Australian National University Fujitsu Limited (2009)
R. Brent, A. Cleary, M. Dow, M. Hegl, J. Jenkinson, Z. Leyk, ...
R. Brent, L. Grosz, D. Harrar Ii, M. Hegl, M. Kahn, G. Keating, ...
Project is a joint research program involving staff at the Aus-tralian National University and Fujitsu Japan. The aim of the project is to produce a library of mathematical subrou-tines for the...
Design of the Scientific Subroutine Library for the Fujitsu VPP300 (2008)
R. Brent, L. Grosz, D. Harrar Ii, M. Hegl, M. Kahn, G. Keating, ...
1.
Takada, Y., Nakanishi, M., Fujii, T., Takada, J., Muraoka, Y.
An ilmenite-hematite solid solution ( Fe2-xTixO3 ) is one of the candidates for practical magnetic semiconductors with a high Curie temperature. We have prepared well-crystallized epitaxial...
Design of the Scientific Subroutine Library for the Fujitsu VPP300 (2008)
R. Brent, L. Grosz, D. Harrar, M. Hegland, M. Kahn, ...
A research agreement between the Australian National University and Fujitsu Japan has led to the development of a library of parallel mathematical subroutines and the extension of the library of...
R. Brent, A. Cleary, M. Dow, M. Hegland, J. Jenkinson, Z. Leyk, ...
We report progress to date on our project to implement high-impact scientific subroutines on Fujitsu's parallel-vector VPP500. Areas covered in the project are generally between the level of...
Ingle, S., Mahoney, J.J., Sato, H., Coffin, M.F., Kimura, J.I., Hirano, N., ...
Numerous large igneous provinces formed in the Pacific Ocean during Early Cretaceous time, but their origins and relations are poorly understood. We present new geochronological and geochemical data...
Possible Impact of Salivary Influence on Cytokine Analysis in Exhaled Breath Condensate (2007)
T. Ichikawa, K. Matsunaga, Y. Minakata, S. Yanagisawa, K. Ueshima, K. Akamatsu, ...
Background: Exhaled breath condensate (EBC) is thought to contain substances of the lower airway epithelial lining fluid (ELF) aerosolized by turbulent flow. However, contamination by saliva may...
Antisense transcription in the mammalian genome (2005)
Katayama, S., Tomaru, Y., Kasukawa, T., Waki, K., Nakanishi, M., Nakamura, M., ...
Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense...
Antisense Transcription in the Mammalian Transcriptome (2005)
Katayama, S., Tomaru, Y., Kasukawa, T., Waki, K., Nakanishi, M., Nakamura, M., ...
Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense...
Antisense Transcription in the Mammalian Transcriptome (2005)
Katayama, S., Tomaru, Y., Kasukawa, T., Waki, K., Nakanishi, M., Nakamura, M., ...
Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense...
Antisense transcription in the mammalian transcriptome (2005)
Wells, C. A., Frith, M., Ravasi, T., Pang, K. C., Hallinan, J. S., ...
Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense...
Antisense transcription in the mammalian transcriptome (2005)
Wells, C. A., Frith, M., Ravasi, T., Pang, K. C., Hallinan, J. S., ...
Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense...
Antisense Transcription in the Mammalian Transcriptome (2005)
Katayama, S., Tomaru, Y., Kasukawa, T., Waki, K., Nakanishi, M., Nakamura, M., ...
Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense...
Ishikawa, N., Fuchigami, T., Matsumoto, T., Kobayashi, H., Sakai, Y., Tabata, H., ...
Objective. The aim of this study was to investigate the impact of Helicobacter pylori infection on clinical features in patients with rheumatoid arthritis (RA) under medication with...
Chk2 activation dependence on Nbs1 after DNA damage (2001)
Buscemi, G., Savio, C., Zannini, L., Micciche, F., Masnada, D., Nakanishi, M., ...
The checkpoint kinase Chk2 has a key role in delaying cell cycle progression in response to DNA damage. Upon activation by low-dose ionizing radiation (IR), which occurs in an ataxia telangiectasia...
