M. Lucila Scimone

A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus

Scimone, M. Lucila, Aifantis, Iannis, Apostolou, Irina, Von Boehmer, Harald, Von Andrian, Ulrich H.

Homing of bone marrow (BM)-derived progenitors to the thymus is essential for T cell development. We have previously reported that two subpopulations of common lymphoid progenitors, CLP-1 and CLP-2,...

A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus

Scimone, M. Lucila, Aifantis, Iannis, Apostolou, Irina, Von Boehmer, Harald, Von Andrian, Ulrich H.

Homing of bone marrow (BM)-derived progenitors to the thymus is essential for T cell development. We have previously reported that two subpopulations of common lymphoid progenitors, CLP-1 and CLP-2,...

Migration of polymorphonuclear leucocytes is influenced by dendritic cells

Scimone, M Lucila, Lutzky, Viviana P, Zittermann, Sandra I, Maffia, Paulo, Jancic, Carolina, Buzzola, Fernanda, ...

Dendritic cells (DCs) are the most potent antigen-presenting cells and populate many tissues where they may participate in inflammatory reactions. The infiltration of polymorphonuclear leucocytes...

The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell–expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches

Halin, Cornelia, Scimone, M. Lucila, Bonasio, Roberto, Gauguet, Jean-Marc, Mempel, Thorsten R., Quackenbush, Elizabeth, ...

Sphingosine-1-phosphate (S1P) and its receptor S1P1 control T-cell egress from thymus and secondary lymphoid organs (SLOs). To further define the role of S1P1 in lymphocyte trafficking, we performed...

CXCL12 Mediates CCR7-independent Homing of Central Memory Cells, But Not Naive T Cells, in Peripheral Lymph Nodes

Scimone, M. Lucila, Felbinger, Thomas W., Mazo, Irina B., Stein, Jens V., Von Andrian, Ulrich H., Weninger, Wolfgang

Central memory CD8+ T cells (TCM) confer superior protective immunity against infections compared with other T cell subsets. TCM recirculate mainly through secondary lymphoid organs, including...