Surto alimentar por Salmonella Enteritidis no Noroeste do Estado de São Paulo, Brasil (1995)
Kaku,M., Peresi,J.T.M., Tavechio,A.T., Fernandes,S.A., Batista,A.B., Castanheira,I.A.Z., ...
Em 1993 ocorreu um surto alimentar em escola, com 211 afetados. Os dados epidemiológicos levantados por entrevista de amostragem de afetados e não afetados mostraram que os sintomas predominantes...
Numata, Y., Saito, K., Yamano, Y., Yasuoka, Y., Kaku, M.
研究概要:To develop new vegetation indices algorithm, some vegetation parameters which are Vegetation Coverage (VC), Leaf Area Index (LAI) and Absorbed Photosynthetically Active Radiation (APAR)...
Numata, Y., Saito, K., Yamano, Y., Yasuoka, Y., Kaku, M.
研究概要:To develop new vegetation indices algorithm, some vegetation parameters which are Vegetation Coverage (VC), Leaf Area Index (LAI) and Absorbed Photosynthetically Active Radiation (APAR)...
Trends in antimicrobial resistance of Streptococcus pneumoniae in Japan.
Yoshida, R, Kaku, M, Kohno, S, Ishida, K, Mizukane, R, Takemura, H, ...
A total of 184 isolates of Streptococcus pneumoniae were recovered from the sputa of patients over a 5-year period in the Nagasaki area and were examined. A total of 30 strains were resistant to...
Takemura, H, Kaku, M, Kohno, S, Hirakata, Y, Tanaka, H, Yoshida, R, ...
Defensins are small cationic bactericidal peptides present abundantly in the granules of polymorphonuclear neutrophils (PMNs). Human PMNs contain four defensins termed HNP-1 to HNP-4. We used a new...
Sawai, T, Tomono, K, Yanagihara, K, Yamamoto, Y, Kaku, M, Hirakata, Y, ...
We describe a novel mouse model of acute staphylococcal pneumonia induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads. For comparison, we also used various strains of...
Maesaki, S, Kohno, S, Kaku, M, Koga, H, Hara, K
The in vitro effects of antifungal agent combinations administered simultaneously and sequentially against 15 strains of Aspergillus fumigatus were tested by the yeast-malt broth method. The...
Efficacy of erythromycin lactobionate for treating Pseudomonas aeruginosa bacteremia in mice.
Hirakata, Y, Kaku, M, Tomono, K, Tateda, K, Furuya, N, Matsumoto, T, ...
We induced endogenous Pseudomonas aeruginosa bacteremia by administering cyclophosphamide and ampicillin to specific pathogen-free mice fed P. aeruginosa. Using this model, we evaluated the efficacy...
Potential effects of erythromycin on host defense systems and virulence of Pseudomonas aeruginosa.
Hirakata, Y, Kaku, M, Mizukane, R, Ishida, K, Furuya, N, Matsumoto, T, ...
We evaluated several potential effects of erythromycin (EM) on host defense systems and the virulence of Pseudomonas aeruginosa. Peritoneal macrophages obtained from mice given 250 mg of EM per kg of...
Efficacy of intravenous itraconazole against experimental pulmonary aspergillosis.
Miyazaki, H M, Kohno, S, Miyazaki, Y, Mitsutake, K, Tomono, K, Kaku, M, ...
The efficacy of intravenous itraconazole solubilized in hydroxypropyl-beta-cyclodextrin was assessed in a rat model of Aspergillus fumigatus pneumonia. Immunosuppressed rats were infected by...
Yamamoto, Y, Kohno, S, Koga, H, Kakeya, H, Tomono, K, Kaku, M, ...
We examined clinical (pulmonary cryptococcosis and cryptococcal meningitis) and environmental (pigeon excreta) isolates of Cryptococcus neoformans var. neoformans (serotype A) in the southern...
Role of bacterial association with Kupffer cells in occurrence of endogenous systemic bacteremia.
Hirakata, Y, Tomono, K, Tateda, K, Matsumoto, T, Furuya, N, Shimoguchi, K, ...