Chk2 activation dependence on Nbs1 after DNA damage (2001)
Buscemi, G., Savio, C., Zannini, L., Micciche, F., Masnada, D., Nakanishi, M., ...
The checkpoint kinase Chk2 has a key role in delaying cell cycle progression in response to DNA damage. Upon activation by low-dose ionizing radiation (IR), which occurs in an ataxia telangiectasia...
Development of a Production Technique for P/M Alloy 625 Clad Low Alloy Steel Pipe. (1998)
Fukuda, T., Ohashi, Y., Nakanishi, M., Nishiguchi, M., Ueda, M.
Powder metallurgy (P/M) coextrusion process for high alloy clad steel pipes was studied; inert gas atomized Alloy 625 powder was extruded with extrusion ratios of between 1 and 12 to 1; stable...
Multinational survey of the Earth’s largest LIP (1998)
Larson, R.L., Abrams, L.J., Coffin, M.F., Eldholm, O., Gladczenko, T., Ito, G.T., ...
Development of a Mathematical Subroutine Library for Fujitsu Vector Parallel Processors (1998)
R. Brent, L. Grosz, D. Harrar, M. Hegland, M. Kahn, ...
The Fujitsu-ANU Parallel Mathematical Subroutine Library Project is a joint research program involving staff at the Australian National University and Fujitsu Japan. The aim of the project is to...
R. Brent, A. Cleary, M. Hegland, J. Jenkinson, Z. Leyk, M. Osborne, ...
We report progress to date on our project to implement high-impact scientific subroutines on Fujitsu's parallel-vector VPP500. Areas covered in the project are generally between the level of...
Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors
Dace, Alexandra, Zhao, Li, Park, Kyung Soo, Furuno, T., Takamura, N., Nakanishi, M., ...
The thyroid hormone 3,3′,5-triiodo-l-thyronine (T3) is essential for growth, differentiation, and development. Its biological activities are mediated by T3 nuclear receptors (TRs). At present, how...
Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA.
Nakanishi, M, Adami, G R, Robetorye, R S, Noda, A, Venable, S F, Dimitrov, D, ...
p21Sdi1 (also known as Cip1 and Waf1), an inhibitor of DNA synthesis cloned from senescent human fibroblasts, is an inhibitor of G1 cyclin-dependent kinases (Cdks) in vitro and is transcriptionally...
Nakanishi, M, Weber, K T, Guntaka, R V
The promoters of alpha1(I) procollagen genes of vertebrates contain two contiguous stretches of polypyrimidine/polypurine sequences, referred to as C1 (-140 to -170) and C2 (-171 to -200)....
Mizojiri, K, Futaguchi, S, Norikura, R, Katsuyama, Y, Nagasaki, T, Yoshimori, T, ...
[pivaloyl-14C]S-1108, which is 14C labeled at the pivalic acid moiety of the pivaloyloxymethyl side chain of S-1108, was administered orally to rats and dogs, and the disposition of pivalic acid...
Dimri, G P, Nakanishi, M, Desprez, P Y, Smith, J R, Campisi, J
p21Sdi1/WAF1/Cip1 inhibits cyclin-dependent protein kinases and cell proliferation. p21 is presumed to inhibit growth by preventing the phosphorylation of growth-regulatory proteins, including the...
Nagao, S, Nakanishi, M, Kutsukake, H, Yagawa, K, Kusumoto, S, Shiba, T, ...
N-Acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide [MDP]) injected intraperitoneally significantly increased the number of cells entering the peritoneal cavity of guinea pigs primed with...
B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene.
Tsang, S Y, Nakanishi, M, Peterlin, B M
We investigated the cis-acting sequences that function in the B-cell-specific and interferon-gamma-inducible expression of the HLA-DR alpha gene, a human class II major histocompatibility complex...
Characterization of oligonucleotide transport into living cells.
