Scientific Commons: M. Kiso

The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin (2001)

Fotinou, C, Emsley, P, Black, I, Ando, H, Ishida, H, Kiso, M, ...

Gangliosides are neuronal ligands for myelin-associated glycoprotein.

Yang, L J, Zeller, C B, Shaper, N L, Kiso, M, Hasegawa, A, Shapiro, R E, ...

Nerve cells depend on specific interactions with glial cells for proper function. Myelinating glial cells are thought to associate with neuronal axons, in part, via the cell-surface adhesion protein,...

Structural requirements for the carbohydrate ligand of E-selectin.

Tyrrell, D, James, P, Rao, N, Foxall, C, Abbas, S, Dasgupta, F, ...

The acute inflammatory response requires that circulating leukocytes adhere to, and then migrate through, the vascular wall at the site of injury or infection. Several receptors have been implicated...

Expression of endotoxic activities by synthetic monosaccharide lipid A analogs with alkyl-branched acyl substituents.

Matsuura, M, Shimada, S, Kiso, M, Hasegawa, A, Nakano, M

Synthetic monosaccharide lipid A analogs with alkyl-branched acyl substituents instead of the usual ester-branched acyl substituents were investigated for their biological activities. The activities...

Importance of fatty acid substituents of chemically synthesized lipid A-subunit analogs in the expression of immunopharmacological activity.

Kumazawa, Y, Nakatsuka, M, Takimoto, H, Furuya, T, Nagumo, T, Yamamoto, A, ...

The immunopharmacological activities of chemically synthesized lipid A-subunit analogs, 4-O-phosphono-D-glucosamine derivatives carrying different N- and 3-O-linked acyl groups, were investigated....

Requirement of a properly acylated beta(1-6)-D-glucosamine disaccharide bisphosphate structure for efficient manifestation of full endotoxic and associated bioactivities of lipid A.

Takahashi, I, Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Shiba, T, ...

Several synthetic acylated glucosamine monophosphates, with structures corresponding to the nonreducing or reducing moiety of the lipid A of the Escherichia coli or Salmonella minnesota type, and a...

Structural requirements of muramylpeptides for induction of necrosis at sites primed with Mycobacterium tuberculosis in guinea pigs.

Nagao, S, Takada, H, Yagawa, K, Kutsukake, H, Shiba, T, Kusumoto, S, ...

Intracutaneous injection of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) in guinea pigs caused an extensive necrotic reaction in footpads prepared by injection of heat-killed Mycobacterium...

Enhancement of immunoglobulin G responses in mice against hepatitis B virus surface antigen, influenza virus hemagglutinin vaccine, and tetanus toxoid by 6-O-acylated muramyl dipeptides.

Furuya, T, Kumazawa, Y, Takimoto, H, Nagumo, T, Watanabe, M, Aizawa, C, ...

The adjuvant activity of chemically synthesized 6-O-acylated muramyl dipeptides (MDP) was tested in aqueous form. The activity was assessed by determining immunoglobulin G (IgG) titers in sera of...

Immunopharmacological activities of 2-keto-3-deoxyoctonic acid-(alpha 2----6)-linked 4-O-phosphono-D-glucosamine derivatives carrying N- and 3-O-acyl substituents.

Kumazawa, Y, Matsuura, M, Homma, J Y, Furuya, T, Takimoto, H, Inagaki, K, ...

The immunopharmacological activities of 2-keto-3-deoxyoctonic acid (KDO)-(alpha 2----6)-linked lipid A-subunit analogs, 4-O-phosphono-D-glucosamine derivatives carrying N- and 3-O-acyl substituents,...

Adjuvant activity of carbohydrate analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine in guinea pigs.

Azuma, I, Okumura, H, Saiki, I, Kiso, M, Hasegawa, A, Tanio, Y, ...

The adjuvant activity of 29 kinds of carbohydrate analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine was...

Two different sialidases, KDN-sialidase and regular sialidase in the starfish Asterina pectinifera.

Yuziuk, J A, Nakagawa, H, Hasegawa, A, Kiso, M, Li, S C, Li, Y T

We have found the coexistence of two different sialidases in the entrails of the starfish Asterina pectinifera: a regular sialidase (RS), which cleaves sialic acid from sialoglycoconjugates, and a...

Sulphatide binds to human and animal influenza A viruses, and inhibits the viral infection.

Suzuki, T, Sometani, A, Yamazaki, Y, Horiike, G, Mizutani, Y, Masuda, H, ...

We found, by using a virus overlay assay, that influenza A virus isolates bind to sulphatide (HSO3-Gal beta 1-->1'Cer), which has no sialic acid residue, and that the infection of Madin-Darby canine...