Statistical methods for estimating divergence times by using multiprotein gamma distances are discussed. When a large number of proteins are used, even a small degree of deviation from the molecular...
Origins and divergence times of mammalian class II MHC gene clusters (2000)
Takahashi, K, Rooney, AP, Nei, M
The class I and II major histocompatibility complex (MHC) gene are apparently subject to evolution by a birth-and-death process. The rate of gene turnover is much slower in the latter genes than in...
Evolutionary change of restriction cleavage sites and phylogenetic inference for man and apes (1985)
To study the mechanism of maintenance of polymorphism at major histocompatibility complex (MHC) loci, synonymous and nonsynonymous (amino acid-altering) nucleotide substitutions in the putative...
Subunit molecular weight and genetic variability of proteins in natural populations.
Nei, M, Fuerst, P A, Chakraborty, R
The relationship between subunit molecular weight and heterozygosity was studied in six different groups of organisms, i.e., 9 species of primates, 32 species of rodents, 56 species of reptiles, 12...
Mathematical model for studying genetic variation in terms of restriction endonucleases.
A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotide...
Infinite allele model with varying mutation rate.
Nei, M, Chakraborty, R, Fuerst, P A
Available data suggest that the variation in mutation rate among protein loci follows the gamma distribution. Thus, taking into account this variation, formulae are developed for the distribution of...
Interlocus variation of genetic distance and the neutral mutation theory.
Theoretical distributions of genetic distance between reproductively isolated taxa are derived by means of computer simulation, taking into account mutation and random genetic drift. The...
Ancient Interlocus Exon Exchange in the History of the Hla-a Locus
The major histocompatibility complex (MHC) in humans and chimpanzees includes three classical class I loci, A, B and C, which encode glycoproteins expressed on the surface of all nucleated cells....
To explain the long-term persistence of polymorphic alleles (trans-specific polymorphism) at the major histocompatibility complex (MHC) loci in rodents and primates, a computer simulation study was...
A simple method is proposed for estimating the average number of nucleotide substitutions per site within and between populations for the case where a large number of individuals are examined for...
A New Method of Inference of Ancestral Nucleotide and Amino Acid Sequences
A statistical method was developed for reconstructing the nucleotide or amino acid sequences of extinct ancestors, given the phylogeny and sequences of the extant species. A model of nucleotide or...
Evolution of Antennapedia-Class Homeobox Genes
Antennapedia (Antp)-class homeobox genes are involved in the determination of pattern formation along the anterior-posterior axis of the animal embryo. A phylogenetic analysis of Antp-class...
Genetic Distances and Reconstruction of Phylogenetic Trees from Microsatellite DNA
Recently many investigators have used microsatellite DNA loci for studying the evolutionary relationships of closely related populations or species, and some authors proposed new genetic distance...
A Case of High Rate of Spontaneous Mutation Affecting Viability in DROSOPHILA MELANOGASTER
Kidwell, Margaret Gale, Kidwell, J. F., Nei, M.
A spontaneous lethal mutation rate approximately twenty to thirty times greater than normal has been discovered in second and third chromosomes derived from an irradiated isogenic line and paired...
Estimation of mutation rate from rare protein variants.
A method for estimating the mutation rate for protein loci from the number of rare alleles in the population is presented. It seems to have a number of advantages compared with Kimura and Ohta's...
To study the mechanism of maintenance of polymorphism at major histocompatibility complex (MHC) loci, synonymous and nonsynonymous (amino acid-altering) nucleotide substitutions in the putative...
Subunit molecular weight and genetic variability of proteins in natural populations.
Nei, M, Fuerst, P A, Chakraborty, R
The relationship between subunit molecular weight and heterozygosity was studied in six different groups of organisms, i.e., 9 species of primates, 32 species of rodents, 56 species of reptiles, 12...
Mathematical model for studying genetic variation in terms of restriction endonucleases.
A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotide...
Infinite allele model with varying mutation rate.
Nei, M, Chakraborty, R, Fuerst, P A
Available data suggest that the variation in mutation rate among protein loci follows the gamma distribution. Thus, taking into account this variation, formulae are developed for the distribution of...
Interlocus variation of genetic distance and the neutral mutation theory.
Theoretical distributions of genetic distance between reproductively isolated taxa are derived by means of computer simulation, taking into account mutation and random genetic drift. The...
Ancient Interlocus Exon Exchange in the History of the Hla-a Locus
The major histocompatibility complex (MHC) in humans and chimpanzees includes three classical class I loci, A, B and C, which encode glycoproteins expressed on the surface of all nucleated cells....
To explain the long-term persistence of polymorphic alleles (trans-specific polymorphism) at the major histocompatibility complex (MHC) loci in rodents and primates, a computer simulation study was...
A simple method is proposed for estimating the average number of nucleotide substitutions per site within and between populations for the case where a large number of individuals are examined for...
A New Method of Inference of Ancestral Nucleotide and Amino Acid Sequences
A statistical method was developed for reconstructing the nucleotide or amino acid sequences of extinct ancestors, given the phylogeny and sequences of the extant species. A model of nucleotide or...
Evolution of Antennapedia-Class Homeobox Genes
Antennapedia (Antp)-class homeobox genes are involved in the determination of pattern formation along the anterior-posterior axis of the animal embryo. A phylogenetic analysis of Antp-class...
Genetic Distances and Reconstruction of Phylogenetic Trees from Microsatellite DNA
Recently many investigators have used microsatellite DNA loci for studying the evolutionary relationships of closely related populations or species, and some authors proposed new genetic distance...
A Case of High Rate of Spontaneous Mutation Affecting Viability in DROSOPHILA MELANOGASTER
Kidwell, Margaret Gale, Kidwell, J. F., Nei, M.
A spontaneous lethal mutation rate approximately twenty to thirty times greater than normal has been discovered in second and third chromosomes derived from an irradiated isogenic line and paired...
Estimation of mutation rate from rare protein variants.
A method for estimating the mutation rate for protein loci from the number of rare alleles in the population is presented. It seems to have a number of advantages compared with Kimura and Ohta's...