Loke, S L, Stein, C A, Zhang, X H, Mori, K, Nakanishi, M, Subasinghe, C, ...
Addition of antisense oligonucleotides to cell cultures has been used to specifically inhibit gene expression. We have investigated the mechanism by which oligonucleotides enter living cells. These...
Utsunomiya, N, Tsuboi, M, Nakanishi, M
We have studied early transmembrane events in mouse alloimmune cytotoxic T-lymphocyte (LC7, H-2b) activation by specific target cells (mouse mastocytoma P815, H-2d) and a mitogenic lectin, Con A, by...
Kohwi-Shigematsu, T, Enomoto, T, Yamada, M A, Nakanishi, M, Tsuboi, M
The reaction of chloroacetaldehyde with adenine bases in DNA to give a fluorescent product was used to study the availability to intermolecular reaction of positions 1 and 6 of adenine in DNA...
Mutational analysis of the DRA promoter: cis-acting sequences and trans-acting factors.
Tsang, S Y, Nakanishi, M, Peterlin, B M
Class II major histocompatibility genes are expressed at high levels in B lymphocytes and are gamma interferon (IFN-gamma) inducible in many other cells. Previously, we observed that DRA promoter...
Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1.
Nakanishi, M, Robetorye, R S, Adami, G R, Pereira-Smith, O M, Smith, J R
The cloning of the negative growth regulatory gene, p21Sdi1, has led to the convergence of the fields of cellular senescence, cell cycle regulation and tumor suppression. This gene was first cloned...
Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cells.
Takemori, T, Mizuguchi, J, Miyazoe, I, Nakanishi, M, Shigemoto, K, Kimoto, H, ...
Immunoglobulin mu chains synthesized in murine pre-B cells are known to be associated with surrogate light chains designated as omega (omega), iota (iota) and B34. In addition to these molecules, we...
Mizuguchi, J, Utsunomiya, N, Nakanishi, M, Arata, Y, Fukazawa, H
A BAL17 B lymphoma cell line bearing mu and delta chains on its surface behaves in a similar manner to normal mature B cells in terms of initial biochemical transmembrane signalling [Mizuguchi,...
Okamoto, Y, Furuno, T, Hamano, T, Nakanishi, M
We studied thapsigargin-induced bivalent-cation entry into antigen-specific B cells (TP67.21) with a confocal fluorescence microscope. Confocal fluorescence images of fluo-3-loaded B cells showed...
Stimulatory effect of pervanadate on calcium signals and histamine secretion of RBL-2H3 cells.
Teshima, R, Ikebuchi, H, Nakanishi, M, Sawada, J
We examined the effect of pervanadate on the activation of rat basophilic leukaemia (RBL-2H3) cells. The pervanadate, generated from a combination of H2O2 and vanadate (Vi), induced concomitantly...
Thapsigargin-induced nuclear calcium signals in rat basophilic leukaemia cells.
Horikoshi, Y, Furuno, T, Teshima, R, Sawada, J, Nakanishi, M
By a confocal fluorescence microscope with an argon-ion laser (488 nm) and a He-Cd laser (325 nm) we have studied thapsigargin-induced calcium signals in individual rat basophilic leukaemia (RBL-2H3)...
Deyashiki, Y, Ogasawara, A, Nakayama, T, Nakanishi, M, Miyabe, Y, Sato, K, ...
Human liver contains two dihydrodiol dehydrogenases, DD2 and DD4, associated with 3 alpha-hydroxysteroid dehydrogenase activity. We have raised polyclonal antibodies that cross-reacted with the two...
Activation of human liver 3 alpha-hydroxysteroid dehydrogenase by sulphobromophthalein.
Matsuura, K, Tamada, Y, Deyashiki, Y, Miyabe, Y, Nakanishi, M, Ohya, I, ...
Human liver contains at least two isoenzymes (DD2 and DD4) of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. The NADP(H)-linked oxidoreductase activities of DD4 were activated more than 4-fold by...
