M. Kimura

Lipopolysacharid-induced alterations of sleep in corticotropin-releasing hormone type 2 receptor knockout mice (2009)

Jakubcakova, V., Flachskamm, C., Deussing, J., Kimura, M.

CENTRAL CORTICOTROPIN-RELEASING HORMONE OVEREXPRESSION ENHANCES REM SLEEP IN CONDITIONAL TRANSGENIC MICE (2009)

Kimura, M., Müller-Preuss, P., Lu, A., Wiesner, E., Flachskamm, C., Wurst, W., ...

CRH-R1 AND CRH-R2 ARE INVOLVED DIFFERENTLY IN EFFECTS OF CRH ON SLEEP AND WAKE REGULATION (2009)

Romanowski, C. P., Fenzl, T., Flachskamm, C., Deussing, J. M., Kimura, M.

Circadian rhythms of basal orexin levels in the hypothalamus are not influenced by an impaired corticotropin-releasing hormone receptor type 1 system (2009)

Fenzl, T., Flachskamm, C., Rossbauer, M., Deussing, J. M., Kimura, M.

Second order numerical scheme for motion of polygonal curves with constant area speed (2008)

Benes, M., Kimura, M., Yazaki, S.

We study polygonal analogues of several moving boundary problems and their time discretization which preserves the constant area speed property. We establish various polygonal analogues of geometric...

Fully automated sleep deprivation in mice as a tool in sleep research (vol. 166, pg 229,2007) (2008)

Fenzl, T., Romanowski, C. P. N., Flachskamm, C., Honsberg, K., Boll, E., Hoehne, A., ...

Endotoxin-induced alterations of sleep in corticotropin-releasing hormone type 2 receptor knockout mice (2008)

Jakubcakova, V., Deussing, J. M., Kimura, M.

Depression and sleep: a comparative study on EEG activity after different antidepressant treatments in mice (2008)

Kimura, M., Müller-Preuss, P., Wiesner, E., Höhne, A., Holsboer, F.

CRH-R2 evidently is not involved in effects of CRH on sleep suppression (2008)

Romanowski, C. P., Fenzl, T., Flachskamm, C., Deussing, J. M., Kimura, M.

SLEEP-EEG Characteristics of Antidepressants in the Mouse Model (2008)

Kimura, M.

Sleep/wake behavior in the stress reactivity mouse model - a new animal model to investigate sleep impairments in major depression (2008)

Fenzl, T., Ruschel, J., Touma, C., Romanowski, C. P., Landgraf, R., Kimura, M.

Application of a curvature adjusted method in image segmentation (2007)

Benes, M., Kimura, M., Paus, P., Sevcovic, D., Tsujikawa, T., Yazaki, S.

This article deals with flow of plane curves driven by the curvature and external force. We make use of such a geometric flow for the purpose of image segmentation. A parametric model for evolving...

Fizika i kemija zračenja u terapiji raka teškim ionima (2007)

Krajcar Bronić, I., Kimura, M.

Teški ioni, kao što su ioni ugljika i kisika, ubrajaju se u zračenje visokog linearnog prijenosa energije (LET) i prolaskom kroz tkivo stvaraju karakterističnu raspodjelu deponirane energije...

Management of localized energy in discrete nonlinear transmission lines (2007)

Sato, M., Yasui, S., Kimura, M., Hikihara, T., Sievers, A. J.

The manipulation of locked intrinsic localized modes/discrete breathers is studied experimentally in nonlinear electric transmission line arrays. Introducing a static lattice impurity in the form of...

Cluster structures in Oxygen isotopes (2007)

Furutachi, N., Kimura, M., Doté, A., Kanada-En'yo, Y., Oryu, S.

Cluster structure of 16O,18O and 20O is investigated by the antisymmettrized molecular dynamics (AMD) plus generator coordinate method (GCM). We have found the K^{\pi}=0$_2^+$ and 0$_1^-$ rotational...

Short telomeres in short-lived males: what are the molecular and evolutionary causes? (2007)

Jemielity, S., Kimura, M., Parker, K.M., Parker, J.D., Cao, X.J., Aviv, A., ...

Telomere length regulation is an important aspect of cell maintenance in eukaryotes, since shortened telomeres can lead to a number of defects, including impaired cell division. Although telomere...

First events from the CNGS neutrino beam detected in the OPERA experiment (2007)

Acquafredda, R., Agafonova, N., Ambrosio, M., Anokhina, A., Aoki, S., Ariga, A., ...

The OPERA neutrino detector at the underground Gran Sasso Laboratory (LNGS) was designed to perform the first detection of neutrino oscillations in appearance mode, through the study of nu_mu to...

Genetics of sleep and sleep disorders (2007)

Kimura, M., Winkelmann, J.

Radiation Physics and Chemistry in Heavy-ion Cancer Therapy (2007)

Krajcar Bronic, I., Kimura, M.

Heavy ions, such as carbon and oxygen ions, are classified as high-LET radiations, and produce a characteristic dose-depth distribution different from that of low-LET radiations such as γ-rays,...

Fully automated sleep deprivation in mice as a tool in sleep research (2007)

Fenzl, T., Romanowski, C. P. N., Flachskamm, C., Honsberg, K., Boll, E., Hoehne, A., ...

Role of CRH in stress-related sleep disturbances: a study using site-specific CRH overexpressing mice (2007)

Kimura, M.

REM sleep enhancement in CNS-specific CRH-overexpressing mice (2007)

Kimura, M., Mueller-Preuss, P., Wiesner, E., Flachskamm, C., Lu, A., Deussing, J. M.

Proteomic search for intrcellular binding sites of antidepressants (2007)

Kirmeier, T., Fessler, B., Wochnik-Veltrup, G., Kozany, C., Kimura, M., Hausch, F., ...

Charge-transfer cross sections of H+ ions in collisions with Ne atoms in the energy range below 4.0 keV (2007)

Kusakabe, T., Tawara, H., Kimura, M., Gu, J. P., Buenker, R. J.

Alpha Cluster Structure and Exotic States in a Self-Consistent Model for Light Nuclei (2006)

Maruhn, J. A., Kimura, M., Schramm, S., Horiuchi, H., Tohsaki, A.

In this paper we examine to what extent traces of alpha-clustering can be found in mean-field ground states of $n\alpha$-nuclei from Be8 through Ar36 as well as in some superdeformed states in S32,...

Angular dependence of double electron capture in collisions of C4+ with He Stueckelberg oscillations in the differential cross-section for capture into C2+(1s22s2 1S) (2006)

Pichl, L., Suzuki, R., Kimura, M., Li, Y., Buenker, R.J., Hoshino, M., ...

Charge-transfer processes in collisions of He2+ ions with H2, N2, O2, CO, and CO2 molecules below 4 keV/u (2006)

Kusakabe, T., Miyamoto, Y., Kimura, M., Tawara, H.

Single- and double-charge-transfer cross sections of 3He2+ ions in collisions with N2, O2, CO, and CO2 molecules have been measured in the energy range of 0.20 to 2.7 keV/u. In addition, the same...

CRH-receptor type 1 knockout mice as a tool to explore the role of orexin a in sleep regulation (2006)

Fenzl, T., Flachskamm, C., Müller-Preuss, P., Romanowski, C., Deussing, J., Kimura, M.

Site-specific CRH overexpression alters sleep in transgenic mice (2006)

Kimura, M., Müller-Preuss, P., Wiesner, E., Lu, A., Deussing, J. M.

Neuroendocrine controls of sleep (2006)

Steiger, A., Kimura, M., Kluge, M., Schüssler, P.

Positron binding to alkali-metal hydrides: The role of molecular vibrations (2006)

Gianturco, F.A., Franz, J., Buenker, R.J., Liebermann, H.P., Pichl, L., Rost, J.M., ...

Steric effect in O+/H2 and H+/H2O collisions - Charge transfer in H2O+ and H3O+ collision intermediate systems (2006)

Kimura, M., Pichl, L., Li, Y., Liebermann, H. P., Buenker, R. J., Schneider, I. F.

Proposal of A New Structure Thermal Vacuum Sensor with Diode-Thermistors Combined with a Micro-Air-Bridge Heater (2006)

Kimura, M., Sakurai, F., Ohta, H., Terada, T., Patino Lopez, L., Gomès, S.

A new structure thermal vacuum sensor with two pn junction diodes, Th-A and Th-B, as a high sensitive temperature sensor working like a thermistor and a micro heater formed on a micro air bridge is...

Proposal of A New Structure Thermal Vacuum Sensor with Diode-Thermistors Combined with a Micro-Air-Bridge Heater (2006)

Kimura, M., Sakurai, F., Ohta, H., Terada, T., Patino Lopez, L., Gomès, S.

A new structure thermal vacuum sensor with two pn junction diodes, Th-A and Th-B, as a high sensitive temperature sensor working like a thermistor and a micro heater formed on a micro air bridge is...

Petrology of a new basaltic shergottite: Dhofar 378 (2006)

Ikeda, Y., Kimura, M., Takeda, H., Shimoda, G., Kita, N. T., Morishita, Y., ...

Dipole resonances in light neutron-rich nuclei studied with time-dependent calculations of antisymmetrized molecular dynamics (2005)

Kanada-En'yo, Y, Kimura, M

Superdeformation and clustering in Ca-40 studied with antisymmetrized molecular dynamics (2005)

Kanada-En'yo, Y, Kimura, M

Superdeformation and clustering in $^{40}$Ca studied with Antisymmetrized Molecular Dynamics (2005)

Kanada-En'yo, Y., Kimura, M.

Deformed states in $^{40}$Ca are investigated with a method of antisymmetrized molecular dynamics. Above the spherical ground state, rotational bands arise from a normal deformation and a...

Dipole resonances in light neutron-rich nuclei studied with time-dependent calculations of antisymmetrized molecular dynamics (2005)

Kanada-En'yo, Y., Kimura, M.

In order to study isovector dipole response of neutron-rich nuclei, we have applied a time-dependent method of antisymmetrized molecular dynamics. The dipole resonances in Be, B and C isotopes have...

Development of low noise cantilever deflection sensor for multienvironment frequency-modulation atomic force microscopy (2005)

Fukuma, T, Kimura, M, Kobayashi, K, Matsushige, K, Yamada, H

High Fos expression during the active phase in orexin neurons of a diurnal rodent, Tamias sibiricus barberi (2005)

Kodama, T., Usui, S., Honda, Y., Kimura, M.

