M. P. Peppelenbosch

Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia (2006)

Diks, S.H., Wanders, R.J.A., Rygiel, A.M., Milano, F., Joore, J., ...

The precursor metaplastic mucosal lesion that predisposes for esophageal adenocarcinoma is Barrett's esophagus. Because the signal transduction events that occur in Barrett's esophagus are poorly...

Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN (2006)

Lowenberg, M, Verhaar, A.P., Bilderbeek, J., Marle, J. Van, Buttgereit, F., Peppelenbosch, M.P., ...

Although glucocorticoid (GC)-induced nongenomic effects have been reported, the underlying mechanisms remain unexplained. We previously described that lymphocyte-specific protein tyrosine kinase...

A promising action of riboflavin as a mediator of leukaemia cell death (2006)

Kodach, L., Gadelha, F.R., Bos, C., Cavagis, A.D.M., Aoyama, H., ...

Besides having a pivotal biological function as a component of coenzymes, riboflavin appears a promissing antitumoral agent, but the underlying molecular mechanism remains unclear. In this work, we...

Tetrahydroxyquinone induces apoptosis of leukemia cells through diminished survival signaling (2006)

Cavagis, A.D.M., Ferreira, C.V., Versteeg, H.H., Assis, C.F., Bos, C., Bleuming, S.A., ...

Objective. Tetrahydroxyquinone is a molecule best known as a primitive anticataract drug but is also a highly redox active molecule that can take part in a redox cycle with semiquinone radicals,...

A phase I trial with Transgenic bacteria expressing interleukin-10 in Crohn's disease (2006)

Braat, H., Rottiers, P., Hommes, D.W., Huyghebaert, N., Remaut, E., Remon, J.P., ...

Background & Aims: The use of living, genetically modified bacteria is an effective approach for topical delivery of immunomodulatory proteins. This strategy circumvents systemic side effects and...

Immunology of Crohn's disease (2006)

Braat, H., Peppelenbosch, M.P., Hommes, D.W.

The immense microbiological load of the gastrointestinal tract poses a daunting challenge for the mucosal immune system: whereas it should tolerate the vast number of commensal bacteria, it should...

Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity (2006)

Bos, C., Diks, S.H., Hardwick, J.C.H., Walburg, K.V., Peppelenbosch, M.P., Richel, D.J.

The rising incidence and poor prognosis of colorectal cancer have aroused substantial interest in novel chemopreventive strategies. Interestingly, treatment of ulcerative colitis with mesalazine,...

Hedgehog turns lipoproteins into janus-faced particles (2006)

Bijlsma, M.F., Spek, C.A., Peppelenbosch, M.P.

Hedgehog is an important morphogenetic signal during embryonic development. The molecule contains several hydrophobic moieties, including cholesterol and palmitoyl groups, apparently incompatible...

Hedgehog morphogen in cardiovascular disease (2006)

Bijlsma, M.F., Peppelenbosch, M.P., Spek, C.A.

In this review, we focus on the basic biology of the important developmental Hedgehog ( Hh) protein family, its general function in development, pathway mechanisms, and gene discovery and...

A dual role for 7-dehydrocholesterol reductase in regulating Hedgehog signalling? (2006)

Bijlsma, M.F., Peppelenbosch, M.P., Spek, C.A.

Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach (2006)

Bleuming, S.A., Kodach, L., Garcia Leon, M.J., Peppelenbosch, M.P., Reitsma, P.H., Hardwick, J.C.H., ...

Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A (2006)

Bos, C., Kodach, L., Diks, S.H., Santen, M.M. Van, Richel, D.J., ...

Repression of smoothened by patched-dependent (Pro-)Vitamin D3 secretion (2006)

Bijlsma, M.F., Spek, C.A., Zivkovic, D., Water, S. Van De, Rezaee, F., Peppelenbosch, M.P.

The developmentally important hedgehog (Hh) pathway is activated by binding of Hh to patched (Ptch1), releasing smoothened (Smo) and the downstream transcription factor glioma associated (Gli) from...

Infliximab induced T lymphocyte apoptosis in Crohn's disease (2005)

A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia (2005)

Milano, F., Rygiel, A., Rosmolen, W.D., ...

Consequence of functional Nod2 and T1r4 mutations on gene transcription in Crohn's disease patients (2005)

Braat, H., Stokkers, P.C.F., Hommes, T., Cohn, D., Vogels, E., Pronk, I., ...

Specific inhibition of c-Raf activity by semapimod induces clinical remission in severe Crohn's disease (2005)

Löwenberg, M., Verhaar, A., Blink, B. Van Den, Peppelenbosch, M.P., ...

Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn (2005)

LÃ¶wenberg, M., Tuynman, J.B., Bilderbeek, J., Gaber, T., Buttgereit, F., ...

A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia (2005)

Milano, F., Rygiel, A., Rosmolen, W.D., ...

