Posttransplantation diabetes mellitus (PTDM) is a frequent complication in immunosuppressive therapy. To better understand the molecular events associated with PTDM we investigated the effect of...
Posttransplantation diabetes mellitus (PTDM) is a frequent complication in immunosuppressive therapy. To better understand the molecular events associated with PTDM we investigated the effect of...
BACKGROUND: The choroid plexus consists of highly differentiated epithelium and functions as a barrier at the interface of the blood-cerebrospinal-fluid (CSF). This tissue may therefore determine the...
BACKGROUND: The choroid plexus consists of highly differentiated epithelium and functions as a barrier at the interface of the blood-cerebrospinal-fluid (CSF). This tissue may therefore determine the...
Kel, A.E., Niehof, M., Matys, V., Zemlin, R., Borlak, J.
We report an application of machine learning algorithms that enables prediction of the functional context of transcription factor binding sites in the human genome. We demonstrate that our method...
HNF4 alpha and the Ca-Channel TRPC1 are novel disease candidate genes in diabetic nephropathy (2008)
OBJECTIVE-The nuclear receptor hepatic nuclear factor 40. (HNF4 alpha) is a master regulatory protein and an essential player in the control of a wide range of metabolic processes. Dysfunction of...
Background Aims: The orphan nuclear receptor HNF4 alpha is a member of the hepatic transcription factor network. This protein plays a pivotal role in liver development and hepatocellular...
Kel, A.E., Niehof, M., Matys, V., Zemlin, R., Borlak, J.
We report an application of machine learning algorithms that enables prediction of the functional context of transcription factor binding sites in the human genome. We demonstrate that our method...
Background Aims: The orphan nuclear receptor HNF4 alpha is a member of the hepatic transcription factor network. This protein plays a pivotal role in liver development and hepatocellular...
Chromatin immunoprecipitation-based identification of gene regulatory networks (2005)
Administered in critical doses, drugs and chemicals can damage organs and tissues by turning numerous genes on or off. Changes in the expression patterns of target genes indicate toxic action and are...
RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain (2005)
The orphan hepatic nuclear factor (HNF) HNF4alpha is of pivotal importance for liver development and hepatocellular differentiation and plays an essential role in a regulatory circuitry to control a...
An optimized method for the isolation and identification of membrane proteins (2003)
Lehner, I., Niehof, M., Borlak, J.
The purpose of this study was to develop a protocol suitable for membrane protein extraction from limited starting material and to identify appropriate conditions for two-dimensional (2-D) gel...
Niehof, M., Kubicka, S., Zender, L., Manns, M.P., Trautwein, C.
CCAAT/enhancer binding protein beta (C/EBP beta) also named liver-enriched transcriptional activating protein (LAP) is a member of the C/EBP family of transcription factors and is involved in...
Niehof, M., Streetz, K., Rakemann, T., Bischoff, S., Manns, M.P., Horn, F., ...
LAP/C/EBPbeta is a member of the C/EBP family of transcription factors and contributes to the regulation of the acute phase response in hepatocytes. Here we show that IL-6 controls LAP/C/EBPbeta gene...
Direct interaction and N-terminal phosphorylation of c-Jun by c-Mil/Raf.
Radziwill, G, Niehof, M, Rommel, C, Moelling, K
c-Mil is the avian homologue of the mammalian serine/threonine kinase c-Raf-1. c-Mil/Raf is a mediator of signal transduction leading to gene expression via the c-Jun DNA-binding site, AP-1. Here we...
CREB controls LAP/C/EBP beta transcription.
Niehof, M, Manns, M P, Trautwein, C
LAP/C/EBP beta is a member of the C/EBP family of transcription factors and is involved in hepatocyte-specific gene expression. Recently we showed that, besides its posttranscriptional regulation,...
Direct interaction and N-terminal phosphorylation of c-Jun by c-Mil/Raf.
Radziwill, G, Niehof, M, Rommel, C, Moelling, K
c-Mil is the avian homologue of the mammalian serine/threonine kinase c-Raf-1. c-Mil/Raf is a mediator of signal transduction leading to gene expression via the c-Jun DNA-binding site, AP-1. Here we...
CREB controls LAP/C/EBP beta transcription.
Niehof, M, Manns, M P, Trautwein, C
LAP/C/EBP beta is a member of the C/EBP family of transcription factors and is involved in hepatocyte-specific gene expression. Recently we showed that, besides its posttranscriptional regulation,...