CNS-specific overexpression of CRH alters sleep-wake behavior in transgenic mice (2005)

Müller-Preuss, P., Wiesner, E., Lu, A., Deussing, J. M., Kimura, M.

The effects of positron binding and annihilation mechanisms in biomolecules on PET resolution (2005)

Pichl, L., Tachikawa, M., Buenker, R.J., Kimura, M., Rost, J.M.

Direct evidence of a strong isomer effect in electron-impact double ionization of C3H4 (2005)

Scully, S. W. J., Senthil, V., Wyer, J. A., Shah, M. B., Montenegro, E. C., Kimura, M., ...

The electron-impact double ionization of two isomers of C3H4 (allene and propyne) between 25 and 1000 eV has been investigated using time-of-flight mass spectrometry. Unambiguous differences in the...

Proposal of A New Structure Thermal Vacuum Sensor with Diode-Thermistors Combined with a Micro-Air-Bridge Heater (2005)

Kimura, M., Sakurai, F., Ohta, H., Terada, T.

A new structure thermal vacuum sensor with two pn junction diodes, Th-A and Th-B, as a high sensitive temperature sensor working like a thermistor and a micro heater formed on a micro...

Proposal of A New Structure Thermal Vacuum Sensor with Diode-Thermistors Combined with a Micro-Air-Bridge Heater (2005)

Kimura, M., Sakurai, F., Ohta, H., Terada, T.

A new structure thermal vacuum sensor with two pn junction diodes, Th-A and Th-B, as a high sensitive temperature sensor working like a thermistor and a micro heater formed on a micro...

Development of low noise cantilever deflection sensor for multienvironment frequency-modulation atomic force microscopy (2005)

Fukuma, T, Kimura, M, Kobayashi, K, Matsushige, K, Yamada, H

Photoinduced electron transfer in self-assembled monolayers of porphyrin-fullerene dyads on ITO (2005)

Chukharev, V, Vuorinen, T, Efimov, A, Tkachenko, NV, Kimura, M, Fukuzumi, S, ...

Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells (2004)

Sasai,K., Katayama,H., Stenoien,D. L., Fujii,S., Honda,R., Kimura,M., ...

Cluster structure in stable and unstable nuclei (2004)

Kanada-En'yo, Y., Kimura, M., Horiuchi, H.

Cluster structure in stable and unstable nuclei has been studied. We report recent developments of theoretical studies on cluster aspect, which is essential for structure study of light unstable...

A proposal to extend the ICRF to multiple frequencies (2004)

REsch, G. M., Jacobs, D., Jones, D., Lanyi, G., Lowe, S., Naudet, C., ...

A proposal to extend the ICRF to higher frequencies (2004)

Resch, G. M., Jacobs, C., Jones, D., Lanyi, G., Lowe, S., Naudet, C., ...

FeII/MgII Emission Line Ratios of QSOs. II. z>6 Objects (2004)

Iwamuro, F., Kimura, M., Eto, S., Maihara, T., Motohara, K., Yoshii, Y., ...

Near-infrared spectra of four QSOs located at $z>6$ are obtained with the OH-airglow suppressor mounted on the Subaru telescope. The FeII/MgII emission-line ratios of these QSOs are examined by the...

Linking microbial community dynamics to rhizosphere carbon flow in a wetland rice soil (2004)

Lu, Y., Murase, J., Watanabe, A., Sugimoto, A., Kimura, M.

Contribution of plant photosynthates to dissolved organic carbon in a flooded rice soil (2004)

Lu, Y., Watanabe, A., Kimura, M.

Carbon cycling in rice field ecosystems in the context of input, decomposition and translocation of organic materials and the fates of their end products (CO2 and CH4) (2004)

Kimura, M., Murase, J., Lu, Y.

Back-transformation of high-pressure phases in a shock melt vein of an H-chondrite during atmospheric passage: Implications for the survival of high-pressure phases after decompression (2004)

Kimura, M., Chen, M., Yoshida, Y., El Goresy, A., Ohtani, E.

Erratum to "Back-transformation of high-pressure phases in a shock melt vein of an H-chondrite during atmospheric passage: implications for the survival of high-pressure phases after decompression" [Earth Planet. Sci. Lett. 217 (2003) 141–150] (2004)

Kimura, M., Chen, M., Yoshida, T., El Goresy, A., Ohtani, E.

Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells (2004)

Sasai, K., Katayama, H., Stenoien, D. L., Fujii, S., Honda, R., Kimura, M., ...

Porphyrin and fullerene-based artificial photosynthetic materials for photovoltaics (2004)

Imahori, H, Kashiwagi, Y, Hasobe, T, Kimura, M, Hanada, T, Nishimura, Y, ...

Vectorial electron relay at ITO electrodes modified with self-assembled monolayers of ferrocene-porphyrin-fullerene triads and porphyrin-fullerene dyads for molecular photovoltaic devices (2004)

Imahori, H, Kimura, M, Hosomizu, K, Sato, T, Ahn, TK, Kim, SK, ...

Porphyrin and fullerene-based photovoltaic devices (2004)

Imahori, H, Kimura, M, Hosomizu, K, Fukuzumi, S

Clustering in stable and unstable nuclei in $p$-shell and $sd$-shell regions (2003)

Kanada-En'yo, Y., Kimura, M., Horiuchi, H.

According to microscopic calculations with antisymmetrized molecular dynamics, we studied cluster features in stable and unstable nuclei. A variety of structure was found in stable and unstable...

$^{16}{\rm O} + ^{16}{\rm O}$ nature of the superdeformed band of $^{32}{\rm S}$ and the evolution of the molecular structure (2003)

Kimura, M., Horiuchi, H.

The relation between the superdeformed band of $^{32}{\rm S}$ and $^{16}{\rm O} + ^{16}{\rm O}$ molecular bands is studied by the deformed-base antisymmetrized molecular dynamics with the Gogny D1S...

Deformed Base Antisymmetrized Molecular Dynamics and its Application to ^{20}Ne (2003)

Kimura, M.

A new theoretical framework named as deformed base antisymmetrized molecular dynamics that uses the localized triaxially deformed Gaussian as the single particle wave packet is presented. The model...

Observation of Significant Differences in Charge Transfer Between Collisions of H+ Ions With H2 and With D2 Molecules in the High-eV to Low-keV Range (2003)

Kusakabe,T., Kimura,M., Pichl,L., Buenker,R.J., Tawara,H.

Subaru Deep Spectroscopy of the Very Extended Emission-Line Region of NGC 4388: Ram Pressure Stripped Gas Ionized by the Nuclear Radiation (2003)

Yoshida, M., Ohyama, Y., Iye, M., Aoki, K., Kashikawa, N., Sasaki, T., ...

We report here the results of deep optical spectroscopy of the very extended emission-line region (VEELR) found serendipitously around the Seyfert 2 galaxy NGC 4388 in the Virgo cluster using the...

Subaru Deep Survey V. A Census of Lyman Break Galaxies at z=4 and 5 in the Subaru Deep Fields: Photometric Properties (2003)

Ouchi, M., Shimasaku, K., Okamura, S., Furusawa, H., Kashikawa, N., Ota, K., ...

(abridged) We investigate photometric properties of Lyman Break Galaxies (LBGs) at z=3.5-5.2 based on large samples of 2,600 LBGs detected in deep (i'~27) and wide-field (1,200 arcmin^2) images taken...

Subaru Deep Survey VI. A Census of Lyman Break Galaxies at z=4 and 5 in the Subaru Deep Fields: Clustering Properties (2003)

Ouchi, M., Shimasaku, K., Okamura, S., Furusawa, H., Kashikawa, N., Ota, K., ...

We investigate the clustering properties of 2,600 Lyman Break Galaxies (LBGs) at z=3.5-5.2 in two large blank fields, the Subaru Deep Field and the Subaru/XMM Deep Field (600arcmin^2 each). The...

Infrared Spectroscopy of 15 Radio Galaxies at 2 (2003)

Iwamuro, F., Motohara, K., Maihara, T., Kimura, M., Eto, S., Shima, T., ...

Near-infrared spectra of 15 high-redshift radio galaxies (HzRGs) located at $2

Subaru Deep Survey. IV. Discovery of a Large-Scale Structure at Redshift \simeq 5 (2003)

Shimasaku, K., Ouchi, M., Okamura, S., Kashikawa, N., Doi, M., Furusawa, H., ...

We report the discovery of a large-scale structure of Lyman alpha emitters (LAEs) at z=4.86 based on wide-field imaging with the prime-focus camera (Suprime-Cam) on the Subaru telescope. We observed...

Letter to Nature. Artemisinins target the SERCA of plasmodium falciparum (2003)

Eckstein-Ludwig, U., Webb, R.J., East, J.M., Lee, A.G., Kimura, M., ...

Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent antimalarials available1, rapidly killing all asexual stages of Plasmodium falciparum2. Artemisinins are...

Observation of Significant Differences in Charge Transfer Between Collisions of H+ Ions With H2 and With D2 Molecules in the High-eV to Low-keV Range (2003)

Kusakabe, T., Kimura, M., Pichl, L., Buenker, R.J., Tawara, H.

Carbon dynamics of rhizodeposits, root- and shoot-residues in a rice soil (2003)

Lu, Y. H., Watanabe, A., Kimura, M.

Back-transformation of high-pressure phases in a shock melt vein of an H-chondrite during atmospheric passage: Implications for the survival of high-pressure phases after decompression (2003)

Kimura, M., Chen, M., Yoshida, T., El Goresy, A., Ohtani, E.

Experimental study on the distribution of earth pressure and surface settlement through three-dimensional trapdoor tests (2003)

Adachi, T, Kimura, M, Kishida, K

Novel autoantibodies to pituitary gland specific factor 1a in patients with rheumatoid arthritis (2003)

Tanaka, S., Tatsumi, K., Tomita, T., Kimura, M., Takano, T., Yoshikawa, H., ...

Objective. We recently identified a new protein, pituitary gland specific factor 1a (PGSF1a), that is specifically transcribed in the pituitary gland. In our investigation of...

Narrow band imaging in [OIII] and Halpha to search for ICPNe in the Virgo cluster (2002)

Arnaboldi, M., Freeman, K. C., Okamura, S., Yasuda, N., Gerhard, O., Napolitano, N. R., ...

We have identified intracluster planetary nebulae in a Virgo cluster core field by imaging with the Subaru Suprime-Cam through two narrow band filters centered at the redshifted wavelengths of the...

