Multimodal monitoring in traumatic brain injury: current status and future directions (2008)
Traumatic brain injury (TBI) remains a major cause of morbidity and mortality, particularly in young people. Despite encouraging animal studies, human trials assessing the use of pharmacological...
Increase in cerebral aerobic metabolism by normobaric hyperoxia after traumatic brain injury (2008)
Tisdall, M.M., Tachtsidis, I., Leung, T.S., Elwell, C.E., Smith, M.
OBJECT: Traumatic brain injury (TBI) is associated with depressed aerobic metabolism and mitochondrial dysfunction. Normobaric hyperoxia (NBH) has been suggested as a treatment for TBI, but studies...
Tisdall, M.M., Tachtsidis, I., Leung, T.S., Elwell, C.E., Smith, M.
The near infrared cytochrome c oxidase (CCO) signal has potential as a clinical marker of changes in mitochondrial oxygen utilization. We examine the CCO signal response to reduced oxygen delivery in...
Cerebral microdialysis: research technique or clinical tool (2006)
Cerebral microdialysis is a well-established laboratory tool that is increasingly used as a bedside monitor to provide on-line analysis of brain tissue biochemistry during neuro-intensive care. This...
Cerebral microdialysis: research technique or clinical tool (2006)
Cerebral microdialysis is a well-established laboratory tool that is increasingly used as a bedside monitor to provide on-line analysis of brain tissue biochemistry during neurointensive care. This...