Langdahl, B.L., Uitterlinden, A.G., Ralston, S.H., Trikalinos, T.A., Balcells, S., Brandi, M.L., ...
INTRODUCTION: The TGFB1 gene which encodes transforming growth factor beta 1, is a strong candidate for susceptibility to osteoporosis and several studies have reported associations between bone...
Non-compliance: the Achilles' heel of anti-fracture efficacy (2007)
Seeman, E., Compston, J., Adachi, J., Brandi, M.L., Cooper, C., Wson-Hughes, B., ...
About 50% of patients fail to comply or persist with anti-osteoporosis treatment regimens within 1 year. Poor compliance is associated with higher fracture rates. Causes of poor compliance are...
Functional estrogen receptors in a human preosteoclastic cell line.
Fiorelli, G, Gori, F, Petilli, M, Tanini, A, Benvenuti, S, Serio, M, ...
The primary biological effect of the estrogen estradiol-17 beta (17 beta E2) on bone is to decrease bone resorption. However, whether 17 beta E2 affects osteoclast differentiation or function...
Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms.
Brandi, M L, Hukkanen, M, Umeda, T, Moradi-Bidhendi, N, Bianchi, S, Gross, S S, ...
Nitric oxide (NO) produces rapid osteoclast detachment and contraction in vitro, and this effect is accompanied by a profound inhibition of bone resorption. Work by others has confirmed these...
Endothelin as an autocrine factor in the regulation of parathyroid cells.
Fujii, Y, Moreira, J E, Orlando, C, Maggi, M, Aurbach, G D, Brandi, M L, ...
Endothelin, originally purified from porcine aortic endothelial cells, is widely distributed in tissues and is recognized as a product of epithelial cells, glial cells, and neurons in addition to...
Fattorossi, A, Aurbach, G D, Sakaguchi, K, Cama, A, Marx, S J, Streeten, E A, ...
In a previous report, we described antibodies in autoimmune hypoparathyroidism (AHP) that are cytotoxic for cultured bovine parathyroid cells. In the present study, we show that sera from six AHP...
Cloned endothelial cells from fetal bovine bone.
Streeten, E A, Ornberg, R, Curcio, F, Sakaguchi, K, Marx, S, Aurbach, G D, ...
Primary cell cultures from fetal bovine sternum were developed in Coon's modified Ham's F-12 medium containing 10% Nu-Serum, 1% Ultroser-G, and 200 mg of galactose per liter. Clones were obtained by...
Cell cultures of neuroblasts from rat olfactory epithelium that show odorant responses.
Coon, H G, Curcio, F, Sakaguchi, K, Brandi, M L, Swerdlow, R D
We have developed procedures that permit isolation and propagation of clonal cell cultures from the olfactory epithelium of the 5- to 7-day-old rat that appear to represent the neuroblasts that...
Pollak, M R, Chou, Y H, Marx, S J, Steinmann, B, Cole, D E, Brandi, M L, ...
Neonatal severe hyperparathyroidism is a rare life-threatening disorder characterized by very high serum calcium concentrations (> 15 mg/dl). Many cases have occurred in families with familial...
Functional epithelial cell line cloned from rat parathyroid glands.
Sakaguchi, K, Santora, A, Zimering, M, Curcio, F, Aurbach, G D, Brandi, M L
Primary cultures of rat parathyroid cells were developed in medium containing 5% calf serum, 1% Nutridoma-SP (a serum-free medium supplement from Boehringer Mannheim), and 0.7 mM calcium. The PT-r...
Bovine parathyroid cells: cultures maintained for more than 140 population doublings.
Brandi, M L, Fitzpatrick, L A, Coon, H G, Aurbach, G D
Primary cultures of bovine parathyroid cells were developed using Coon's modified Ham's F-12 medium containing low (0.3 mM) concentrations of calcium and supplements of bovine hypothalamic extract,...
Antibodies cytotoxic to bovine parathyroid cells in autoimmune hypoparathyroidism.
Brandi, M L, Aurbach, G D, Fattorossi, A, Quarto, R, Marx, S J, Fitzpatrick, L A
We utilized a recently developed long-term serum-free culture system for bovine parathyroid cells to detect antibodies in seven patients with autoimmune hypoparathyroidism (AHP). Antibodies were...
Homozygotes for the autosomal dominant neoplasia syndrome (MEN1).
Brandi, M L, Weber, G, Svensson, A, Falchetti, A, Tonelli, F, Castello, R, ...