Candidates for Intracluster Planetary Nebulae in the Virgo Cluster based on the Suprime-Cam Narrow-Band Imaging in O[III] and Halpha (2002)

Okamura, S., Yasuda, N., Arnaboldi, M., Freeman, K. C., Ando, H., Doi, M., ...

We have identified 38 candidates of intracluster planetary nebulae (ICPNe) in a $34'\times27'$ field in the core of the Virgo cluster based on the Suprime-Cam imaging through two narrow-band filters...

Evolution of Elliptical Galaxies at z >~ 1 Revealed from a Large, Multicolor Sample of Extremely Red Objects (2002)

Miyazaki, M., Shimasaku, K., Kodama, T., Okamura, S., Furusawa, H., Ouchi, M., ...

We study the evolution of elliptical galaxies at z >~ 1 on the basis of a sample of 247 Extremely Red Objects (EROs) with R-Ks >= 3.35 (AB) and Ks

Searching for dark matter halos in the Suprime-Cam 2 sq deg field (2002)

Miyazaki, S., Hamana, T., Shimasaku, K., Furusawa, H., Doi, M., Hamabe, M., ...

We report the first result of weak gravitational lensing survey on a 2.1 sq deg Rc-band image taken with a wide field camera (Suprime-Cam) on the prime focus of 8.2 m Subaru Telescope. The weak...

Cosmic shear statistics in the Suprime-Cam 2.1 sq deg field: Constraints on Omega_m and sigma_8 (2002)

Hamana, T., Miyazaki, S., Shimasaku, K., Furusawa, H., Doi, M., Hamabe, M., ...

We present measurements of the cosmic shear correlation in the shapes of galaxies in the Suprime-Cam 2.1 deg^2 R_c-band imaging data. As an estimator of the shear correlation originated from the...

Exotic shapes in Ca-40 and Ar-36 studied with Antisymmetrized Molecular Dynamics (2002)

Kanada-En'yo, Y., Kimura, M., Horiuchi, H.

The structures of the ground and excited states of sd-shell nuclei: Ca-40 and Ar-36 were studied with a method of antisymmetrized molecular dynamics. Recently observed rotational bands were described...

Subaru Deep Survey II. Luminosity Functions and Clustering Properties of Lya Emitters at z=4.86 in the Subaru Deep Field (2002)

Ouchi, M., Shimasaku, K., Furusawa, H., Miyazaki, M., Doi, M., Hamabe, M., ...

We report on early results from deep and wide-field narrow-band imaging on a 543 arcmin^2 area of the Subaru Deep Field. We find 87 Lya emitters (LAEs) at z=4.86(+/-0.03) which are photometrically...

Elasticity of Steel and Silica Glass Spheres Under Gas Pressure by RUS (2002)

Ohno, I., Abe, M., Kimura, M., Hanayama, Y., Oda, H.

Elasticity of minerals under high pressure are of great importance from geophysical view point. In order to develop a new method to measure pressure dependence of elastic constants, resonant...

Back transformation of high-pressure phases in shock-melt veins in ordinary chondrites during atmospheric passage (2002)

Kimura, M., Chen, M., El Goresy, A., Ohtani, E.

Statnamic load tests on model piles and their 3D-elastoplastic FEM analyses (2002)

Kimura, M, Boonyatee, T

Numerical prediction of the dynamic behaviors of an RC group-pile foundation (2002)

Zhang, F, Kimura, M

Absolute differential cross sections for electron impact excitation of the 10.8-11.5 eV energy-loss states Of CO2 (2002)

Tanaka, H, Green, Michael, Teubner, Peter, Campbell, Laurence, Brunger, Michael, Buenker, R, ...

http://ezproxy.flinders.edu.au/login?url=http://www.scopus.com/scopus/openurl/link.url?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&svc_val_fmt=info:ofi/fmt:kev:mtx:sch_svc&svc.abstract=yes&rft_id=i...

Absolute differential cross sections for electron impact excitation of the 10.8-11.5 eV energy-loss states Of CO2 (2002)

Tanaka, H, Green, Michael, Teubner, Peter, Campbell, Laurence, Brunger, Michael, Buenker, R, ...

http://ezproxy.flinders.edu.au/login?url=http://www.scopus.com/scopus/openurl/link.url?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&svc_val_fmt=info:ofi/fmt:kev:mtx:sch_svc&svc.abstract=yes&rft_id=i...

Absolute differential cross sections for electron impact excitation of the 10.8-11.5 eV energy-loss states Of CO2 (2002)

Tanaka, H, Green, Michael, Teubner, Peter, Campbell, Laurence, Brunger, Michael, Buenker, R, ...

http://ezproxy.flinders.edu.au/login?url=http://www.scopus.com/scopus/openurl/link.url?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&svc_val_fmt=info:ofi/fmt:kev:mtx:sch_svc&svc.abstract=yes&rft_id=i...

Absolute differential cross sections for electron impact excitation of the 10.8-11.5 eV energy-loss states Of CO2 (2002)

Tanaka, H, Green, Michael, Teubner, Peter, Campbell, Laurence, Brunger, Michael, Buenker, R, ...

http://ezproxy.flinders.edu.au/login?url=http://www.scopus.com/scopus/openurl/link.url?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&svc_val_fmt=info:ofi/fmt:kev:mtx:sch_svc&svc.abstract=yes&rft_id=i...

Absolute differential cross sections for electron impact excitation of the 10.8-11.5 eV energy-loss states Of CO2 (2002)

Tanaka, H, Green, Michael, Teubner, Peter, Campbell, Laurence, Brunger, Michael, Buenker, R, ...

http://ezproxy.flinders.edu.au/login?url=http://www.scopus.com/scopus/openurl/link.url?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&svc_val_fmt=info:ofi/fmt:kev:mtx:sch_svc&svc.abstract=yes&rft_id=i...

Absolute differential cross sections for electron impact excitation of the 10.8-11.5 eV energy-loss states Of CO2 (2002)

Tanaka, H, Green, Michael, Teubner, Peter, Campbell, Laurence, Brunger, Michael, Buenker, R, ...

http://ezproxy.flinders.edu.au/login?url=http://www.scopus.com/scopus/openurl/link.url?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&svc_val_fmt=info:ofi/fmt:kev:mtx:sch_svc&svc.abstract=yes&rft_id=i...

Expression and functional characterization of a Plasmodium falciparum Ca2+-ATPase (PfATP4) belonging to a subclass unique to apicomplexan organisms (2001)

Krishna, S., Woodrow, C., Webb, R., Penny, J., Takeyasu, K., Kimura, M., ...

We have obtained a full-length P type ATPase sequence (PfATP4) encoded by Plasmodium falciparum and expressed PfATP4 in Xenopus laevis oocytes to study its function. Comparison of the hitherto...

Large-scale slope failure and active erosion occurring in the southwest Ryukyu fore-arc area (2001)

T. Matsumoto, M. Kimura, M. Nakamura, T. Ono

The southwestern Ryukyu area east of Taiwan Island is an arcuate boundary between Philippine Sea Plate and Eurasian Plate. The topographic features in the area are characterised by (1) a large-scale...

Large-scale slope failure and active erosion occurring in the southwest Ryukyu fore-arc area (2001)

Matsumoto, T., Kimura, M., Nakamura, M., Ono, T.

The southwestern Ryukyu area east of Taiwan Island is an arcuate boundary between Philippine Sea Plate and Eurasian Plate. The topographic features in the area are characterised by (1) a large-scale...

Large-scale slope failure and active erosion occurring in the southwest Ryukyu fore-arc area (2001)

Matsumoto, T., Kimura, M., Nakamura, M., Ono, T.

The southwestern Ryukyu area east of Taiwan Island is an arcuate boundary between Philippine Sea Plate and Eurasian Plate. The topographic features in the area are characterised by (1) a large-scale...

Observation of the Isomer Effect on Charge Transfer from C3H4 Molecules (Allene and Propyne) at keV Energies (2001)

Kimura, M., Kusakabe, T., Satoh, S., Tawara, H.

Ribosomal protein L5 has a highly twisted concave surface and flexible arms responsible for rRNA binding (2001)

Nakashima, T., Yao, M., Kawamura, S., Iwasaki, K., Kimura, M., Tanaka, I.

Deep-Imaging Observations of a Candidate of an Absorbed QSO at z=0.653, AX J131831+3341 (2000)

Akiyama, M., Ohta, K., Tamura, N., Doi, M., Kimura, M., Komiyama, Y., ...

The results of deep-imaging observations of a candidate of an absorbed QSO at z=0.653, AX J131831+3341, are presented. AX J131831+3341 was found during the course of optical follow-up observations of...

Pair Plasma Dominance in the Parsec-Scale Relativistic Jet of 3C345 (2000)

Hirotani, K., Iguchi, S., Kimura, M., Wajima, K.

We investigate whether a pc-scale jet of 3C345 is dominated by a normal plasma or an electron-positron plasma. We present a general condition that a jet component becomes optically thick for...

Alkoxyalumoxanes (2000)

Inoue, M, Kimura, M, Inui, T

Alkyl derivatives of boehmite having the second stage structure (2000)

Inoue, M, Kimura, M

Anomalous H-chondrites, Y-792947, Y-793408 and Y-82038, with high abundance of refractory inclusions and very low metamorphic grade. (2000)

Kimura, M., Hiyagon, H., Palme, H., Spettel, B., Wolf, D., ...

Second cancers after adjuvant tamoxifen therapy for breast cancer in Japan (2000)

Matsuyama, Y., Tominaga, T., Nomura, Y., Koyama, H., Kimura, M., Sano, M., ...

Background: Women treated with tamoxifen for breast cancer are at increased risk of endometrial cancer. We conducted a retrospective cohort study to evaluate the risk of second primary cancers after...

Evidence for the presence of major peripheral myelin glycoprotein P0 in mammalian spinal cord and a change of its glycosylation state during aging (1999)

Sato, Y, Kimura, M, Yasuda, C, Nakano, Y, Tomita, M, Kobata, A, ...

Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene (1999)

Oka, A, Tamiya, G, Tomizawa, M, Ota, M, Katsuyama, Y, Makino, S, ...

Ternary Alloying of Gamma Titanium-Aluminides for Hot-Workability. (1998)

Masahashi, Naoya, Mizuhara, Y., Matsuo, M., Hashimoto, K., Kimura, M.

