The long term survivors (1996)
Recent research indicates that approximately 60% of children diagnosed with cancer in Britain are cured and as a result, about 1 in a 1000 of the general population will soon be survivors of...
Few studies have examined human population data for evidence of an association between environmental mutagens and genetic disease. Our objective was to determine whether study of pregnancies and...
Congenital anomalies and childhood cancer in Great Britain.
Narod, S A, Hawkins, M M, Robertson, C M, Stiller, C A
The presence of cancer and a congenital anomaly in the same child may be explained in certain cases by an underlying genetic abnormality. The study of these associations may lead to the...
Hawkins, M. M., Wilson, L. M., Stovall, M. A., Marsden, H. B., Potok, M. H., Kingston, J. E., ...
OBJECTIVE--To investigate the incidence and aetiology of secondary leukaemia after childhood cancer in Britain. DESIGN--Cohort study and a case-control study. SETTING--Britain and population based...
Long term survival and cure after childhood cancer.
Investigations of long term survival and evidence concerning cure among children surviving at least three years after most of the more common childhood cancers treated in Britain between 1960 and...
Late deaths after treatment for childhood cancer.
Hawkins, M M, Kingston, J E, Kinnier Wilson, L M
An investigation of 749 deaths occurring among 4082 patients surviving at least five years after the diagnosis of childhood cancer in Britain before 1971 has been undertaken. Of the 738 with...
Late deaths and survival after childhood cancer: implications for cure.
Robertson, C. M., Hawkins, M. M., Kingston, J. E.
OBJECTIVES--To investigate causes of death and survival in subjects who had survived at least five years after diagnosis of childhood cancer; to compare observed mortality with that expected in the...
Hawkins, M. M., Swerdlow, A. J.
For the last 20 years the National Health Service Central Register (NHSCR) has been used as the principal source of follow-up for mortality, and often for cancer incidence, in many cohort and...
Patterns of risk of hereditary retinoblastoma and applications to genetic counselling.
Draper, G. J., Sanders, B. M., Brownbill, P. A., Hawkins, M. M.
A registry including information about nearly 1,600 cases of retinoblastoma diagnosed in Britain has been created at the Childhood Cancer Research Group. Cases have been classified as 'old germ cell...
Incidence of second primary tumours among childhood cancer survivors.
Hawkins, M. M., Draper, G. J., Kingston, J. E.
Among a cohort of 10,106 three-year survivors of childhood cancer, 90 second primary tumours (SPTs) were observed. Within 25 years of 3-year survival about 4% developed a SPT, about 6-fold expected,...
Patterns of multiple primary tumours in patients treated for cancer during childhood.
Kingston, J. E., Hawkins, M. M., Draper, G. J., Marsden, H. B., Kinnier Wilson, L. M.
One hundred and sixty one children who have developed more than one primary neoplasm have been identified. Children with tumours of the central nervous system, retinoblastoma and leukaemia were those...
Cancer in the offspring of survivors of childhood leukaemia and non-Hodgkin lymphomas.
Hawkins, M. M., Draper, G. J., Winter, D. L.
Understanding the extent to which childhood leukaemia and non-Hodgkin lymphomas are heritable is important to the survivors of these diseases, their families and clinicians who provide genetic...
Offspring sex ratio and gonadal irradiation in the British Childhood Cancer Survivor Study
Reulen, R C, Zeegers, M P, Lancashire, E R, Winter, D L, Hawkins, M M
We investigated offspring sex ratio among 6232 offspring born to 3218 survivors of childhood cancer in relation to therapeutic irradiation, and pooled our data with those from two other large-scale...
A study of soft tissue sarcomas after childhood cancer in Britain
Jenkinson, H C, Winter, D L, Marsden, H B, Stovall, M A, Stevens, M C G, Stiller, C A, ...
Among 16 541 3-year survivors of childhood cancer in Britain, 39 soft tissue sarcomas (STSs) occurred and 1.1 sarcomas were expected, yielding a standardised incidence ratio (SIR) of 16.1. When...