Ishikawa, T, Akimaru, K, Nakanishi, M, Tomokiyo, K, Furuta, K, Suzuki, M, ...
The A and J series of prostaglandins (PGs) accumulate in the nuclei to suppress the proliferation of cancer cells. Here we report that Delta7-PGA1 methyl ester, a synthetic anti-cancer PG, increased...
Furuno, T, Hamano, T, Nakanishi, M
We have studied receptor-mediated calcium signals in antigen-specific B cells (trinitrophenol-specific B cell clone, TP67.21) using a confocal fluorescence microscope with an argon ion laser (488 nm)...
Microvessel and astroglial cell densities in the mouse hippocampus.
Shimada, M, Akagi, N, Goto, H, Watanabe, H, Nakanishi, M, Hirose, Y, ...
In order to study the factors responsible for glucose uptake in the mouse hippocampus, microvessel and astroglial cell densities were measured and compared in each laminal region. Microvessel density...
Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors
Dace, Alexandra, Zhao, Li, Park, Kyung Soo, Furuno, T., Takamura, N., Nakanishi, M., ...
The thyroid hormone 3,3′,5-triiodo-l-thyronine (T3) is essential for growth, differentiation, and development. Its biological activities are mediated by T3 nuclear receptors (TRs). At present, how...
Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA.
Nakanishi, M, Adami, G R, Robetorye, R S, Noda, A, Venable, S F, Dimitrov, D, ...
p21Sdi1 (also known as Cip1 and Waf1), an inhibitor of DNA synthesis cloned from senescent human fibroblasts, is an inhibitor of G1 cyclin-dependent kinases (Cdks) in vitro and is transcriptionally...
Nakanishi, M, Weber, K T, Guntaka, R V
The promoters of alpha1(I) procollagen genes of vertebrates contain two contiguous stretches of polypyrimidine/polypurine sequences, referred to as C1 (-140 to -170) and C2 (-171 to -200)....
Mizojiri, K, Futaguchi, S, Norikura, R, Katsuyama, Y, Nagasaki, T, Yoshimori, T, ...
[pivaloyl-14C]S-1108, which is 14C labeled at the pivalic acid moiety of the pivaloyloxymethyl side chain of S-1108, was administered orally to rats and dogs, and the disposition of pivalic acid...
Dimri, G P, Nakanishi, M, Desprez, P Y, Smith, J R, Campisi, J
p21Sdi1/WAF1/Cip1 inhibits cyclin-dependent protein kinases and cell proliferation. p21 is presumed to inhibit growth by preventing the phosphorylation of growth-regulatory proteins, including the...
Nagao, S, Nakanishi, M, Kutsukake, H, Yagawa, K, Kusumoto, S, Shiba, T, ...
N-Acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide [MDP]) injected intraperitoneally significantly increased the number of cells entering the peritoneal cavity of guinea pigs primed with...
B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene.
Tsang, S Y, Nakanishi, M, Peterlin, B M
We investigated the cis-acting sequences that function in the B-cell-specific and interferon-gamma-inducible expression of the HLA-DR alpha gene, a human class II major histocompatibility complex...
Characterization of oligonucleotide transport into living cells.
Loke, S L, Stein, C A, Zhang, X H, Mori, K, Nakanishi, M, Subasinghe, C, ...
Addition of antisense oligonucleotides to cell cultures has been used to specifically inhibit gene expression. We have investigated the mechanism by which oligonucleotides enter living cells. These...
Utsunomiya, N, Tsuboi, M, Nakanishi, M
We have studied early transmembrane events in mouse alloimmune cytotoxic T-lymphocyte (LC7, H-2b) activation by specific target cells (mouse mastocytoma P815, H-2d) and a mitogenic lectin, Con A, by...
Kohwi-Shigematsu, T, Enomoto, T, Yamada, M A, Nakanishi, M, Tsuboi, M
The reaction of chloroacetaldehyde with adenine bases in DNA to give a fluorescent product was used to study the availability to intermolecular reaction of positions 1 and 6 of adenine in DNA...