A microstructurally controlled gamma(TiAl)-based alloy containing beta(bcc) has shown remarkable tensile properties at high temperature; it exhibits over 450% tensile elongation at 1473 K; the strain...

Antibacterial Activated Carbon Fibre Derived from Phenolic Resin Fibre by Use of Co-Graftpolymerization. (1998)

Oya, A., Kimura, M., Sugo, T., Kataki, A., Abe, Y.

Phenolic-resin fibre was co-graftpolymerized with methyl methacrylate and methacrylic acid. the weight of the fibre increased by 26% after grafting. the grafted fibre was soaked in silver-nitrate...

Thermal Stability and Characterization of Gamma-Al2O3 Modified with Lanthanum or Cerium. (1998)

Ozawa, M., Kimura, M., Isogai, A.

The influence of a modifier, either an alkaline earth or a rare earth element, on the physical properties of a transition-alumina support with a high surface area, has been studied for improving...

Requirement for p56(lck) tyrosine kinase activation in Th subset differentiation (1998)

Yamashita, M, Hashimoto, K, Kimura, M, Kubo, M, Tada, T, Nakayama, T

Cyclophosphamide, adriamycin, 5-fluorouracil and high-dose toremifene for patients with advanced/recurrent breast cancer. The Japan Toremifene Cooperative Study Group (1998)

Tominaga, T, Nomura, Y, Uchino, J, Hirata, K, Kimura, M, Yoshida, M, ...

Despite low plasma renin ACE inhibitor treatment causes recovery from acute renal failure in a patient with malignant Hypertension (1998)

Watanabe, T, Yonemura, K, Fujigaki, Y, Suzuki, T, Motomura, E, Sano, K, ...

Granulocyte-macrophage colony-stimulating factor crosses the blood-- brain and blood--spinal cord barriers (1997)

McLay, RN, Kimura, M, Banks, WA, Kastin, AJ

Molecular cloning of a RNA binding protein, S1-1 (1996)

Inoue, A, Takahashi, KP, Kimura, M, Watanabe, T, Morisawa, S

Surgery for T4 lung cancer: the prognoses of T4 lung cancer (1994)

Kimura, M, Mizumoto, T, Namikawa, S, Yada, I

A Comparison of Genetic Variability in Strains of Japanese Quail Selected for Heavy Body Weight (1992)

Cheng, K. M., Kimura, M., Fujii, S.

Electrophoretic analyses of body tissues from three strains of Japanese quail from the Quail Genetic Stock Centre at the University of British Columbia, two selected for heavy body weight and one...

Angular differential cross sections for the excitation of 11S helium to the 21S and 21P states by 25- to 100-keV-proton impact (1985)

Kvale, T. J., Seely, D. G., Blakenship, D. M., Redd, E., Gay, Timothy J., Kimura, M., ...

Angular differential cross sections for the proton-impact excitation of ground-state helium (11S) to the 21S and 21P states have been measured for the first time in the energy range 25 to 100 keV...

Rare variant alleles in the light of the neutral theory (1983)

Kimura, M

充填層表面よりの物質および熱移動 (1956)

木村, 允, Kimura, M., キムラ, ミツル, Kimura, Mitsuru

Ueber die Behandlung der Nachgeburtsperiode bei den letzten 500 Geburten : a) expectative, b) Expression, c) manuelle Entfernung und deren Erfolge / (1906)

Kimura, M.

Thesis (doctoral)--Ludwig-Maximilians Universität München, 1906.

Steric effect in H2O+ and H3O+ collision complexes

Kimura,M., Pichl,L., Li,Y., Buenker,R.J., Schneider,I.F.

Angular dependence of double electron capture in collisions of C4+ with He

Pichl,L., Suzuki,R., Kimura,M., Li,Y., Buenker,R.J., Hoshino,M., ...

The Effects of Positron Binding and Annihilation Mechanisms in Biomolecules on PET Resolution

Pichl,L., Tachikawa,M., Buenker,R.J., Kimura,M., Rost,J.M.

Role of leptin in hypothalamic–pituitary function

Yu, W. H., Kimura, M., Walczewska, A., Karanth, S., McCann, S. M.

A defect in the structure of the obese gene is responsible for development of obesity in the ob/ob mouse. The product of expression of the gene is the protein hormone leptin. Leptin causes weight...

Limitations of Darwinian selection in a finite population.

Kimura, M

In a finite population, the rate at which favorable mutations at several loci can evolve simultaneously is limited by the reproductive capacity of the species and the effective population number. The...

Genetic alteration of catecholamine specificity in transgenic mice.

Kobayashi, K, Sasaoka, T, Morita, S, Nagatsu, I, Iguchi, A, Kurosawa, Y, ...

Epinephrine-producing cells are characterized by the presence of phenylethanolamine N-methyltransferase (PNMT), which catalyzes the formation of epinephrine from norepinephrine. We generated a line...

Recent development of the neutral theory viewed from the Wrightian tradition of theoretical population genetics.

Kimura, M

In contrast to the Darwinian theory of evolution by natural selection, the neutral theory emphasizes the great importance of random genetic drift (due to finite population size) and mutation pressure...

Molecular clock of viral evolution, and the neutral theory.

Gojobori, T, Moriyama, E N, Kimura, M

Evolution of viral genes is characterized by enormously high speed compared with that of nuclear genes of eukaryotic organisms. In this paper, the evolutionary rates and patterns of base...

Molecular cloning of a RNA binding protein, S1-1.

Inoue, A, Takahashi, K P, Kimura, M, Watanabe, T, Morisawa, S

S1 proteins A-D constitute a nuclear protein family that are liberated rapidly in a set from chromatin by mild digestion with a DNA or RNA hydrolyzing enzyme. With an anti-S1-protein B antiserum that...

Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa.

Nakano, M, Deguchi, T, Kawamura, T, Yasuda, M, Kimura, M, Okano, Y, ...

We determined partial sequences of the gyrA and parC genes of the fluoroquinolone-susceptible strain ATCC 27853 and 22 clinical isolates of Pseudomonas aeruginosa. While a single amino acid change in...

Cloning and characterization of a gene involved in aerial mycelium formation in Streptomyces griseus.

Kudo, N, Kimura, M, Beppu, T, Horinouchi, S

A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) is essentially required for aerial mycelium formation and streptomycin production in Streptomyces griseus. A DNA fragment which induced...

In vitro and in vivo antichlamydial activities of newly developed quinolone antimicrobial agents.

Kimura, M, Kishimoto, T, Niki, Y, Soejima, R

The in vitro and in vivo activities of three newly developed quinolone antimicrobial agents (sparfloxacin, tosufloxacin, and OPC-17116) were investigated. All three agents showed potent in vitro...

Cloning and physical mapping of the dnaA region of the Escherichia coli chromosome.

Miki, T, Kimura, M, Hiraga, S, Nagata, T, Yura, T

The dnaA gene of Escherichia coli K-12, supposedly present in the deoxyribonucleic acid (DNA) of specialized transducing phase lambda i21 dnaA-2, was cloned onto plasmid pBR322. The new plasmid was...

Conditionally lethal amber mutations in the dnaA region of the Escherichia coli chromosome that affect chromosome replication.

Kimura, M, Miki, T, Hiraga, S, Nagata, T, Yura, T

Three amber mutations, dna-801, dna-803, and dna-806, were isolated by localized mutagenesis of the dnaA-oriC region of the chromosome from an Escherichia coli strain carrying temperature-sensitive...

A stochastic model concerning the maintenance of genetic variability in quantitative characters.

Kimura, M

Species-specific PCR detection of malaria parasites by microtiter plate hybridization: clinical study with malaria patients.

Kimura, M, Miyake, H, Kim, H S, Tanabe, M, Arai, M, Kawai, S, ...

A simple and convenient PCR method that amplifies the 18S rRNA genes has been developed for the purpose of detecting and differentiating four species causing malaria in humans. The advantage of the...

Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from southern Vietnam.

Kawamoto, F, Miyake, H, Kaneko, O, Kimura, M, Nguyen, T D, Nguyen, T D, ...

Field surveys of malaria were performed in southern Vietnam by using an acridine orange staining method for rapid diagnosis and a PCR-based, microtiter plate hybridization method for accurate...

Comparative study of penetration of lomefloxacin and ceftriaxone into transudative and exudative pleural effusion.

Kimura, M, Matsushima, T, Nakamura, J, Kobashi, Y

We investigated the transpleural penetration of lomefloxacin (LFLX) and ceftriaxone (CTRX). LFLX (200 mg) was administered orally to three patients with transudative fluid and four with exudative...

Enhancement of resistance to Escherichia coli infection in mice by dihydroheptaprenol, a synthetic polyprenol derivative.

Araki, S, Kagaya, K, Kitoh, K, Kimura, M, Fukazawa, Y

The effect of a chemically synthesized polyprenol derivative, dihydroheptaprenol (DHP), on the nonspecific resistance of mice to infection with Escherichia coli was investigated. Mice that had been...

In vitro and in vivo activities of azithromycin, a new azalide antibiotic, against chlamydia.

Niki, Y, Kimura, M, Miyashita, N, Soejima, R

The in vitro and in vivo activities of azithromycin against chlamydia were investigated. The MIC of azithromycin for five standard strains of different species of chlamydia and six wild-type strains...

Isolation and characterization of Escherichia coli dnaA amber mutants.

Kimura, M, Yura, T, Nagata, T

Specialized transducing phage lambda (formula, see text) dnaA-2 was mutagenized, and two derivatives designated lambda (formula) dnaA17(Am) and lambda (formula) dnaA452(Am) were obtained. They did...

Restoration of myelin formation by a single type of myelin basic protein in transgenic shiverer mice.

Kimura, M, Sato, M, Akatsuka, A, Nozawa-Kimura, S, Takahashi, R, Yokoyama, M, ...

A minigene containing mouse cDNA coding for the smallest type of myelin basic protein and including the native promoter was constructed and used to produce transgenic shiverer mice. The...

A micronucleus-specific sequence exists in the 5'-upstream region of calmodulin gene in Tetrahymena thermophila.

Katoh, M, Hirono, M, Takemasa, T, Kimura, M, Watanabe, Y

Tetrahymena thermophila possesses a transcriptionally inactive micronucleus and an active macronucleus. Both nuclei are developed from micronucleus-derived germ nuclei during conjugation. Extensive...

Estimation of evolutionary distances between homologous nucleotide sequences.

Kimura, M

By using two models of evolutionary base substitutions--"three-substitution-type" and "two-frequency-class" models--some formulae are derived which permit a simple estimation of the evolutionary...

