promoted endothelium-dependent...

Dietary calcium and magnesium supplements in spontaneously hypertensive rats and isolated arterial reactivity.

Mäkynen, H., Kähönen, M., Arvola, P., Wuorela, H., Vapaatalo, H., Pörsti, I.

1. High calcium diet attenuates the development of hypertension but an associated undesirable effect is that Mg2+ loss to the urine is enhanced. Therefore, we studied the effects of high calcium diet...

Enhancement of arterial relaxation by long-term atenolol treatment in spontaneously hypertensive rats.

Kähönen, M., Mäkynen, H., Arvola, P., Pörsti, I.

1. The effects of long-term atenolol (25 mg kg-1 day-1) therapy on arterial function were studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. The 14-week treatment...

Effect of celiprolol therapy on arterial dilatation in experimental hypertension.

Tolvanen, J. P., Wu, X., Kähönen, M., Sallinen, K., Mäkynen, H., Pekki, A., ...

1. It has recently been suggested that therapy with beta-adrenoceptor blockers reduces peripheral arterial resistance via enhanced vascular dilatation. Therefore, we studied the effects of...