Scientific Commons: M. Konrad

Photoproduction of eta-mesons off nuclei for Eg < 2.2 GeV (2008)

Mertens, T., Jaegle, I., Muehlich, P., Bacelar, J. C. S., Bantes, B., Bartholomy, O., ...

Photoproduction of $\eta$ mesons off $^{12}$C, $^{40}$Ca, $^{93}$Nb, and $^{nat}$Pb nuclei has been measured with a tagged photon beam with energies between 0.6 and 2.2 GeV. The experiment was...

Linearly polarised photon beams at ELSA and measurement of the beam asymmetry in pi^0-photoproduction off the proton (2008)

Elsner, D., Bantes, B., Bartholomy, O., Bayadilov, D. E., Beck, R., Beloglazov, Y. A., ...

At the electron accelerator ELSA a linearly polarised tagged photon beam is produced by coherent bremsstrahlung off a diamond crystal. Orientation and energy range of the linear polarisation can be...

Quasi-free photoproduction of eta-mesons of the neutron (2008)

Jaegle, I., Mertens, T., Anisovich, A. V., Bacelar, J. C. S., Bantes, B., Bartholomy, O., ...

Quasi-free photoproduction of eta-mesons off nucleons bound in the deuteron has been measured with the CBELSA/TAPS detector for incident photon energies up to 2.5 GeV at the Bonn ELSA accelerator....

Modification of the $\omega$-Meson Lifetime in Nuclear Matter (2008)

Kotulla, M., Trnka, D., Mühlich, P., Anton, G., Bacelar, J. C. S., Bartholomy, O., ...

The photo production of $\omega$ mesons on the nuclei C, Ca, Nb and Pb has been measured using the Crystal Barrel/TAPS detector at the ELSA tagged photon facility in Bonn. The dependence of the...

Ultra short yeast tropomyosins show novel myosin regulation. (2008)

Maytum, R., Hatch, V., Konrad, M., Lehmann, W., Geeves, M. A.

Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues. (2008)

McSorley, T., Ort, S., Hazra, S., Lavie, A., Konrad, M.

Structural basis for substrate promiscuity of dCK. (2008)

Sabini, E., Hazra, S., Ort, S., Konrad, M., Lavie, A.

Co-regulation of yeast purine and phosphate pathways in response to adenylic nucleotide variations. (2008)

Gauthier, S., Coulpier, F., Jourdren, L., Merle, M., Beck, S., Konrad, M., ...

Restoration of the antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cells. (2008)

Lavie, A., Su, Y., Ghassemi, M., Novak, R. M., Caffrey, M., Sekulic, N., ...

Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase. (2008)

Sabini, E., Hazra, S., Konrad, M., Lavie, A.

N* and Delta* decays into N pi0 pi0 (2007)

Thoma, U., Fuchs, M., Anisovich, A. V., Anton, G., Bantes, R., Bartholomy, O., ...

Decays of baryon resonances in the second and the third resonance region into N pi0 pi0 are studied by photoproduction of two neutral pions off protons. Partial decay widths of N* and Delta*...

Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase (2007)

Sabini, E., Hazra, S., Konrad, M., Burley, S. K., Lavie, A.

Elucidation of the active conformation of the APS-kinase domain of human PAPS synthetase 1 (2007)

Sekulic, N., Dietrich, K., Paarmann, I., Ort, S., Konrad, M., Lavie, A.

Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy (2007)

Sato, T., Neschadim, A., Konrad, M., Fowler, D. H., Lavie, A., Medin, J. A.

Binding of ATP to TK1-like enzymes is associated with a conformational change in the quaternary structure (2007)

Segura-Pena, D., Lutz, S., Monnerjahn, C., Konrad, M., Lavie, A.

Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-Nucleosides (2007)

Sabini, E., Hazra, S., Konrad, M., Lavie, A.