Some calculations on the amount of selfish DNA.

Ohta, T, Kimura, M

A population genetical theory is developed to treat the amount of selfish DNA in a genome. We assume that the selfish DNA consists of replicating units and that it evolves by multiplication within a...

Cloning and sequencing of the gene encoding the ribosomal L7/L12-like protein of Mycobacterium bovis BCG.

Ohara, N, Kimura, M, Wada, N, Yamada, T

The c1 repressor of bacteriophage P1 operator-repressor interaction of wild-type and mutant repressor proteins.

Heinrich, J, Riedel, H D, Baumstark, B R, Kimura, M, Schuster, H

The c1 repressor gene of bacteriophage P1 and the temperature-sensitive mutants P1c1.100 and P1c1.162 was cloned into an expression vector and the repressor proteins were overproduced. A rapid...

Primary structure of Escherichia coli ribosomal protein S1 and of its gene rpsA.

Schnier, J, Kimura, M, Foulaki, K, Subramanian, A R, Isono, K, Wittmann-Liebold, B

The primary structure of proteins S1, the largest protein component of the Escherichia coli ribosome, has been elucidated by determining the amino acid sequence of the protein (from E. coli MRE600)...

Possibility of extensive neutral evolution under stabilizing selection with special reference to nonrandom usage of synonymous codons.

Kimura, M

The rate of evolution in terms of the number of mutant substitutions in a finite population is investigated assuming a quantitative character subject to stabilizing selection, which is known to be...

Metal-binding and detoxification effect of synthetic oligopeptides containing three cysteinyl residues.

Yoshida, A, Kaplan, B E, Kimura, M

Metallothionein is a naturally occurring metal-binding protein with high cysteine content. Oligopeptides containing three cysteinyl residues and having amino acid sequences analogous to portions of...

Fixation of a deleterious allele at one of two "duplicate" loci by mutation pressure and random drift.

Kimura, M, King, J L

We consider a diploid population and assume two gene loci with two alleles each, A and a at one locus and B and b at the second locus. Mutation from wild-type alleles A and B to deleterious alleles a...

Population genetics of multigene family with special reference to decrease of genetic correlation with distance between gene members on a chromosome.

Kimura, M, Ohta, T

A mathematical method is developed which enables us to treat exactly the process of coincidental evolution under mutation, unequal intrachromosomal crossing-over as well as ordinary crossing-over...

Tonically discharging putamen neurons exhibit set-dependent responses.

Kimura, M, Rajkowski, J, Evarts, E

Previous microelectrode recordings in the putamen of monkeys have revealed a class of tonically active neurons without apparent behavioral correlates. The present study shows that such neurons have...

Change of gene frequencies by natural selection under population number regulation.

Kimura, M

By incorporating a population number regulating mechanism into the formulation of genic selection involving a pair of alleles (A1 and A2) with respective frequencies x and I-x, it is shown that the...

Stepwise mutation model and distribution of allelic frequencies in a finite population.

Kimura, M, Ohta, T

A mathematical theory is developed that enables us to derive a formula for the equilibrium distribution of allelic frequencies in a finite population when selectively neutral alleles are produced in...

Effect of overall phenotypic selection on genetic change at individual loci.

Kimura, M, Crow, J F

The selective advantage of an allele Gi (relative to the mean of alleles at this locus) is given by (formula: see text) in which Ai is the average excess of the allele on the character, X; W(X) is...

Theoretical study of genetic variability, assuming stepwise production of neutral and very slightly deleterious mutations.

Maruyama, T, Kimura, M

Mathematical treatments are presented that enable us to compute the amount of genetic variability maintained in a finite population, assuming that mutations occur in stepwise fashion and that both...

Moments for sum of an arbitrary function of gene frequency along a stochastic path of gene frequency change.

Maruyama, T, Kimura, M

A diffusion model is developed to compute any moment of the sum of an arbitrary function of the gene frequency along sample paths between any two specified frequencies. This is used to calculate the...

Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles.

Kimura, M, Ota, T

A formula for the distribution of allelic frequencies in a finite population is derived assuming stepwise production of multiple alleles. Monte Carlo experiments were performed to check the validity...

Cyclic nucleotides attenuate thrombin-evoked alterations in parameters of platelet Na/H antiport. The role of cytosolic Ca.

Kimura, M, Lasker, N, Aviv, A

In this work, we explored the role of cyclic nucleotides in modulating parameters of the Na/H antiport in human platelets. Sodium nitroprusside and iloprost, as well as cyclic nucleotide analogues,...

Clostridium perfringens and other anaerobes isolated from bile.

Sakaguchi, Y, Murata, K, Kimura, M

Clostridium perfringens was isolated from bile in 13 cases of 150 patients examined. The serotypes of C perfringens strains isolated from bile and faeces were investigated using antisera to Hobbs'...

Role of cyclic nucleotides in store-mediated external Ca2+ entry in human platelets.

Nakamura, K, Kimura, M, Aviv, A

This study explores the role of cyclic nucleotides (i.e. cyclic AMP and cyclic GMP) in store-regulated external Ca2+ entry in human platelets. To stimulate store-regulated external Ca2+ entry,...

Cd2+-induced synthesis of metallothionein in HeLa cells.

Koizumi, S, Sone, T, Otaki, N, Kimura, M

HeLa cells synthesize metallothioneins in response to Cd2+. The kinetics of thionein (apoprotein of metallothionein) synthesis was studied by pulse-labelling the cells with [35S]cysteine and...

The three-dimensional structure of the RNA-binding domain of ribosomal protein L2; a protein at the peptidyl transferase center of the ribosome.

Nakagawa, A, Nakashima, T, Taniguchi, M, Hosaka, H, Kimura, M, Tanaka, I

Ribosomal protein L2 is the largest protein component in the ribosome. It is located at or near the peptidyl transferase center and has been a prime candidate for the peptidyl transferase activity....

Metabolism of polycyclic compounds. 26. The hydroxylation of some aromatic hydrocarbons by the ascorbic acid model hydroxylating system and by rat-liver microsomes

Boyland, E., Kimura, M., Sims, P.

Granulocyte/macrophage colony-stimulating factor is an intrinsic keratinocyte-derived growth factor for human melanocytes in UVA-induced melanosis.

Imokawa, G, Yada, Y, Kimura, M, Morisaki, N

Recently we demonstrated that endothelins secreted from human keratinocytes act as intrinsic mitogens and melanogens for human melanocytes in UVB-induced melanosis. We show here that UVA-induced...

Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes.

Imokawa, G, Yada, Y, Kimura, M

To understand the signalling mechanisms involved in the dual stimulatory effects of endothelin-1 (ET-1) on DNA synthesis and melanization in cultured human melanocytes, we analysed the biological...

Biological characterization of human fibroblast-derived mitogenic factors for human melanocytes.

Imokawa, G, Yada, Y, Morisaki, N, Kimura, M

To clarify the paracrine linkage between human fibroblasts and melanocytes in cutaneous pigmentation, we studied the effects of human fibroblast-derived factors on the proliferation of human...

Ribosomal protein L5 has a highly twisted concave surface and flexible arms responsible for rRNA binding.

Nakashima, T, Yao, M, Kawamura, S, Iwasaki, K, Kimura, M, Tanaka, I

Ribosomal protein L5 is a 5S rRNA binding protein in the large subunit and plays an essential role in the promotion of a particular conformation of 5S rRNA. The crystal structure of the ribosomal...

The critical region for Behçet disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping.

Ota, M, Mizuki, N, Katsuyama, Y, Tamiya, G, Shiina, T, Oka, A, ...

The HLA-B51 allele is known to be associated with Behçet disease. Recently, we found a higher risk for Behçet disease in the MICA gene, 46 kb centromeric of HLA-B, by investigation of GCT...

Phorbol 12,13-dibutyrate binding to intact human platelets. The role of cytosolic free Ca2+.

Takaya, J, Kimura, M, Lasker, N, Aviv, A

The role of Ca2+ was examined in regulating the binding of phorbol 12,13-dibutyrate (PdBu) to intact human platelets. Alterations in the cytosolic free Ca2+ concn. [( Ca2+]i), but not extracellular...

Is the SII portion of the cross-bridge in glycerinated rabbit psoas fibers compliant in the rigor state?

Kimura, M, Tawada, K

To see whether the SII portion of the cross-bridge in rigor fibers is longitudinally compliant, we chemically cross-linked with dimethyl suberimidate the entire rod portion (including the SII...

Stiffness of glycerinated rabbit psoas fibers in the rigor state. Filament-overlap relation.

Tawada, K, Kimura, M

The stiffness of glycerinated rabbit psoas fibers in the rigor state was measured at various sarcomere lengths in order to determine the distribution of the sarcomere compliance between the...

Inhibition of Ca2+ entry by Ca2+ overloading of intracellular Ca2+ stores in human platelets.

Kimura, M, Cho, J H, Reeves, J P, Aviv, A

1. This study examined the effect of overloading human platelet intracellular Ca2+ stores on the rate of agonist-evoked external Ca2+ entry. To overload the Ca2+ stores (presumably dense tubules),...

Thapsigargin-evoked changes in human platelet Ca2+, Na+, pH and membrane potential.

Kimura, M, Lasker, N, Aviv, A

1. In this work we explored the effect of thapsigarin on the intracellular Ca2+, pH, Na+ and membrane potential in human platelets. These parameters were monitored using the fluorescent probes...

Springtime peaks of trace metals in Antarctic snow.

Ikegawa, M, Kimura, M, Honda, K, Makita, K, Fujii, Y, Itokawa, Y

Drifting snow samples were collected at Asuka Station (71 degrees 32'S, 24 degrees 08'E, 930 m above sea level) over a period from July to December 1991; 36 elements (including Na, Mg, K, Ca, Fe, Al,...

The Probability of Consanguineous Marriages

Cavalli-Sforza, L. L., Kimura, M., Barrai, I.

Role of leptin in hypothalamic–pituitary function

Yu, W. H., Kimura, M., Walczewska, A., Karanth, S., McCann, S. M.

A defect in the structure of the obese gene is responsible for development of obesity in the ob/ob mouse. The product of expression of the gene is the protein hormone leptin. Leptin causes weight...

Limitations of Darwinian selection in a finite population.

Kimura, M

In a finite population, the rate at which favorable mutations at several loci can evolve simultaneously is limited by the reproductive capacity of the species and the effective population number. The...

