M. Ohtsuki

Epidermal growth factor and transforming growth factor alpha specifically induce the activation- and hyperproliferation-associated keratins 6 and 16.

Jiang, C K, Magnaldo, T, Ohtsuki, M, Freedberg, I M, Bernerd, F, Blumenberg, M

Epidermal injury results in activation of keratinocytes which produce and respond to growth factors and cytokines and become migratory. Activated keratinocytes express a specific pair of keratin...

Solid phase synthesis of oligoribonucleotides using the 1-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl (Ctmp) group for the protection of the 2'-hydroxy functions and the H-phosphonate approach.

Sakatsume, O, Ohtsuki, M, Takaku, H, Reese, C B

The solid phase synthesis of oligoribonucleotides using the H-phosphonate approach and the 1-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl (Ctmp) and dimethoxytrityl (DMTr) groups,...

Optimal imaging techniques in the scanning transmission electron microscope: applications to biological macromolecules.

Ohtsuki, M, Crewe, A V

We show applications of the optimal imaging method to stained biological macromolecules. This optimal imaging method involves the following basic procedures: (i) for any given resolution, which is...

Disease-activated transcription factor: allergic reactions in human skin cause nuclear translocation of STAT-91 and induce synthesis of keratin K17.

Jiang, C K, Flanagan, S, Ohtsuki, M, Shuai, K, Freedberg, I M, Blumenberg, M

Epidermal keratinocytes have important immunologic functions, which is apparent during wound healing, in psoriasis, and in allergic and inflammatory reactions. In these processes, keratinocytes not...

Evidence for the involvement of protein kinase activity in transforming growth factor-beta signal transduction.

Ohtsuki, M, Massagué, J

Transforming growth factor-beta 1 (TGF-beta 1) rapidly increases the expression of junB transcription factor and plasminogen activator inhibitor-1 (PAI-1) and prevents the cell cycle-dependent...

Electron microscopy of fibers and discs of hemoglobin S having sixfold symmetry

Ohtsuki, M., White, S. L., Zeitler, E., Wellems, T. E., Fuller, S. D., Zwick, M., ...

Aggregated forms of deoxyhemoglobin S were examined with a field emission transmission electron microscope. Images of isolated helical fibers were obtained from sickled cell lysates stained directly...

Electron microscopy of negatively stained and freeze-etched high density lipoprotein-3 from human serum.

Ohtsuki, M, Edelstein, C, Sogard, M, Scanu, A M

High density lipoproteins of d = 1.12 to 1.21 g/ml from human serum (HDL3) were studied by electron microscopy with both negative staining and freeze-etching techniques. For the negatively stained...

Epidermal growth factor and transforming growth factor alpha specifically induce the activation- and hyperproliferation-associated keratins 6 and 16.

Jiang, C K, Magnaldo, T, Ohtsuki, M, Freedberg, I M, Bernerd, F, Blumenberg, M

Epidermal injury results in activation of keratinocytes which produce and respond to growth factors and cytokines and become migratory. Activated keratinocytes express a specific pair of keratin...

Solid phase synthesis of oligoribonucleotides using the 1-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl (Ctmp) group for the protection of the 2'-hydroxy functions and the H-phosphonate approach.

Sakatsume, O, Ohtsuki, M, Takaku, H, Reese, C B

The solid phase synthesis of oligoribonucleotides using the H-phosphonate approach and the 1-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl (Ctmp) and dimethoxytrityl (DMTr) groups,...

Optimal imaging techniques in the scanning transmission electron microscope: applications to biological macromolecules.

Ohtsuki, M, Crewe, A V

We show applications of the optimal imaging method to stained biological macromolecules. This optimal imaging method involves the following basic procedures: (i) for any given resolution, which is...

Disease-activated transcription factor: allergic reactions in human skin cause nuclear translocation of STAT-91 and induce synthesis of keratin K17.

Jiang, C K, Flanagan, S, Ohtsuki, M, Shuai, K, Freedberg, I M, Blumenberg, M

Epidermal keratinocytes have important immunologic functions, which is apparent during wound healing, in psoriasis, and in allergic and inflammatory reactions. In these processes, keratinocytes not...

Evidence for the involvement of protein kinase activity in transforming growth factor-beta signal transduction.

Ohtsuki, M, Massagué, J

Transforming growth factor-beta 1 (TGF-beta 1) rapidly increases the expression of junB transcription factor and plasminogen activator inhibitor-1 (PAI-1) and prevents the cell cycle-dependent...

Electron microscopy of fibers and discs of hemoglobin S having sixfold symmetry

Ohtsuki, M., White, S. L., Zeitler, E., Wellems, T. E., Fuller, S. D., Zwick, M., ...

Aggregated forms of deoxyhemoglobin S were examined with a field emission transmission electron microscope. Images of isolated helical fibers were obtained from sickled cell lysates stained directly...

Electron microscopy of negatively stained and freeze-etched high density lipoprotein-3 from human serum.

Ohtsuki, M, Edelstein, C, Sogard, M, Scanu, A M

High density lipoproteins of d = 1.12 to 1.21 g/ml from human serum (HDL3) were studied by electron microscopy with both negative staining and freeze-etching techniques. For the negatively stained...