Dorsal Striatum in Instrumental (2008)
R Eports, M. Becker-hapak, S. S. Mcallister, S. F. Dowdy, H. P. Grill, J. L. Zweier, ...
24. We thank D. Eliezer and T. McGraw for helpful discussions, K. D’Amico and L. Tong for help with data collection at the Advanced Photon Source, and D. Landry for help with the surface plasmon...
FRANZ, M. R., BURKHOFF, D., SPURGEON, H., WEISFELDT, M. L., LAKATTA, E. G.
Monophasic action potential (MAP) recording with non-suction, ‘contact’ electrode catheters has been shown possible and safe during clinical catheterization, but direct validation of this new...
Weisfeldt, M. L., Weiss, J. L., Frederiksen, J. T., Yin, F. C. P.
We initially found that the fall in left ventricular pressure during isovolumic relaxation is exponential and therefore characterized by a time constant (T). To the extent that isovolumic pressure...
Prolonged contraction duration in aged myocardium.
Lakatta, E G, Gerstenblith, G, Angell, C S, Shock, N W, Weisfeldt, M L
Isometric performance at 29degreesC was measured in left ventricular trabeculae carneae from young adult (6-mo) and aged (25-mo) rats (n equals 18 in each group). Active tension and maximal rate of...
Acidosis during early reperfusion prevents myocardial stunning in perfused ferret hearts.
Kitakaze, M, Weisfeldt, M L, Marban, E
Cellular calcium overload figures prominently in the pathogenesis of the contractile dysfunction observed after brief periods of ischemia (myocardial stunning). Because acidosis is known to...
Direct measurement of free radical generation following reperfusion of ischemic myocardium.
Zweier, J L, Flaherty, J T, Weisfeldt, M L
Electron paramagnetic resonance spectroscopy was used to directly measure free radical generation in perfused rabbit hearts. Hearts were freeze-clamped at 77 degrees K during control perfusion, after...
Hemodynamic determinants of the time-course of fall in canine left ventricular pressure.
Weiss, J L, Frederiksen, J W, Weisfeldt, M L
The hemodynamic determinants of the time-course of fall in isovolumic left ventricular pressure were assessed in isolated canine left ventricular preparations. Pressure fall was studied in isovolumic...
Yin, F C, Weisfeldt, M L, Milnor, W R
The diminished cardiac output response to exercise with advancing age may be attributable to intrinsic inability of the old ventricle to respond appropriately and/or to an additional loading imposed...
Kusuoka, H, Porterfield, J K, Weisman, H F, Weisfeldt, M L, Marban, E
Contractile dysfunction in stunned myocardium could result from a decrease in the intracellular free [Ca2+] transient during each beat, a decrease in maximal Ca2+-activated force, or a shift in...
Ciuffo, A A, Ouyang, P, Becker, L C, Levin, L, Weisfeldt, M L
Eight open chest dogs underwent 25 min of coronary occlusion to determine whether brief myocardial ischemia disrupts the normal myocardial inotropic response to sympathetic nervous stimulation. If...
Zweier, J L, Rayburn, B K, Flaherty, J T, Weisfeldt, M L
It has been proposed that oxygen free radicals mediate damage that occurs during postischemic reperfusion. Recombinant human superoxide dismutase (r-h-SOD) has been shown to be effective at reducing...
Prolonged contraction duration in aged myocardium.
Lakatta, E G, Gerstenblith, G, Angell, C S, Shock, N W, Weisfeldt, M L
Isometric performance at 29degreesC was measured in left ventricular trabeculae carneae from young adult (6-mo) and aged (25-mo) rats (n equals 18 in each group). Active tension and maximal rate of...
Acidosis during early reperfusion prevents myocardial stunning in perfused ferret hearts.
Kitakaze, M, Weisfeldt, M L, Marban, E
Cellular calcium overload figures prominently in the pathogenesis of the contractile dysfunction observed after brief periods of ischemia (myocardial stunning). Because acidosis is known to...
Direct measurement of free radical generation following reperfusion of ischemic myocardium.
Zweier, J L, Flaherty, J T, Weisfeldt, M L
Electron paramagnetic resonance spectroscopy was used to directly measure free radical generation in perfused rabbit hearts. Hearts were freeze-clamped at 77 degrees K during control perfusion, after...
Hemodynamic determinants of the time-course of fall in canine left ventricular pressure.
Weiss, J L, Frederiksen, J W, Weisfeldt, M L
The hemodynamic determinants of the time-course of fall in isovolumic left ventricular pressure were assessed in isolated canine left ventricular preparations. Pressure fall was studied in isovolumic...
Yin, F C, Weisfeldt, M L, Milnor, W R
The diminished cardiac output response to exercise with advancing age may be attributable to intrinsic inability of the old ventricle to respond appropriately and/or to an additional loading imposed...
Kusuoka, H, Porterfield, J K, Weisman, H F, Weisfeldt, M L, Marban, E
Contractile dysfunction in stunned myocardium could result from a decrease in the intracellular free [Ca2+] transient during each beat, a decrease in maximal Ca2+-activated force, or a shift in...
Ciuffo, A A, Ouyang, P, Becker, L C, Levin, L, Weisfeldt, M L
Eight open chest dogs underwent 25 min of coronary occlusion to determine whether brief myocardial ischemia disrupts the normal myocardial inotropic response to sympathetic nervous stimulation. If...
Zweier, J L, Rayburn, B K, Flaherty, J T, Weisfeldt, M L
It has been proposed that oxygen free radicals mediate damage that occurs during postischemic reperfusion. Recombinant human superoxide dismutase (r-h-SOD) has been shown to be effective at reducing...
Transseptal pressure gradient with leftward septal displacement during the Mueller manoeuvre in man.
Guzman, P A, Maughan, W L, Yin, F C, Eaton, L W, Brinker, J A, Weisfeldt, M L, ...
Septal displacement is postulated as an important mediator of ventricular interdependence. During acute right ventricular loading with the Mueller manoeuvre the septum flattens and shifts leftward....
Role of sublingual nitroglycerin in patients with acute myocardial infarction.
Delgado, C E, Pitt, B, Taylor, D R, Weisfeldt, M L, Kelly, D T
Fourteen patients with acute myocardial infarction were given 0.3 mg sublingual nitroglycerin within the first 12 hours of their acute myocardial infarction. Five minutes after sublingual...