Genetic alteration of catecholamine specificity in transgenic mice.

Kobayashi, K, Sasaoka, T, Morita, S, Nagatsu, I, Iguchi, A, Kurosawa, Y, ...

Epinephrine-producing cells are characterized by the presence of phenylethanolamine N-methyltransferase (PNMT), which catalyzes the formation of epinephrine from norepinephrine. We generated a line...

Recent development of the neutral theory viewed from the Wrightian tradition of theoretical population genetics.

Kimura, M

In contrast to the Darwinian theory of evolution by natural selection, the neutral theory emphasizes the great importance of random genetic drift (due to finite population size) and mutation pressure...

Molecular clock of viral evolution, and the neutral theory.

Gojobori, T, Moriyama, E N, Kimura, M

Evolution of viral genes is characterized by enormously high speed compared with that of nuclear genes of eukaryotic organisms. In this paper, the evolutionary rates and patterns of base...

Molecular cloning of a RNA binding protein, S1-1.

Inoue, A, Takahashi, K P, Kimura, M, Watanabe, T, Morisawa, S

S1 proteins A-D constitute a nuclear protein family that are liberated rapidly in a set from chromatin by mild digestion with a DNA or RNA hydrolyzing enzyme. With an anti-S1-protein B antiserum that...

Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa.

Nakano, M, Deguchi, T, Kawamura, T, Yasuda, M, Kimura, M, Okano, Y, ...

We determined partial sequences of the gyrA and parC genes of the fluoroquinolone-susceptible strain ATCC 27853 and 22 clinical isolates of Pseudomonas aeruginosa. While a single amino acid change in...

Cloning and characterization of a gene involved in aerial mycelium formation in Streptomyces griseus.

Kudo, N, Kimura, M, Beppu, T, Horinouchi, S

A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) is essentially required for aerial mycelium formation and streptomycin production in Streptomyces griseus. A DNA fragment which induced...

In vitro and in vivo antichlamydial activities of newly developed quinolone antimicrobial agents.

Kimura, M, Kishimoto, T, Niki, Y, Soejima, R

The in vitro and in vivo activities of three newly developed quinolone antimicrobial agents (sparfloxacin, tosufloxacin, and OPC-17116) were investigated. All three agents showed potent in vitro...

Cloning and physical mapping of the dnaA region of the Escherichia coli chromosome.

Miki, T, Kimura, M, Hiraga, S, Nagata, T, Yura, T

The dnaA gene of Escherichia coli K-12, supposedly present in the deoxyribonucleic acid (DNA) of specialized transducing phase lambda i21 dnaA-2, was cloned onto plasmid pBR322. The new plasmid was...

Conditionally lethal amber mutations in the dnaA region of the Escherichia coli chromosome that affect chromosome replication.

Kimura, M, Miki, T, Hiraga, S, Nagata, T, Yura, T

Three amber mutations, dna-801, dna-803, and dna-806, were isolated by localized mutagenesis of the dnaA-oriC region of the chromosome from an Escherichia coli strain carrying temperature-sensitive...

A stochastic model concerning the maintenance of genetic variability in quantitative characters.

Kimura, M

Species-specific PCR detection of malaria parasites by microtiter plate hybridization: clinical study with malaria patients.

Kimura, M, Miyake, H, Kim, H S, Tanabe, M, Arai, M, Kawai, S, ...

A simple and convenient PCR method that amplifies the 18S rRNA genes has been developed for the purpose of detecting and differentiating four species causing malaria in humans. The advantage of the...

Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from southern Vietnam.

Kawamoto, F, Miyake, H, Kaneko, O, Kimura, M, Nguyen, T D, Nguyen, T D, ...

Field surveys of malaria were performed in southern Vietnam by using an acridine orange staining method for rapid diagnosis and a PCR-based, microtiter plate hybridization method for accurate...

Comparative study of penetration of lomefloxacin and ceftriaxone into transudative and exudative pleural effusion.

Kimura, M, Matsushima, T, Nakamura, J, Kobashi, Y

We investigated the transpleural penetration of lomefloxacin (LFLX) and ceftriaxone (CTRX). LFLX (200 mg) was administered orally to three patients with transudative fluid and four with exudative...

Enhancement of resistance to Escherichia coli infection in mice by dihydroheptaprenol, a synthetic polyprenol derivative.

Araki, S, Kagaya, K, Kitoh, K, Kimura, M, Fukazawa, Y

The effect of a chemically synthesized polyprenol derivative, dihydroheptaprenol (DHP), on the nonspecific resistance of mice to infection with Escherichia coli was investigated. Mice that had been...

In vitro and in vivo activities of azithromycin, a new azalide antibiotic, against chlamydia.

Niki, Y, Kimura, M, Miyashita, N, Soejima, R

The in vitro and in vivo activities of azithromycin against chlamydia were investigated. The MIC of azithromycin for five standard strains of different species of chlamydia and six wild-type strains...

Isolation and characterization of Escherichia coli dnaA amber mutants.

Kimura, M, Yura, T, Nagata, T

Specialized transducing phage lambda (formula, see text) dnaA-2 was mutagenized, and two derivatives designated lambda (formula) dnaA17(Am) and lambda (formula) dnaA452(Am) were obtained. They did...

Restoration of myelin formation by a single type of myelin basic protein in transgenic shiverer mice.

Kimura, M, Sato, M, Akatsuka, A, Nozawa-Kimura, S, Takahashi, R, Yokoyama, M, ...

A minigene containing mouse cDNA coding for the smallest type of myelin basic protein and including the native promoter was constructed and used to produce transgenic shiverer mice. The...

A micronucleus-specific sequence exists in the 5'-upstream region of calmodulin gene in Tetrahymena thermophila.

Katoh, M, Hirono, M, Takemasa, T, Kimura, M, Watanabe, Y

Tetrahymena thermophila possesses a transcriptionally inactive micronucleus and an active macronucleus. Both nuclei are developed from micronucleus-derived germ nuclei during conjugation. Extensive...

Estimation of evolutionary distances between homologous nucleotide sequences.

Kimura, M

By using two models of evolutionary base substitutions--"three-substitution-type" and "two-frequency-class" models--some formulae are derived which permit a simple estimation of the evolutionary...

Some calculations on the amount of selfish DNA.

Ohta, T, Kimura, M

A population genetical theory is developed to treat the amount of selfish DNA in a genome. We assume that the selfish DNA consists of replicating units and that it evolves by multiplication within a...

Cloning and sequencing of the gene encoding the ribosomal L7/L12-like protein of Mycobacterium bovis BCG.

Ohara, N, Kimura, M, Wada, N, Yamada, T

The c1 repressor of bacteriophage P1 operator-repressor interaction of wild-type and mutant repressor proteins.

Heinrich, J, Riedel, H D, Baumstark, B R, Kimura, M, Schuster, H

The c1 repressor gene of bacteriophage P1 and the temperature-sensitive mutants P1c1.100 and P1c1.162 was cloned into an expression vector and the repressor proteins were overproduced. A rapid...

Primary structure of Escherichia coli ribosomal protein S1 and of its gene rpsA.

Schnier, J, Kimura, M, Foulaki, K, Subramanian, A R, Isono, K, Wittmann-Liebold, B

The primary structure of proteins S1, the largest protein component of the Escherichia coli ribosome, has been elucidated by determining the amino acid sequence of the protein (from E. coli MRE600)...

Possibility of extensive neutral evolution under stabilizing selection with special reference to nonrandom usage of synonymous codons.

Kimura, M

The rate of evolution in terms of the number of mutant substitutions in a finite population is investigated assuming a quantitative character subject to stabilizing selection, which is known to be...

Metal-binding and detoxification effect of synthetic oligopeptides containing three cysteinyl residues.

Yoshida, A, Kaplan, B E, Kimura, M

Metallothionein is a naturally occurring metal-binding protein with high cysteine content. Oligopeptides containing three cysteinyl residues and having amino acid sequences analogous to portions of...

Fixation of a deleterious allele at one of two "duplicate" loci by mutation pressure and random drift.

Kimura, M, King, J L

We consider a diploid population and assume two gene loci with two alleles each, A and a at one locus and B and b at the second locus. Mutation from wild-type alleles A and B to deleterious alleles a...

Population genetics of multigene family with special reference to decrease of genetic correlation with distance between gene members on a chromosome.

Kimura, M, Ohta, T

A mathematical method is developed which enables us to treat exactly the process of coincidental evolution under mutation, unequal intrachromosomal crossing-over as well as ordinary crossing-over...

Tonically discharging putamen neurons exhibit set-dependent responses.

Kimura, M, Rajkowski, J, Evarts, E

Previous microelectrode recordings in the putamen of monkeys have revealed a class of tonically active neurons without apparent behavioral correlates. The present study shows that such neurons have...

Change of gene frequencies by natural selection under population number regulation.

Kimura, M

By incorporating a population number regulating mechanism into the formulation of genic selection involving a pair of alleles (A1 and A2) with respective frequencies x and I-x, it is shown that the...

Stepwise mutation model and distribution of allelic frequencies in a finite population.

Kimura, M, Ohta, T

A mathematical theory is developed that enables us to derive a formula for the equilibrium distribution of allelic frequencies in a finite population when selectively neutral alleles are produced in...

Effect of overall phenotypic selection on genetic change at individual loci.

Kimura, M, Crow, J F

The selective advantage of an allele Gi (relative to the mean of alleles at this locus) is given by (formula: see text) in which Ai is the average excess of the allele on the character, X; W(X) is...

Theoretical study of genetic variability, assuming stepwise production of neutral and very slightly deleterious mutations.

Maruyama, T, Kimura, M

Mathematical treatments are presented that enable us to compute the amount of genetic variability maintained in a finite population, assuming that mutations occur in stepwise fashion and that both...

Moments for sum of an arbitrary function of gene frequency along a stochastic path of gene frequency change.

Maruyama, T, Kimura, M

A diffusion model is developed to compute any moment of the sum of an arbitrary function of the gene frequency along sample paths between any two specified frequencies. This is used to calculate the...

Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles.

Kimura, M, Ota, T

A formula for the distribution of allelic frequencies in a finite population is derived assuming stepwise production of multiple alleles. Monte Carlo experiments were performed to check the validity...

Cyclic nucleotides attenuate thrombin-evoked alterations in parameters of platelet Na/H antiport. The role of cytosolic Ca.

