Alpha1-antitrypsin Granules in the Liver-Always Important? (1990)
BRIND, A. M., BASSENDINE, M. F., BENNETT, M. K., JAMES, O. F. W.
We have studied the clinical histories and liver biopsy findings in 1951 consecutive adult patients with suspected chronic liver disease, and in four known Piz-homozygous α1-antitrypsin-deficient...
Lopez, J M, Bennett, M K, Sanchez, H B, Rosenfeld, J M, Osborne, T E
Transcription from the housekeeping promoter for the acetyl coenzyme A carboxylase (ACC) gene, which encodes the rate-controlling enzyme of fatty acid biosynthesis, is shown to be regulated by...
The molecular machinery for secretion is conserved from yeast to neurons.
A variety of approaches have been utilized to identify and characterize the molecules that mediate vesicular trafficking along the secretory pathway. Two approaches that have been particularly...
Volchuk, A, Wang, Q, Ewart, H S, Liu, Z, He, L, Bennett, M K, ...
Syntaxins are thought to be membrane receptors that bind proteins of the synaptobrevin/vesicle-associated membrane protein (VAMP) family found on transport vesicles. Recently, we detected...
Differential localization of syntaxin isoforms in polarized Madin-Darby canine kidney cells.
Low, S H, Chapin, S J, Weimbs, T, Kömüves, L G, Bennett, M K, Mostov, K E
Syntaxins, integral membrane proteins that are part of the ubiquitous membrane fusion machinery, are thought to act as target membrane receptors during the process of vesicle docking and fusion....
Distinct cellular locations of the syntaxin family of proteins in rat pancreatic acinar cells.
Gaisano, H Y, Ghai, M, Malkus, P N, Sheu, L, Bouquillon, A, Bennett, M K, ...
Syntaxins are cytoplasmically oriented integral membrane soluble NEM-sensitive factor receptors (SNAREs; soluble NEM-sensitive factor attachment protein receptors) thought to serve as targets for the...
Peng, X R, Yao, X, Chow, D C, Forte, J G, Bennett, M K
H+/K(+)-ATPase is the proton pump in the gastric parietal cell that is responsible for gastric acid secretion. Stimulation of acid secretion is associated with a reorganization of the parietal cells...
cDNA clones coding for the beta subunit of rat brain type II Ca2+/calmodulin-dependent protein kinase were isolated and sequenced. The clones, including one containing the entire coding region,...
Kennedy, M B, Bennett, M K, Erondu, N E
By three criteria, two biochemical and one immunochemical, the major postsynaptic density protein (mPSDp) is indistinguishable from the 50-kilodalton (kDa) alpha subunit of a brain...
Functional interaction of syntaxin and SNAP-25 with voltage-sensitive L- and N-type Ca2+ channels.
Wiser, O, Bennett, M K, Atlas, D
We have used an electrophysiological assay to investigate the functional interaction of syntaxin 1A and SNAP-25 with the class C, L-type, and the class B, N-type, voltage-sensitive calcium channels....
Release of putative exocytic transport vesicles from perforated MDCK cells.
Bennett, M K, Wandinger-Ness, A, Simons, K
Mechanically perforated MDCK cells were used to study membrane transport between the trans-Golgi network and the apical and basolateral plasma membrane domains in vitro. Three membrane transport...
Dieulafoy's vascular malformation as a cause of large intestinal bleeding.
Four cases of Dieulafoy's vascular malformation of the caecum are reported. Three were associated with massive large bowel haemorrhage, one of which was fatal. The remaining case had a calibre...
Ageing and duodenal morphometry.
Lipski, P S, Bennett, M K, Kelly, P J, James, O F
Small bowel morphometry was studied in 25 subjects under the age of 70 years and 22 over the age of 70. There was no evidence of malabsorption or malnutrition in either group. Two distal duodenal...
D'Ardenne, A J, Burns, J, Sykes, B C, Bennett, M K
The distribution of fibronectin (FN) and collagen type III (IIIC) have been compared in a series of epithelial neoplasms from the gastrointestinal tract and salivary gland. The difficulty of...
Jejunal mucosal morphology in healthy north Indian subjects.
Bennett, M K, Sachdev, G K, Jewell, D P, Anand, B S
Morphometric measurements have been performed on small intestinal biopsy specimens obtained from 18 healthy adult Indian volunteers. The measurements were made using a computer aided measuring...
Post-infantile giant cell hepatitis: histological and immunohistochemical study.
Johnson, S J, Mathew, J, MacSween, R N, Bennett, M K, Burt, A D
AIM--To determine the composition of the inflammatory infiltrate and to check for the presence of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in nine cases of post-infantile giant cell...
Timmers, K I, Clark, A E, Omatsu-Kanbe, M, Whiteheart, S W, Bennett, M K, Holman, G D, ...