Infliximab induced T lymphocyte apoptosis in Crohn's disease (2005)

Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn (2005)

Löwenberg, M., Tuynman, J.B., Bilderbeek, J., Gaber, T., Buttgereit, F., ...

Consequence of functional Nod2 and T1r4 mutations on gene transcription in Crohn's disease patients (2005)

Braat, H., Stokkers, P.C.F., Hommes, T., Cohn, D., Vogels, E., Pronk, I., ...

Specific inhibition of c-Raf activity by semapimod induces clinical remission in severe Crohn's disease (2005)

Löwenberg, M., Verhaar, A., Blink, B. Van Den, Peppelenbosch, M.P., ...

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation [research letter] (2004)

Bleuming, S.A., Hardwick, J.C.H., Schepman, B.L., Offerhaus, G.J.A., Keller, J.J., ...

COX-2 inhibition as a tool to treat and prevent colorectal cancer (2004)

Tuynman, J.B., Peppelenbosch, M.P., Richel, D.J.

T cell apoptosis and inflammatory bowel disease (2004)

Therapeutic modulation of signal transduction pathways (2004)

Lowenberg, M, Peppelenbosch, M.P., Hommes, D.W.

P38 mitogen activated protein kinase is involved in the downregulation of granulocyte CXC chemokine receptors 1 and 2 during human endotoxemia (2004)

Blink, B. Van Den, Branger, J., Weijer, S., Gupta, A., Peppelenbosch, M.P., ...

DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1 (2004)

Hardwick, J.C.H., Santen, H.M. Van, Peppelenbosch, M.P.

Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon (2004)

Hardwick, J.C.H., Bleuming, S.A., Ballester, I., Keller, J.J., ...

Molecular mechanism of violacein-mediated human leukemia cell death (2004)

Ferreira, C.V., Bos, C.L., Versteeg, H.H., Justo, G.Z., Duran, N., Peppelenbosch, M.P.

LPS signal transduction: the picture is becoming more complex (2004)

Diks, S.H., Richel, D.J., Peppelenbosch, M.P.

Homeostasis of the adult colonic epithelium: a role for morphogens (2004)

Bleuming, S.A., Roberts, D.J., Peppelenbosch, M.P.

Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function (2004)

Braat, H., Jong, E.C. De, Kapsenberg, M.L., Peppelenbosch, M.P., ...

Prostanoids and prostanoid receptors in signal transduction (2004)

Bos, C., Richel, D.J., Ritsema, T., Peppelenbosch, M.P., Versteeg, H.H.

P38 mitogen activated protein kinase is involved in the downregulation of granulocyte CXC chemokine receptors 1 and 2 during human endotoxemia (2004)

Blink, B. Van Den, Branger, J., Weijer, S., Gupta, A., Peppelenbosch, M.P., ...

Hedgehog: an unusual signal transducer (2004)

Bijlsma, M.F., Spek, C.A., Peppelenbosch, M.P.

Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathways (2004)

Versteeg, H.H., Spek, C.A., Peppelenbosch, M.P., Richel, D.J.

FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production (2004)

Versteeg, H.H., Spek, C.A., Slofstra, S.H., Diks, S.H., Richel, D.J., Peppelenbosch, M.P.

Concerted action of coagulation factors on cell survival [letter] (2004)

Versteeg, H.H., Richel, D.J., Peppelenbosch, M.P., Spek, C.A.

Coagulation factors VIIa and Xa inhibit apoptosis and anoikis (2004)

Versteeg, H.H., Spek, C.A., Richel, D.J., Peppelenbosch, M.P.

LPS signal transduction: the picture is becoming more complex (2004)

Diks, S.H., Richel, D.J., Peppelenbosch, M.P.

Prostanoids and prostanoid receptors in signal transduction (2004)

Bos, C., Richel, D.J., Ritsema, T., Peppelenbosch, M.P., Versteeg, H.H.

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation [ research letter] (2004)

Bleuming, S.A., Hardwick, J.C.H., Schepman, B.L., Offerhaus, G.J.A., Keller, J.J., ...

Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function (2004)

Braat, H., Jong, E.C. De, Kapsenberg, M.L., Peppelenbosch, M.P., ...

Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon (2004)

Hardwick, J.C.H., Bleuming, S.A., Ballester, I., Keller, J.J., ...

Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets (2003)

Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract (2003)

Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia (2003)

Branger, J., Blink, B. Van Den, Weijer, S., Gupta, A., Hack, C.E., ...

Activation of the canonical beta-catenin pathway by histamine (2003)

Diks, S.H., Hardwick, J.C.H., Diab, R.M., Santen, M.M. Van, Versteeg, H.H., ...

Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract (2003)

Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia (2003)

Branger, J., Blink, B. Van Den, Weijer, S., Gupta, A., Hack, C.E., ...

Tissue factor signal transduction in angiogenesis (2003)

Versteeg, H.H., Peppelenbosch, M.P., Spek, C.A.

Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease (2003)

Braat, H., Versteeg, H.H., Bauer, C.A., Hoedemaeker, I., ...

