Human small-cell lung cancers show amplification and expression of the N-myc gene.
Nau, M M, Brooks, B J, Carney, D N, Gazdar, A F, Battey, J F, Sausville, E A, ...
We have found that 6 of 31 independently derived human small-cell lung cancer (SCLC) cell lines have 5- to 170-fold amplified N-myc gene sequences. The amplification is seen with probes from two...
Seidman, J G, Nau, M M, Norman, B, Kwan, S P, Scharff, M, Leder, P
A site-specific recombination event is responsible for the somatic activation of immunoglobulin genes and for generating a major share of immunoglobulin gene diversity. Although several possible...
Johnson, B E, Ihde, D C, Makuch, R W, Gazdar, A F, Carney, D N, Oie, H, ...
44 small cell lung cancer cell lines established from 227 patients were studied for myc family DNA amplification (c-myc, N-myc, and L-myc). Two of 19 lines (11%) established from untreated patients'...
Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.
Felix, C A, Nau, M M, Takahashi, T, Mitsudomi, T, Chiba, I, Poplack, D G, ...
The p53 gene was examined in primary lymphoblasts of 25 pediatric patients with acute lymphoblastic leukemia by the RNase protection assay and by single strand conformation polymorphism analysis in...
Absence of hereditary p53 mutations in 10 familial leukemia pedigrees.
Felix, C A, D'Amico, D, Mitsudomi, T, Nau, M M, Li, F P, Fraumeni, J F, ...
Germline p53 mutations have been identified in the Li-Fraumeni syndrome but the role of such mutations in familial leukemia is not established. The p53 gene was examined by single-strand conformation...
Unger, T, Nau, M M, Segal, S, Minna, J D
Gal4-p53 fusion constructs demonstrate that wild type p53 is a potent transactivator in human lung cancer cells with the transactivation domain for p53 residing in amino acids 1-42. Strikingly, a...
Human small-cell lung cancers show amplification and expression of the N-myc gene.
Nau, M M, Brooks, B J, Carney, D N, Gazdar, A F, Battey, J F, Sausville, E A, ...
We have found that 6 of 31 independently derived human small-cell lung cancer (SCLC) cell lines have 5- to 170-fold amplified N-myc gene sequences. The amplification is seen with probes from two...
Seidman, J G, Nau, M M, Norman, B, Kwan, S P, Scharff, M, Leder, P
A site-specific recombination event is responsible for the somatic activation of immunoglobulin genes and for generating a major share of immunoglobulin gene diversity. Although several possible...
Johnson, B E, Ihde, D C, Makuch, R W, Gazdar, A F, Carney, D N, Oie, H, ...
44 small cell lung cancer cell lines established from 227 patients were studied for myc family DNA amplification (c-myc, N-myc, and L-myc). Two of 19 lines (11%) established from untreated patients'...
Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.
Felix, C A, Nau, M M, Takahashi, T, Mitsudomi, T, Chiba, I, Poplack, D G, ...
The p53 gene was examined in primary lymphoblasts of 25 pediatric patients with acute lymphoblastic leukemia by the RNase protection assay and by single strand conformation polymorphism analysis in...
Absence of hereditary p53 mutations in 10 familial leukemia pedigrees.
Felix, C A, D'Amico, D, Mitsudomi, T, Nau, M M, Li, F P, Fraumeni, J F, ...
Germline p53 mutations have been identified in the Li-Fraumeni syndrome but the role of such mutations in familial leukemia is not established. The p53 gene was examined by single-strand conformation...
Unger, T, Nau, M M, Segal, S, Minna, J D
Gal4-p53 fusion constructs demonstrate that wild type p53 is a potent transactivator in human lung cancer cells with the transactivation domain for p53 residing in amino acids 1-42. Strikingly, a...