Structural mechanism for substrate inhibition of the adenosine 5'-phosphosulfate kinase domain of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 and its ramifications for enzyme regulation (2007)

Sekulic, N., Konrad, M., Lavie, A.

Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes (2007)

Segura-Pena, D., Lichter, J., Trani, M., Konrad, M., Lavie, A., Lutz, S.

Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: Illuminating the role of main-chain reorganization. (2006)

Godsey, M. H., Ort, S., Sabini, E., Konrad, M., Lavie, A.

Engineering of nucleoside kinases to improve the activation of nucleoside analog prodrugs (2006)

Konrad, M., Ort, S., Monnerjahn, C., Lavie, A.

Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine (2006)

Malito, E., Sekulic, N., Too, W. C. S., Konrad, M., Lavie, A.

Development of a novel lentivirus-based suicide gene therapy approach using modified human thymidylate monophosphate kinase (2006)

Sato, T., Neschadim, A., Rasaiah, V., Konrad, M., Lavie, A., Medin, J. A.

Mutations in the Tight-Junction Gene Claudin 19 (CLDN19) Are Associated with Renal Magnesium Wasting, Renal Failure, and Severe Ocular Involvement (2006)

Konrad, M, Schaller, A, Seelow, D, Pandey, AV, Waldegger, S, Lesslauer, A, ...

Claudins are major components of tight junctions and contribute to the epithelial-barrier function by restricting free diffusion of solutes through the paracellular pathway. We have mapped a new...

Bacterial motility measured by fluorescence correlation spectroscopy, and its relationship to heat capacity anomalies in the membrane (2005)

Heimburg, T., Hac, A. E., Pollakowski, D., Konrad, M.

A novel suicide gene therapy approach for reduction of GvHD using lentiviral delivery of a modified human thymidylate monophosphate kinase (2005)

Sato, T., Neschadim, A., Rasaiah, V., Konrad, M., Fowler, D. H., Lavie, A., ...

Improved suicide gene therapy: Lentiviral gene transfer of equine herpes virus type 4 thymidine kinase into target cells (2005)

Sato, T., Neschadim, A., Rasaiah, V., Konrad, M., Fowler, D. H., Lavie, A., ...

Expressing engineered thymidylate kinase variants in human cells to improve AZT phosphorylation and human immunodeficiency virus inhibition (2005)

Wohrl, B. M., Loubiere, L., Brundiers, R., Goody, R. S., Klatzmann, D., Konrad, M.

Observation of In-Medium Modifications of the Omega Meson (2005)

Trnka, D., Anton, G., Bacelar, J. C. S., Bartholomy, O., Bayadilov, D., Beloglazov, Y. A., ...

This version is available at the following Publisher URL: http://prl.aps.org

Neutral-pion photoproduction off protons in the energy range 0.3 GeV kleiner E(gamma) kleiner 3 GeV (2005)

Bartholomy, O., Crede, V., Anisovich, A., Anton, G., Bantes, R., Beloglazov, Y. A., ...

This version is available at the following Publisher URL: http://prl.aps.org

Photoproduction of eta mesons off protons for 0.75 GeV kleiner E(gamma) kleiner 3 GeV (2005)

Crede, V., Bartholomy, O., Anisovich, A., Anton, G., Bantes, R., Beloglazov, Y. A., ...

This version is available at the following Publisher URL: http://prl.aps.org

Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase (2004)

Lavie, A., Konrad, M.

Tropomyosin exon 6b is troponin-specific and required for correct acto-myosin regulation (2004)

Maytum, R., Bathe, F., Konrad, M., Geeves, M. A.

Substrate-induced conformational changes in human UMP/CMP kinase (2004)

Segura-Pena, D., Sekulic, N., Ort, S., Konrad, M., Lavie, A.

Structural characterization of the closed conformation of mouse guanylate kinase (2004)

Sekulic, N., Shuvalova, L., Spangenberg, O., Konrad, M., Lavie, A.

Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase (2004)

Lavie, A., Konrad, M.

