M. Laskowski

SEPARATION OF ENVIRONMENTAL FROM CHROMOPHORE-SPECIFIC INFORMATION CONTAINED IN ULTRAVIOLET SOLUTION SPECTRA (1966)

Laskowski, Jr. M., Tilley, George L.

Author Institution: Chemistry Department, Purdue University

A reinvestigation of a synthetic peptide (TrPepz) designed to mimic trypsin.

Wells, J A, Fairbrother, W J, Otlewski, J, Laskowski, M, Burnier, J

Recently, a 29-residue cyclic peptide was synthesized (TrPepz) that was reported to possess nearly the same catalytic activity and specificity as the pancreatic serine protease, trypsin, for...

Refined crystal structure of the molecular complex of Streptomyces griseus protease B, a serine protease, with the third domain of the ovomucoid inhibitor from turkey.

Fujinaga, M, Read, R J, Sielecki, A, Ardelt, W, Laskowski, M, James, M N

We have determined the crystal structure of the molecular complex between Streptomyces griseus protease B (SGPB), a bacterial serine protease, and the third domain of the ovomucoid inhibitor from...

A reinvestigation of a synthetic peptide (TrPepz) designed to mimic trypsin.

Wells, J A, Fairbrother, W J, Otlewski, J, Laskowski, M, Burnier, J

Recently, a 29-residue cyclic peptide was synthesized (TrPepz) that was reported to possess nearly the same catalytic activity and specificity as the pancreatic serine protease, trypsin, for...

Refined crystal structure of the molecular complex of Streptomyces griseus protease B, a serine protease, with the third domain of the ovomucoid inhibitor from turkey.

Fujinaga, M, Read, R J, Sielecki, A, Ardelt, W, Laskowski, M, James, M N

We have determined the crystal structure of the molecular complex between Streptomyces griseus protease B (SGPB), a bacterial serine protease, and the third domain of the ovomucoid inhibitor from...

Binding of amino acid side chains to preformed cavities: interaction of serine proteinases with turkey ovomucoid third domains with coded and noncoded P1 residues.

Bigler, T. L., Lu, W., Park, S. J., Tashiro, M., Wieczorek, M., Wynn, R., ...

In the association of serine proteinases with their cognate substrates and inhibitors an important interaction is the fitting of the P1 side chain of the substrate or inhibitor into a preformed...

Water molecules participate in proteinase-inhibitor interactions: crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with Streptomyces griseus proteinase B.

Huang, K., Lu, W., Anderson, S., Laskowski, M., James, M. N.

Crystal structures of the complexes of Streptomyces griseus proteinase B (SGPB) with three P1 variants of turkey ovomucoid inhibitor third domain (OMTKY3), Leu18, Ala18, and Gly18, have been...

Deleterious effects of beta-branched residues in the S1 specificity pocket of Streptomyces griseus proteinase B (SGPB): crystal structures of the turkey ovomucoid third domain variants Ile18I, Val18I, Thr18I, and Ser18I in complex with SGPB.

Bateman, K. S., Anderson, S., Lu, W., Qasim, M. A., Laskowski, M., James, M. N.

Turkey ovomucoid third domain (OMTKY3) is a canonical inhibitor of serine proteinases. Upon complex formation, the inhibitors fully exposed P1 residue becomes fully buried in the preformed cavity of...