Bacteremia in immunocompromised hosts often arises from their endogenous intestinal flora. We produced experimental endogenous bacteremia by administering cyclophosphamide and ampicillin to...
Ichinose, Y, Yagawa, K, Kaku, M, Hara, N, Ohta, M
The effect of phorbol myristate acetate (PMA) on the antibody-dependent cellular cytotoxicity (ADCC) of human polymorphonuclear leukocytes (PMNs) against human erythroleukemic K562 cells was studied...
Detection of Bacteroides fragilis in clinical specimens by PCR.
Yamashita, Y, Kohno, S, Koga, H, Tomono, K, Kaku, M
The direct detection of Bacteroides fragilis from clinical specimens was examined by using the PCR method for amplifying a specific fragment of the glutamine synthetase gene from B. fragilis. By this...
Yagawa, K, Kaku, M, Ichinose, Y, Nagao, S, Tanaka, A, Tomoda, A
The superoxide anion (O2-)-generating activity of guinea pig macrophages stimulated by wheat germ agglutinin (WGA), immune complexes, or phorbol myristate acetate (PMA) was studied after short- and...
Rapid and highly reproducible method for antifungal susceptibility testing of Aspergillus species.
Yamada, H, Kohno, S, Maesaki, S, Koga, H, Kaku, M, Hara, K, ...
A new method for determining the MICs for Aspergillus species with slant-shaking incubation is described. The method was rapid (24 h), produced sharp visual end points, and showed high...
Pneumonia caused by Stenotrophomonas maltophilia with a mucoid phenotype.
Irifune, K, Ishida, T, Shimoguchi, K, Ohtake, J, Tanaka, T, Morikawa, N, ...
We describe the first known case of pneumonia caused by a mucoid Stenotrophomonas maltophilia (Xanthomonas maltophilia) strain in a patient with bronchiectasis. The patient was admitted because of...
Nested polymerase chain reaction for detection of Mycobacterium tuberculosis in clinical samples.
Miyazaki, Y, Koga, H, Kohno, S, Kaku, M
The nested polymerase chain reaction technique was compared with the conventional smear and culture methods for detection of Mycobacterium tuberculosis. The nested polymerase chain reaction used in...
Hirakata, Y, Furuya, N, Tateda, K, Kaku, M, Yamaguchi, K
We have examined the production of Pseudomonas aeruginosa exotoxin A (ETA) and its role in endogenous bacteremia in mice. Mice given P. aeruginosa D4 orally died of bacteremia between days 10 and 13...
Mizukane, R, Hirakata, Y, Kaku, M, Ishii, Y, Furuya, N, Ishida, K, ...
The inhibitory effects of azithromycin (AZM), a new 15-membered macrolide antibiotic, on the production of exotoxin A, total protease, elastase, and phospholipase C by Pseudomonas aeruginosa were...
In vitro and in vivo activities of sparfloxacin against Mycoplasma pneumoniae.
Kaku, M, Ishida, K, Irifune, K, Mizukane, R, Takemura, H, Yoshida, R, ...
The in vitro and in vivo activities of sparfloxacin against Mycoplasma pneumoniae were compared with those of erythromycin, levofloxacin, ofloxacin, and minocycline. The MICs of sparfloxacin,...
In vitro and in vivo activities of macrolides against Mycoplasma pneumoniae.
Ishida, K, Kaku, M, Irifune, K, Mizukane, R, Takemura, H, Yoshida, R, ...
We investigated the in vitro and in vivo activities of macrolides against Mycoplasma pneumoniae. In vitro MICs of azithromycin, erythromycin, clarithromycin, and roxithromycin were determined....
Enhanced superoxide anion release from phagocytes by muramyl dipeptide or lipopolysaccharide.
Kaku, M, Yagawa, K, Nagao, S, Tanaka, A
Muramyl dipeptide (MDP) and lipopolysaccharide (LPS) from Escherichia coli were tested for the ability to influence superoxide anion (O2-) release from guinea pig phagocytes. Both MDP and LPS alone...
Kanemitsu, K., Kunishima, H., Hatta, M., Inden, K., Saga, T., Ouchi, H., ...
