Ouali, M, Gousset, H, Geinguenaud, F, Liquier, J, Gabarro-Arpa, J, Le Bret, M, ...
We present a comparative analysis of the water organization around the dTn.dAn x dTn triple helix and the Watson-Crick double helix dTn.dAn respectively by means of gravimetric measurements, infrared...
Stability of G,A triple helices.
Debin, A, Laboulais, C, Ouali, M, Malvy, C, Le Bret, M, Svinarchuk, F
In this work we selected double-stranded DNA sequences capable of forming stable triplexes at 20 or 50 degrees C with corresponding 13mer purine oligonucleotides. This selection was obtained by a...
The pH dependent configurations of the C.A mispair in DNA.
Boulard, Y, Cognet, J A, Gabarro-Arpa, J, Le Bret, M, Sowers, L C, Fazakerley, G V
The structure of the cytosine-adenine mispair in a 7 base pair duplex has been investigated by proton NMR spectroscopy. At low pH, the predominant structure is protonated on the A residue and assumes...
Revet, B, Malinge, J M, Delain, E, Le Bret, M, Leng, M
The antitumor drug cis-diamminedichloroplatinum (II) (cis-Pt) forms bidentate adducts with guanine residues of poly(dG-dC).poly(dG-dC). The secondary structure of the polymer is altered. In this...
Fossé, P, René, B, Le Bret, M, Paoletti, C, Saucier, J M
Various antitumor drugs stabilize DNA topoisomerase II-DNA transient covalent complexes. The complexes distribution along pBR322 DNA was shown previously to depend upon the nature of the drug (Tewey...
Boulard, Y, Gabarro-Arpa, J, Cognet, J A, Le Bret, M, Guy, A, Téoule, R, ...
We have determined by two-dimensional nuclear magnetic resonance studies and molecular mechanics calculations the three-dimensional solution structure of a 21 residue oligonucleotide capable of...
Cognet, J A, Gabarro-Arpa, J, Le Bret, M, Van Der Marel, G A, Van Boom, J H, Fazakerley, G V
We have determined by two-dimensional nuclear magnetic resonance studies and molecular mechanics calculations the three dimensional solution structure of the non-selfcomplementary oligonucleotide,...
Le Bret, M, Le Pecq, J B, Barbet, J, Roques, B P
The rate of energy transfer between DNA intercalated ethidium cations calculated by Paoletti and Le Pecq1 using the Forster theory differs from the measured one by a factor of twenty two, if the...
DNA polyintercalating drugs: DNA binding of diacridine derivatives.
Le Pecq, J B, Le Bret, M, Barbet, J, Roques, B
As a first step in the synthesis and the study of DNA polyintercalating drugs, dimers of acridines have been prepared. Their DNA binding properties have been studied. It has been determined that when...
HIV-1 integrase catalytic core: molecular dynamics and simulated fluorescence decays.
Laboulais, C, Deprez, E, Leh, H, Mouscadet, J F, Brochon, J C, Le Bret, M
Two molecular dynamics simulations have been carried out on the HIV-1 integrase catalytic core starting from fully determined crystal structures. During the first one, performed in the absence of...
Ouali, M, Gousset, H, Geinguenaud, F, Liquier, J, Gabarro-Arpa, J, Le Bret, M, ...
We present a comparative analysis of the water organization around the dTn.dAn x dTn triple helix and the Watson-Crick double helix dTn.dAn respectively by means of gravimetric measurements, infrared...
Stability of G,A triple helices.
Debin, A, Laboulais, C, Ouali, M, Malvy, C, Le Bret, M, Svinarchuk, F
In this work we selected double-stranded DNA sequences capable of forming stable triplexes at 20 or 50 degrees C with corresponding 13mer purine oligonucleotides. This selection was obtained by a...
The pH dependent configurations of the C.A mispair in DNA.
Boulard, Y, Cognet, J A, Gabarro-Arpa, J, Le Bret, M, Sowers, L C, Fazakerley, G V
The structure of the cytosine-adenine mispair in a 7 base pair duplex has been investigated by proton NMR spectroscopy. At low pH, the predominant structure is protonated on the A residue and assumes...
Revet, B, Malinge, J M, Delain, E, Le Bret, M, Leng, M
The antitumor drug cis-diamminedichloroplatinum (II) (cis-Pt) forms bidentate adducts with guanine residues of poly(dG-dC).poly(dG-dC). The secondary structure of the polymer is altered. In this...
Fossé, P, René, B, Le Bret, M, Paoletti, C, Saucier, J M
Various antitumor drugs stabilize DNA topoisomerase II-DNA transient covalent complexes. The complexes distribution along pBR322 DNA was shown previously to depend upon the nature of the drug (Tewey...
Boulard, Y, Gabarro-Arpa, J, Cognet, J A, Le Bret, M, Guy, A, Téoule, R, ...
We have determined by two-dimensional nuclear magnetic resonance studies and molecular mechanics calculations the three-dimensional solution structure of a 21 residue oligonucleotide capable of...
Cognet, J A, Gabarro-Arpa, J, Le Bret, M, Van Der Marel, G A, Van Boom, J H, Fazakerley, G V
We have determined by two-dimensional nuclear magnetic resonance studies and molecular mechanics calculations the three dimensional solution structure of the non-selfcomplementary oligonucleotide,...
Le Bret, M, Le Pecq, J B, Barbet, J, Roques, B P
The rate of energy transfer between DNA intercalated ethidium cations calculated by Paoletti and Le Pecq1 using the Forster theory differs from the measured one by a factor of twenty two, if the...
DNA polyintercalating drugs: DNA binding of diacridine derivatives.
Le Pecq, J B, Le Bret, M, Barbet, J, Roques, B
As a first step in the synthesis and the study of DNA polyintercalating drugs, dimers of acridines have been prepared. Their DNA binding properties have been studied. It has been determined that when...
HIV-1 integrase catalytic core: molecular dynamics and simulated fluorescence decays.
Laboulais, C, Deprez, E, Leh, H, Mouscadet, J F, Brochon, J C, Le Bret, M
Two molecular dynamics simulations have been carried out on the HIV-1 integrase catalytic core starting from fully determined crystal structures. During the first one, performed in the absence of...