Mutational analysis of the DRA promoter: cis-acting sequences and trans-acting factors.
Tsang, S Y, Nakanishi, M, Peterlin, B M
Class II major histocompatibility genes are expressed at high levels in B lymphocytes and are gamma interferon (IFN-gamma) inducible in many other cells. Previously, we observed that DRA promoter...
Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1.
Nakanishi, M, Robetorye, R S, Adami, G R, Pereira-Smith, O M, Smith, J R
The cloning of the negative growth regulatory gene, p21Sdi1, has led to the convergence of the fields of cellular senescence, cell cycle regulation and tumor suppression. This gene was first cloned...
Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cells.
Takemori, T, Mizuguchi, J, Miyazoe, I, Nakanishi, M, Shigemoto, K, Kimoto, H, ...
Immunoglobulin mu chains synthesized in murine pre-B cells are known to be associated with surrogate light chains designated as omega (omega), iota (iota) and B34. In addition to these molecules, we...
Mizuguchi, J, Utsunomiya, N, Nakanishi, M, Arata, Y, Fukazawa, H
A BAL17 B lymphoma cell line bearing mu and delta chains on its surface behaves in a similar manner to normal mature B cells in terms of initial biochemical transmembrane signalling [Mizuguchi,...
Okamoto, Y, Furuno, T, Hamano, T, Nakanishi, M
We studied thapsigargin-induced bivalent-cation entry into antigen-specific B cells (TP67.21) with a confocal fluorescence microscope. Confocal fluorescence images of fluo-3-loaded B cells showed...
Stimulatory effect of pervanadate on calcium signals and histamine secretion of RBL-2H3 cells.
Teshima, R, Ikebuchi, H, Nakanishi, M, Sawada, J
We examined the effect of pervanadate on the activation of rat basophilic leukaemia (RBL-2H3) cells. The pervanadate, generated from a combination of H2O2 and vanadate (Vi), induced concomitantly...
Thapsigargin-induced nuclear calcium signals in rat basophilic leukaemia cells.
Horikoshi, Y, Furuno, T, Teshima, R, Sawada, J, Nakanishi, M
By a confocal fluorescence microscope with an argon-ion laser (488 nm) and a He-Cd laser (325 nm) we have studied thapsigargin-induced calcium signals in individual rat basophilic leukaemia (RBL-2H3)...
Deyashiki, Y, Ogasawara, A, Nakayama, T, Nakanishi, M, Miyabe, Y, Sato, K, ...
Human liver contains two dihydrodiol dehydrogenases, DD2 and DD4, associated with 3 alpha-hydroxysteroid dehydrogenase activity. We have raised polyclonal antibodies that cross-reacted with the two...
Activation of human liver 3 alpha-hydroxysteroid dehydrogenase by sulphobromophthalein.
Matsuura, K, Tamada, Y, Deyashiki, Y, Miyabe, Y, Nakanishi, M, Ohya, I, ...
Human liver contains at least two isoenzymes (DD2 and DD4) of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. The NADP(H)-linked oxidoreductase activities of DD4 were activated more than 4-fold by...
Ishikawa, T, Akimaru, K, Nakanishi, M, Tomokiyo, K, Furuta, K, Suzuki, M, ...
The A and J series of prostaglandins (PGs) accumulate in the nuclei to suppress the proliferation of cancer cells. Here we report that Delta7-PGA1 methyl ester, a synthetic anti-cancer PG, increased...
Microvessel and astroglial cell densities in the mouse hippocampus.
Shimada, M, Akagi, N, Goto, H, Watanabe, H, Nakanishi, M, Hirose, Y, ...
In order to study the factors responsible for glucose uptake in the mouse hippocampus, microvessel and astroglial cell densities were measured and compared in each laminal region. Microvessel density...
Furuno, T, Hamano, T, Nakanishi, M
We have studied receptor-mediated calcium signals in antigen-specific B cells (trinitrophenol-specific B cell clone, TP67.21) using a confocal fluorescence microscope with an argon ion laser (488 nm)...