Families in which both parents are heterozygotes for the same autosomal dominant neoplasia syndrome are extremely unusual. Recently, we had the unique opportunity to evaluate three symptomatic...
Functional estrogen receptors in a human preosteoclastic cell line.
Fiorelli, G, Gori, F, Petilli, M, Tanini, A, Benvenuti, S, Serio, M, ...
The primary biological effect of the estrogen estradiol-17 beta (17 beta E2) on bone is to decrease bone resorption. However, whether 17 beta E2 affects osteoclast differentiation or function...
Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms.
Brandi, M L, Hukkanen, M, Umeda, T, Moradi-Bidhendi, N, Bianchi, S, Gross, S S, ...
Nitric oxide (NO) produces rapid osteoclast detachment and contraction in vitro, and this effect is accompanied by a profound inhibition of bone resorption. Work by others has confirmed these...
Endothelin as an autocrine factor in the regulation of parathyroid cells.
Fujii, Y, Moreira, J E, Orlando, C, Maggi, M, Aurbach, G D, Brandi, M L, ...
Endothelin, originally purified from porcine aortic endothelial cells, is widely distributed in tissues and is recognized as a product of epithelial cells, glial cells, and neurons in addition to...
Fattorossi, A, Aurbach, G D, Sakaguchi, K, Cama, A, Marx, S J, Streeten, E A, ...
In a previous report, we described antibodies in autoimmune hypoparathyroidism (AHP) that are cytotoxic for cultured bovine parathyroid cells. In the present study, we show that sera from six AHP...
Cloned endothelial cells from fetal bovine bone.
Streeten, E A, Ornberg, R, Curcio, F, Sakaguchi, K, Marx, S, Aurbach, G D, ...
Primary cell cultures from fetal bovine sternum were developed in Coon's modified Ham's F-12 medium containing 10% Nu-Serum, 1% Ultroser-G, and 200 mg of galactose per liter. Clones were obtained by...
Cell cultures of neuroblasts from rat olfactory epithelium that show odorant responses.
Coon, H G, Curcio, F, Sakaguchi, K, Brandi, M L, Swerdlow, R D
We have developed procedures that permit isolation and propagation of clonal cell cultures from the olfactory epithelium of the 5- to 7-day-old rat that appear to represent the neuroblasts that...
Pollak, M R, Chou, Y H, Marx, S J, Steinmann, B, Cole, D E, Brandi, M L, ...
Neonatal severe hyperparathyroidism is a rare life-threatening disorder characterized by very high serum calcium concentrations (> 15 mg/dl). Many cases have occurred in families with familial...
Functional epithelial cell line cloned from rat parathyroid glands.
Sakaguchi, K, Santora, A, Zimering, M, Curcio, F, Aurbach, G D, Brandi, M L
Primary cultures of rat parathyroid cells were developed in medium containing 5% calf serum, 1% Nutridoma-SP (a serum-free medium supplement from Boehringer Mannheim), and 0.7 mM calcium. The PT-r...
Bovine parathyroid cells: cultures maintained for more than 140 population doublings.
Brandi, M L, Fitzpatrick, L A, Coon, H G, Aurbach, G D
Primary cultures of bovine parathyroid cells were developed using Coon's modified Ham's F-12 medium containing low (0.3 mM) concentrations of calcium and supplements of bovine hypothalamic extract,...
Antibodies cytotoxic to bovine parathyroid cells in autoimmune hypoparathyroidism.
Brandi, M L, Aurbach, G D, Fattorossi, A, Quarto, R, Marx, S J, Fitzpatrick, L A
We utilized a recently developed long-term serum-free culture system for bovine parathyroid cells to detect antibodies in seven patients with autoimmune hypoparathyroidism (AHP). Antibodies were...
Homozygotes for the autosomal dominant neoplasia syndrome (MEN1).
Brandi, M L, Weber, G, Svensson, A, Falchetti, A, Tonelli, F, Castello, R, ...
Families in which both parents are heterozygotes for the same autosomal dominant neoplasia syndrome are extremely unusual. Recently, we had the unique opportunity to evaluate three symptomatic...
D'Adda, T., Amorosi, A., Bussolati, G., Brandi, M. L., Bordi, C.
The basic fibroblast growth factor-like mitogen detected in the plasma of patients with the multiple endocrine neoplasia type 1 (MEN-1) syndrome was found to have a specific mitogenic effect on...