Campbell, A P, Merrett, M N, Kettlewell, M, Mortensen, N J, Jewell, D P
AIMS--To investigate colonic metaplasia of goblet and columnar epithelial cells in ileal pouch mucosa; to correlate this with the degree of morphological and inflammatory change; and to assess...
Campbell, A P, Merrett, M N, Kettlewell, M, Mortensen, N J, Jewell, D P
AIMS--To investigate colonic metaplasia of goblet and columnar epithelial cells in ileal pouch mucosa; to correlate this with the degree of morphological and inflammatory change; and to assess...
5-Aminosalicylic acid inhibits the impaired epithelial barrier function induced by gamma interferon.
Di Paolo, M C, Merrett, M N, Crotty, B, Jewell, D P
Gamma interferon (IFN gamma) impairs epithelial barrier function and induces HLA-DR expression on colonic cancer cell lines. Salicylates have been shown to reduce IFN gamma induced HLA-DR expression....
Smoking may prevent pouchitis in patients with restorative proctocolectomy for ulcerative colitis.
Merrett, M N, Mortensen, N, Kettlewell, M, Jewell, D O
Epidemiological studies have shown an increased risk of ulcerative colitis (UC) in non-smokers and particularly recent ex-smokers. Patients with UC have an increased risk of pouchitis following ileal...
Intestinal permeability in the ileal pouch.
Merrett, M N, Soper, N, Mortensen, N, Jewell, D P
BACKGROUND: Villous atrophy, mucin changes ('colonic metaplasia'), and chronic inflammation occur to varying degrees in all patients with ileal pouchanal anastomosis whereas acute inflammation...