RAISUS is a system for rapid bacterial identification and antimicrobial susceptibility testing. RAISUS and VITEK showed 97.8% and 75.9% agreement in identification of 45 Staphylococcus aureus strains...
Trends in antimicrobial resistance of Streptococcus pneumoniae in Japan.
Yoshida, R, Kaku, M, Kohno, S, Ishida, K, Mizukane, R, Takemura, H, ...
A total of 184 isolates of Streptococcus pneumoniae were recovered from the sputa of patients over a 5-year period in the Nagasaki area and were examined. A total of 30 strains were resistant to...
Takemura, H, Kaku, M, Kohno, S, Hirakata, Y, Tanaka, H, Yoshida, R, ...
Defensins are small cationic bactericidal peptides present abundantly in the granules of polymorphonuclear neutrophils (PMNs). Human PMNs contain four defensins termed HNP-1 to HNP-4. We used a new...
Sawai, T, Tomono, K, Yanagihara, K, Yamamoto, Y, Kaku, M, Hirakata, Y, ...
We describe a novel mouse model of acute staphylococcal pneumonia induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads. For comparison, we also used various strains of...
Maesaki, S, Kohno, S, Kaku, M, Koga, H, Hara, K
The in vitro effects of antifungal agent combinations administered simultaneously and sequentially against 15 strains of Aspergillus fumigatus were tested by the yeast-malt broth method. The...
Efficacy of erythromycin lactobionate for treating Pseudomonas aeruginosa bacteremia in mice.
Hirakata, Y, Kaku, M, Tomono, K, Tateda, K, Furuya, N, Matsumoto, T, ...
We induced endogenous Pseudomonas aeruginosa bacteremia by administering cyclophosphamide and ampicillin to specific pathogen-free mice fed P. aeruginosa. Using this model, we evaluated the efficacy...
Potential effects of erythromycin on host defense systems and virulence of Pseudomonas aeruginosa.
Hirakata, Y, Kaku, M, Mizukane, R, Ishida, K, Furuya, N, Matsumoto, T, ...
We evaluated several potential effects of erythromycin (EM) on host defense systems and the virulence of Pseudomonas aeruginosa. Peritoneal macrophages obtained from mice given 250 mg of EM per kg of...
Efficacy of intravenous itraconazole against experimental pulmonary aspergillosis.
Miyazaki, H M, Kohno, S, Miyazaki, Y, Mitsutake, K, Tomono, K, Kaku, M, ...
The efficacy of intravenous itraconazole solubilized in hydroxypropyl-beta-cyclodextrin was assessed in a rat model of Aspergillus fumigatus pneumonia. Immunosuppressed rats were infected by...
Yamamoto, Y, Kohno, S, Koga, H, Kakeya, H, Tomono, K, Kaku, M, ...
We examined clinical (pulmonary cryptococcosis and cryptococcal meningitis) and environmental (pigeon excreta) isolates of Cryptococcus neoformans var. neoformans (serotype A) in the southern...
Role of bacterial association with Kupffer cells in occurrence of endogenous systemic bacteremia.
Hirakata, Y, Tomono, K, Tateda, K, Matsumoto, T, Furuya, N, Shimoguchi, K, ...
Bacteremia in immunocompromised hosts often arises from their endogenous intestinal flora. We produced experimental endogenous bacteremia by administering cyclophosphamide and ampicillin to...
Ichinose, Y, Yagawa, K, Kaku, M, Hara, N, Ohta, M
The effect of phorbol myristate acetate (PMA) on the antibody-dependent cellular cytotoxicity (ADCC) of human polymorphonuclear leukocytes (PMNs) against human erythroleukemic K562 cells was studied...
Detection of Bacteroides fragilis in clinical specimens by PCR.
Yamashita, Y, Kohno, S, Koga, H, Tomono, K, Kaku, M
The direct detection of Bacteroides fragilis from clinical specimens was examined by using the PCR method for amplifying a specific fragment of the glutamine synthetase gene from B. fragilis. By this...
