M. N. James

Publication List Details

Period

1998 - 2001

Number

22

Co-Authors

A Phtoelastic Technique for Characterising Fatigue Crack Closure and the effective stress intensivity Factor (2001)

Zeszyty Naukowe, Politechniki Opolskiej, M. N. Pacey, E. A. Patterson, M. N. James

this paper shows that these difficulties can be overcome to yield useful insights into closure on a cycle-by-cycle basis for cracks in standard fracture mechanics specimens. Indeed, when combined...

Fracture Toughness Testing of Hardmetals Using Compression-Compression Precracking. (1998)

James, M. N., Human, A. M., Luyckx, S.

Compression-compression precracking of brittle materials has been applied to fracture toughness testing; this paper reports the results of an experimental program of fracture toughness testing of a...

Fatigue Strength of Welded Cover Plates on 6261 Aluminium Alloy I-Beams. (1998)

James, M. N., Lambrecht, H. O., Paterson, A. E.

S-n data were acquired in bending from some 50 extruded 6261 aluminium alloy l-beams (100 mm deep, 75 wide and 4.2 mm thick) with cover plates welded to them. cover plate end details were...

The Anisotropic Work-Hardening of WC Crystals. (1998)

Luyckx, S. B., Nabarro, F. R. N., Wai, Siu-Wah, James, M. N.

It has been found that indented (1 0 -1 0) surfaces of WC crystals exhibit pile-up material next to the indentations while (0001) surfaces exhibit sunk-in material. Since in some metals sunk-in...

The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition.

Bergmann, E M, Mosimann, S C, Chernaia, M M, Malcolm, B A, James, M N

The virally encoded 3C proteinases of picornaviruses process the polyprotein produced by the translation of polycistronic viral mRNA. The X-ray crystallographic structure of a catalytically active...

Refined crystal structure of the molecular complex of Streptomyces griseus protease B, a serine protease, with the third domain of the ovomucoid inhibitor from turkey.

Fujinaga, M, Read, R J, Sielecki, A, Ardelt, W, Laskowski, M, James, M N

We have determined the crystal structure of the molecular complex between Streptomyces griseus protease B (SGPB), a bacterial serine protease, and the third domain of the ovomucoid inhibitor from...

Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin.

James, M N, Sielecki, A, Salituro, F, Rich, D H, Hofmann, T

Crystals of the molecular complex between the esterified tripeptide fragment of pepstatin and the aspartyl proteinase penicillopepsin are isomorphous with crystals of native penicillopepsin. The...

Crystallographic and kinetic investigations of the covalent complex formed by a specific tetrapeptide aldehyde and the serine protease from Streptomyces griseus.

Brayer, G D, Delbaere, L T, James, M N, Bauer, C A, Thompson, R C

X-ray crystallographic data show that a specific tetrapeptide aldehyde inhibitor (N-acetylprolylalanylprolylphenylalaninal) forms a stable, covalent, tetrahedral addition complex with the serine...

Crystal structure of a flavoprotein related to the subunits of bacterial luciferase.

Moore, S A, James, M N, O'Kane, D J, Lee, J

The molecular structure of the luxF protein from the bioluminescent bacterium Photobacterium leiognathi has been determined by X-ray diffraction techniques and refined to a conventional R-factor of...

The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis.

Petersen, J F, Cherney, M M, Liebig, H D, Skern, T, Kuechler, E, James, M N

The crystal structure of the 2A proteinase from human rhinovirus serotype 2 (HRV2-2A(pro)) has been solved to 1.95 A resolution. The structure has an unusual, although chymotrypsin-related, fold...

The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition.

Bergmann, E M, Mosimann, S C, Chernaia, M M, Malcolm, B A, James, M N

The virally encoded 3C proteinases of picornaviruses process the polyprotein produced by the translation of polycistronic viral mRNA. The X-ray crystallographic structure of a catalytically active...

Refined crystal structure of the molecular complex of Streptomyces griseus protease B, a serine protease, with the third domain of the ovomucoid inhibitor from turkey.

Fujinaga, M, Read, R J, Sielecki, A, Ardelt, W, Laskowski, M, James, M N

We have determined the crystal structure of the molecular complex between Streptomyces griseus protease B (SGPB), a bacterial serine protease, and the third domain of the ovomucoid inhibitor from...

Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin.

James, M N, Sielecki, A, Salituro, F, Rich, D H, Hofmann, T

Crystals of the molecular complex between the esterified tripeptide fragment of pepstatin and the aspartyl proteinase penicillopepsin are isomorphous with crystals of native penicillopepsin. The...

Crystallographic and kinetic investigations of the covalent complex formed by a specific tetrapeptide aldehyde and the serine protease from Streptomyces griseus.

Brayer, G D, Delbaere, L T, James, M N, Bauer, C A, Thompson, R C

X-ray crystallographic data show that a specific tetrapeptide aldehyde inhibitor (N-acetylprolylalanylprolylphenylalaninal) forms a stable, covalent, tetrahedral addition complex with the serine...

Crystal structure of a flavoprotein related to the subunits of bacterial luciferase.

Moore, S A, James, M N, O'Kane, D J, Lee, J

The molecular structure of the luxF protein from the bioluminescent bacterium Photobacterium leiognathi has been determined by X-ray diffraction techniques and refined to a conventional R-factor of...

The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis.

Petersen, J F, Cherney, M M, Liebig, H D, Skern, T, Kuechler, E, James, M N

The crystal structure of the 2A proteinase from human rhinovirus serotype 2 (HRV2-2A(pro)) has been solved to 1.95 A resolution. The structure has an unusual, although chymotrypsin-related, fold...

Common structural features of the luxF protein and the subunits of bacterial luciferase: evidence for a (beta alpha)8 fold in luciferase.

Moore, S. A., James, M. N.

The amino acid sequence identity and potential structural similarity between the subunits of bacterial luciferase and the recently determined structure of the luxF molecule are examined. The unique...

Water molecules participate in proteinase-inhibitor interactions: crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with Streptomyces griseus proteinase B.

Huang, K., Lu, W., Anderson, S., Laskowski, M., James, M. N.

Crystal structures of the complexes of Streptomyces griseus proteinase B (SGPB) with three P1 variants of turkey ovomucoid inhibitor third domain (OMTKY3), Leu18, Ala18, and Gly18, have been...

Crystal structure of human pepsin and its complex with pepstatin.

Fujinaga, M., Chernaia, M. M., Tarasova, N. I., Mosimann, S. C., James, M. N.

The three-dimensional crystal structure of human pepsin and that of its complex with pepstatin have been solved by X-ray crystallographic methods. The native pepsin structure has been refined with...

Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes.

Khan, A. R., James, M. N.

Proteolytic enzymes are synthesized as inactive precursors, or "zymogens," to prevent unwanted protein degradation, and to enable spatial and temporal regulation of proteolytic activity. Upon sorting...

Deleterious effects of beta-branched residues in the S1 specificity pocket of Streptomyces griseus proteinase B (SGPB): crystal structures of the turkey ovomucoid third domain variants Ile18I, Val18I, Thr18I, and Ser18I in complex with SGPB.

Bateman, K. S., Anderson, S., Lu, W., Qasim, M. A., Laskowski, M., James, M. N.

Turkey ovomucoid third domain (OMTKY3) is a canonical inhibitor of serine proteinases. Upon complex formation, the inhibitors fully exposed P1 residue becomes fully buried in the preformed cavity of...