The vesicle-associated membrane proteins [VAMPs; vesicle SNAP receptors (v-SNAREs)] present on GLUT4-enriched vesicles prepared from rat adipose cells [Cain, Trimble and Lienhard (1992) J. Biol....
Targeting to intestinal M cells.
Jepson, M A, Clark, M A, Foster, N, Mason, C M, Bennett, M K, Simmons, N L, ...
The specialised, antigen-transporting, epithelial M cells in the follicle-associated epithelium (FAE) overlying gut-associated lymphoid tissues constitute the primary target for oral delivery of...
Lopez, J M, Bennett, M K, Sanchez, H B, Rosenfeld, J M, Osborne, T E
Transcription from the housekeeping promoter for the acetyl coenzyme A carboxylase (ACC) gene, which encodes the rate-controlling enzyme of fatty acid biosynthesis, is shown to be regulated by...
The molecular machinery for secretion is conserved from yeast to neurons.
A variety of approaches have been utilized to identify and characterize the molecules that mediate vesicular trafficking along the secretory pathway. Two approaches that have been particularly...
Volchuk, A, Wang, Q, Ewart, H S, Liu, Z, He, L, Bennett, M K, ...
Syntaxins are thought to be membrane receptors that bind proteins of the synaptobrevin/vesicle-associated membrane protein (VAMP) family found on transport vesicles. Recently, we detected...
Differential localization of syntaxin isoforms in polarized Madin-Darby canine kidney cells.
Low, S H, Chapin, S J, Weimbs, T, Kömüves, L G, Bennett, M K, Mostov, K E
Syntaxins, integral membrane proteins that are part of the ubiquitous membrane fusion machinery, are thought to act as target membrane receptors during the process of vesicle docking and fusion....
Distinct cellular locations of the syntaxin family of proteins in rat pancreatic acinar cells.
Gaisano, H Y, Ghai, M, Malkus, P N, Sheu, L, Bouquillon, A, Bennett, M K, ...
Syntaxins are cytoplasmically oriented integral membrane soluble NEM-sensitive factor receptors (SNAREs; soluble NEM-sensitive factor attachment protein receptors) thought to serve as targets for the...
Peng, X R, Yao, X, Chow, D C, Forte, J G, Bennett, M K
H+/K(+)-ATPase is the proton pump in the gastric parietal cell that is responsible for gastric acid secretion. Stimulation of acid secretion is associated with a reorganization of the parietal cells...
cDNA clones coding for the beta subunit of rat brain type II Ca2+/calmodulin-dependent protein kinase were isolated and sequenced. The clones, including one containing the entire coding region,...
Kennedy, M B, Bennett, M K, Erondu, N E
By three criteria, two biochemical and one immunochemical, the major postsynaptic density protein (mPSDp) is indistinguishable from the 50-kilodalton (kDa) alpha subunit of a brain...
Functional interaction of syntaxin and SNAP-25 with voltage-sensitive L- and N-type Ca2+ channels.
Wiser, O, Bennett, M K, Atlas, D
We have used an electrophysiological assay to investigate the functional interaction of syntaxin 1A and SNAP-25 with the class C, L-type, and the class B, N-type, voltage-sensitive calcium channels....
Release of putative exocytic transport vesicles from perforated MDCK cells.
Bennett, M K, Wandinger-Ness, A, Simons, K
Mechanically perforated MDCK cells were used to study membrane transport between the trans-Golgi network and the apical and basolateral plasma membrane domains in vitro. Three membrane transport...
Dieulafoy's vascular malformation as a cause of large intestinal bleeding.
Farrell, D. J., Bennett, M. K.
Four cases of Dieulafoy's vascular malformation of the caecum are reported. Three were associated with massive large bowel haemorrhage, one of which was fatal. The remaining case had a calibre...
Ageing and duodenal morphometry.
Lipski, P. S., Bennett, M. K., Kelly, P. J., James, O. F.
Small bowel morphometry was studied in 25 subjects under the age of 70 years and 22 over the age of 70. There was no evidence of malabsorption or malnutrition in either group. Two distal duodenal...
D'Ardenne, A J, Burns, J, Sykes, B C, Bennett, M K
The distribution of fibronectin (FN) and collagen type III (IIIC) have been compared in a series of epithelial neoplasms from the gastrointestinal tract and salivary gland. The difficulty of...
Jejunal mucosal morphology in healthy north Indian subjects.
Bennett, M K, Sachdev, G K, Jewell, D P, Anand, B S
Morphometric measurements have been performed on small intestinal biopsy specimens obtained from 18 healthy adult Indian volunteers. The measurements were made using a computer aided measuring...
Post-infantile giant cell hepatitis: histological and immunohistochemical study.
