M. Lees

Publication List Details

Period

1961 - 2006

Number

21

Co-Authors

The phenotypic spectrum in patients with arginine to cysteine mutations in the COL2A1 gene (2006)

Hoornaert, K.P., Dewinter, C., Vereecke, I., Beemer, F.A., Courtens, W., Fryer, A., ...

Background: The majority of COL2A1 missense mutations are substitutions of obligatory glycine residues in the triple helical domain. Only a few non-glycine missense mutations have been reported and...

Submucous cleft palate: a grading system and review of 40 consecutive submucous cleft palate repairs (2004)

Sommerlad, B.C., Fenn, C., Harland, K., Sell, D., Birch, M.J., Dave, R., ...

Objective: This study was designed to determine whether velar surgery was worthwhile for submucous cleft palate (SMCP) and evaluate whether results were dependent on the degree of the anatomical...

A Framework for Dynamic Load Balancing: A Case Study on Explosive Containment Simulation (2000)

Schoneveld, A., Sloot, P.M.A., Lees, M., Karyadi, E.

Methods that can circumvent the implementation of parallelization steps are usually warmly welcomed by parallel simulation architects. In this paper we apply the parallel cellular automata modeling...

Activation of precursors for matrix metalloproteinases 1 (interstitial collagenase) and 3 (stromelysin) by rat mast-cell proteinases I and II.

Suzuki, K, Lees, M, Newlands, G F, Nagase, H, Woolley, D E

Histological studies have previously demonstrated an association between mast-cell activation/degranulation and areas of connective-tissue lysis in vivo; in addition, mast-cell extracts have been...

Activation of precursors for matrix metalloproteinases 1 (interstitial collagenase) and 3 (stromelysin) by rat mast-cell proteinases I and II.

Suzuki, K, Lees, M, Newlands, G F, Nagase, H, Woolley, D E

Histological studies have previously demonstrated an association between mast-cell activation/degranulation and areas of connective-tissue lysis in vivo; in addition, mast-cell extracts have been...

Optic disc anomalies and frontonasal dysplasia

Hodgkins, P, Lees, M, Lawson, J, Reardon, W, Leitch, J, Thorogood, P, ...

AIMS—To document the optic disc abnormalities in patients with frontonasal dysplasia in association with basal encephalocele.
METHODS—Names and hospital numbers of patients with midline clefts...

Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site.

Weaver, T., Lees, M., Banaszak, L.

Two mutant forms of fumarase C from E. coli have been made using PCR and recombinant DNA. The recombinant form of the protein included a histidine arm on the C-terminal facilitating purification....

Popliteal pterygium syndrome: a clinical study of three families and report of linkage to the Van der Woude syndrome locus on 1q32

Lees, M., Winter, R., Malcolm, S., Saal, H., Chitty, L.

Popliteal pterygium syndrome (PPS) is a rare autosomal dominant disorder, thought to occur with an incidence of approximately 1 in 300 000 live births. The main clinical manifestations are...

Economic Evaluation of Gemcitabine Alone and in Combination with Cisplatin in the Treatment of Nonsmall Cell Lung Cancer

M. Lees, M. Aristides, N. Maniadakis, J. McKendrick, N. Botwood, D. Stephenson

Objective: To evaluate the cost effectiveness of gemcitabine in the treatment of nonsmall cell lung cancer (NSCLC). Methods: Gemcitabine was compared with best supportive care and...

P107-M A Workflow to Enable Intelligent and Targeted Second-Chance in High-Throughput Mass Spectrometry Experiments

Prakash, A., Robinson, D., Sutton, J., Zumwalt, A., Lees, M., Bonilla, L., ...

In a typical mass spectrometry experiment, the state-of-the-art sequencing algorithms are able to identify only about 10% to 20% of the tandem-MS spectra. Moreover, due to the high dynamic range and...