Kimura, M, Lasker, N, Aviv, A

In this work, we explored the role of cyclic nucleotides in modulating parameters of the Na/H antiport in human platelets. Sodium nitroprusside and iloprost, as well as cyclic nucleotide analogues,...

Clostridium perfringens and other anaerobes isolated from bile.

Sakaguchi, Y, Murata, K, Kimura, M

Clostridium perfringens was isolated from bile in 13 cases of 150 patients examined. The serotypes of C perfringens strains isolated from bile and faeces were investigated using antisera to Hobbs'...

Role of cyclic nucleotides in store-mediated external Ca2+ entry in human platelets.

Nakamura, K, Kimura, M, Aviv, A

This study explores the role of cyclic nucleotides (i.e. cyclic AMP and cyclic GMP) in store-regulated external Ca2+ entry in human platelets. To stimulate store-regulated external Ca2+ entry,...

Cd2+-induced synthesis of metallothionein in HeLa cells.

Koizumi, S, Sone, T, Otaki, N, Kimura, M

HeLa cells synthesize metallothioneins in response to Cd2+. The kinetics of thionein (apoprotein of metallothionein) synthesis was studied by pulse-labelling the cells with [35S]cysteine and...

Phorbol 12,13-dibutyrate binding to intact human platelets. The role of cytosolic free Ca2+.

Takaya, J, Kimura, M, Lasker, N, Aviv, A

The role of Ca2+ was examined in regulating the binding of phorbol 12,13-dibutyrate (PdBu) to intact human platelets. Alterations in the cytosolic free Ca2+ concn. [( Ca2+]i), but not extracellular...

Inhibition of Ca2+ entry by Ca2+ overloading of intracellular Ca2+ stores in human platelets.

Kimura, M, Cho, J H, Reeves, J P, Aviv, A

1. This study examined the effect of overloading human platelet intracellular Ca2+ stores on the rate of agonist-evoked external Ca2+ entry. To overload the Ca2+ stores (presumably dense tubules),...

The three-dimensional structure of the RNA-binding domain of ribosomal protein L2; a protein at the peptidyl transferase center of the ribosome.

Nakagawa, A, Nakashima, T, Taniguchi, M, Hosaka, H, Kimura, M, Tanaka, I

Ribosomal protein L2 is the largest protein component in the ribosome. It is located at or near the peptidyl transferase center and has been a prime candidate for the peptidyl transferase activity....

Thapsigargin-evoked changes in human platelet Ca2+, Na+, pH and membrane potential.

Kimura, M, Lasker, N, Aviv, A

1. In this work we explored the effect of thapsigarin on the intracellular Ca2+, pH, Na+ and membrane potential in human platelets. These parameters were monitored using the fluorescent probes...

Metabolism of polycyclic compounds. 26. The hydroxylation of some aromatic hydrocarbons by the ascorbic acid model hydroxylating system and by rat-liver microsomes

Boyland, E., Kimura, M., Sims, P.

The Probability of Consanguineous Marriages

Cavalli-Sforza, L. L., Kimura, M., Barrai, I.

Granulocyte/macrophage colony-stimulating factor is an intrinsic keratinocyte-derived growth factor for human melanocytes in UVA-induced melanosis.

Imokawa, G, Yada, Y, Kimura, M, Morisaki, N

Recently we demonstrated that endothelins secreted from human keratinocytes act as intrinsic mitogens and melanogens for human melanocytes in UVB-induced melanosis. We show here that UVA-induced...

Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes.

Imokawa, G, Yada, Y, Kimura, M

To understand the signalling mechanisms involved in the dual stimulatory effects of endothelin-1 (ET-1) on DNA synthesis and melanization in cultured human melanocytes, we analysed the biological...

Biological characterization of human fibroblast-derived mitogenic factors for human melanocytes.

Imokawa, G, Yada, Y, Morisaki, N, Kimura, M

To clarify the paracrine linkage between human fibroblasts and melanocytes in cutaneous pigmentation, we studied the effects of human fibroblast-derived factors on the proliferation of human...

Ribosomal protein L5 has a highly twisted concave surface and flexible arms responsible for rRNA binding.

Nakashima, T, Yao, M, Kawamura, S, Iwasaki, K, Kimura, M, Tanaka, I

Ribosomal protein L5 is a 5S rRNA binding protein in the large subunit and plays an essential role in the promotion of a particular conformation of 5S rRNA. The crystal structure of the ribosomal...

The critical region for Behçet disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping.

Ota, M, Mizuki, N, Katsuyama, Y, Tamiya, G, Shiina, T, Oka, A, ...

The HLA-B51 allele is known to be associated with Behçet disease. Recently, we found a higher risk for Behçet disease in the MICA gene, 46 kb centromeric of HLA-B, by investigation of GCT...

Is the SII portion of the cross-bridge in glycerinated rabbit psoas fibers compliant in the rigor state?

Kimura, M, Tawada, K

To see whether the SII portion of the cross-bridge in rigor fibers is longitudinally compliant, we chemically cross-linked with dimethyl suberimidate the entire rod portion (including the SII...

Stiffness of glycerinated rabbit psoas fibers in the rigor state. Filament-overlap relation.

Tawada, K, Kimura, M

The stiffness of glycerinated rabbit psoas fibers in the rigor state was measured at various sarcomere lengths in order to determine the distribution of the sarcomere compliance between the...

Springtime peaks of trace metals in Antarctic snow.

Ikegawa, M, Kimura, M, Honda, K, Makita, K, Fujii, Y, Itokawa, Y

Drifting snow samples were collected at Asuka Station (71 degrees 32'S, 24 degrees 08'E, 930 m above sea level) over a period from July to December 1991; 36 elements (including Na, Mg, K, Ca, Fe, Al,...

The effective number of a population with overlapping generations: a correction and further discussion.

Crow, J F, Kimura, M

Steric effect in H2O+ and H3O+ collision complexes

Kimura, M., Pichl, L., Li, Y., Buenker, R.J., Schneider, I.F.

A novel immunosuppressant, FTY720, increases the efficiency of a superantigen-induced peripheral T-cell deletion whilst inhibiting negative selection in the thymus.

Shimizu, C, Li, X, Kimura, M, Hashimoto, K, Sugaya, K, Kubo, M, ...

A novel immunosuppressant, FTY720, was generated by chemical modification of ISP-I, an immunosuppressive compound purified from culture filtrates of Isaria sinclairii. FTY720 directly induces...

A crucial role of the thymus in induction by the lprcg gene of lymphadenopathy with autoimmunity in the mouse.

Matsuzawa, A, Moriyama, T, Ogata, Y, Katagiri, T, Kimura, M

The new mutation at the lpr locus, lprcg, induces massive lymphoproliferation characterized by the selective expansion of CD4-, CD8-, B220+, Thy-1+ cells or double-negative T lymphocytes and...

Characterization of intermediate T-cell receptor cells expanding in the liver, thymus and other organs in autoimmune lpr mice: parallel analysis with their normal counterparts.

Iiai, T, Kimura, M, Kawachi, Y, Hirokawa, K, Watanabe, H, Hatakeyama, K, ...

Autoimmune MRL-lpr/lpr (lpr) mice were previously demonstrated to have an abnormal proliferation of intermediate T-cell receptor (TCR) cells of extrathymic origin in the liver. Despite this...

Nephritogenicity of the lprcg gene on the MRL background.

Kimura, M, Ogata, Y, Shimada, K, Wakabayashi, T, Onoda, H, Katagiri, T, ...

The novel lymphoproliferative and autoimmune lprcg gene, originally discovered in the CBA/K1Jms (CBA) strain of mice, was transferred onto the MRL/MpJ (MRL) strain background, and the resultant...

An immunoelectron microscopic study of immunoglobulin G in the postcapillary venules of normal and nude mouse lymph nodes.

Kimura, M

Ultrastructural localization of immunoglobulin G (IgG) in the postcapillary venules (PVC) of normal and nude mouse lymph nodes was examined in thin sections which had been stained sequentially with...

Changes in the incidence and prevalence of rheumatoid arthritis in Kamitonda, Wakayama, Japan, 1965-1996

Shichikawa, K., Inoue, K., Hirota, S., Maeda, A., Ota, H., Kimura, M., ...

OBJECTIVE—To evaluate secular trends in the incidence and prevalence of rheumatoid arthritis (RA) in Japan.
METHODS—The incidence and prevalence of RA were determined in a longitudinal...

Genetic evidence for the effect of a postglacial population expansion on the phylogeography of a North American songbird.

Milá, B, Girman, D J, Kimura, M, Smith, T B

Phylogeographical studies of Nearctic songbirds conducted to date have yielded unexpectedly low levels of genetic differentiation and weak phylogeographical structure in mitochondrial DNA lineages as...

Transforming and differentiation-inducing potential of constitutively activated c-kit mutant genes in the IC-2 murine interleukin-3-dependent mast cell line.

Hashimoto, K., Tsujimura, T., Moriyama, Y., Yamatodani, A., Kimura, M., Tohya, K., ...

Two mutations of c-kit receptor tyrosine kinase (KIT), valine-559 to glycine (G559) and aspartic acid-814 to valine (V814), resulted in its constitutive activation. To examine the transforming and...

Intramesangial passage of mononuclear phagocytes in murine lupus glomerulonephritis.

Kimura, M., Nagase, M., Hishida, A., Honda, N.

By repeated biopsies, time-sequential changes of the injected colloidal carbon distribution were investigated in glomeruli of NZB/W F1 mice. The intraglomerular shift of the carbon, evaluated by...

Intraocular irrigating solutions and barrier function of retinal pigment epithelium

Araie, M., Kimura, M.

AIM—To study the effect of intraocular irrigating solutions on the barrier property of the retinal pigment epithelium (RPE).
METHODS—The isolated rabbit RPE-choroid mounted on Ussing-type...

Serological and histological characterization of the new mutant strain of lpr mice, CBA/KlJms-lprcg/lprcg.

Kimura, M, Mohri, H, Shimada, K, Wakabayashi, T, Kanai, Y, Matsuzawa, A

CBA/KlJms-lprcg/lprcg mice with a novel mutation producing systemic lymphoproliferation were investigated for their serological and histological characteristics. The mutant mice showed elevated...

Injection of mouse thyroglobulin and/or adult thymectomy do not break tolerance to thyroglobulin during the lupus like graft versus host disease in mice.

