M. K. Dosanjh

Evidence from in vitro replication that O6-methylguanine can adopt multiple conformations.

Dosanjh, M K, Loechler, E L, Singer, B

The effect of O6-methylguanine (m6G) on replication, in a partially double-stranded defined 25-base oligonucleotide, has been studied under nonlimiting conditions of unmodified dNTPs and over an...

Both purified human 1,N6-ethenoadenine-binding protein and purified human 3-methyladenine-DNA glycosylase act on 1,N6-ethenoadenine and 3-methyladenine.

Singer, B, Antoccia, A, Basu, A K, Dosanjh, M K, Fraenkel-Conrat, H, Gallagher, P E, ...

We previously described a protein, isolated from human tissues and cells, that bound to a defined double-stranded oligonucleotide containing a single site-specifically placed 1,N6-ethenoadenine. It...

Human cells contain protein specifically binding to a single 1,N6-ethenoadenine in a DNA fragment.

Rydberg, B, Dosanjh, M K, Singer, B

A human DNA binding protein has been characterized from cell-free extracts of liver, placenta, and cultured cells. This protein, apparent molecular mass approximately 35 kDa, to our knowledge, does...

The vinyl chloride DNA derivative N2,3-ethenoguanine produces G----A transitions in Escherichia coli.

Cheng, K C, Preston, B D, Cahill, D S, Dosanjh, M K, Singer, B, Loeb, L A

Vinyl chloride is a known human and rodent carcinogen that forms several cyclic base derivatives in DNA. The mutagenic potential of these derivatives has been examined in vitro but not in vivo. One...

Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes.

Dosanjh, M K, Collins, D W, Fan, W, Lennon, G G, Albala, J S, Shen, Z, ...

The yeast and human RAD51 genes encode strand-transfer proteins that are thought to be involved in both recombinational repair of DNA damage and meiotic recombination. In yeast, the Rad51 family of...

Effect of 3' flanking neighbors on kinetics of pairing of dCTP or dTTP opposite O6-methylguanine in a defined primed oligonucleotide when Escherichia coli DNA polymerase I is used.

Singer, B, Chavez, F, Goodman, M F, Essigmann, J M, Dosanjh, M K

O6-Methylguanine (m6G) was incorporated site-specifically into two 25-base oligonucleotides differing only in the nucleotide on the 3' side of the modified base. Templates were primed with...

All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase.

Dosanjh, M K, Chenna, A, Kim, E, Fraenkel-Conrat, H, Samson, L, Singer, B

We have previously reported that human cells and tissues contain a 1,N6-ethenoadenine (epsilon A) binding protein, which, through glycosylase activity, releases both 3-methyladenine (m3A) and epsilon...

Evidence from in vitro replication that O6-methylguanine can adopt multiple conformations.

Dosanjh, M K, Loechler, E L, Singer, B

The effect of O6-methylguanine (m6G) on replication, in a partially double-stranded defined 25-base oligonucleotide, has been studied under nonlimiting conditions of unmodified dNTPs and over an...

Both purified human 1,N6-ethenoadenine-binding protein and purified human 3-methyladenine-DNA glycosylase act on 1,N6-ethenoadenine and 3-methyladenine.

Singer, B, Antoccia, A, Basu, A K, Dosanjh, M K, Fraenkel-Conrat, H, Gallagher, P E, ...

We previously described a protein, isolated from human tissues and cells, that bound to a defined double-stranded oligonucleotide containing a single site-specifically placed 1,N6-ethenoadenine. It...

Human cells contain protein specifically binding to a single 1,N6-ethenoadenine in a DNA fragment.

Rydberg, B, Dosanjh, M K, Singer, B

A human DNA binding protein has been characterized from cell-free extracts of liver, placenta, and cultured cells. This protein, apparent molecular mass approximately 35 kDa, to our knowledge, does...

The vinyl chloride DNA derivative N2,3-ethenoguanine produces G----A transitions in Escherichia coli.

Cheng, K C, Preston, B D, Cahill, D S, Dosanjh, M K, Singer, B, Loeb, L A

Vinyl chloride is a known human and rodent carcinogen that forms several cyclic base derivatives in DNA. The mutagenic potential of these derivatives has been examined in vitro but not in vivo. One...

Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes.

Dosanjh, M K, Collins, D W, Fan, W, Lennon, G G, Albala, J S, Shen, Z, ...

The yeast and human RAD51 genes encode strand-transfer proteins that are thought to be involved in both recombinational repair of DNA damage and meiotic recombination. In yeast, the Rad51 family of...

Effect of 3' flanking neighbors on kinetics of pairing of dCTP or dTTP opposite O6-methylguanine in a defined primed oligonucleotide when Escherichia coli DNA polymerase I is used.

Singer, B, Chavez, F, Goodman, M F, Essigmann, J M, Dosanjh, M K

O6-Methylguanine (m6G) was incorporated site-specifically into two 25-base oligonucleotides differing only in the nucleotide on the 3' side of the modified base. Templates were primed with...

All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase.

Dosanjh, M K, Chenna, A, Kim, E, Fraenkel-Conrat, H, Samson, L, Singer, B

We have previously reported that human cells and tissues contain a 1,N6-ethenoadenine (epsilon A) binding protein, which, through glycosylase activity, releases both 3-methyladenine (m3A) and epsilon...