Regulation of IgE and IgG4 synthesis in patients with hyper IgE syndrome.
Ishizaka, A, Joh, K, Shibata, R, Wagatsuma, Y, Nakanishi, M, Tomizawa, K, ...
In order to investigate the imbalance of IgG subclasses and its relationship to IgE level, 14 patients with hyper IgE syndrome (HIE syndrome) were examined for serum IgG subclasses and IgE levels and...
Location of membrane-bound hapten with different length spacers.
Kimura, K, Arata, Y, Yasuda, T, Kinosita, K, Nakanishi, M
Immunogenic activity of a lipid hapten is strongly dependent of the length and nature of the linker chain (spacer) connecting the hapten to the head group of the lipid. A derivative containing a very...
Kimura, K, Nakanishi, M, Ueda, M, Ueno, J, Nariuchi, H, Furukawa, S, ...
We have studied the antibody-dependent binding of macrophages to supported planar lipid monolayers containing haptenated phospholipids (Tnp-Cap-DPPE). Eight monoclonal anti-TNP IgG1s, which had...
Yokoi, K, Hosoi, E, Nakanishi, M, Goto, T, Saito, S
OBJECTIVE--To evaluate the relationship between high serum levels of IgE and the release of interleukin-4 (IL-4) from cultured lymphocytes of a patient with adult onset Still's disease. METHODS--IL-4...
Ishizaka, A, Sakiyama, Y, Nakanishi, M, Tomizawa, K, Oshika, E, Kojima, K, ...
Using murine monoclonal antibodies against human IgG subclasses, specific and sensitive ELISAs assay to quantify the four human IgG subclasses in cell culture supernatants were established. The...
Interleukin-4 regulates the interleukin-2 receptors on human peripheral blood B lymphocytes.
Tomizawa, K, Ishizaka, A, Kojima, K, Nakanishi, M, Sakiyama, Y, Matsumoto, S
The high-affinity interleukin-2 (IL-2) receptor (IL-2R) consists of the non-covalent association of at least two subunits, p55 and p70-75, capable of binding IL-2 with low and intermediate affinity,...
Expression of Fc receptors is suppressed in alveolar macrophages from patients with sarcoidosis.
Hayashi, S, Yagawa, K, Nakanishi, M, Ogata, K, Maruyama, M, Shigematsu, N
To study the expression of Fc receptors in human alveolar macrophages (AM), the cells were collected from 12 healthy controls and 22 patients with sarcoidosis and the activity involved in binding to...
Microvascular hyperpermeability in COPD airways
Minakata, Y, Nakanishi, M, Hirano, T, Matsunaga, K, Yamagata, T, Ichinose, M
Possible Impact of Salivary Influence on Cytokine Analysis in Exhaled Breath Condensate
Ichikawa, T., Matsunaga, K., Minakata, Y., Yanagisawa, S., Ueshima, K., Akamatsu, K., ...
Application of fusogenic liposomes containing fragment A of diphtheria toxin to cancer therapy.
Mizuguchi, H., Nakanishi, M., Nakanishi, T., Nakagawa, T., Nakagawa, S., Mayumi, T.
Previously we reported that fusogenic liposomes, prepared by fusing simple liposomes with Sendai virus particles, could introduce their contents directly and efficiently into the cytoplasm. In this...
Sakakura, C, Hagiwara, A, Yasuoka, R, Fujita, Y, Nakanishi, M, Masuda, K, ...
Our recent analysis of gastric cancers using comparative genomic hybridization (CGH) revealed a novel high frequent copy number increase in the long arm of chromosome 20. Tumour-amplified kinase BTAK...
Sakakura, C, Hagiwara, A, Nakanishi, M, Shimomura, K, Takagi, T, Yasuoka, R, ...
Advanced gastric cancer is often accompanied by metastasis to the peritoneum, resulting in a high mortality rate. Mechanisms involved in gastric cancer metastasis have not been fully clarified...