Kong, Y M, Rose, N R, Kimura, M, Gleichmann, E

In a previous paper (Gleichmann, van Elven & van der Veen, 1982), it had been reported that, in contrast to lupus like autoantibodies such as anti-DNA, autoantibodies to mouse thyroglobulin (MTg)...

Specificity of anti-nuclear antibodies induced in F1 mice undergoing the graft-vs-host reaction: isotypes and cross-reactivities.

Kimura, M, Ida, S, Shimada, K, Kanai, Y

(C57BL/6 X DBA/2)F1 mice undergoing the graft-vs-host reaction (GVHR) produce autoantibodies after the injection of DBA/2 lymphoid cells. The anti-nuclear antibodies, including anti-poly (ADP-ribose)...

Requirement of H-2-subregion differences for graft-versus-host autoimmunity in mice: superiority of the differences at class-II H-2 antigens (I-A/I-E).

Kimura, M, Gleichmann, E

The effect of various H-2-subregion differences on graft-versus-host (GVH) autoimmunity in mice was investigated by testing a variety of GVH combinations in which non-irradiated adult F1 hybrid mice...

Differences in cytokine production by peripheral blood mononuclear cells (PBMC) between patients with atopic dermatitis and bronchial asthma

Kimura, M, Tsuruta, S, Yoshida, T

It is widely accepted that type 2 helper T (Th2) lymphocytes play a crucial role in the pathogenesis of atopic dermatitis (AD) as well as bronchial asthma (BA). We measured the amounts of IL-5 and...

A pivotal role of cell-bound but not soluble CD4 molecules in full development of lupus-like manifestations in MRL-Faslprcg/Faslprcg mice

Zhang, Y, Yasuda, T, Wang, C R, Yoshimoto, T, Nagase, H, Takamoto, M, ...

The role of CD4 molecules in the autoimmune and lymphoproliferative syndrome caused by murine Fas mutations was studied using the novel systemic lupus erythematosus (SLE) model, MRL-Faslprcg/Faslprcg...

Postsynaptic nicotinic receptor desensitized by non-contractile Ca2+ mobilization via protein kinase-C activation at the mouse neuromuscular junction.

Kimura, I, Dezaki, K, Tsuneki, H, Kimura, M

1. Non-contractile Ca2+ mobilization (unaccompanied by muscle contraction) was initiated by nerve stimulation in the presence of neostigmine (more than 0.03 microM) at the endplate region of mouse...

Effects of tetrodotoxin on relaxation of pig duodenal circular muscle induced by C-terminal fragments of cholecystokinin.

Kimura, I., Kondoh, T., Kimura, M.

1. The mechanisms by which cholecystokinin (CCK)-C-terminal peptides relax the isolated duodenal circular muscles of pigs were compared with mechanisms involving high potassium and electrical...

Cytosolic calcium increase in coronary endothelial cells after H2O2 exposure and the inhibitory effect of U78517F.

Kimura, M., Maeda, K., Hayashi, S.

1. Cytosolic calcium concentrations ([Ca2+]i) were determined with fura-2 on both resting (unstimulated) and A23187-stimulated coronary endothelial cells following injury by hydrogen peroxide (H2O2)....

Cellular mechanism of U78517F in the protection of porcine coronary artery endothelial cells from oxygen radical-induced damage.

Maeda, K., Kimura, M., Hayashi, S.

1. The aim of this study was to clarify the role of lipid peroxidation in cellular injury as assessed by lactate dehydrogenase (LDH) release from cultured coronary artery endothelial cells of the...

Indirect inhibitory effect of succinylcholine on acetylcholine-activated channel activities and its modulation by external Ca2+ in mouse skeletal muscles.

Nojima, H., Muroi, M., Kimura, I., Kimura, M.

1. The effect of extracellular calcium on single acetylcholine (ACh)-activated channel activities when desensitizing concentrations of succinylcholine (SuCh) were applied to the surrounding endplate...

Accelerated desensitization of nicotinic receptor channels and its dependence on extracellular calcium in isolated skeletal muscles of streptozotocin-diabetic mice.

Nojima, H., Tsuneki, H., Kimura, I., Kimura, M.

1. To elucidate the influence of the diabetic state on desensitization of nicotinic acetylcholine (ACh) receptor channels, we investigated the time course of the decrease in amplitude of ACh...

Diabetic state-induced rapid inactivation of noncontractile Ca2+ mobilization operated by nicotinic acetylcholine receptor in mouse diaphragm muscle.

Kimura, I., Tsuneki, H., Dezaki, K., Kimura, M.

1. Diabetic modifications of nicotinic receptor-operated noncontractile Ca2- mobilization observed in the presence of anticholinesterase were investigated by measuring Ca(2+)-aequorin luminescence in...

Enhancement by calcitonin gene-related peptide of non-contractile Ca2(+)-induced nicotinic receptor desensitization at the mouse neuromuscular junction.

Dezaki, K., Kimura, I., Tsuneki, H., Kimura, M.

1. Nicotinic acetylcholine receptor (AChR)-operated non-contractile Ca2+ mobilization (unaccompanied by muscle contraction) depressed contractile Ca2+ mobilization (accompanied by muscle contraction)...

Inhibitory effects of fluvastatin, a new HMG-CoA reductase inhibitor, on the increase in vascular ACE activity in cholesterol-fed rabbits.

Mitani, H., Bandoh, T., Ishikawa, J., Kimura, M., Totsuka, T., Hayashi, S.

1. The effects of fluvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on the vascular angiotensin converting enzyme (ACE) activity in hyperlipidaemic rabbits were...

Modification by dantrolene, procaine and suxamethonium of caffeine-induced changes in aequorin luminescence transients and twitch tensions of directly-stimulated diaphragm muscle of mouse.

Kimura, I., Kimura, M., Kimura, M.

A convenient method is described for measuring simultaneously Ca2+-related aequorin luminescence and twitch tension in the isolated diaphragm muscle of the mouse. Forty to fifty fibres were injected...

Potassium induces relaxation and hyperpolarization of circular muscles but contraction of longitudinal muscles of pig duodenum.

Kimura, I., Kimura, M., Kimura, M.

The mechanisms by which K+ relaxes circular muscles of pig duodenum were investigated, and compared with the response of the longitudinal muscles to K+. Circular muscles were...

Stereoselective 4′-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese

Ieiri, I., Mamiya, K., Urae, A., Wada, Y., Kimura, M., Irie, S., ...

Aims The aim of this study was to clarify whether phenytoin (PHT) stereoselective hydroxylation cosegregates with (S)-mephenytoin phenotype.

Enhancement by calcitonin gene-related peptide of nicotinic receptor-operated noncontractile Ca2+ mobilization at the mouse neuromuscular junction.

Kimura, I., Tsuneki, H., Dezaki, K., Kimura, M.

1. The involvement of calcitonin gene-related peptide (CGRP) in the mechanism of nicotinic acetylcholine receptor-operated noncontractile Ca2+ mobilization (not accompanied by twitch tension) was...

Partial atrial resection in advanced lung carcinoma with and without cardiopulmonary bypass.

Shirakusa, T, Kimura, M

Combined pneumonectomy and partial resection of the left atrium was performed in 12 patients with advanced lung carcinoma (T3 and T4 in the new UICC classification). In the eight patients with a T3...

An unusual phenotype of McLeod syndrome with late onset axonal neuropathy

Wada, M, Kimura, M, Daimon, M, Kurita, K, Kato, T, Johmura, Y, ...

Quantitative evaluation of anterior tibial translation during isokinetic motion in knees with anterior cruciate ligament reconstruction using either patellar or hamstring tendon grafts

Sato, N., Higuchi, H., Terauchi, M., Kimura, M., Takagishi, K.

We studied 79 patients with unilateral injury to the anterior cruciate ligament (ACL). The patients were randomly allocated to reconstruction with autologous patellar bone-tendon-bone (BTB) grafts...

Changes in biochemical parameters after anterior cruciate ligament injury

Higuchi, H., Shirakura, K., Kimura, M., Terauchi, M., Shinozaki, T., Watanabe, H., ...

We studied the biochemical characteristics of human knees with deficient anterior cruciate ligaments (ACL) and analysed their relationship to the time after ligamentous injury. Thirty-two patients...

Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer.

Katagiri, A., Tomita, Y., Nishiyama, T., Kimura, M., Sato, S.

P-glycoprotein (Pgp) and pi-class glutathione S-transferase (GSTP1-1) are thought to be correlated with multiple drug resistance. In immunohistochemical staining, non-seminomatous germ cell tumours,...

Development of insusceptibility to serum factor during the radiation transformation process.

Terasima, T., Yasukawa, M., Kimura, M.

Significance of epidermal growth factor receptor and c-erbB-2 protein expression in transitional cell cancer of the upper urinary tract for tumour recurrence at the urinary bladder.

Imai, T., Kimura, M., Takeda, M., Tomita, Y.

An immunohistochemical study of the expression of epidermal growth factor receptor (EGFR) and c-erbB-2 protein was performed in fresh-frozen sections from 30 patients with transitional cell cancers...

Correlation between integrin alpha 5 expression and the malignant phenotype of transitional cell carcinoma.

Saito, T., Kimura, M., Kawasaki, T., Sato, S., Tomita, Y.

We examined the expression of alpha 1, alpha 2, alpha 3, alpha 4, alpha 5 and beta 1 integrin on 36 transitional cell cancers (TCCs) in the bladder by immunohistochemistry. Only alpha 2, alpha 3 and...

Combination therapy with PEG-IFN-α and 5-FU inhibits HepG2 tumour cell growth in nude mice by apoptosis of p53

Hagiwara, S, Kudo, M, Nakatani, T, Sakaguchi, Y, Nagashima, M, Fukuta, N, ...

When the tumour suppressor p53 is activated by DNA damage, it stimulates the transcription of its target genes, which then induce cell cycle arrest or apoptosis. Here, we examined the role p53 plays...

A possible involvement of aberrant expression of the FHIT gene in the carcinogenesis of squamous cell carcinoma of the uterine cervix

Nakagawa, S, Yoshikawa, H, Kimura, M, Kawana, K, Matsumoto, K, Onda, T, ...

To investigate involvement of an aberrant expression of the FHIT (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by...

Significance of serum-soluble CD95 (Fas/APO-1) on prognosis in renal cell cancer patients

Kimura, M, Tomita, Y, Imai, T, Saito, T, Katagiri, A, Tanikawa, T, ...

Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population‐based study

Zhai, G, Aviv, A, Hunter, D J, Hart, D J, Gardner, J P, Kimura, M, ...