Substrate-induced conformational changes in human UMP/CMP kinase. (2004)

Segura, D., Sekulic, N., Ort, S., Konrad, M., Lavie, A.

Hereditary Hypokalemic Salt-losing Tubular Disorders (2003)

Peters, M, Konrad, M, Seyberth, HW

Blind Chip-Rate Equalisation for DS-CDMA Downlink Receiver (2003)

Weiss, S, Hadef, M, Konrad, M, Rupp, M

A dispersive channel in the DS-CDMA downlink destroys the orthogonality of the synchronous users' spreading sequences. In this paper, we aim to re-establish this orthogonality blindly by means of a...

Blind Chip-Rate Equalisation for DS-CDMA Downlink Receiver (2003)

Weiss, S, Hadef, M, Konrad, M, Rupp, M

A dispersive channel in the DS-CDMA downlink destroys the orthogonality of the synchronous users' spreading sequences. In this paper, we aim to re-establish this orthogonality blindly by means of a...

Blind Chip-Rate Equalisation for DS-CDMA Downlink Receiver (2003)

Weiss, S, Hadef, M, Konrad, M, Rupp, M

A dispersive channel in the DS-CDMA downlink destroys the orthogonality of the synchronous users' spreading sequences. In this paper, we aim to re-establish this orthogonality blindly by means of a...

Modulated nucleoside kinases as tools to improve the activation of therapeutic nucleoside analogues (2003)

Monnerjahn, C., Konrad, M.

The use of nucleoside anaolgues in anticancer and antiviral treatments is often impaired by the slow intracellular activation of these drugs. This problem can be addressed by the modulation of...

Structures of human thymidylate kinase in complex with prodrugs: Implications for the structure-based design of novel compounds (2003)

Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, C., Konrad, M., ...

Nucleoside analogue prodrugs are dependent on efficient intracellular stepwise phosphorylation to their triphosphate form to become therapeutically active. In many cases it is this activation pathway...

Liposomes for microcompartmentation of enzymes and their influence on catalytic activity (2003)

Wichmann, C., Naumann, P. T., Spangenberg, O., Konrad, M., Mayer, F., Hoppert, M.

Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases (2003)

Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.

Structure of human dCK suggests strategies to improve anticancer and antiviral therapy (2003)

Sabini, E., Ort, S., Monnerjahn, C., Konrad, M., Lavie, A.

Blind Chip-Rate Equalisation for DS-CDMA Downlink Receiver (2003)

Weiss, S, Hadef, M, Konrad, M, Rupp, M

A dispersive channel in the DS-CDMA downlink destroys the orthogonality of the synchronous users' spreading sequences. In this paper, we aim to re-establish this orthogonality blindly by means of a...

Structural characterization of the closed conformation of mouse guanylate kinase (2002)

Sekulic, N., Shuvalova, L., Spangenberg, O., Konrad, M., Lavie, A.

Guanylate kinase (GMPK) is a nucleoside monophosphate kinase that catalyzes the reversible phosphoryl transfer from ATP to GMP to yield ADP and GDP. In addition to phosphorylating GMP, antiviral...

Formation of complexes between Ca2+center dot calmodulin and the synapse-associated protein SAP97 requires the SH3 domain- guanylate kinase domain-connecting HOOK region (2002)

Paarmann, I., Spangenberg, O., Lavie, A., Konrad, M.

Mammalian synapse-associated protein SAP97, a structural and functional homolog of Drosophila Dlg, is a membrane-associated guanylate kinase (MAGUK) that is present at pre- and postsynaptic sites as...

Structural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domains (2002)

Li, Y., Spangenberg, O., Paarmann, I., Konrad, M., Lavie, A.

CASK is a member of the membrane-associated guanylate kinases (MAGUK) homologs, a family of proteins that scaffold protein complexes at particular regions of the plasma membrane by utilizing multiple...