Yagawa, K, Kaku, M, Ichinose, Y, Nagao, S, Tanaka, A, Tomoda, A
The superoxide anion (O2-)-generating activity of guinea pig macrophages stimulated by wheat germ agglutinin (WGA), immune complexes, or phorbol myristate acetate (PMA) was studied after short- and...
Rapid and highly reproducible method for antifungal susceptibility testing of Aspergillus species.
Yamada, H, Kohno, S, Maesaki, S, Koga, H, Kaku, M, Hara, K, ...
A new method for determining the MICs for Aspergillus species with slant-shaking incubation is described. The method was rapid (24 h), produced sharp visual end points, and showed high...
Pneumonia caused by Stenotrophomonas maltophilia with a mucoid phenotype.
Irifune, K, Ishida, T, Shimoguchi, K, Ohtake, J, Tanaka, T, Morikawa, N, ...
We describe the first known case of pneumonia caused by a mucoid Stenotrophomonas maltophilia (Xanthomonas maltophilia) strain in a patient with bronchiectasis. The patient was admitted because of...
Nested polymerase chain reaction for detection of Mycobacterium tuberculosis in clinical samples.
Miyazaki, Y, Koga, H, Kohno, S, Kaku, M
The nested polymerase chain reaction technique was compared with the conventional smear and culture methods for detection of Mycobacterium tuberculosis. The nested polymerase chain reaction used in...
Hirakata, Y, Furuya, N, Tateda, K, Kaku, M, Yamaguchi, K
We have examined the production of Pseudomonas aeruginosa exotoxin A (ETA) and its role in endogenous bacteremia in mice. Mice given P. aeruginosa D4 orally died of bacteremia between days 10 and 13...
Mizukane, R, Hirakata, Y, Kaku, M, Ishii, Y, Furuya, N, Ishida, K, ...
The inhibitory effects of azithromycin (AZM), a new 15-membered macrolide antibiotic, on the production of exotoxin A, total protease, elastase, and phospholipase C by Pseudomonas aeruginosa were...
In vitro and in vivo activities of sparfloxacin against Mycoplasma pneumoniae.
Kaku, M, Ishida, K, Irifune, K, Mizukane, R, Takemura, H, Yoshida, R, ...
The in vitro and in vivo activities of sparfloxacin against Mycoplasma pneumoniae were compared with those of erythromycin, levofloxacin, ofloxacin, and minocycline. The MICs of sparfloxacin,...
In vitro and in vivo activities of macrolides against Mycoplasma pneumoniae.
Ishida, K, Kaku, M, Irifune, K, Mizukane, R, Takemura, H, Yoshida, R, ...
We investigated the in vitro and in vivo activities of macrolides against Mycoplasma pneumoniae. In vitro MICs of azithromycin, erythromycin, clarithromycin, and roxithromycin were determined....
Enhanced superoxide anion release from phagocytes by muramyl dipeptide or lipopolysaccharide.
Kaku, M, Yagawa, K, Nagao, S, Tanaka, A
Muramyl dipeptide (MDP) and lipopolysaccharide (LPS) from Escherichia coli were tested for the ability to influence superoxide anion (O2-) release from guinea pig phagocytes. Both MDP and LPS alone...
Kanemitsu, K., Kunishima, H., Hatta, M., Inden, K., Saga, T., Ouchi, H., ...
RAISUS is a system for rapid bacterial identification and antimicrobial susceptibility testing. RAISUS and VITEK showed 97.8% and 75.9% agreement in identification of 45 Staphylococcus aureus strains...
Numata, Y., Saito, K., Yamano, Y., Yasuoka, Y., Kaku, M.
研究概要:To develop new vegetation indices algorithm, some vegetation parameters which are Vegetation Coverage (VC), Leaf Area Index (LAI) and Absorbed Photosynthetically Active Radiation (APAR)...
Yagawa, K, Kaku, M, Ichinose, Y, Aida, Y, Tomoda, A
Guinea-pig macrophages were pretreated with soluble immune complexes (1 hr, at 37 degrees). By this procedure, the capacity of the cells to produce superoxide anions (O2-) upon stimulation with...