In silico tissue factor analysis: a bit-to-bit comparison (2003)

Peppelenbosch, M.P., Versteeg, H.H., Spek, C.A.

Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease (2003)

Braat, H., Versteeg, H.H., Bauer, C.A., Hoedemaeker, I., ...

Interleukin-10-based therapy for inflammatory bowel disease (2003)

Braat, H., Peppelenbosch, M.P., Hommes, D.W.

Activation of the canonical beta-catenin pathway by histamine (2003)

Diks, S.H., Hardwick, J.C.H., Diab, R.M., Santen, M.M. Van, Versteeg, H.H., ...

Regulation of the p21 Ras-MAP kinase pathway by factor VIIa (2003)

Versteeg, H.H., Bresser, H.L., Spek, C.A., Richel, D.J., Peppelenbosch, M.P.

Activation of the canonical beta-catenin pathway by histamine (2003)

Diks, S.H., Hardwick, J.C.H., Diab, R.M., Santen, H.M. Van, Versteeg, H.H., ...

Interleukin-10-based therapy for inflammatory bowel disease (2003)

Braat, H., Peppelenbosch, M.P., Hommes, D.W.

Regulation of the p21 Ras-MAP kinase pathway by factor VIIa (2003)

Versteeg, H.H., Bresser, H.L., Spek, C.A., Richel, D.J., Peppelenbosch, M.P.

Activation of the canonical beta-catenin pathway by histamine (2003)

Diks, S.H., Hardwick, J.C.H., Diab, R.M., Santen, H.M. Van, Versteeg, H.H., ...

Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets (2003)

Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract (2003)

Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia (2003)

Branger, J., Blink, B. Van Den, Weijer, S., Gupta, A., Hack, C.E., ...

Activation of the canonical beta-catenin pathway by histamine (2003)

Diks, S.H., Hardwick, J.C.H., Diab, R.M., Santen, M.M. Van, Versteeg, H.H., ...

Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease (2003)

Braat, H., Versteeg, H.H., Bauer, C.A., Hoedemaeker, I., ...

FVIIa : TF induces activation of the JAK/STAT pathway; Inflammatory signaling via non-inflammatory receptors (2002)

Versteeg, H.H., Slofstra, S.H., Peppelenbosch, M.P.

VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation (2002)

Versteeg, H.H., Sorensen, B.B., Slofstra, S.H., Stam, J.C., ...

Farnesyl Protein Transferase Inhibition Interferes with Activation of MAP Kinase Family Members in Human Peripheral Blood Monocytes (2002)

Vervenne, W.L., Bos, C.L., Rens, L.S., Peppelenbosch, M.P., Richel, D.J.

Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia (2002)

Branger, J., Blink, B. Van Den, Weijer, S., Madwed, J., Bos, C.L., Gupta, A., ...

Feed a cold, starve a fever? (2002)

Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease (2002)

Hove, T. Ten, Montfrans, C. Van, Peppelenbosch, M.P.

Treating Crohn's disease by inducing T lymphocyte apoptosis (2002)

From extracellular to intracellular targets, inhibiting MAP kinases in treatment of Crohn's disease (2002)

Blink, B. Van Den, Hove, T. Ten, Peppelenbosch, M.P.

Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract (2002)

Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis (2002)

Hove, T. Ten, Blink, B. Van Den, Pronk, I., Drillenburg, P., Peppelenbosch, M.P.

Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia (2002)

Branger, J., Blink, B. Van Den, Weijer, S., Madwed, J., Bos, C.L., Gupta, A., ...

Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis (2002)

Hove, T. Ten, Blink, B. Van Den, Pronk, I., Drillenburg, P., Peppelenbosch, M.P.

Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis (2002)

Camoglio, L., Juffermans, N.P., Peppelenbosch, M.P., Velde, A.A. Te, ...

Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract (2002)

Farnesyl Protein Transferase Inhibition Interferes with Activation of MAP Kinase Family Members in Human Peripheral Blood Monocytes (2002)

Vervenne, W.L., Bos, C.L., Rens, L.S., Peppelenbosch, M.P., Richel, D.J.

VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation (2002)

Versteeg, H.H., Sorensen, B.B., Slofstra, S.H., Stam, J.C., ...

Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis (2002)

Camoglio, L., Juffermans, N.P., Peppelenbosch, M.P., Velde, A.A. Te, ...

VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation (2002)

Versteeg, H.H., Sorensen, B.B., Slofstra, S.H., Stam, J.C., ...

Farnesyl Protein Transferase Inhibition Interferes with Activation of MAP Kinase Family Members in Human Peripheral Blood Monocytes (2002)

Vervenne, W.L., Bos, C.L., Rens, L.S., Peppelenbosch, M.P., Richel, D.J.

Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia (2002)

Branger, J., Blink, B. Van Den, Weijer, S., Madwed, J., Bos, C.L., Gupta, A., ...

Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract (2002)