Structural and catalytic properties and homology modelling of the human nucleoside diphosphate kinase C, product of the DRnm23 gene. (2001)

Erent, M., Gonin, P., Cherfils, J., Tissier, P., Raschellà, G., Giartosio, A., ...

YLR 209 c encodes Saccharomyces cerevisiae purine nucleoside phosphorylase. (2001)

Lecoq, K., Belloc, I., Desgranges, C., Konrad, M., Daignan-Fornier, B.

Regulatory properties of tropomyosin effects of length, isoform, and N-terminal sequence. (2001)

Maytum, R., Konrad, M., Lehrer, S. S., Geeves, M. A.

Cloning of the guanylate kinase homologues AGK-1 and AGK-2 from Arabidopsis thaliana and characterization of AGK-1. (2000)

Kumar, V., Spangenberg, O., Konrad, M.

Yeast GMP kinase mutants constitutively express AMP biosynthesis genes by phenocopying a hypoxanthine-guanine phosphoribosyltransferase defect. (2000)

Lecoq, K., Konrad, M., Daignan-Fornier, B.

Actomyosin regulatory properties of yeast tropomyosin are dependent upon N-terminal modification. (2000)

Maytum, R., Geeves, M. A., Konrad, M.

Potentiating AZT activation: Structure of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP. (2000)

Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reinstein, J., ...

Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate. (2000)

Ostermann, N., Schlichting, I., Brundiers, R., Konrad, M., Reinstein, J., Veit, T., ...

Modifying human thymidylate kinase to potentiate AZT activation. (1999)

Brundiers, R., Lavie, A., Veit, T., Reinstein, J., Schlichting, I., Ostermann, N., ...

Binding of nucleotides to guanylate kinase, p21ras, and nucleoside-diphosphate kinase studied by nano-electrospray mass spectrometry. (1999)

Prinz, H., Lavie, A., Scheidig, A. J., Spangenberg, O., Konrad, M.

Human nucleoside diphosphate kinase B (Nm23-H2) from melanoma cells shows altered phosphoryl transfer activity due to the S122P mutation. (1999)

Schaertl, S., Geeves, M. A., Konrad, M.

RADC (Rome Air Development Center) System/Software Requirements Engineering Testbed Research and Development Program. (1998)

Balzer, R., Konrad, M., Ramamoorthy, C. V., Royce, W., Rzepka, W.

This report defines a ten-year R&D program for requirements engineering. The program will assist in the development of a Requirements Engineering Testbed of tools and methodologies for defining...

Transient kinetic studies on phosphoryl transfer reactions of human nucleoside diphosphate kinase. (1998)

Schaertl, S., Konrad, M., Geeves, M. A.

Functional analysis of the guanylate kinase-like domain in the synapse-associated protein SAP97. (1998)

Kuhlendahl, S., Spangenberg, O., Konrad, M., Kim, E., Garner, C. C.

Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5′-adenosyl)P5-(5′-thymidyl) pentaphosphate (TP5A) at 2.0 Å resolution: Implications for catalysis and AZT activation. (1998)

Lavie, A., Konrad, M., Brundiers, R., Goody, R. S., Schlichting, I., Reinstein, J.

Structural basis for efficient phosphorylation of 3′-azidothymidine monophosphate by Escherichia coli thymidylate kinase. (1998)

Lavie, A., Ostermann, N., Brundiers, R., Goody, R. S., Reinstein, J., Konrad, M., ...

A hyperprostaglandin E syndrome mutation in Kir1.1 (renal outer medullary potassium) channels reveals a crucial residue for channel function in Kir1.3 channels. (1998)

Derst, C., Wischmeyer, E., Preisig-Mueller, R., Spauschus, A., Konrad, M., Hensen, P., ...

Mutations in the gene encoding the inwardly-rectifying renal potassium channel, ROMK, cause the antenatal variant of Barrter syndrome : evidence for genetic heterogeneity (1997)

Hebert, S.C., Madrigal, G., Wright, C.J., Guay-Woodford, L.M., Monnens, L.A.H., ...