Johnson, S J, Mathew, J, MacSween, R N, Bennett, M K, Burt, A D
AIM--To determine the composition of the inflammatory infiltrate and to check for the presence of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in nine cases of post-infantile giant cell...
Targeting to intestinal M cells.
Jepson, M A, Clark, M A, Foster, N, Mason, C M, Bennett, M K, Simmons, N L, ...
The specialised, antigen-transporting, epithelial M cells in the follicle-associated epithelium (FAE) overlying gut-associated lymphoid tissues constitute the primary target for oral delivery of...
Timmers, K I, Clark, A E, Omatsu-Kanbe, M, Whiteheart, S W, Bennett, M K, Holman, G D, ...
The vesicle-associated membrane proteins [VAMPs; vesicle SNAP receptors (v-SNAREs)] present on GLUT4-enriched vesicles prepared from rat adipose cells [Cain, Trimble and Lienhard (1992) J. Biol....
Collier, J D, Bennett, M K, Hall, A, Cattan, A R, Lendrum, R, Bassendine, M F
The glutathione S-transferases (GSTs) are a family of detoxification and metabolising enzymes, which have been linked with the susceptibility of tissues to environmental carcinogens and resistance of...
Brown, A S, Fiaterone, J R, Day, C P, Bennett, M K, Kelly, P J, James, O F
Blood ethanol concentrations after separate oral dosing and intravenous infusion of ethanol (0.15 g/kg) were measured in 16 control subjects and 13 subjects treated with ranitidine. All subjects...
Inflammatory obstruction of oesophageal tubes.
Philp, T, Gunning, A J, Bennett, M K
Two patients, intubated for inoperable carcinoma of the oesophagus, recently presented with their tubes blocked by granulation tissue. This complication has not been previously reported. The tissue...
Makiyama, K, Bennett, M K, Jewell, D P
The magnified endoscopic appearances of the rectum are described in 12 patients with Crohn's disease with apparent rectal sparing on sigmoidoscopy. Five of them had minor abnormalities on colonoscopy...
Role of the faecal stream in the maintenance of Crohn's colitis.
Harper, P H, Lee, E C, Kettlewell, M G, Bennett, M K, Jewell, D P
The role of the faecal stream in the maintenance of the inflammation in Crohn's disease has been studied. Small bowel effluent and a sterile ultrafiltrate of it were reintroduced into the...
Sellers, L A, Allen, A, Bennett, M K
A gelatinous coat, heterogeneous in appearance, was formed over damaged rat gastric mucosa recovering from acute ethanol injury. This coat, in places 1.6 mm thick (median thickness 680 microns), was...
A matrix metalloproteinase inhibitor to treat unresectable cholangiocarcinoma
French, J. J, Midwinter, M. J., Bennett, M. K., Manas, D. M., Charnley, R. M.
Matrix metalloproteinases (MMPs) are implicated in tumour invasion and metastasis. We report the first use of an MMP inhibitor to treat unresectable cholangiocarcinoma. Four men with stage IV...
Protein S deficiency: early presentation and pulmonary hypertension.
O'Sullivan, J, Chatuverdi, R, Bennett, M K, Hunter, S
Protein S deficiency usually presents in adults with recurrent or unexplained thrombosis and is thought to have autosomal dominant inheritance. We describe the case of a 5 year old girl with...
Gastrointestinal amyloidosis complicating psoriatic arthropathy
Willoughby, C. P., Banerji, A., Bennett, M. K., Jewell, D. P.
A patient is described who developed gastrointestinal amyloidosis complicating psoriatic arthropathy. The presenting symptom was progressive dysphagia due to oesophageal involvement. Other clinical...
Hepatic epithelioid haemangioendothelioma: difficult name, difficult diagnosis?
Cobden, I., Johri, S., Terry, G., Robinson, K. B., Bennett, M. K., Lendrum, R.
Two patients with epithelioid haemangioendotheliomata of the liver are described. Both presented with abdominal pain and malaise, with hepatomegaly and a variable degree of hepatocellular...
Expression of the pNR-2/pS2 protein in diverse human epithelial tumours.
Henry, J. A., Bennett, M. K., Piggott, N. H., Levett, D. L., May, F. E., Westley, B. R.
The pNR-2/pS2 protein is regulated by oestrogens in breast cancer cell lines. This report describes a systematic survey of pNR-2/pS2 expression in a number of common epithelial tumours. Expression...
The pattern of recurrence of adenocarcinoma of the oesophago-gastric junction
Wayman, J, Bennett, M K, Raimes, S A, Griffin, S M
Knowledge of the pattern of recurrence of surgically treated cases of adenocarcinoma of the oesophago-gastric junction is important both for better understanding of their biological nature and for...