DNA replication initiates non-randomly at multiple sites near the c-myc gene in HeLa cells.
Waltz, S E, Trivedi, A A, Leffak, M
The origin of replication of the c-myc gene in HeLa cells was previously identified at low resolution within 3.5 kb 5' to the P1 promoter, based on replication fork polarity and the location of DNA...
DNA topology of the ordered chromatin domain 5' to the human c-myc gene.
DNA restriction fragments located 5' to the human c-myc gene display anomalous electrophoretic mobility on polyacrylamide gels. Computer modeling of the c-myc flanking DNA suggests that the...
Nucleosomal semihistone A24 (uH2A) is composed of histone H2A and ubiquitin peptides. The kinetics of incorporation of nascent H2A and ubiquitin into A24 of transformed chicken lymphocytes (MSB...
Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus.
We have studied the assembly of histone H1 and the high mobility group nonhistones 14/17 by isopycnic analysis after crosslinking density labeled MSB cell nuclei or chromatin. Carbodiimide...
The c-myc genes of HeLa cells are preferentially replicated in the transcriptional direction, from chromosomal origin sequences which display cell type-specific activity. Using a run-off replication...
To study the cell type specificity of the direction of replication of the human c-myc genes and the relationship of replication polarity to transcriptional activity, we analyzed the directions of...
Opposite replication polarities of transcribed and nontranscribed histone H5 genes.
Trempe, J P, Lindstrom, Y I, Leffak, M
We used an in vitro nuclear runoff replication assay to analyze the direction of replication of the active and inactive histone H5 genes in avian cells. In embryonic erythrocytes the transcribed...
Polarity of DNA replication through the avian alpha-globin locus.
Toward understanding the controls affecting eucaryotic chromosome replication, we used a runoff replication assay to investigate whether the activity of a gene is related to its use of an upstream or...
Transcription Factor Binding and Induced Transcription Alter Chromosomal c-myc Replicator Activity
Ghosh, M., Liu, G., Randall, G., Bevington, J., Leffak, M.
The observation that transcriptionally active genes generally replicate early in S phase and observations of the interaction between transcription factors and replication proteins support the thesis...
Globin gene transcription is activated in chick embryo fibroblasts (CEF) transformed by Rous sarcoma virus (RSV). To determine whether this activation is correlated with a change in the replication...
DNA replication initiates non-randomly at multiple sites near the c-myc gene in HeLa cells.
Waltz, S E, Trivedi, A A, Leffak, M
The origin of replication of the c-myc gene in HeLa cells was previously identified at low resolution within 3.5 kb 5' to the P1 promoter, based on replication fork polarity and the location of DNA...
DNA topology of the ordered chromatin domain 5' to the human c-myc gene.
DNA restriction fragments located 5' to the human c-myc gene display anomalous electrophoretic mobility on polyacrylamide gels. Computer modeling of the c-myc flanking DNA suggests that the...
Nucleosomal semihistone A24 (uH2A) is composed of histone H2A and ubiquitin peptides. The kinetics of incorporation of nascent H2A and ubiquitin into A24 of transformed chicken lymphocytes (MSB...
Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus.
We have studied the assembly of histone H1 and the high mobility group nonhistones 14/17 by isopycnic analysis after crosslinking density labeled MSB cell nuclei or chromatin. Carbodiimide...
The c-myc genes of HeLa cells are preferentially replicated in the transcriptional direction, from chromosomal origin sequences which display cell type-specific activity. Using a run-off replication...
To study the cell type specificity of the direction of replication of the human c-myc genes and the relationship of replication polarity to transcriptional activity, we analyzed the directions of...
Opposite replication polarities of transcribed and nontranscribed histone H5 genes.
Trempe, J P, Lindstrom, Y I, Leffak, M
We used an in vitro nuclear runoff replication assay to analyze the direction of replication of the active and inactive histone H5 genes in avian cells. In embryonic erythrocytes the transcribed...
Polarity of DNA replication through the avian alpha-globin locus.
Toward understanding the controls affecting eucaryotic chromosome replication, we used a runoff replication assay to investigate whether the activity of a gene is related to its use of an upstream or...
Transcription Factor Binding and Induced Transcription Alter Chromosomal c-myc Replicator Activity
Ghosh, M., Liu, G., Randall, G., Bevington, J., Leffak, M.
The observation that transcriptionally active genes generally replicate early in S phase and observations of the interaction between transcription factors and replication proteins support the thesis...
Globin gene transcription is activated in chick embryo fibroblasts (CEF) transformed by Rous sarcoma virus (RSV). To determine whether this activation is correlated with a change in the replication...